Role of Imbalance of Lipid Peroxidation and Articular Cartilage Remodeling in the Pathogenesis of Early Primary and Post-Traumatic Gonarthrosis in Rats.

We studied serum indicators of LPO and antioxidant system mechanisms in nonlinear male white rats at the early stages of simulated primary knee osteoarthrosis (n=60) and posttraumatic knee osteoarthrosis (n=60) as well as in intact animals (n=20). An imbalance in the peroxidation-antioxidant system with accumulation of lipoperoxides and malondialdehyde along with a decrease in catalase and superoxide dismutase activities was revealed. Early stages of osteoarthrosis were characterized by increased production of primary and intermediate LPO products and exhaustion of the antioxidant system enzymes.

High-k Three-Phase Epoxy/K(NiTi)O/CNT Composites with Synergetic Effect.

Polymer matrix composites based on ED-20 epoxy resin, hollandite K(NiTi)O and carbon nanotubes with a variable content of 0.107; 0.213 and 0.

Benchtop versus high field NMR: Comparable performance found for the molecular weight determination of lignin.

Lignin is a promising renewable biopolymer being investigated worldwide as an environmentally benign substitute of fossil-based aromatic compounds, e.g. for the use as an excipient with antioxidant and antimicrobial properties in drug delivery or even as active compound.

[The labor motivation in professional groups of medical organization].

The motivation of work is based on personnel needs. The directivity of organization management to meeting needs of employees of any professional group is capable to increase their labor motivation and job satisfaction creating at that favorable working environment. The purpose of the study is to determine value of motivational factors-needs for employees of professional groups of medical organization and to justify application of obtained motivational complexes of factors-requirements for increasing labor motivation of personnel.

[The typology of social predictors as a research tool of studying personnel crisis in Russian health care: The publications review].

In conditions of societal transformations, social institutions undergo significant alterations that are manifested by institutional inconsistency and dysfunctionality. The transformation of social professional structure of health care system resulted in change of status and trends of social mobility of social professional groups. The purpose of the study is to typologize social predictors of professional activity of physicians in health care of the Russian Federation.

MR and fluorescence imaging of gadobutrol-induced optical clearing of red fluorescent protein signal in an in vivo cancer model.

Multimodality registration of optical and MR images in the same tissue volume in vivo may be enabled by MR contrast agents with an optical clearing (OC) effect. The goals of this study were to (a) investigate the effects of clinical MR contrast agent gadobutrol (GB) and its combinations as a potential OC agent assisting in fluorescence intensity (FI) imaging in vivo and (b) evaluate MRI as a tool for imaging of topical or systemic application of GB for the purpose of OC. Subcutaneous tumor xenografts expressing red fluorescent marker protein were used as disease models.

Unbalanced clustering and solitary states in coupled excitable systems.

We discover the mechanisms of emergence and the link between two types of symmetry-broken states, the unbalanced periodic two-cluster states and solitary states, in coupled excitable systems with attractive and repulsive interactions. The prevalent solitary states in non-locally coupled arrays, whose self-organization is based on successive (order preserving) spiking of units, derive their dynamical features from the corresponding unbalanced cluster states in globally coupled networks. Apart from the states with successive spiking, we also find cluster and solitary states where the interplay of excitability and local multiscale dynamics gives rise to so-called leap-frog activity patterns with an alternating order of spiking between the units.

Graphene-based plasmonic metamaterial for terahertz laser transistors.

This paper reviews recent advances in the research and development of graphene-based plasmonic metamaterials for terahertz (THz) laser transistors. The authors' theoretical discovery on THz laser transistors in 2007 was realized as a distributed-feedback dual-gate graphene-channel field-effect transistor (DFB-DG-GFET) in 2018, demonstrating ∼0.1 µW single-mode emission at 5.

Synchronization of the Processes of Autonomic Control of Blood Circulation in Humans Is Different in the Awake State and in Sleep Stages.

The influence of higher nervous activity on the processes of autonomic control of the cardiovascular system and baroreflex regulation is of considerable interest, both for understanding the fundamental laws of the functioning of the human body and for developing methods for diagnostics and treatment of pathologies. The complexity of the analyzed systems limits the possibilities of research in this area and requires the development of new tools. Earlier we propose a method for studying the collective dynamics of the processes of autonomic control of blood circulation in the awake state and in different stages of sleep.

Call for contributions to the Special Issue on the 9th Congress of the Russian Photobiological Society held in Shepsi, Krasnodar region, Russia, on September 12-19, 2021.

This Commentary describes a call for submissions for the upcoming Special Issue focused on the science presented at the 9th Congress of The Russian Photobiological Society entitled "Actual Problems in Photobiology."

Microfluidic Synthesis and Analysis of Bioinspired Structures Based on CaCO for Potential Applications as Drug Delivery Carriers.

Naturally inspired biomaterials such as calcium carbonate, produced in biological systems under specific conditions, exhibit superior properties that are difficult to reproduce in a laboratory. The emergence of microfluidic technologies provides an effective approach for the synthesis of such materials, which increases the interest of researchers in the creation and investigation of crystallization processes. Besides accurate tuning of the synthesis parameters, microfluidic technologies also enable an analysis of the process in situ with a range of methods.

