Synthesis of biopolymer blends nanocomposites embedded with mono-(Ag, Fe) and bi-(Ag-Fe) metallic nanoparticles using an eco-friendly approach for antimicrobial activities.

Plant-mediated solution casting is used to develop eco-friendly polymer blend nanocomposites from polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) doped with Silver (Ag), Ferrous (Fe) monometallic and Silver-Ferrous (Ag-Fe) bimetallic nanoparticles (NPs). These nanocomposites were studied to understand their electromagnetic interface (EMI) shielding efficiency and antimicrobial activities, besides evaluating their physical and chemical properties. The Fourier transform infrared (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and energy dispersive X-ray (EDX) characterization techniques were used to examine the interactions between the polymers, the presence of silver and ferrous particles in the composites, the crystallinity shift, the surface morphology, the shape and size of the nanoparticles and the distribution of the nanoparticles in the composites.

The role of WO and dopants (ZrO and SiO) on CeO-based nanostructure catalysts in the selective oxidation of benzyl alcohol to benzaldehyde under ambient conditions.

Herein, the efficacy of WO-promoted CeO-SiO and CeO-ZrO mixed oxide catalysts in the solvent-free selective oxidation of benzyl alcohol to benzaldehyde using molecular oxygen as an oxidant is reported. We evaluated the effects of the oxidant and catalyst concentration, reaction duration, and temperature on the reaction with an aim to optimize the reaction conditions. The as-prepared CeO, CeO-ZrO, CeO-SiO, WO/CeO, WO/CeO-ZrO, and WO/CeO-SiO catalysts were characterized by X-ray diffraction (XRD), N adsorption-desorption, Raman spectroscopy, temperature-programmed desorption of ammonia (TPD-NH), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM).

Woodfordia fruticosa (L.) Kurz: in vitro biotechnological interventions and perspectives.

Woodfordia fruticosa (L.) Kurz is a woody medicinal shrub (Lythraceae) commonly known as the "fire flame bush." W.

Design, synthesis of benzimidazole tethered 3,4-dihydro-2H-benzo[e] [1, 3] oxazines as anticancer agents.

A series of novel 3-(1H-benzo[d]imidazol-2-yl)-3,4-dihydro-2H-benzo[e][1,3] oxazine analogues synthesized through a two-step synthetic protocol. The structure of the compounds were established by interpretation H NMR, C NMR and Mass spectral data recorded after purification. All the title compounds 4a-k were screened for their in vitro anti-cancer activity against two breast cancer cell lines MCF 7 and MDA-MB-231 by using Doxorubicin as standard reference.

Porous carbon supported calcium oxide for CO adsorption and separation of CO/CH.

Calcium oxide incorporated porous carbon materials were synthesized by the impregnation method to study CO adsorption and separation of CO/CH. The X-ray diffraction, Raman analysis, N isotherms at 77 K, and SEM with EDX analysis were used to characterize synthesized materials. XRD and N isotherm results have confirmed that synthesized carbon has porosity, and EDX analysis has reported that the presence of CaO on porous carbon.

Indole-fused spirochromenes as potential anti-tubercular agents: design, synthesis and in vitro evaluation.

As part of an ongoing effort to develop new anti-tubercular agents, a series of novel indole-fused spirochromene hybrids (7a-l) were efficiently synthesized in excellent yields by the popular 'Fisher-Indole synthesis' approach. The structure elucidation of the target compounds was carried out by different spectral techniques including H-NMR, C-NMR, ESI Mass, and FTIR analysis. Additionally, the proposed structure of 7i was proved by single-crystal X-ray analysis.

Microwave-assisted synthesis, biological evaluation and molecular docking studies of new coumarin-based 1,2,3-triazoles.

Coumarin-based 1,4-disubstituted 1,2,3-triazole derivatives were synthesized using a highly efficient, eco-friendly protocol a copper(i)-catalyzed click reaction between various substituted arylazides and terminal alkynes. The synthetic route was easy to access and gave excellent yields under microwave irradiation conditions compared to the conventional heating route. The structures of all the compounds were characterized by IR, H NMR, C NMR spectroscopy and mass spectrometry.

