From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment.

Nanoparticle technology has revolutionized breast cancer treatment by offering innovative solutions addressing the gaps in traditional treatment methods. This paper aimed to comprehensively explore the historical journey and advancements of nanoparticles in breast cancer treatment, highlighting their transformative impact on modern medicine. The discussion traces the evolution of nanoparticle-based therapies from their early conceptualization to their current applications and future potential.

Severe gastrointestinal symptoms during first year after laparoscopic cholecystectomy.

Background & Objective: Many patients after cholecystectomy, develop gastrointestinal (GI) symptoms and are worried. The objective of this study was to find out the risk factors for severe GI symptoms following laparoscopic cholecystectomy (LC) during first year of follow-up.

Methods: It is a multi-center prospective observational study.

Dates fruit effects on dyslipidemia among patients with Type-2 diabetes mellitus: A systematic review and meta-analysis of randomized trials.

Objectives: Dyslipidemias are major risk factors for cardiovascular disease, and other comorbidities. The focus on food and nutrition to prevent and treat cardiovascular risk factors including dyslipidemia is a paradigm shift. This is the first meta-analysis to assess the association of dates fruit and dyslipidemia in Type-2 diabetes.

Finite Element Analysis (FEA) for Influence of Variation in Dental Implant Dimensions (Length and Diameter) on Peri-implant Bone Stress/Strain Distribution: A Systematic Review.

Background & Objective: Currently, there are many implants in clinical use, making it hard to choose the right one for the patient. The success rate of an implant depends on its diameter, length, and direction of insertion in bone. In implant dentistry, Finite Element Analysis (FEA) simulates intraoral conditions in vitro and analyzes the effects of implant material, diameter, size, and other components related to oral structure on the implant and peri-implant tissues.

Examining factor structure and psychometric properties of Ethical Leadership Questionnaire with Healthcare Professionals in Saudi Arabia.

Objective: The study aimed to examine the factor structure and psychometric properties of ethical leadership questionnaire (ELQ) by using a healthcare professional sample in Saudi Arabia.

Methods: A cross-sectional study was conducted, and a total of 387 healthcare professionals completed the 15-items ELQ questionnaire between 18 October, 2023 and 17 January, 2024. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and a reliability test were performed on the obtained data.

Study protocol for a randomized control trial investigating the effectiveness of a multifaceted mHealth approach on adherence to antihypertensive treatment among patients in Pakistan.

Background & Objectives: Poor medication adherence is an essential contributor to Pakistan's high prevalence of uncontrolled hypertension. This study will be aimed to assess the efficacy of a one-of-a-kind developed intervention in improving medication adherence and treatment outcomes in hypertension patients.

Methods: Twleve months duration long randomized controlled trial from January to December 2021 will be carried out at Shaikh Zayed Medical Complex (SZMC), Lahore.

Prophylactic vs therapeutic blood transfusions impact on pregnant sickle cell patients.

Objective: To observe the fetomaternal outcome of therapeutic versus prophylactic blood transfusions in patients with sickle cell disease (SCD) during pregnancy.

Method: This single-center retrospective observational study was conducted on consecutive pregnant women with SCD between January 2018 and December 2020. All the pregnant women with SCD were included in this study.

Retrospective Analysis of Antibiotic Resistance Patterns of Uropathogenic With Focus on Extended-Spectrum -Lactamase at a Tertiary Central Hospital in Saudi Arabia.

Background And Aims: Urinary tract infections (UTIs) are a prevalent bacterial infection that has substantial implications for healthcare on a global scale. () is a gram-negative rod responsible for most UTI cases. ESBL-producing is widely recognized as a significant contributor to antibiotic resistance.

Developing and validating a scale to measure perceived barriers to prosthodontics treatments among partially edentulous patients.

Background: People experiencing tooth loss need dental prostheses to preserve the integrity of their oral structures and replace the missing teeth. Patient-related outcome measures (PROMs) for perceived barriers to prosthodontics treatment are scarce in the literature.

