725 results match your criteria: "Sastra Deemed University[Affiliation]"

Article Synopsis
  • Acacia gum (AG) is used to enhance the strength of three types of cohesive soils, showing flexibility and slight changes in pH after being hydrated for 48 hours.
  • The soil samples were mixed with AG and tested for their physical properties, revealing that AG alters soil consistency and moisture content, yielding better performance metrics like Unconfined Compressive Strength (UCS) and California Bearing Ratio (CBR).
  • Key tests showed a 1.5% dose of AG significantly improved the UCS and CBR of low compressible clay, attributed to AG’s ability to fill pores and bond through interactions observed in advanced microscopy techniques.
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Energy harvesters based on nanomaterials are getting more and more popular, but on their way to commercial availability, some crucial issues still need to be solved. The objective of the study is to select an appropriate nanomaterial. Using features of the Reinforcement Deep Q-Network (DQN) in conjunction with Fuzzy PROMETHEE, the proposed model, we present in this work a hybrid fuzzy approach to selecting appropriate materials for a vehicle-environmental-hazardous substance (EHS) combination that operates in roadways and under traffic conditions.

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The research objective in the context of the study relates to the major concern of corrosion affecting the wind turbines in operation to find materials with high durability in relation to environmental conditions of operation, strength, and cost. A method is an integration of the Analytical Hierarchy Process (AHP) and VIKOR Multi-Criteria Decision Making (MCDM) techniques that will assess seven different material options on sixteen criteria that comprise corrosion resistance, mechanical properties, cost, and a negative environmental impact. From this result, the AHP method calculated the weights for the indicators and chose potential materials, and finally, the VIKOR method used these materials and compared and ranked them to obtain a compromise solution.

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Genomic instability in ovarian cancer: Through the lens of single nucleotide polymorphisms.

Clin Chim Acta

January 2025

Cancer Genomics Laboratory, Department of Biotechnology, School of Chemical and Biotechnology, SASTRA- Deemed University, Thanjavur 613 401, India. Electronic address:

Article Synopsis
  • * SNPs are prevalent in the population and have a significant role in sporadic ovarian cancers, emphasizing the importance of understanding their genetic basis for improving molecular diagnostics and developing personalized treatments.
  • * This review focuses on the impact of SNPs in critical caretaker genes responsible for genomic integrity and discusses the challenges of SNP-based research, highlighting the most studied pathways (DDR and HRR) while noting that other relevant pathways are underexplored.
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  • *A high-temperature composite inorganic PCM (ZnO-NaNO) was developed, showing a 22.7% increase in thermal conductivity and a 43.5% rise in specific heat due to the addition of ZnO nanoparticles.
  • *The study found that this composite maintained stability over 500 cycles, indicating its viability as a reliable energy storage solution.*
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  • * Early detection of PD is important because it helps start treatments sooner, which can slow the disease down and improve life for longer.
  • * Researchers are using advanced brain imaging techniques like MRI and deep learning models to diagnose PD more accurately, achieving impressive accuracy results, with one method reaching up to 95%.
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Exigency in search of an ideal candidate for an effective detoxification of chemical warfare agents is still continuing. Zirconium-based Metal-organic Framework (MOF) UiO-66 has shown a significant detoxification of such toxic chemicals owing to its tunable physio-chemical properties and profuse catalytic sites. In this context, a series of UiO-66 MOFs synthesized by tuning the acidity constant (p ) and concentration of the modulator, synthesis temperature and water molecules was tested for their detoxification efficiency against the simulant 'methyl-paraoxon' at room temperature.

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Mechanism of Alzheimer type II astrocyte development in hepatic encephalopathy.

Neurochem Int

November 2024

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Miami School of Medicine, Miami, FL, USA; General Medical Research, R&D Services, Department of Veterans Affairs, Miami, FL, USA; Neuropathology Section, Veterans Affairs Medical Center, Miami, FL, USA; R&D Services and South Florida VA Foundation for Research and Education Inc, Veterans Affairs Medical Center, Miami, FL, USA. Electronic address:

Article Synopsis
  • Type C hepatic encephalopathy (Type C HE) is a neurological disorder resulting from chronic liver failure, presenting symptoms like mental confusion and motor difficulties.
  • The increase in Alzheimer type II astrocytes (AT2A) is a significant finding linked to Type C HE, though the development of AT2A and its role in cognitive impairments is still unclear.
  • Research in rats indicates that elevated oxidative stress, inflammation, and specific signaling pathways contribute to the rise of GMF and AT2A, leading to cognitive and motor deficits, suggesting potential targets for treatment.
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Recent evolution in connected devices modelled a massive stipulation for network traffic resources and classification. Software-defined networking (SDN) enables ML techniques with the Internet of Things (IoT) to automate network traffic. This helps to reduce accuracy and improves latency.

