Editorial for Special Issue "Antibiotic Combination Therapy: A Strategy to Overcome Bacterial Resistance".

Multidrug-resistant (MDR) bacterial infections have emerged as a critical global health threat, challenging the efficacy of existing antibiotics and undermining advances in modern medicine [...

Targeting Cutaneous Leishmaniasis with Thiadiazine Thione Derivatives: An In Vivo Study of Its Anti-Inflammatory, Anti-Pyretic, Anti-Nociceptive, and Anti-Sedative Properties.

Thiadiazine thione (THTT) has gained significant interest owing to its pharmacological potentials, particularly its antiparasitic and anti-inflammatory properties. Leishmaniasis is a clinical syndrome caused by infection with species and is associated with an inflammatory response and nociception. The available treatments against leishmaniasis are inadequate, as they are associated with high cost, toxicity, and increased resistance.

Advancements in Cardiac Amyloidosis Treatment.

Cardiac amyloidosis (CA) is a progressive condition resulting from the deposition of amyloid fibrils in the heart, which leads to severe diastolic dysfunction and restrictive cardiomyopathy. The disease has two main subtypes: light-chain and transthyretin (TTR) CA, with the latter subdivided into wild-type and hereditary forms. Despite advances in diagnostic imaging, early detection remains a challenge due to non-specific symptoms that mimic other cardiac conditions.

The Combination Effect of Strain (AUMC 10620) and Avermectin (B1a and B1b) on Control Citrus Nematode (Cobb) Under Laboratory and Field Conditions.

This study investigates the nematicidal efficacy of strain (AUMC 10620) combined with avermectin (B1a and B1b) against the citrus nematode , both in vitro and in vivo. Laboratory experiments tested four concentrations of (2.5, 5, 10, and 15 × 10 spores/mL) mixed with 250 ppm avermectin, assessing their effects on nematode juveniles (J2) and eggs.

Proline Promotes Drought Tolerance in Maize.

Drought stress significantly affects maize ( L.) growth by disrupting vital physiological and biochemical processes. This study investigates the potential of proline supplementation to alleviate drought-induced stress in maize plants.

Antibacterial Potential of Honeybee Venom and Extracellular Metabolites Against Multidrug-Resistant Pathogenic Bacteria.

Antimicrobial resistance (AMR) poses a critical global health threat, driving the search for alternative treatments to conventional antibiotics. In this study, the antibacterial properties of honeybee venom (BV) and fungal red dye (RD) were evaluated against three multidrug-resistant bacterial pathogens. Extracts of BV and RD exhibited dose-dependent antibacterial activity against the three tested bacteria, with their strongest effectiveness against (minimum inhibitory concentrations [MIC] = 3.

Lifecycle Completion and Reproductive Improvement of (Stephens) (Neuroptera: Chrysopidae), Following a Prey Shift Routine During Larval Development.

The present study aimed to assess the lifecycle completion and reproductive improvement of green lacewing, (Stephens), larval instars in a prey shift routine while alternatively feeding on motiles of two-spotted spider mite, Koch (natural prey), and the eggs of almond moth, (Walker) (factitious prey). The results showed that . larvae successfully completed their lifecycle and life span in the treatments where either the 2nd (T2) or 3rd (T3) instar larvae were fed with the eggs of .

Knowledge, Attitude, and Practice in Dental Trauma Management Among Schoolteachers in Taif, Saudi Arabia.

In Saudi Arabia, dental trauma is regarded as one of the most important issues affecting schoolchildren. This study evaluated Saudi Arabian schoolteachers' knowledge, attitude, and practice regarding emergency dental trauma management. A cross-sectional study was conducted on 263 schoolteachers from 25 schools; 50.

Toxoplasmosis Knowledge and Preventive Behaviours Among Pregnant Women in Jeddah, Saudi Arabia: A Cross-Sectional Study.

Toxoplasmosis is an infection caused by the parasite and is considered asymptomatic in most cases. In pregnant women, however, the disease can be transmitted to the foetus, causing severe congenital consequences. Congenital toxoplasmosis can be avoided by practising simple preventive lifestyle measures during pregnancy.

Prevalence of Being Obese, Overweight, and Underweight Among Jordanian Children and Adolescents Based on International Growth Standards.

Objectives: The rise of obesity and other nutrition-related conditions among children and adolescents is a global challenge, particularly in the Middle East. This study aimed to determine the prevalence of being underweight, overweight, and obese among Jordanian children and adolescents using the body mass index (BMI) percentiles of the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) standards.

Methods: This retrospective cross-sectional/longitudinal study analyzed 58,474 (42.

The Role of the Discharge Planning Team on the Length of Hospital Stay and Readmission in Patients with Neurological Conditions: A Single-Center Retrospective Study.

Emerging evidence highlights the critical role of discharge planning teams in enhancing patient care. However, there is lack of data regarding how the implementation of a discharge planning system influences the length of stay (LOS) in hospital and readmission rates among patients with neurological diseases. We conducted a retrospective analysis to examine the effects of discharge planning application on the LOS and readmission rates for patients admitted under the neurology service in Saudi Arabia.

Journey of Hope for Patients with Fibromyalgia: From Diagnosis to Self-Management-A Qualitative Study.

Background/objectives: Fibromyalgia syndrome (FMS) is a chronic, debilitating condition characterized by widespread pain, fatigue, and psychological distress. There is a lack of qualitative studies on the unique experiences of patients with FMS in Arab countries, particularly through social media. Despite the availability of diagnostic criteria, diagnosing and managing patients remains challenging.

Prevalence of and Factors Associated with Hypertension Among Bank Employees: A Cross-Sectional Study in Saudi Arabia.

