730 results match your criteria: "Sastra Deemed University[Affiliation]"
J Biomol Struct Dyn
June 2024
Department of Bioinformatics, School of Chemical and Biotechnology, SASTRA Deemed University, Thirumalaisamudram, Thanjavur, Tamilnadu, India.
Myelin Oligodendrocyte Glycoprotein (MOG) is a transmembrane protein in the myelin sheath. It acts as an auto-antigen under certain unknown conditions causing demyelination, thus resulting in Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD). The significance of glycosylation in the conformational dynamics of the extracellular region (EC1) of the MOG were evident from the previous computational studies.
View Article and Find Full Text PDFPhys Rev E
May 2024
School of Physics, Indian Institute of Science Education and Research, Thiruvananthapuram-695551, Kerala, India.
Phase transitions are crucial in shaping the collective dynamics of a broad spectrum of natural systems across disciplines. Here, we report two distinct heterogeneous nucleation facilitating single step and multistep phase transitions to global synchronization in a finite-size adaptive network due to the trade off between time scale adaptation and coupling strength disparities. Specifically, small intracluster nucleations coalesce either at the population interface or within the populations resulting in the two distinct phase transitions depending on the degree of the disparities.
View Article and Find Full Text PDFPolymers (Basel)
June 2024
Applied Geotechnical Research Group, Department of Civil Engineering, Universidad de Cartagena, Cartagena de Indias 130015, Colombia.
The freeze-drying of biopolymers presents a fresh option with greater potential for application in soil subgrade stabilization. A freeze-dried combination of β-glucan (BG) and γ-poly-glutamic acid (GPA) biopolymers was used to treat low compressible clay (CL) and low compressible silt (ML) soils in dosages of 0.5%, 1%, 1.
View Article and Find Full Text PDFJ Mol Model
June 2024
School of Electrical & Electronics Engineering, SASTRA Deemed University, Thanjavur -613 401, Tirumalaisamudram, India.
Microb Pathog
August 2024
Department of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, 613401, Tamil Nadu, India. Electronic address:
Antibiotic resistance and re-emergence of highly resistant pathogens is a grave concern everywhere and this has consequences for all kinds of human activities. Herein, we showed that N-palmitoylethanolamine-derived cationic lipid (cN16E) had a lower minimum inhibitory concentration (MIC) against both Gram-positive and Gram-negative bacteria when it was loaded with Butea monosperma seed lectin (BMSL). The analysis using lectin-FITC conjugate labelling indicated that the improved antibacterial activity of BMSL conjugation was due to bacterial cell surface glycan recognition.
View Article and Find Full Text PDFDeep learning has emerged as a highly effective and precise method for classifying images. The presence of plant diseases poses a significant threat to food security. However, accurately identifying these diseases in plants is challenging due to limited infrastructure and techniques.
View Article and Find Full Text PDFOrg Biomol Chem
July 2024
Department of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur 613 401, Tamil Nadu, India.
A highly efficient and innovative method involving base-mediated oxidative annulation between 2-naphthols and phenylglyoxal monohydrate under visible light irradiation has been successfully developed. This method leads to the formation of oxygen-containing heterocyclic compounds, particularly hydroxy-naphthofuranone derivatives, encompassing a unique quaternary carbon center. An X-ray diffraction study has unambiguously confirmed the structure of one such derivative.
View Article and Find Full Text PDFSci Rep
June 2024
L&T Ocular Pathology Department, Vision Research Foundation, Sankara Nethralaya, No. 41, College Road, Nungambakkam, Chennai, Tamil Nadu, 600006, India.
Antibodies have been extensively used in numerous applications within proteomics-based technologies, requiring high sensitivity, specificity, a broad dynamic range for detection, and precise, reproducible quantification. Seeking alternatives to antibodies due to several inherent limitations of antibodies is an area of active research of tremendous importance. Recently, aptamers have been receiving increasing attention, because they not only have all of the advantages of antibodies, but also have unique advantages, such as thermal stability, low cost, and unlimited applications.
View Article and Find Full Text PDFClin Chim Acta
July 2024
School of Chemical & Biotechnology (SCBT), SASTRA Deemed University, Thanjavur 613 401, Tamil Nadu, India; Center for Nanotechnology & Advanced Biomaterials (CENTAB), SASTRA Deemed University, Thanjavur 613 401, Tamil Nadu, India. Electronic address:
This review provides a comprehensive overview of the latest advancements in wearable biosensors, emphasizing their applications in cardiovascular disease monitoring. Initially, the key sensing signals and biomarkers crucial for cardiovascular health, such as electrocardiogram, phonocardiography, pulse wave velocity, blood pressure, and specific biomarkers, are highlighted. Following this, advanced sensing techniques for cardiovascular disease monitoring are examined, including wearable electrophysiology devices, optical fibers, electrochemical sensors, and implantable cardiac devices.