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Fabrication of Anatomically Equivalent Pectin-Based Multifilament Nerve Conduits.

ACS Appl Bio Mater

October 2024

Centre for Nanotechnology and Advanced Biomaterials, ABCDE Innovation Centre, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur 613 401, India.

Reuniting denuded nerve ends after a long segmental peripheral nerve defect is challenging due to delayed axonal regeneration and incomplete, nonspecific reinnervation, as conventional hollow nerve guides fail to ensure proper fascicular complementation and obstruct axonal guidance across the defects. This study focuses on fabricating multifilament conduits using a plant-derived anionic polysaccharide, pectin, where the abundant availability of carboxylate (COO-) functional groups in pectin facilitates instantaneous sol-gel transition upon interaction with divalent cations. Despite their advantages, pectin hydrogels encounter structural instability under physiological conditions.

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Carbazole-picoline based π-conjugated zwitterionic fluorophores, (E)-3-(4-(4-(9H-carbazol-9-yl)styryl)pyridin-1-ium-1-yl)propane-1-sulfonate (Cz-PS) and (E)-4-(4-(4-(9H-carbazol-9-yl)styryl)pyridin-1-ium-1-yl)butane-1-sulfonate (Cz-BS) were synthesized and investigated the stimuli-responsive solid-state fluorescence properties. Cz-PS and Cz-BS displayed enhanced fluorescence in the solid-state (555 and 542 nm) with the quantum yield (Φ) of 32.9 and 28.

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"Urinary tract infection: Conventional testing to developing Technologies".

Clin Chim Acta

January 2025

Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India; School of Electrical and Electronics Engineering, SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India. Electronic address:

Urinary tract infections (UTIs) present an escalating global health concern, precipitating increased hospitalizations and antibiotic utilization, thereby fostering the emergence of antimicrobial resistance. Current diagnostic modalities exhibit protracted timelines and substantial financial burdens, necessitating specialized infrastructures. Addressing these impediments mandates the development of a precise diagnostic paradigm to expedite identification and augment antibiotic stewardship.

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Article Synopsis
  • The reaction of thiophene-2-carbohydrazide and 5-bromothiophene-2-carbohydrazide with haloaryl isothiocyanates led to the creation of 4-haloaryl-5-(thiophen-2-yl or 5-bromothiophen-2-yl)-2,4-dihydro-3-1,2,4-triazole-3-thiones through cyclization in an alkaline environment.
  • Various secondary amines and formaldehyde were then used to synthesize 2-aminomethyl-4-haloaryl-2,4-dihydro-3-1,2,4-triazole-3-thiones,
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Comparative evaluation of single and multiple exposure to PM in respirable air on cardiac physiology, structure and function in a Wistar rat model.

J Environ Sci (China)

April 2025

Vascular Biology lab, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India; School of Chemical and Biotechnology, SASTRA Deemed University, Tirumalaisamudram, Thanjavur 613401, Tamil Nadu, India. Electronic address:

Many studies have shown the negative relationship between long term exposure to PM and cardiac dysfunction. Recently, studies have shown that even a single exposure of PM from air sample in permissible range can induce very mild cardiac pathological changes. In the present study, we revisited the toxic effect of PM on rat heart by adopting single and multiple exposure durations.

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Modern food supply chains are intrinsically sophisticated due to their multi-participant and multi-echelon structure, which are challenging to handle high turbulent business environment. The development of Perishable Food Supply Chains (PFSC) has to be strong enough to manage any type of disruptions in the food industry. At the same time, the food processing industry must also take responsibility for the social and environmental consequences of their deeds.

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Article Synopsis
  • Transcription factors like estrogen receptor α (ERα) regulate gene expression by binding to DNA and can interact with RNA, which may influence their binding to chromatin.
  • This study found that RNA binding is crucial for maintaining proper recruitment of ERα to DNA, especially at weaker binding sites, and without this RNA interaction, ERα becomes more mobile in the nucleus.
  • Increased mobility of ERα leads to enhanced transcription of genes with low-strength motifs, but stable binding at stronger sites may hinder ligand-dependent gene expression, suggesting RNA interactions help balance transcription regulation.
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Phenotypic and genotypic characterization of methicillin resistant associated with pyogenic infections.