Facile synthesis, characterization and enhanced catalytic reduction of 4-nitrophenol using NaBH by undoped and Sm, Gd, Hf doped LaO nanoparticles.

This work focuses on the synthesis of undoped and doped lanthanum oxide nanoparticles (LaO NPs) by a simple co-precipitation method for the catalytic reduction of 4-nitrophenol (4-NP) using NaBH as a reducing agent. Their optical properties, morphologies, structure, chemical compositions and electronic properties were carefully characterized by XRD, FTIR, SEM, TEM, PL and UV-visible absorption spectroscopy. The SEM and TEM images showed various shape morphologies and sizes of the particles.

Synthesis of 8',11'-dihydrospiro[cyclohexane-1,2'-oxepino[2,3-] chromen]-4'(3')-ones with ring closing metathesis as a key step.

A series of novel hybrid molecular entities incorporating various spiro chromanone scaffolds onto the benzannulated oxepine core moiety were synthesised using allylation, Claisen rearrangement, Kabbe condensation and Ring Closing Metathesis (RCM) as a key step. During the synthesis we found that the nitrogen functionality in the substrate influences significantly the catalyst load due to electronic effects. Several iterations have been carried out to achieve complete conversion to products 6a-6e.

1,2,3-Triazole-fused spirochromenes as potential anti-tubercular agents: synthesis and biological evaluation.

A facile and convenient approach has been designed for the synthesis of novel prototypes that possess the advantage of the two pharmacophores of chromene and 1,2,3-triazole in a single molecular backbone, were evaluated against H37Rv strain. The new analogues 1,2,3-triazole-fused spirochromenes were accomplished in four step synthetic strategy utilizing click chemistry ([3 + 2] Huisgen cycloaddition) in the ultimate step. The synthesized compounds were established based on the spectral data and X-ray crystal structure for 7a.

Study on Depressant Effects and Muscle Coordination Activity of Stem Methanol Extract.

Background: is an evergreen shrub found across peninsular India, belonging to family .

Objective: The objective of this study was to assess the depressant effects and muscle coordination activity of stem methanol extract (GGSME).

Materials And Methods: The stem methanol extract was administered in Swiss albino mice in 1 day to study the central nervous system (CNS) depressant and muscle coordination activity employing animal models such as sodium pentobarbital-induced sleep test, hole-board test, open field test, pentylenetetrazole (PTZ)-induced convulsions, picrotoxin-induced convulsions, grip strengthening test in mice, and Rota-rod test.

Metabolic inhibition of meloxicam by specific CYP2C9 inhibitors in Cunninghamella blakesleeana NCIM 687: in silico and in vitro studies.

Specific inhibitors of Cytochrome P4502C9 enzyme (CYP2C9) viz. clopidogrel, fenofibrate fluvoxamine and sertraline at concentration of 50, 100, 150 and 200 µM were employed to investigate the nature of enzyme involved in bioconversion of meloxicam to its main metabolite 5-OH methyl meloxicam by Cunninghamella blakesleeana. Virtual screening for interaction of specific CYP2C9 inhibitors with human CYP2C9 enzyme was performed by molecular docking using Auto dock vina 4.

Pd-N-heterocyclic carbene catalyzed synthesis of piperidine alkene-alkaloids and their anti-cancer evaluation.

A facile synthesis of piperidine alkene-alkaloids including natural (+)-Caulophyllumine B in high yields has been developed by Heck cross-coupling reaction catalyzed by simple in situ formed palladium-N-heterocyclic carbenes (Pd-NHCs). Formation of Pd(0) nanoparticles has been noticed during the reaction course. The synthesized piperidine alkene-alkaloids were evaluated for in vitro anti-cancer activity against a panel of human tumor cell lines of lung, breast and ovarian.