37 results match your criteria: "Santosh Deemed to be University[Affiliation]"

The prevalence of Alzheimer's disease (AD) is rising with an aging population worldwide and is expected to surpass 130 million by 2050. India is no exception, but the true prevalence data on AD is not conclusive. By 2050, India will have almost 15% of the population aged 60 years or above.

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Background The rising demand for orthodontic services is juxtaposed with concerns regarding economic accessibility for diverse socioeconomic groups. Aim This study aims to investigate the economic accessibility of orthodontic care in India through a comprehensive questionnaire-based approach. Material and methods The survey involved a random sample of 5,000 patients actively seeking orthodontic treatment, recruited from both dental college clinics and private dental practices.

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Polycyclic aromatic hydrocarbons (PAHs), one of the major environmental pollutants, produced from incomplete combustion of materials like coal, oil, gas, wood, and charbroiled meat, that contaminate the air, soil, and water, necessitating urgent remediation. Understanding the metabolic pathways for PAHs degradation is crucial to preventing environmental damage and health issues. Biological methods are gaining increasing interest due to their cost-effectiveness and environmental friendliness.

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Cancer has arisen from both genetic mutations and epigenetic changes, making epigenetics a crucial area of research for innovative cancer prevention and treatment strategies. This dual perspective has propelled epigenetics into the forefront of cancer research. This review highlights the important roles of DNA methylation, histone modifications and non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs, which are key regulators of cancer-related gene expression.

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Background: Orthodontic treatment often induces pain, especially post appliance placement. This study compares transcutaneous electrical nerve stimulation (TENS) and acetaminophen for orthodontic pain management.

Materials And Methods: A randomized trial included 120 fixed orthodontic patients divided into three groups (n = 40): Group A received TENS, group B received acetaminophen, and group C was the control.

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Introduction: Bladder cancer disproportionately affects men and often presents as nonmuscle-invasive bladder cancer (NMIBC). Despite initial treatments, the recurrence and progression of NMIBC are linked to autophagy. This study investigates the expression of autophagy genes (mTOR, ULK1, Beclin1, and LC3) in low and high-grade NMIBC, providing insights into potential prognostic markers and therapeutic targets.

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Enamel Hypomineralization: Prevalence, Defect Characteristics in Primary Dentition in a Northern Indian Region.

Int J Clin Pediatr Dent

April 2024

Department of Pediatric and Preventive Dentistry, Santosh Deemed to be University, Ghaziabad, Uttar Pradesh, India.

Background: No data is available on hypomineralization in the full complement of primary dentition.

Aim: To report on the prevalence and clinical presentation of enamel hypomineralization (EH) in the primary dentition.

Design: A cross-sectional observational study with a random sample of 948, 4-6-year-old schoolchildren of Gautam Buddh Nagar, Uttar Pradesh, India, was conducted after approval from the Institutional Ethics Committee.

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A Comparative Evaluation of Herbal Extracts and Triple Antibiotic Paste as Intracanal Medicament against A Microbiological Study.

Int J Clin Pediatr Dent

March 2024

Department of Pediatric and Preventive Dentistry, Santosh Dental College & Hospital, Santosh (Deemed to be University), Ghaziabad, Uttar Pradesh, India.

Article Synopsis
  • The study aims to assess how effective herbal extracts (ginger, turmeric, and nutmeg) are in comparison to modified triple antibiotic paste (MTAP) as treatments for canal infections.
  • A total of 103 samples were tested with various concentrations of herbal extracts and MTAP; combinations of these extracts were also evaluated for their antibacterial properties.
  • Results indicate that the combination of ginger and nutmeg at a 12.5% concentration showed the most effectiveness against bacteria, similar to MTAP's performance.
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Elucidation of the CadA Protein 3D Structure and Affinity for Metals.

Bioinform Biol Insights

August 2024

Postdoctoral Fellow, Department of Animal Science, Manonmaniam Sundaranar University, Tirunelveli, India.

The mitigation of cadmium (Cd) pollution, a significant ecological threat, is of paramount importance. harbors 2 Cd resistance genes, namely, and . Presently, our focus is on the identification and characterization of the cation-transporting P-type ATPase (cadA) in BC15 through methods.

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Male breast cancer (MBC), one of the rare types of cancer among men where the global incidence rate is 1.8% of all breast cancers cases with a yearly increase in a pace of 1.1%.

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Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been shown to reduce the risk of hospitalizations from heart failure and cardiovascular mortality. However, SGLT2i therapy's potential effects on the risks of dementia and Parkinson's disease are not well established, with conflicting results based on observational studies. Hence, we sought to evaluate the association between SGLT2i and the risk of dementia and Parkinson's disease in patients with type 2 diabetes mellitus, heart failure, or chronic kidney disease.

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Background: Oral cancer is a major public health concern worldwide, with oral squamous cell carcinoma (OSCC) being one of its most common subtypes. Despite advances in diagnosis and management of this disease, there remains a need to develop new therapeutic approaches for better outcomes.

Objective: This study aimed to investigate the molecular mechanisms through which cinnamoyl sulfonamide hydroxamate derivatives exert their anticancer effects on OSCC.

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Background: Defects in apoptosis regulation are one of the classical features of cancer cells, often associated with more aggressiveness and failure to therapeutic options. We investigated the combinatorial antitumor effects of a natural product, physachenolide C (PCC) and bortezomib, in KRAS/P53 lung cancer cells and xenograft mice models.