Iran J Microbiol

August 2024

Biofilm Biology Laboratory, Centre for Research on Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed University, Tirumalaisamudram, Thanjavur, Tamil Nadu, India.

Background And Objectives: Staphylococcal infections are one of the major infectious diseases affecting globally in spite of advances in development of antimicrobial agents. Knowledge and awareness about the local pattern and prevalence of MRSA infections plays a key role in treatment. The aim of this study was to identify MRSA strains by phenotypic and genotypic methods and to analyze the antibiotic susceptibility pattern of MRSA strains from patients attending a tertiary care hospital.

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Article Synopsis
  • * The study investigates how exposure to fine particulate matter (PM) affects UC's susceptibility to ischemia-reperfusion injury (IR) using a rat model with chronic kidney disease.
  • * Results show that UC hearts exposed to PM experienced worse cardiac function and increased injury, attributed to mitochondrial damage, oxidative stress, and disruptions in important cellular signaling pathways.
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Biofabrication & cryopreservation of tissue engineered constructs for on-demand applications.

Biofabrication

September 2024

Tissue Engineering & Additive Manufacturing (TEAM) Lab, Centre for Nanotechnology & Advanced Biomaterials, ABCDE Innovation Centre, School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, India.

Tissue engineered constructs prepared using conventional scaffold-based approaches have the potential to repair or regenerate damaged tissues and organs. Various scaffold fabrication strategies such as electrospinning, solvent casting, particulate leaching, gas foaming, hydrogels, freeze-drying, and 3D bioprinting have been used to fabricate artificial tissues. In recent times, 3D bioprinting has been predominantly used in various biomedical fields, including healthcare and pharmaceutical applications due to precision in 3D geometry.

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Article Synopsis
  • - A new method uses visible light to activate triplet oxygen in reactions between pyrazole amine and phenylglyoxal monohydrate at room temperature, with water acting as both solvent and reagent.
  • - The process relies on several factors including light, a photocatalyst, oxygen, and water, leading to the successful synthesis of various dicarbonylpyrazole amines and pyrazolooxazine derivatives in moderate to good yields.
  • - This technique shows sustainability and environmentally-friendly aspects while demonstrating high selectivity in producing specific compounds, with mechanistic insights obtained through computational analysis.
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Prcis: We quantified and compared the gaze metrics during target-oriented visual search tasks between glaucoma and healthy controls. On the basis of a mathematical concept we showed that due to glaucoma, focal search becomes prominent over global search.

Purpose: Visual search (VS) which is essential for target identification and navigation is significantly impacted by glaucoma.

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Drought is an extended shortage of rainfall resulting in water scarcity and affecting a region's social and economic conditions through environmental deterioration. Its adverse environmental effects can be minimised by timely prediction. Drought detection uses only ground observation stations, but satellite-based supervision scans huge land mass stretches and offers highly effective monitoring.

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Tuning the physical and chemical interaction between metal-metal' (M-M') and metal-support is an ideal way to realize enhanced catalytic activity of metal nanoparticles (NPs). As a proof of concept, herein we report the fabrication of nickel-gold (Ni-Au) alloy nanoparticles attached to N-doped nanoporous carbon (NPC) intervened with MgO (NiAu@MgO-NPC), achieved through the impregnation of metal precursors into Schiff-base network polymer (SNP) framework along with Mg(OH) and pyrolysis at 800 °C in N atmosphere. With high stability and heterogeneity, the nickel rich NiAu@MgO-NPC exhibited higher catalytic activities with turnover frequencies of 29,272 h (hydrogenation of p-nitrophenol), 93,843 h (degradation of methyl orange), and 2,218 h (epoxidation of stilbene), compared to commercial 10 wt % Pd/C.

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Lower airway club cells (CCs) serve the dual roles of a secretory cell and a stem cell. Here, we probe how the CC fate is regulated. We find that, in response to acute perturbation of Notch signaling, CCs adopt distinct fates.

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Text classification plays a major role in research such as sentiment analysis, opinion mining, and customer feedback analysis. Text classification using hypergraph algorithms is effective in capturing the intricate relationships between words and phrases in documents. The method entails text preprocessing, keyword extraction, feature selection, text classification, and performance metric evaluation.

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