Physico-Chemical Properties of Granular Sorbents Based on Natural Bentonite Modified by Polyhydroxocations of Aluminum and Iron (III) by Co-Precipitation.

The physicochemical and adsorption properties of granular sorbents based on natural bentonite and modified sorbents based on it have been studied. It was found that modification of natural bentonite with iron (III) polyhydroxocations (mod. 1_Fe_5 GA) and aluminum (III) (mod.

Novel Pyrroloquinoline Quinone-Modified Cerium Oxide Nanoparticles and Their Selective Cytotoxicity Under X-Ray Irradiation.

Ionizing radiation leads to the development of oxidative stress and damage to biologically important macromolecules (DNA, mitochondria, etc.), which in turn lead to cell death. In the case of radiotherapy, both cancer cells and normal cells are damaged.

Changes in Functional Activity of Platelets under the Influence of Submicron Particles Based on Mesoporous Silica and pH-Sensitive Polymers.

In vitro and in vivo effects of mesoporous silica nanoparticles (MSN) on the functional activity of platelets were studied in experiments on white rats. MSN particles, neither uncoated nor coated with calcium alginate, induced spontaneous platelet aggregation when added to platelet-rich plasma, but significantly enhanced ADP-induced platelet aggregation. Subcutaneous administration of uncoated and calcium alginate-coated MSN resulted in increased maximum size and rate of platelet aggregate formation 1 day post-injection.

Laser speckle contrast imaging with principal component and entropy analysis: a novel approach for depth-independent blood flow assessment.

Current study presents an advanced method for improving the visualization of subsurface blood vessels using laser speckle contrast imaging (LSCI), enhanced through principal component analysis (PCA) filtering. By combining LSCI and laser speckle entropy imaging with PCA filtering, the method effectively separates static and dynamic components of the speckle signal, significantly improving the accuracy of blood flow assessments, even in the presence of static scattering layers located above and below the vessel. Experiments conducted on optical phantoms, with the vessel depths ranging from 0.

Exploring salinity induced adaptations in marine diatoms using advanced photonic techniques.

Photonic-based methods are crucial in biology and medicine due to their non-invasive nature, allowing remote measurements without affecting biological specimens. The study of diatoms using advanced photonic methods remains a relatively underexplored area, presenting significant opportunities for pioneering discoveries. This research provides a comprehensive analysis of marine diatoms, specifically Nitzschia sp.

Transient destabilization of interhemispheric functional connectivity induced by spreading depolarization.

Cortical spreading depolarization (CSD), a slowly propagating wave of transient cellular depolarization, is a reliable cortical response to various brain insults (stroke, trauma, seizures) and underlying mechanism of migraine aura. Little is known about CSD effects on brain network activity. Using undirected (mutual information, MI) and directed (transfer entropy, TE) measures, we studied the dynamics of cross-hemispheric connectivity associated with the development of unilateral CSD in freely behaving rats and the involvement of inhibitory transmission in mechanisms of the coupling changes.

The association between melatonin-containing food consumption and sleep/meal timing and behavior in children with language difficulties.

The purpose of this study was to investigate the sleep characteristics, circadian rhythms, behavior, and postnatal development of children with and without language difficulties (LDs) and the association of these variables with melatonin-containing food (FMT) consumption. The study involved parents who anonymously and voluntarily provided their children's personal data and assessed LDs, bedtime, meal timing, behavioral problems, gross motor skill development, and FMT consumption. Multiple regression analysis was used to analyze the associations between study variables.

[Application of modern methods for activation of brain functions in obese patients (literature review)].

Unlabelled: The problem of rational activation of functions of the central nervous system of a human remains highly relevant.

Objective: To analyze scientific data on the use of transcranial exposure method in obesity.

Results: The literature review presents current data on the effectiveness of non-invasive hardware brain neurostimulation in obese patients.

[Evaluation of the effectiveness of the drug Cortexin in combination with the use of the application Aphasia.No (Afaziyam.Net) in the correction of speech disorders in patients with cerebral infarction].

Objective: Assessing the effectiveness of using a complex that includes the use of the drug Cortexin and classes using the mobile application Aphasia.No (Afaziyam.Net) in working with speech disorders in patients with acute stroke.

Plasmalogens Improve Lymphatic Clearance of Amyloid Beta from Mouse Brain and Cognitive Functions.

Amyloid beta (Aβ) is a neuronal metabolic product that plays an important role in maintaining brain homeostasis. Normally, intensive brain Aβ formation is accompanied by its effective lymphatic removal. However, the excessive accumulation of brain Aβ is observed with age and during the development of Alzheimer's disease (AD) leading to cognitive impairment and memory deficits.

QSAR Modeling and Biological Testing of Some 15-LOX Inhibitors in a Series of Homo- and Heterocyclic Compounds.

This paper examines the quantitative structure-inhibitory activity relationship of 15-lipoxygenase (15-LOX) in sets of 100 homo- and heterocyclic compounds using GUSAR 2019 software. Statistically significant valid models were built to predict the IC50 parameter. A combination of MNA and QNA descriptors with three whole molecular descriptors (topological length, topological volume and lipophilicity) was used to develop 18 statistically significant, valid consensus QSAR models.

Delayed-feedback oscillators replicate the dynamics of multiplex networks: Wavefront propagation and stochastic resonance.