View Article and Find Full Text PDFAnn Med Surg (Lond)
June 2024
School of Biosciences, Biotechnology, University of Nottingham, England, UK.
Spinocerebellar ataxias (SCAs) are a rare autosomal dominant neurodegenerative disorder. To date, approximately 50 different subtypes of SCAs have been characterized. The prevalent types of SCAs are usually of PolyQ origin, wherein the disease pathology is a consequence of multiple glutamine residues being encoded onto the disease proteins, causing expansions.
View Article and Find Full Text PDFInt J Biol Macromol
July 2024
Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland. Electronic address:
The development of a long-acting injectable drug delivery systems (DDS) of active pharmaceutical ingredients (API) holds great promise in addressing the challenges of treatment adherence, predominantly in HIV/AIDS. Polymers are inevitable carriers for the preparation of DDS, which are typically composed of polylactide (PLA), carbohydrates such as chitosan or cellulose derivatives. In this study, the tenofovir alafenamide (TAF) laden PLA-stereocomplex-chitosan nanoparticles (Sc-PLA-chitosan NPs) were developed through the spray-dried technique.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
October 2024
School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India. Electronic address:
The photophysical properties of conformationally flexible (TPA-C) and partially rigidified (Cz-C) triarylamine acids were explored in solid as well as solution state and correlated with the structure. TPA-C and Cz-C exhibited moderate solid-state fluorescence (Φ = 6.2 % (TPA-C) and 5.
View Article and Find Full Text PDFACS Appl Bio Mater
June 2024
Department of Physics, School of Electrical and Electronics Engineering, SASTRA Deemed University, Thirumalaisamudhram, Thanjavur 613401, India.
Nanotechnology offers an innovative application as an eco-friendly food packaging film fabricated along with a degradable active mixture (AM). The AM is an assortment of alloyed metal oxide nanoparticles (Ag-ZnO), citron powder (AA), and Curcuma peel powder (CPP). Alloyed nanoparticles (NPs) were observed to exhibit a hexagonal structure from the experimental X-ray diffraction.
View Article and Find Full Text PDFHeliyon
May 2024
Vascular Biology Lab, ASK-1, SASTRA Deemed University, Tirumalaisamudram, Thanjavur, Tamil Nadu, India.
Background: Renal dysfunction is known to cause heart failure. However, renal dysfunction associated with kidney surgeries (mediated by reperfusion injury) that affects the cardiac physiological function, especially during the recovery and repair phase of renal surgery is unknown.
Method: Male Wistar rats (238 ± 18 g) were subjected to renal sham and ischemia-reperfusion (IR-bilateral clamping for 15 min/45 min and reperfusion for 24 h/48 h/7 days) surgeries.
J Pharm Sci
August 2024
Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China. Electronic address:
Nanoparticles composed of Levan and Dolutegravir (DTG) have been successfully synthesized using a spray drying procedure specifically designed for milk/food admixture applications. Levan, obtained from the microorganism Bacillus subtilis, was thoroughly characterized using MALDI-TOF and solid-state NMR technique to confirm its properties. In the present study, this isolated Levan was utilized as a carrier for drug delivery applications.
View Article and Find Full Text PDFPhys Rev E
April 2024
School of Physics, Indian Institute of Science Education and Research Thiruvananthapuram, Kerala 695551, India.
Swarmalators are oscillators that can swarm as well as sync via a dynamic balance between their spatial proximity and phase similarity. Swarmalator models employed so far in the literature comprise only one-dimensional phase variables to represent the intrinsic dynamics of the natural collectives. Nevertheless, the latter can indeed be represented more realistically by high-dimensional phase variables.
View Article and Find Full Text PDFJ Org Chem
June 2024
School of Chemical Sciences, IIT Mandi, Himachal Pradesh, Mandi 175005, India.
The biological and medicinal importance of indolocarbazoles has been known for the past several decades. However, in recent times, these compounds have been emerging as potential candidates for optoelectronic applications, although several challenges are associated with their synthesis. We report here a Pd(II)-catalyzed process for the synthesis of indolo[3,2-]carbazoles.
View Article and Find Full Text PDFCrit Rev Anal Chem
May 2024
Department of Medical Chemistry and Clinical Biochemistry, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.