Aims: The aim of this study was to develop a comprehensive scale to identify and measure barriers to prosthodontic treatment as perceived by partially edentulous patients.

Identifying targets for antibiotic stewardship interventions in pediatric patients in Punjab, Pakistan: point prevalence surveys using AWaRe guidance.

Introduction: Surveillance of antibiotic use is crucial for identifying targets for antibiotic stewardship programs (ASPs), particularly in pediatric populations within countries like Pakistan, where antimicrobial resistance (AMR) is escalating. This point prevalence survey (PPS) seeks to assess the patterns of antibiotic use in pediatric patients across Punjab, Pakistan, employing the WHO AWaRe classification to pinpoint targets for intervention and encourage rational antibiotic usage.

Methods: A PPS was conducted across 23 pediatric wards of 14 hospitals in the Punjab Province of Pakistan using the standardized Global-PPS methodology developed by the University of Antwerp.

Immediate and Intermediate-Term Outcomes of Infants With Transposition of Great Arteries Who Underwent Balloon Atrial Septostomy in Sudan.

Transposition of great arteries (TGA) is a critical congenital heart disease leading to a fatal outcome if timely management is not provided. Management in low-income countries is challenging. A retrospective analysis was carried out at Sudan Heart Center for infants with TGA who underwent balloon atrial septostomy (BAS) from January 2010 to December 2020.

Duration, score, and timing: factors influencing the success of offensive transitions in top, marginal, and emerging football leagues.

Objective: The study aimed to increase our understanding of offensive transitions in football, focusing on the time spent executing them and how it is influenced by the period in which they occur and the instant score. The objective is to understand its temporal variables and how they influence the unfolding of the scoreline during a match.

Methodology: This study analyzes 1,649 goals resulting from offensive transitions in 1,151 games across three leagues categories: Top, Marginal, and Emerging leagues.

Improving stabilization of α-tocopherol and α-tocopheryl acetate against oxidation, light and UV radiation by complexation with β-cyclodextrin and starch.

Unlabelled: Despite the remarkably high antioxidant activity of tocopherols, their applications in the food industry are limited because of their instability under various conditions. Complexes of α-tocopherol (α-TQ) or α-tocopheryl acetate (α-TQA) with β-cyclodextrin (β-CD) or starch were prepared and characterized by UV-vis, IR and thermal analysis. Oxidative stability of α-TQ and α-TQA against HO was 74.

The Mediating Role of Cognitive Reappraisal on Bedtime Procrastination and Sleep Quality in Higher Educational Context: A Three-Wave Longitudinal Study.

Background: While bedtime procrastination is commonly associated with adverse outcomes such as poor sleep quality, the mechanisms mediating these effects remain underexplored. Grounded in the Self-Regulation Model of Behavior and the Transactional Model of Stress and Coping, this study examines the mediating role of cognitive reappraisal in the relationship between bedtime procrastination and sleep quality over time.

Methods: Employing a longitudinal design, the study examined the progression of bedtime procrastination, cognitive reappraisal, and sleep quality among university students at three distinct time points throughout an academic semester.

Knowledge and Awareness About the Basics of Cardiopulmonary Resuscitation in the Saudi Population.

Introduction According to the World Health Organization (WHO), cardiovascular diseases are the leading cause of death globally, accounting for approximately 17 million deaths annually, with sudden cardiac arrest (SCA) as a significant contributor to this alarming statistic. SCA, the abrupt loss of heart function, is a critical medical emergency that requires early recognition and immediate cardiopulmonary resuscitation (CPR) for the effective resuscitation of victims. Various studies have shown a low level of knowledge regarding CPR in the community.

Awareness of Peri-Implantitis Among General Dental Practitioners in Southern Saudi Arabia: A Cross-Sectional Study.