The widespread development and use of neural networks have significantly enriched a wide range of computer algorithms and promise higher speed at lower cost. However, the imitation of neural networks by means of modern computing substrates is highly inefficient, whereas physical realization of large scale networks remains challenging. Fortunately, delayed-feedback oscillators, being much easier to realize experimentally, represent promising candidates for the empirical implementation of neural networks and next generation computing architectures.

Input signal accumulation capability of the FitzHugh-Nagumo neuron.

We present numerical results on the effects of two presynaptic FitzHugh-Nagumo neurons on a postsynaptic neuron under unidirectional electrical coupling. The presynaptic neurons affect the postsynaptic neuron not simultaneously but with a certain time shift. We consider cases where the amplitudes of the presynaptic spikes can be both higher and lower than the excitation threshold level.

Traveling waves in an ensemble of excitable oscillators: The interplay of memristive coupling and noise.

Using methods of numerical simulation, we demonstrate the constructive role of memristive coupling in the context of the traveling wave formation and robustness in an ensemble of excitable oscillators described by the FitzHugh-Nagumo neuron model. First, the revealed aspects of the memristive coupling action are shown in an example of the deterministic model where the memristive properties of the coupling elements provide for achieving traveling waves at lower coupling strength as compared to non-adaptive diffusive coupling. In the presence of noise, the positive role of memristive coupling is manifested as significant, increasing a noise intensity critical value corresponding to the noise-induced destruction of traveling waves as compared to classical diffusive interaction.

Drug delivery using gold nanoparticles.

Modern nanotechnologies provide various possibilities for efficiently delivering drugs to biological targets. This review focuses on using functionalized gold nanoparticles (GNPs) as a drug delivery platform. Owing to their exceptional size and surface characteristics, GNPs are a perfect drug delivery vehicle for targeted and selective distribution.

Dummy-template imprinted bovine serum albumin for extraction of zearalenone.

The aim of this study is to develop molecularly imprinted protein specific to zearalenone (ZEN). The primary idea of our study was to replace the toxic template-ZEN-with a dummy-template-4-hydroxicoumarin-during the synthesis of imprinted proteins (IPs). The choice of the dummy-template was based on the results of comprehensive evaluation that included a combination of blind docking and molecular dynamics simulations.

Optical Clearing of Ex Vivo Adipose Tissue.

Objectives: The paper focuses on the development of technology of adipose tissue optical clearing using different complex hyperosmotic optical clearing agents and tissue permeability enhancers.

Methods: To quantify optical clearing efficiency, reduced scattering coefficient was estimated from the ex vivo spatially resolved backreflectance measurements using a multi-distant fiber optical device. Tissue morphology modification was monitored with the help of histological studies.

Serum Irisin, Myostatin, and Myonectin Correlate with Metabolic Health Markers, Liver Disease Progression, and Blood Pressure in Patients with Metabolic Dysfunction-Associated Fatty Liver Disease and Hypertension.

Background/objectives: Recent data indicate the involvement of skeletal muscles in the regulation of metabolism and in the pathogenesis of chronic noncommunicable diseases. The goal of our study was to describe the serum concentrations of myokines in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and hypertension (HTN) and their correlation with laboratory parameters, blood pressure (BP), and MASLD severity.

Methods: A total of 67 patients with MASLD and HTN underwent anthropometric measurements, laboratory tests, and point shear-wave elastography.

Mimicking Marker Spread After Disruption of the Blood-Brain Barrier with a Collagen-Based Hydrogel Phantom.

Recent studies of the spread of substances penetrating the disrupted blood-brain barrier have revealed that the spread in the parenchyma surrounding a vessel has a complex character. In particular, a flow-like motion occurred for a short time that exhibits a smooth transition to diffusional spread. To address the possible physical background of such behavior, we created a system formed by a hydrogel medium with a channel filled by a marker solution, which can serve as a physical model mimicking the process of a substance passively spreading to the brain's parenchyma when the blood-brain barrier is disrupted.

Wavelet-Detected Changes in Nocturnal Brain Electrical Activity in Patients with Non-Motor Disorders Indicative of Parkinson's Disease.

Background/Objectives-Parkinson's disease (PD) is the second most common neurodegenerative disorder caused by the destruction of neurons in the substantia nigra of the brain. Clinical diagnosis of this disease, based on monitoring motor symptoms, often leads to a delayed start of PD therapy and control, where over 60% of dopaminergic nerve cells are damaged in the brain substantia nigra. The search for simple and stable characteristics of EEG recordings is a promising direction in the development of methods for diagnosing PD and methods for diagnosing the preclinical stage of PD development.

[Molecular genetic causes of epilepsy in children].

The molecular genetic approach to the study of epilepsy in childhood allows us to come closer to understanding the role of heredity in the development of epilepsy, as well as provide a personalized approach to the treatment and rehabilitation of severe, often resistant forms of epilepsy. In this article we demonstrate the genetic factors that cause the development of epilepsy in children. The review is devoted to the most common mechanisms of development of genetic epilepsies.

[Automated system for supporting medical decision-making in the treatment of patients with renal parenchyma neoplasms first experience of using the web-platform Sechenov.AI_nephro results of multicenter testing].

Aim: To evaluate the automated medical decision support system "Sechenov.AI_nephro" in the treatment of patients with renal parenchymal tumors.

Materials And Methods: The beta version of the web-platform "Sechenov.