411 results match your criteria: "Sasebo City General Hospital.[Affiliation]"

Introduction: The number of female doctors is increasing worldwide, but the percentage of female general surgeons and gastrointestinal surgeons remains low, at only 6% in Japan. Furthermore, in rural areas, the number of doctors is small and training opportunities are limited, and training in surgical techniques is reportedly inadequate compared with urban areas. This study examined the current status and surgical outcomes of colorectal cancer surgery by surgeon sex using a multicenter database in a Japanese rural area.

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Background: Lateral pelvic lymph node dissection (LPND) is a challenging surgical technique with complex anatomy and narrow pelvic manipulation. The outcomes of robotic and laparoscopic surgery for LPND are still unclear.

Methods: We retrospectively reviewed 169 consecutive patients who underwent rectal cancer surgery with LPND between 2016 and 2023.

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Gangrenous cholecystitis (GC) is classified as moderate acute cholecystitis according to the Tokyo Guidelines from 2018 (TG18). We evaluated the risk factors for GC and the outcomes of early cholecystectomy. A total of 136 patients who underwent emergency cholecystectomy for acute cholecystitis were retrospectively analyzed; 58 of these patients (42.

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Immune complexome analysis reveals an autoimmune signature predictive of COVID-19 severity.

Clin Biochem

January 2025

Department of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki, Japan; Department of Molecular Pathochemistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. Electronic address:

Background: The factors contributing to the development of severe coronavirus disease 2019 (COVID-19) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain unclear. Although the presence of immune complexes (ICs), formed between antibodies and their antigens, has been linked to COVID-19 severity, their role requires further investigation, and the antigens within these ICs are yet to be characterized.

Method: Here, a C1q enzyme-liked immunosorbent assay and immune complexome analysis were used to determine IC concentrations and characterize IC antigens, respectively, in the sera of 64 unvaccinated COVID-19 patients with PCR-confirmed SARS-CoV-2 infection, enrolled at seven participating centers in 2020.

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Background: The number of elderly people undergoing surgery for colorectal cancer has been increasing. We examine prognosis, including risks of surgery by age and cancer- and noncancer-related deaths.

Methods: This study retrospectively reviewed 1830 patients who underwent curative resection colorectal surgery.

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Introduction: Although robot-assisted surgery has been rapidly gaining popularity in recent years, few reports have examined the impact of individual robotic arm movements on surgical outcomes. This study investigated the relationship between extra arm (EA) usage and experience of surgeons in robot-assisted surgery.

Methods: A total of 176 robot-assisted rectal resections were performed by three surgeons from 2018 to 2022.

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Recent Advances in Pathogenesis, Diagnostic Imaging, and Treatment of Sjögren's Syndrome.

J Clin Med

November 2024

Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.

It is our pleasure to present the Special Issue "Diagnosis and Treatment of Sjögren's Syndrome" to the readers of the [...

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Introduction: Patients undergoing cardiovascular surgery may experience hemodynamic instability during the induction of general anesthesia, and anesthetic agents with minimal hemodynamic effects should be administered. Midazolam, a classic benzodiazepine anesthetic, is known to have relatively weak circulatory depression during anesthesia induction compared to other sedatives. On the other hand, remimazolam, a newly approved short-acting benzodiazepine anesthetic, is expected to have fewer circulatory depressant effects.

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Background: Laparoscopic rectal surgery is often technically difficult. The Endoscopic Surgical Skill Qualification System (ESSQS) was established in Japan as an objective measure of skill for laparoscopic surgeons. However, the advantages of the ESSQS qualification for laparoscopic rectal surgery have been limited.

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Background: Some patients with postoperative hip fractures (HF) experience persistent severe pain. In this longitudinal study, we examined the characteristics of patients with persistent pain after HF surgery, and the factors influencing pain intensity.

Methods: We conducted an 8-week prospective study in patients with postsurgical HF.

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Background: Esophageal neuroendocrine carcinomas (NECs) are extremely rare. Published information on their clinical features, pathological findings, and prognosis is lacking. The optimal treatment for esophageal NECs has not yet been determined because they appear extremely malignant histologically and have a poor prognosis.

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Background: The prognosis of patients with lung cancer and malignant pleural effusion (MPE) caused by carcinomatous pleurisy is poor. Chemical pleurodesis is commonly performed clinically, however, often has a high failure rate. Furthermore, prolonged sustained drainage and delayed introduction of systemic chemotherapy could increase the risk of worsening the Eastern Cooperative Oncology Group Performance Status (ECOG PS) in the treatment of patients with non-small cell lung cancer (NSCLC).

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Background Aims: Allogeneic hematopoietic stem cell transplantation (HSCT) improves outcomes for myelodysplastic syndrome (MDS) patients, but relapse rates remain high, and postrelapse treatment options are limited. Therefore, this study aimed to identify the factors contributing to the response to donor lymphocyte infusion (DLI) in relapsed MDS patients post-HSCT.

Methods: This study included 107 patients with relapsed and DLI-treated MDS who underwent their first HSCT between 2002 and 2022 and were registered in the Transplant Registry Unified Program.

