Structure similarity based screening coupled to integrated structural biochemistry approach for exploring the high affinity inhibitors against histone deacetylase (HDAC)-6.

Histone deacetylase (HDAC)-6 has overwhelming implications in multiple cancers and neurodegenerative disorders. Unusual HDAC6 expression modulates various signalling mechanisms which in turn forms the aetiology of the above-mentioned disorders. Thus, restoring the typical activity of HDAC6 through small molecules may prove as a promising approach to beat these disorders.

Reinforcement and characterization of biopolymer-rhamnolipid nanoparticles: Biocompatibility, in-vitro stability, physico-chemical, rheological and bioactive properties.

In the present study, biopolymer (chitosan and alginate)-reinforced rhamnolipid nanoparticles were prepared and represented as 'ALG-RHLP-NPs' and 'CHI-RHLP-NPs'. The sizes of the nanoparticles ranged from 150 to 300 nm. The encapsulation efficiencies of ALG-RHLP-NPs and CHI-RHLP-NPs were found to be 81.

Piggyback Scleral Contact Lens to Enhance Cosmesis and Comfort in Uniocular Stevens-Johnson Syndrome.

Stevens-Johnson syndrome often results in a significant reduction in vision, dryness, and photophobia based on severity. Scleral lenses are well-considered visual interventions that enhance vision and comfort, resulting in an increased quality of life for patients. This case report describes the enhancement of comfort, cosmesis, and reduction of photophobia using a piggyback system (scleral contact lenses over a prosthetic contact lens), whereas the other modalities were unsatisfactory.

Effect of low high dietary-advanced glycation end products on insulin-sensitivity and inflammatory- markers among overweight/obese Asian-Indian adults-A randomised controlled trial.

The present study investigated the effect of low high-dietary-Advanced Glycation End products-based diets on oral disposition index-(DIo)-a marker of islet β-cell function and cardiometabolic risks factors in 38-overweight and obese Asian Indian-adults (aged 25-45 years with body-mass-index (BMI) ≥23kg/m) through 12-week isocaloric crossover feeding trial. Biochemical-measures included-glucose tolerance test (GTT), Insulin assay (0,30 and 120 min), lipid-profile, serum-adiponectin, serum-AGE and serum-Thiobarbituric acid reactive substances-(TBARS) assessed both at baseline and end of each intervention. Generalised linear models showed that low-dAGE diet significantly improved in oral disposition index [Least Square Mean (SE), +0.

An advanced double-phase stacking ensemble technique with active learning classifier: Toward reliable disruption prediction in Aditya tokamak.

Disruptions in tokamak nuclear reactors, where plasma confinement is suddenly lost, pose a serious threat to the reactor and its components. Classifying discharges as disruptive or non-disruptive is crucial for effective plasma operation and advanced prediction. Traditional disruption identification systems often struggle with noise, variability, and limited adaptability.

Evaluation of a multiphase cascaded H-bridge inverter for induction motor operation.

Multi-phase systems are becoming more popular for applications requiring high power and precise motor control, even if single-phase AC power is still frequently utilized in households and some enterprises. While both systems have benefits over single-phase, there are trade-offs associated with each. Because of its balanced operation and effective power transfer, the three-phase (3-Φ) system is the most widely used multi-phase system.

Wound-induced small-peptide-mediated signaling cascade, regulated by OsPSKR, dictates balance between growth and defense in rice.

Wounding is a general stress in plants that results from various pest and pathogenic infections in addition to environment-induced mechanical damages. Plants have sophisticated molecular mechanisms to recognize and respond to wounding, with those of monocots being distinct from dicots. Here, we show the involvement of two distinct categories of temporally separated, endogenously derived peptides, namely, plant elicitor peptides (PEPs) and phytosulfokine (PSK), mediating wound responses in rice.

Plasticity of the proteasome-targeting signal Fat10 enhances substrate degradation.

The proteasome controls levels of most cellular proteins, and its activity is regulated under stress, quiescence, and inflammation. However, factors determining the proteasomal degradation rate remain poorly understood. Proteasome substrates are conjugated with small proteins (tags) like ubiquitin and Fat10 to target them to the proteasome.

Effect of Trough Incidence Angle on the Aerodynamic Characteristics of a Biomimetic Leading-Edge Protuberanced (LEP) Wing at Various Turbulence Intensities.

A series of wind tunnel tests were performed to investigate the effect of turbulent inflows on the aerodynamic characteristics of variously modified trough incident leading-edge-protuberanced (LEP) wing configurations at various turbulence intensities. A self-developed passive grid made of parallel arrays of round bars was placed at different locations of the wind tunnel to generate desired turbulence intensity. The aerodynamic forces acting over the trough incidence LEP wing configuration where obtained from surface pressure measurements made over the wing at different turbulence intensities using an MPS4264 Scanivalve simultaneous pressure scanner corresponding to a sampling frequency of 700 Hz.

Electrochemical Sensors for Heavy Metal Ion Detection in Aqueous Medium: A Systematic Review.

Heavy metal ions (HMIs) are very harmful to the ecosystem when they are present in excess of the recommended limits. They are carcinogenic in nature and can cause serious health issues. So, it is important to detect the metal ions quickly and accurately.

The Thermodynamic Properties of Fat10ylated Proteins Are Regulated by the Fat10ylation Site.