"Smart" Polylactic Acid Films with Ceftriaxone Loaded Microchamber Arrays for Personalized Antibiotic Therapy.

Bacterial infections are a severe medical problem, especially in traumatology, orthopedics, and surgery. The local use of antibiotics-elution materials has made it possible to increase the effectiveness of acute infections treatment. However, the infection prevention problem remains unresolved.

Reinforced Epoxy Composites Modified with Functionalized Graphene Oxide.

The possibility of using graphene oxide as a modifying additive for polymer fiber-reinforced composites based on epoxy resin and basalt roving has been studied. The content of graphene oxide in the system has been experimentally selected, which has the best effect on the physico-mechanical properties of the obtained polymer composite material. The efficiency of the modification of the graphene oxide surface with APTES finishing additives and aminoacetic acid, which provides chemical interaction at the polymer matrix-filler interface, has been considered.

Construction of Customized Palatal Orthodontic Devices on Skeletal Anchorage Using Biomechanical Modeling.

Orthodontic implants have been developed for the implementation of skeletal anchorage and are effectively used in the design of individual orthodontic devices. However, despite a significant amount of clinical research, the biomechanical aspects of the use of skeletal anchorage have not been adequately studied. The aim of this work was to numerically investigate the stress-strain state of the developed palatal orthodontic device supported by mini-implants.

The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds.

Hydrogels, which are versatile three-dimensional structures containing polymers and water, are very attractive for use in biomedical fields, but they suffer from rather weak mechanical properties. In this regard, biocompatible particles can be used to enhance their mechanical properties. The possibility of loading such particles with drugs (e.

Assessing the reliability of zygomatic bone landmarks as guides to reach the inferior orbital fissure in orbitozygomatic osteotomy: anatomical study of 83 human skulls.

To perform an adequate orbitozygomatic craniotomy, it is very important that the bone cut which passes through the body of the zygoma reaches the inferior orbital fissure (IOF). To reach the IOF, two surface landmarks on the body of the zygoma are described: a point located directly superior to the malar eminence and the zygomaticofacial foramen. The article explores the reliability of these landmarks and three other alternative points to reach the IOF.

[Erratum: clinical and molecular characteristics of patients with 46,xy dsd due to nr5a1 gene mutations (Probl Endokrinol (Mosk). 2020 Sep 16;66(3):62-69. Russian. doi: 10.14341/probl12445)].

n the article some corrections were needed. Abstract: "Heterozygous SF1 variants were found in 36 out of 310 (11.6%) of cases, among them 15 were not previously described".

A Blueprint for the Synthesis and Characterization of Thiolated Graphene.

Graphene derivatization to either engineer its physical and chemical properties or overcome the problem of the facile synthesis of nanographenes is a subject of significant attention in the nanomaterials research community. In this paper, we propose a facile and scalable method for the synthesis of thiolated graphene via a two-step liquid-phase treatment of graphene oxide (GO). Employing the core-level methods, the introduction of up to 5.

[Experimental studies of geroprotective and anti-aging effects of chemical compounds of Portulaca oleracea L. (review).].

The analysis presented in the review of publications shows that extract of Portulaca oleracea L. or its individual components (polysaccharides, oleracea, alkaloids tetrahydroisoquinoline operatein E) is able to increase the lifespan of laboratory animals to activate telomerase and increase telomere length, and provide antioxidant and antistaatiline impact. Various neuroprotective effects (improvement of memory and learning ability, inhibition of acetylcholinesterase, protection of dopaminergic neurons, improvement of motor functions, etc.

Hypersonic magnetoelastic waves in inhomogeneous structures.

This work focuses on the propagation of surface magnetoelastic waves in a inhomogeneous structure containing ferromagnetic layer of smooth and slowly variable thickness. The dispersion relation of magnetoelastic waves and the wave attenuation due to the thickness variation in the studied structure were analytically obtained. We found that the magnetoelastic resonance frequency is changed at different positions in this structure.

Genome Features of Probiotic Bifidobacteria Determining Their Strain-Specific Properties.

Unlabelled: was to analyze the genome features of the probiotic strains 379, 1, and 791 and study their antiviral activity.

Materials And Methods: Whole genome sequencing of three strains of bifidobacteria was performed on the MiSeq platform (Illumina Inc., USA).

[The efficiency of combined regimens for the treatment of urinary tract infections in women using the herbal drug Canephron N].

Introduction: Currently, empiric antibiotic therapy is considered the standard for acute cystitis. However, additional treatment may be required to alleviate the patient's condition and shorten the time to subjective recovery.

Aim: To evaluate the efficiency of the combined administration of fosfomycin trometamol and herbal drug Canephron N in comparison with a single oral dose of fosfomycin trometamol in women with uncomplicated bacterial cystitis.

Effect of Size on Magnetic Polyelectrolyte Microcapsules Behavior: Biodistribution, Circulation Time, Interactions with Blood Cells and Immune System.

Drug carriers based on polyelectrolyte microcapsules remotely controlled with an external magnetic field are a promising drug delivery system. However, the influence of capsule parameters on microcapsules' behavior in vivo is still ambiguous and requires additional study. Here, we discuss how the processes occurring in the blood flow influence the circulation time of magnetic polyelectrolyte microcapsules in mouse blood after injection into the blood circulatory system and their interaction with different blood components, such as WBCs and RBCs.