Aim And Background: The success of dental implants is contingent upon various biological conditions, and any lapse in meeting these criteria can lead to complications such as peri-implantitis or implant failure. The objective of this research is to evaluate the level of understanding regarding peri-implant among general dentists practicing in Saudi Arabia.

Materials And Methods: A quantitative approach was employed, utilizing an online questionnaire distributed to general dental practitioners (GDPs) in Saudi Arabia.

Partial directed coherence analysis of resting-state EEG signals for alcohol use disorder detection using machine learning.

Introduction: Excessive alcohol consumption negatively impacts physical and psychiatric health, lifestyle, and societal interactions. Chronic alcohol abuse alters brain structure, leading to alcohol use disorder (AUD), a condition requiring early diagnosis for effective management. Current diagnostic methods, primarily reliant on subjective questionnaires, could benefit from objective measures.

Corneal Epithelial Thickness Mapping in Healthy Population Corneas Using MS-39 Anterior Segment Optical Coherence Tomography.

Purpose: The corneal epithelium is the outermost layer of the cornea. It plays a vital role in both normal and pathological conditions of the eye surface and serves as a protective layer. This study aimed to evaluate corneal epithelial thickness (ET) and create a normative database of corneal ET for pediatric and adult age groups using MS-39 AS-OCT.

Correction: Novel pyrimidine linked acyl thiourea derivatives as potent α-amylase and proteinase K inhibitors: design, synthesis, molecular docking and ADME studies.

[This corrects the article DOI: 10.1039/D4RA05799F.].

Crafting the architecture of biomass-derived activated carbon electrochemical insights for supercapacitors: a review.

Escalating energy demands have often ignited ground-breaking innovations in the current era of electrochemical energy storage systems. Supercapacitors (SCs) have emerged as frontrunners in this regard owing to their exclusive features such ultra-high cyclic stability, power density, and ability to be derived from sustainable sources. Despite their promising attributes, they typically fail in terms of energy density, which poses a significant hindrance to their widespread commercialization.

SERS profiling of blood serum filtrate components from patients with type II diabetes using 100 kDa filtration devices.

Blood carries some of the most valuable biomarkers for disease screening as it interacts with various tissues and organs in the body. Human blood serum is a reservoir of high molecular weight fraction (HMWF) and low molecular weight fraction (LMWF) proteins. The LMWF proteins are considered disease marker proteins and are often suppressed by HMWF proteins during analysis.

Fusidic Acid and Lidocaine-Loaded Electrospun Nanofibers as a Dressing for Accelerated Healing of Infected Wounds.

Introduction: Wound treatment is a significant health burden in any healthcare system, which requires proper management to minimize pain and prevent bacterial infections that can complicate the wound healing process.

Rationale: There is a need to develop innovative therapies to accelerate wound healing cost-effectively. Herein, two polymer-based nanofibrous systems were developed using poly-lactic-co-glycolic-acid (PLGA) and polyvinylpyrrolidone (PVP) loaded with a combination of an antibiotic (Fusidic acid, FA) and a local anesthetic (Lidocaine, LDC) via electrospinning technique for an expedited healing process by preventing bacterial infections while reducing the pain sensation.

Minimising diagnostic error in paediatric critical care: a checklist approach.

Caring for critically ill children presents unique challenges due to their rapid deterioration and the need for immediate, complex interventions. The assessment, diagnosis and treatment of deteriorating paediatric patients require a comprehensive and holistic, systematic approach. However, the dynamic nature of critical illness and the need for stabilisation can often lead to missed opportunities for assessment and intervention.

Near-Field Mixing in a Coaxial Dual Swirled Injector.

Improving mixing between two coaxial swirled jets is a subject of interest for the development of next generations of fuel injectors. This is particularly crucial for hydrogen injectors, where the separate introduction of fuel and oxidizer is preferred to mitigate the risk of flashback. Raman scattering is used to measure the mean compositions and to examine how mixing between fuel and air streams evolves along the axial direction in the near-field of the injector outlet.