7 results match your criteria: "Sanyo-Onoda Municipal Hospital[Affiliation]"
Prognostic risk score and index including the platelet-to-lymphocyte ratio and lactate dehydrogenase in patients with metastatic or unresectable urothelial carcinoma treated with immune checkpoint inhibitors.
Jpn J Clin Oncol
October 2024
Department of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Article Synopsis
- A study examined the effectiveness of avelumab and pembrolizumab, treatments for metastatic urothelial carcinoma post-chemotherapy, focusing on factors predicting patient outcomes.
- The research included 243 patients, analyzing characteristics and blood data to identify independent prognostic factors like performance status and specific blood markers.
- Findings indicate a new risk score utilizing platelet-to-lymphocyte ratio and lactate dehydrogenase levels could effectively predict overall survival after starting immune checkpoint inhibitors, outperforming existing models.
Comparative Efficacy of Avelumab Maintenance Therapy Versus Continued Chemotherapy Followed by Pembrolizumab in Metastatic Urothelial Carcinoma With No Progression After 4 Cycles of Chemotherapy: A Retrospective Study Using Propensity Score Matching.
Clin Genitourin Cancer
December 2024
Department of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Article Synopsis
- A study examined the effectiveness of avelumab maintenance therapy compared to pembrolizumab in patients with metastatic and unresectable urothelial carcinoma after 4 cycles of chemotherapy without disease progression.
- Data from 243 patients treated between January 2017 and December 2022 was analyzed, with a focus on oncological outcomes and adverse events using a method called propensity score matching.
- The findings indicated that both avelumab and pembrolizumab had similar progression-free survival rates, but avelumab required a lower rate of high-dose glucocorticoid treatment.
Testicular Temperature and the Effects of Orchiopexy in Infants with Cryptorchidism.
J Urol
October 2021
Department of Urology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Purpose: Testicular temperature should remain low to maintain optimal function of germ cells; however, information regarding testicular temperature in infants and the effect of cryptorchidism and its correction, including laparoscopic staged Fowler-Stephens orchiopexy (LSFSO), is limited.
Materials And Methods: A total of 82 infants with unilateral palpable cryptorchidism, 24 with nonpalpable testes who underwent unilateral LSFSO and 20 with scrotal hydrocele were included. Ultrasonographic determination of testicular volume and measurement of testicular temperature but not scrotal surface temperature using a Coretemp CTM204 (Terumo, Tokyo) were performed before and 12 months after orchiopexy.
Prognostic value of pre-treatment risk stratification and post-treatment neutrophil/lymphocyte ratio change for pembrolizumab in patients with advanced urothelial carcinoma.
Int J Clin Oncol
January 2021
Department of Urology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-kogushi, Ube, Yamaguchi, 755-8505, Japan.
Background: Pembrolizumab is effective in a limited number of patients with advanced urothelial carcinoma (UC). Therefore, we evaluated the prognostic value of clinical biomarkers following pembrolizumab treatment in patients with advanced UC.
Methods: We retrospectively reviewed the medical records of 121 patients with platinum-refractory advanced UC who received pembrolizumab.
Transperitoneal versus retroperitoneal laparoscopic adrenalectomy for large pheochromocytoma: Comparative outcomes.
Int J Urol
February 2019
Department of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan.
Objectives: To evaluate operative and oncological outcomes of laparoscopic adrenalectomy through a transperitoneal approach and retroperitoneal approach for large (>5 cm in diameter) pheochromocytomas.
Methods: We retrospectively compared the results of a transperitoneal approach with those of a retroperitoneal approach in 22 patients (mean age 57.5 years, range 38-76 years) with unilateral large pheochromocytomas (12 right, 10 left).
Identification of curable high-risk prostate cancer using radical prostatectomy alone: who are the good candidates for undergoing radical prostatectomy among patients with high-risk prostate cancer?
Int J Clin Oncol
August 2018
Department of Urology, Sanyo-Onoda Municipal Hospital, 1863-1 Higashi-Takadomari, Sanyo-Onoda, Yamaguchi, 756-0094, Japan.
Background: Currently, there is no consensus regarding which patients with high-risk prostate cancer (PCa) would benefit the most by radical prostatectomy (RP). We aimed to identify patients with high-risk PCa who are treatable by RP alone.
Methods: We retrospectively reviewed data on 315 patients with D'Amico high-risk PCa who were treated using RP without neoadjuvant or adjuvant therapy at the institutions of the Yamaguchi Uro-Oncology Group between 2009 and 2013.
Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology.
Int J Urol
June 2012
Department of Urology, Yamaguchi University School of Medicine, Sanyo-Onoda Municipal Hospital, Yamaguchi, Japan.
Varicocele is the most common and treatable cause of male infertility. Studies of a rat experimental left varicocele model and human testicular biopsy samples have shown the involvement of various factors in its pathophysiology. Among them, oxidative stress plays a major role in impairing spermatogenesis and sperm function.
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