: Hypertension (HTN) is one of the most common non-communicable medical conditions and the leading preventable risk factor for early mortality worldwide. As a result of their exposure to sedentary work and job strain, bank employees comprise an occupational group at risk for HTN. Due to the lack of previous research addressing this issue in Saudi Arabia, this study aimed to assess the prevalence of HTN and its associated factors among bankers in the Qassim region, Saudi Arabia.

Stress and Burnout Among Anesthesia Technologists, Technicians, and Trainees: A Cross-Sectional Study in a Tertiary Hospital in Saudi Arabia.

Occupational burnout poses a significant burden to healthcare personnel, institutions, and service users. Anesthesia technologists and technicians work in the shadow of the perioperative team, and a lack of attention to anesthesia support personnel may pose a significant risk to their wellbeing and the quality of care delivered. To date, only a few studies have investigated the prevalence of burnout among anesthesia technologists and technicians worldwide and in Saudi Arabia.

Healthcare Priorities, Barriers, and Preferences According to a Community Health Needs Assessment in Jazan, Saudi Arabia: A Cross-Sectional Study.

: Community needs assessments can provide valuable insights concerning the health of communities. This study aims to measure health priorities according to community members in Jazan, Saudi Arabia, to assess healthcare service utilization, barriers to accessing these services, and preferences for utilizing government or private healthcare services. : Multistage sampling was utilized to reach a sample of adults in community settings.

Exploring Social Support and Quality of Life Among Mothers of Children with Autism Spectrum Disorders: A Cross-Sectional Study.

: Mothers of children with autism spectrum disorder (ASD) often experience significant stress, which can adversely affect their quality of life (QoL) and increase their reliance on social support. This study aimed to explore the relationship between social support and QoL among mothers of ASD children and identify associated factors. : A cross-sectional study was conducted from December 2022 to March 2023, involving 218 mothers of ASD children in Saudi Arabia.

Unlocking the Potential of RNA Sequencing in COVID-19: Toward Accurate Diagnosis and Personalized Medicine.

COVID-19 has caused widespread morbidity and mortality, with its effects extending to multiple organ systems. Despite known risk factors for severe disease, including advanced age and underlying comorbidities, patient outcomes can vary significantly. This variability complicates efforts to predict disease progression and tailor treatment strategies.

Determinants of Success in Revision Cochlear Implant Surgeries: A Comprehensive Evaluation of Patient, Surgical, and Radiological Factors.

This study aims to evaluate factors influencing revision cochlear implant surgeries, including patient demographics, surgical techniques, and radiological findings. The main aim was to identify factors influencing surgical success to inform clinical treatment and enhance patient outcomes. This cross-sectional study included adult patients over the age of 18 who underwent revision cochlear implant surgery due to implant-related complications.

Explainable AI in Diagnostic Radiology for Neurological Disorders: A Systematic Review, and What Doctors Think About It.

Artificial intelligence (AI) has recently made unprecedented contributions in every walk of life, but it has not been able to work its way into diagnostic medicine and standard clinical practice yet. Although data scientists, researchers, and medical experts have been working in the direction of designing and developing computer aided diagnosis (CAD) tools to serve as assistants to doctors, their large-scale adoption and integration into the healthcare system still seems far-fetched. Diagnostic radiology is no exception.

Prevalence and Molecular Characterization of Carbapenemase-Producing Multidrug-Resistant Bacteria in Diabetic Foot Ulcer Infections.

Diabetic foot ulcers (DFUs) represent severe complications in diabetic patients, often leading to chronic infections and potentially resulting in nontraumatic lower-limb amputations. The increasing incidence of multidrug-resistant (MDR) bacteria in DFUs complicates treatment strategies and worsens patient prognosis. Among these pathogens, carbapenemase-producing pathogens have emerged as particularly concerning owing to their resistance to β-lactam antibiotics, including carbapenems.

DeepGenMon: A Novel Framework for Monkeypox Classification Integrating Lightweight Attention-Based Deep Learning and a Genetic Algorithm.

: The rapid global spread of the monkeypox virus has led to serious issues for public health professionals. According to related studies, monkeypox and other types of skin conditions can spread through direct contact with infected animals, humans, or contaminated items. This disease can cause fever, headaches, muscle aches, and enlarged lymph nodes, followed by a rash that develops into lesions.

Age predicts peak gamma frequency and N1 amplitude of visual evoked potential.

The current study investigated whether the age of healthy adults could predict the peak gamma frequency and the peak amplitudes of VEP components (N1, P2). 49 healthy participants (aged between 19 and 52 years) underwent EEG recordings during a visual task eliciting clear gamma frequency oscillations and VEP activities. After eliminating noisy and outlier data, data from 41 participants were analysed using simple linear regression.

Network Analysis of Psychological Empowerment, Need for Cognition, and Academic Self-Efficacy among Graduate Students.

The present study employed network analysis to explore the interrelationships between academic self-efficacy, psychological empowerment, and the need for knowledge at the symptom level among graduate students. Three hundred fifty-three graduate students from King Faisal University, Hofuf, Saudi Arabia (63.5% male, 72.

Cellular plasticity and non-small cell lung cancer: role of T and NK cell immune evasion and acquisition of resistance to immunotherapies.

Lung cancer is a leading global cause of mortality, with non-small cell lung cancer (NSCLC) accounting for a significant portion of cases. Immune checkpoint inhibitors (ICIs) have transformed NSCLC treatment; however, many patients remain unresponsive. ICI resistance in NSCLC and its association with cellular plasticity, epithelial-mesenchymal transition (EMT), enhanced adaptability, invasiveness, and resistance is largely influenced by epigenetic changes, signaling pathways, tumor microenvironment, and associated immune cells, fibroblasts, and cytokines.