Degradation of proteins by the proteasome is crucial in regulating their levels in the cell. Post-translational modifications, such as ubiquitylation and Fat10ylation, trigger proteasomal degradation of the substrate proteins. While ubiquitylation regulates multiple cellular pathways, Fat10ylation functions explicitly in the inflammatory response pathway.

phytochemicals regulate fibroblast cell migration via modulation of focal adhesions.

The plant contains phytochemicals that have been used extensively in traditional medicine to treat various diseases. More recently it has been shown to accelerate wound healing, though its mechanism of action is largely unknown. Here we investigated the cellular pathways activated by a methanol extract of in human dermal fibroblasts, which play many critical roles in the wound healing program.

Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin.

Dysregulated macrophage responses and changes in tissue metabolism are hallmarks of chronic inflammation in the skin. However, the metabolic cues that direct and support macrophage functions in the skin are poorly understood. Here, we show that during sterile skin inflammation, the epidermis and macrophages uniquely depend on glycolysis and the TCA cycle, respectively.

Turn-on RNA Mango Beacons for -acting fluorogenic nucleic acid detection.

The Mango I and II RNA aptamers have been widely used in vivo and in vitro as genetically encodable fluorogenic markers that undergo large increases in fluorescence upon binding to their ligand, TO1-Biotin. However, while studying nucleic acid sequences, it is often desirable to have -acting probes that induce fluorescence upon binding to a target sequence. Here, we rationally design three types of light-up RNA Mango Beacons based on a minimized Mango core that induces fluorescence upon binding to a target RNA strand.

Hybrid de novo genome assembly of the sexually dimorphic Lady Amherst's pheasant.

Pheasants are an important group of birds, valued for their economic benefit as poultry birds, game birds, and as ornamental species for their plumage. Lady Amherst's pheasant Chrysolophus amherstiae is an ornamental species, valued for its elaborate and beautiful plumage. In this study, we present a high-quality de novo hybrid genome assembly of C.

Plant histone variants at the nexus of chromatin readouts, stress and development.

Histones are crucial proteins that are involved in packaging the DNA as condensed chromatin inside the eukaryotic cell nucleus. Rather than being static packaging units, these molecules undergo drastic variations spatially and temporally to facilitate accessibility of DNA to replication, transcription as well as wide range of gene regulatory machineries. In addition, incorporation of paralogous variants of canonical histones in the chromatin is ascribed to specific functions.

Reconfigurable Metasurface: Enabling Tunable Reflection in 6G Wireless Communications.

With the continuous advancement of technology, there is an increasing need for innovative solutions that can handle complex applications such as haptic communications, Internet of Things for smart cities, automation, and manufacturing. One technology that has received much attention is the phase reconfigurable metasurface for reconfigurable intelligent surfaces (RISs). The RIS demands low-power consumption, simple configuration, angular stability, and polarization insensitivity.

Bone-Adhesive Hydrogel for Effective Inhibition of and Osteoblast Regeneration.

Currently, bone tuberculosis (TB) treatment largely involves lifelong drug prescriptions and surgical intervention, resulting in poor quality of life for patients. Therefore, the fabrication of injectable scaffolds to form a solid framework around the defective bone region is gaining importance over the extensive use of antimicrobial inhibitors. Herein, we synthesized a novel bone-adhesive and thermoresponsive hydrogel via conjugation of poly(-isopropylacrylamide--glycidyl methacrylate) (PNIPAM--GMA) and cysteine (CYS).

Eggs of the mosquito Aedes aegypti survive desiccation by rewiring their polyamine and lipid metabolism.

Upon water loss, some organisms pause their life cycles and escape death. While widespread in microbes, this is less common in animals. Aedes mosquitoes are vectors for viral diseases.

Underwater Wireless Sensor Networks with RSSI-Based Advanced Efficiency-Driven Localization and Unprecedented Accuracy.

Deep-sea object localization by underwater acoustic sensor networks is a current research topic in the field of underwater communication and navigation. To find a deep-sea object using underwater wireless sensor networks (UWSNs), the sensors must first detect the signals sent by the object. The sensor readings are then used to approximate the object's position.

A Study on the Candidate Gene Association and Interaction with Measures of UV Exposure in Pseudoexfoliation Patients from India.

Purpose: Environmental and genetic factors are associated with development of Pseudoexfoliation syndrome (XFS). Here we intended to elucidate the association of candidate genes in relevance to UV exposure in these patients.

Methods: This is a case-control study of 309 subjects ( = 219 controls and 90 XFS cases) from India.

Correction: Platinum nanoparticles inhibit bacteria proliferation and rescue zebrafish from bacterial infection.

[This corrects the article DOI: 10.1039/C6RA03732A.].

Regulation of store-operated Ca entry by IP receptors independent of their ability to release Ca.

Loss of endoplasmic reticular (ER) Ca activates store-operated Ca entry (SOCE) by causing the ER localized Ca sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS). Here, we demonstrate a novel mechanism by which the inositol 1,4,5 trisphosphate receptor (IPR), an ER-localized IP-gated Ca channel, regulates neuronal SOCE. In human neurons, SOCE evoked by pharmacological depletion of ER-Ca is attenuated by loss of IPRs, and restored by expression of IPRs even when they cannot release Ca, but only if the IPRs can bind IP.