Methods: The in vitro anticancer effects of the bortezomib and PCC combination were investigated using cell viability, migration, and invasion assays in 344SQ, H23, and H358 cell lines.

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There is an urgent requirement for the improvement of the white leg shrimp, Litopenaeus vannamei; health-related indices; and immunity due to emerging diseases. Recently, probiotics have been playing an important role in L. vannamei health management.

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An interesting case-report of ex-ameloblastic carcinoma.

J Oral Maxillofac Pathol

July 2023

Department of Oral and Maxillofacial Pathology and Microbiology, Santosh Dental College, Santosh Deemed to be University, Ghaziabad, Uttar Pradesh, India.

Ameloblastoma (AM) is considered one of the most common lesions of odontogenic origin. Although it is always considered as benign neoplasm, ameloblastic carcinoma (AC) represents its malignant counterpart. It is characterized by the expansion of jaws, rapid growth, and a perforated cortex with well-defined unilocular/multilocular radiolucent lesions.

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Background Cancer is the second most common cause of death. Oral squamous cell carcinoma (OSCC) represents the most frequent of all oral neoplasms. Many treatment modalities such as chemotherapy, radiotherapy, surgery, and immunotherapy are emerging but still, the patients' quality of life is questionable.

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Introduction Supracondylar elbow fractures are prevalent in the pediatric age group, and retrograde intramedullary nailing of the humerus is a common treatment approach. The anatomy of the medullary canal and the presence of the supratrochlear foramen (STF) significantly influence the stabilization of the nail. This study aimed to determine the incidence and morphology of the STF and compare the width of the medullary canal in humeri with and without the STF.

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Comparative Evaluation of Intracanal Smear Layer Removal by Different Root Canal Irrigants: A Scanning Electron Microscope Study.

Int J Clin Pediatr Dent

January 2023

Department of Pediatric and Preventive Dentistry, Santosh Dental College, Santosh (Deemed to be University), Ghaziabad, Uttar Pradesh, India.

Aim: The purpose of the study is to compare and evaluate the efficacy of different root canal irrigants-100, 75, 50, and 25% extract, 100, 75, 50, and 25% apple cider vinegar (ACV), a combination of 5.25% sodium hypochlorite (NaOCl) and 17% ethylenediaminetetraacetic acid (EDTA), and saline on smear layer removal using a scanning electron microscope (SEM).

Materials And Methods: A total of 80 freshly extracted single-rooted teeth were collected and divided into 10 groups-group I: normal saline (negative control), group II: NaOCl with EDTA (positive control), group III: 100% extract, group IV: 75% extract, group V: 50% extract, group VI: 25% extract, group VII: 100% ACV, group VIII: 75% ACV, group IX: 50% ACV, and group X: 25% ACV.

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Introduction: Uniplanar devices have been criticized for being insufficient to correct complex mandibular deformities and associated problems of open bite and cross bite. The use of oblique vector to correct complex multiplanar deformities using uniplanar mandibular distraction devices is the uniqueness of the present case series.

Aim And Objective: The aim of the present case series is to describe the successful use of uniplanar mandibular distraction devices for the correction of complex multiplanar deformities.

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Liquid biopsy and its significance in tumour - Detection in the field of pathology.

J Oral Maxillofac Pathol

March 2023

Department of Oral and Maxillofacial Pathology and Microbiology, Santosh Dental College and Hospital, Santosh Deemed to be University, Ghaziabad, NCR Delhi, India.

The treatment of cancer has remarkably improved because of increased knowledge of the abnormalities at the molecular level, which results in human cancer growth. This has initiated the development of ever more successful as well as effective targeted cancer therapies. Detection of cancer is diagnosed basically by performing routine biopsy/cytology, which has many drawbacks.

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Different parts of are the common components of various traditional formulations for the treatment of several blood disorders. The new-fangled stem buds' powder was extracted with 80% ethanol and successively fractionated by chloroform and methanol. Chloroform and methanol fractions of (CFFR and MFFR) were tested for antiplatelet, antithrombotic, thrombolytic, and antioxidant activity in ex vivo mode.

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The development of new pharmaceutical solutions for treating various diseases results from a growing understanding of the benefits of using essential oils. One of the most often used volatile materials among essential oils is the oil of the citronella plant, termed citronella essential oil (CITEO), which has potential for use in food and medicine. Its wide use is limited due to lipophilicity, high volatility and poor physicochemical stability.

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Miscarriage in the first and second trimesters of pregnancy is very common, and coagulopathy can be a contributing factor. Protein C and S deficiency are rare, inherited disorders that can increase the risk of thrombophilia. Women with these deficiencies have a higher risk of developing blood clots in the placenta, which can lead to placental insufficiency and, ultimately, to a miscarriage.

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The aim of this study was to examine the hypothesis that use of dimethyl fumarate (DMF) may mitigate arthritic symptoms in collagen-induced arthritis (CIA) rats through activation of NF-E2-related factor 2(Nrf-2) and suppression of NF-kB pathway. Arthritis in rats was induced by subcutaneous injection of collagen type II (200 µl) at the base of the tail. After induction arthritic rats were treated with DMF (25 mg/kg b.

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Aim: Screw loosening is a very common cause of failures in implant prosthodontics. In order to avoid screw fracture, it is imperative to understand the mechanical behavior of the screw and the dynamics it is subjected to intraorally. The present study was conducted to qualitatively evaluate and compare the morphological changes, surface defects, and cracks observed under a scanning electron microscope (SEM) in the prosthetic screw.

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