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Article Synopsis
  • Left ventricular noncompaction (LVNC) is a hereditary heart condition marked by unusual heart muscle structure, and this study specifically focused on biventricular noncompaction (BiVNC) in children to understand its clinical characteristics and genetic factors.
  • The research involved 234 pediatric patients and revealed that BiVNC often leads to serious complications, including a higher incidence of congenital heart disease and reduced survival rates compared to other heart conditions.
  • Findings indicated that patients with BiVNC frequently exhibited left ventricular dysfunction and a notable percentage had genetic variants linked to mitochondrial and developmental issues, emphasizing the need for thorough genetic screening for better patient outcomes.
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Purpose: Postoperative management for colonic perforation is an important prognostic factor, but whether intensivists perform postoperative management varies between institutions.

Methods: We investigated 291 patients with colonic perforation between 2018 and 2022. Patients were divided into those managed by an intensivists (ICU group; n = 40) and those not managed by an intensivists (non-ICU group; n = 251).

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Article Synopsis
  • A 63-year-old man with relapsed acute myeloid leukemia underwent a third stem cell transplant and was given voriconazole to prevent fungal infections.
  • On day 42 post-transplant, he developed septic arthritis without the typical skin signs associated with fungal infections.
  • Despite surgery and treatment with liposomal amphotericin B, he died due to a resistant fungal infection, highlighting the need to consider azole-resistant infections as potential causes of septic arthritis in similar patients.
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We herein report three cases of microscopic polyangiitis (MPA). Two patients were administered avacopan in combination with glucocorticoid (GC), whereas one patient was treated with avacopan monotherapy; none of the patients were co-administered either rituximab or cyclophosphamide. The doses of GC were successfully reduced after the introduction of avacopan in the two patients, and the serum C-reactive protein levels decreased in the patient treated with avacopan monotherapy.

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Article Synopsis
  • The study investigates the effectiveness of the fludarabine/intravenous busulfan (FB4) regimen in patients with myelodysplastic syndrome (MDS) undergoing stem cell transplantation from unrelated donors, comparing FB4 alone, FB4 with anti-thymoglobulin (ATG), and FB4 with low-dose total body irradiation (TBI).
  • Results show that the combination of FB4 with low-dose ATG significantly improved overall survival (OS) and reduced nonrelapse mortality (NRM) compared to FB4 alone, whereas the FB4 with TBI did not demonstrate notable advantages over the FB4 regimen.
  • The study highlights that using FB4 plus low-dose ATG is associated with better outcomes
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Article Synopsis
  • A 79-year-old woman had an abnormal shadow in her lung detected during a medical exam, which led to further imaging studies revealing a solid nodule in her right upper lobe.
  • Despite inconclusive bronchoscopy results, PET-CT indicated potential lung cancer, prompting surgery to remove the nodule.
  • The final diagnosis was high-grade fetal adenocarcinoma with lymph node metastasis, but the patient is currently 3.5 years post-surgery without signs of recurrence, highlighting the need for more research on this cancer type.
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Article Synopsis
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can lead to long-lasting remission in adult T-cell leukemia/lymphoma (ATL) patients, but there's a lack of research on post-transplant outcomes for younger patients (≤49 years).
  • A study found that patients aged <40 years had a significantly better overall survival rate (61.8%) compared to those aged 40-49 years (43.1%), indicating younger patients fare better post-transplant.
  • Moreover, while there were no major differences in survival outcomes between different conditioning regimens, the reduced-intensity conditioning (RIC) regimen resulted in lower non-relapse mortality compared to the myeloablative conditioning (MAC) regimen
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Feasibility of a problem-solving exercise program based on short physical performance battery for older patients with chronic respiratory diseases: A multicenter, pilot clinical trial.

Respir Investig

November 2024

Department of Rehabilitation Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, Japan; Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Japan.

Article Synopsis
  • The study evaluated the feasibility and safety of a problem-solving exercise program for older patients with chronic respiratory diseases, focusing on balance, walking, and chair stands.
  • With 36 participants, the program showed high adherence (100%) and no related adverse events, with significant improvements in daily step count and physical performance scores over four weeks.
  • While results indicate that the exercise program is both feasible and safe, further validation in larger randomized controlled trials is necessary to confirm its effectiveness.
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Introduction: The American Society of Anesthesiologists (ASA) classification is used to assess the fitness of a patient for surgery. Whether laparoscopic surgery is appropriate for colorectal cancer patients with poor ASA performance status (PS) remains unclear.

Methods: Among 4585 patients who underwent colorectal surgery between 2016 and 2023, this study retrospectively reviewed all 458 patients with ASA-PS ≥3.

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Article Synopsis
  • - TSC2/PKD1 contiguous gene syndrome results from deletions of the TSC2 and PKD1 genes, causing serious kidney issues like early-onset cystic kidney disease and tuberous sclerosis complex.
  • - An infant girl with this syndrome exhibited symptoms including epileptic seizures and underwent imaging that revealed kidney enlargement and cysts, as well as brain abnormalities.
  • - Genetic testing confirmed the deletion of the TSC2 and PKD1 genes, highlighting the need for ongoing imaging to monitor kidney changes and manage complications like hypertension.
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Background: Several methods are used for reconstruction in colon cancer surgery, including hand-sewn or stapled anastomosis. However, few reports have compared short-term outcomes among reconstruction methods. This study compared short-term outcomes between delta-shaped anastomosis (Delta) and functional end-to-end anastomosis (FEEA).

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