Due to their life cycle, viruses can disrupt the metabolism of their hosts, causing diseases. If we want to disrupt their life cycle, it is necessary to identify their presence. For this purpose, it is possible to use several molecular-biological and bioanalytical methods.
View Article and Find Full Text PDFJ Biochem Mol Toxicol
May 2024
Vascular Biology Lab, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
According to the pathophysiological mechanisms linking particulate matter (PM) exposure and cardiovascular diseases, PM may directly translocate into the blood stream and remote target organs and thereby induce cardiovascular effects. The toxicity of PM is known to induce oxidative stress in pulmonary tissue, but its impact on the redox state in heart (distant organ) is unknown and how it modulates the cardiac response to ischemia reperfusion (IR) remains unclear. In the present study, we evaluated the toxic effect of PM on cardiac physiology in the presence and absence of IR after introducing PM into the blood.
View Article and Find Full Text PDFClin Chim Acta
June 2024
School of Chemical & Biotechnology (SCBT), SASTRA Deemed University, Thanjavur 613 401, Tamil Nadu, India; Center for Nanotechnology & Advanced Biomaterials (CENTAB), SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India. Electronic address:
Colorectal cancer, breast cancer, oxidative DNA damage, and viral infections are all significant and major health threats to human health, presenting substantial challenges in early diagnosis. In this regard, a wide range of nucleic acid-based electrochemical platforms have been widely employed as point-of-care diagnostics in health care and biosensing technologies. This review focuses on biosensor design strategies, underlying principles involved in the development of advanced electrochemical genosensing devices, approaches for immobilizing DNA on electrode surfaces, as well as their utility in early disease diagnosis, with a particular emphasis on cancer, leukaemia, oxidative DNA damage, and viral pathogen detection.
View Article and Find Full Text PDFEnviron Pollut
August 2024
Vascular Biology lab, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, India; School of Chemical and Biotechnology, SASTRA Deemed University, Tirumalaisamudram, Thanjavur-613401, Tamil Nadu, India. Electronic address:
Exposure to PM is widely acknowledged to induce cardiotoxic effects, leading to decreased myocardial tolerance to revascularization procedures and subsequent ischemia reperfusion injury (IR). However, the temporal relationship between PM exposure and vulnerability to IR, along with the underlying mechanisms, remains unclear and is the focus of this study. Female Wistar rats were exposed to PM at a concentration of 250 μg/m³ for 3 h daily over varying durations (7, 14, and 21 days), followed by IR induction.
View Article and Find Full Text PDFCommun Biol
April 2024
Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK-Post, Bellary Rd, Bengaluru, 560065, Karnataka, India.
Adaptation to hypothermia is important for skeletal muscle cells under physiological stress and is used for therapeutic hypothermia (mild hypothermia at 32 °C). We show that hypothermic preconditioning at 32 °C for 72 hours improves the differentiation of skeletal muscle myoblasts using both C2C12 and primary myoblasts isolated from 3 month and 18-month-old mice. We analyzed the cold-shock proteome of myoblasts exposed to hypothermia (32 °C for 6 and 48 h) and identified significant changes in pathways related to RNA processing and central carbon, fatty acid, and redox metabolism.
View Article and Find Full Text PDFBiology (Basel)
March 2024
General Medical Research, Neuropathology Section, R&D Service, Veterans Affairs Medical Center, Miami, FL 33125, USA.
Hepatic encephalopathy (HE) is a neurological condition linked to liver failure. Acute HE (Type A) occurs with acute liver failure, while chronic HE (Type C) is tied to cirrhosis and portal hypertension. HE treatments lag due to gaps in understanding its development by gender and age.
View Article and Find Full Text PDFMol Biol Rep
April 2024
Department of Engineering Design, Indian Institute of Technology Madras, Chennai, India.
Introduction: Spinal cord injury (SCI) leads to significant destruction of nerve tissue, causing the degeneration of axons and the formation of cystic cavities. This study aimed to examine the characteristics of human umbilical cord-derived mesenchymal stem cells (HUCMSCs) cultured in a serum-free conditioned medium (CM) and assess their effectiveness in a well-established hemitransection SCI model.
Materials And Methods: In this study, HUCMSCs cultured medium was collected and characterized by measuring IL-10 and identifying proteomics using mass spectroscopy.
Heliyon
April 2024
Department of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, 613 401, Tamil Nadu, India.
Lectins are renowned for recognizing specific carbohydrates, but there is evidence that they can bind to other endogenous ligands. Therefore, lectin can be used as a carrier to recognize glycoconjugates on the cell surface. The anticancer, antibacterial, and immunomodulatory properties of some lectins are established.
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