Association Between Early Childhood P300 Deficits and Risk for Preadolescence Depressive Disorder Mediated by Responsiveness to PCIT-ED Treatment.

Preschool-onset major depressive disorder (PO-MDD) is an impairing pediatric mental health disorder that impacts children as young as three years old. There is limited work dedicated to uncovering neural measures of this early childhood disorder which could be leveraged to further understand both treatment responsiveness and future depression risk. Event-related potentials (ERPs) such as the P300 have been employed extensively in adult populations to examine depression-related deficits in cognitive and motivational systems.

A Randomized Controlled Trial Assessing the Psychological Benefits of a Daily Examen-Based Practice.

This is a randomized controlled trial of an Examen-based practice, an intervention reflecting a five-step daily reflection and prayer practice developed by St. Ignatius of Loyola, founder of the Catholic Jesuit order. Like other practices (e.

Haralick Texture Analysis for Differentiating Suspicious Prostate Lesions from Normal Tissue in Low-Field MRI.

This study evaluates the feasibility of using Haralick texture analysis on low-field, T2-weighted MRI images for detecting prostate cancer, extending current research from high-field MRI to the more accessible and cost-effective low-field MRI. A total of twenty-one patients with biopsy-proven prostate cancer (Gleason score 4+3 or higher) were included. Before transperineal biopsy guided by low-field (58-74mT) MRI, a radiologist annotated suspicious regions of interest (ROIs) on high-field (3T) MRI.

Testing the relationships of hope and negotiable fate with sleep quality among university students in Hong Kong.

For university students, who are often under significant stress to perform well, sleep is particularly important, playing roles in learning and academic performance. Research demonstrates a relationship between hope and sleep quality. However, most work concerns Western samples, and the hope construct has been criticized for a Western bias.

An Interprofessional Collaboration Between a Community-Based Doula Organization and Clinical Partners: The Champion Dyad Initiative.

As access to doula services expands through state Medicaid coverage and specific initiatives aimed at improving maternal health equity, there is a need to build and improve upon relationships between the doula community, hospital leaders, and clinical staff. Previous research and reports suggest rapport-building, provider education, and forming partnerships between community-based organizations and hospitals can improve such relationships. However, few interventions or programs incorporating such approaches are described in the literature.

The Role of Perceived Neighborhood Factors and the Built Environment on Depression and Stress Among Latinas on US-Mexico Border.

Neighborhood factors and the built environment (e.g., sidewalks, bike lanes and public transportation) are important social determinants of mental health.

Evaluating racial disparities in cancer patient-provider communication about cannabis in a state without a legal cannabis marketplace.

Purpose: Cancer survivors in a state with no legal access to cannabis may be hesitant to discuss their cannabis use with providers, particularly in light of legal consequences which disproportionately affect certain racial groups. This study examined potential racial disparities in the relationship of cannabis use status with patient-provider discussions of and attitudes toward cannabis in a state where there is no legal cannabis marketplace.

Methods: Survivors of cancer (N = 1003, M = 62.

Inner engineering is associated with perceived improvements in relationship quality, interpersonal connections, and interpersonal compassion.

Objectives: Interpersonal relationships are a cornerstone of wellbeing. Mindfulness-based practices have been shown to improve relationship quality and reduce perceived stress. Inner Engineering (IE) is a transformative program that includes meditative and yogic practices associated with improvements in mindfulness and wellbeing.

Stepwise isolation of diverse metabolic cell populations using sorting by interfacial tension (SIFT).

We present here a passive and label-free droplet microfluidic platform to sort cells stepwise by lactate and proton secretion from glycolysis. A technology developed in our lab, Sorting by Interfacial Tension (SIFT), sorts droplets containing single cells into two populations based on pH by using interfacial tension. Cellular glycolysis lowers the pH of droplets through proton secretion, enabling passive selection based on interfacial tension and hence single-cell glycolysis.

Neurotyping depression using multiple event-related potentials (ERPs): Leveraging task-based variation to predict remission in depression.

Aims: Depression is a prevalent, burdensome, and difficult mental health disorder to treat. Significant heterogeneity in clinical characteristics and course of depression hinders treatment success. Efforts to identify more homogeneous subgroups of depression could reduce heterogeneity of depression and therefore improve treatment development and randomized clinical trial outcomes.

Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages.

Immunomodulation has emerged as a promising strategy for promoting bone regeneration. However, designing osteoimmunomodulatory biomaterial that can respond to mechanical stress in the unique microenvironment of alveolar bone under continuous occlusal stress remains a significant challenge. Herein, a wireless piezoelectric stimulation system, namely, piezoelectric hydrogel incorporating BaTiO nanoparticles (BTO NPs), is successfully developed to generate piezoelectric potentials for modulating macrophage reprogramming.

Optimal Cell Length for Exploration and Exploitation in Chemotactic Planktonic Bacteria.

Elongated morphologies are prevalent among motile bacterioplankton in aquatic systems. This is often attributed to enhanced chemotactic ability, but how long is best? We hypothesized the existence of an optimal cell length for efficient chemotaxis resulting from shape-imposed physical constraints acting on the trade-off between rapid exploration versus efficient exploitation of nutrient sources. To test this hypothesis, we evaluated the chemotactic performance of elongated cephalexin-treated Escherichia coli towards α-methyl-aspartate in a microfluidic device creating linear, stable and quiescent chemical gradients.

Machine Learning-based Prognostic Subgrouping of Glioblastoma: A Multi-center Study.

Background: Glioblastoma is the most aggressive adult primary brain cancer, characterized by significant heterogeneity, posing challenges for patient management, treatment planning, and clinical trial stratification.

Methods: We developed a highly reproducible, personalized prognostication and clinical subgrouping system using machine learning (ML) on routine clinical data, MRI, and molecular measures from 2,838 demographically diverse patients across 22 institutions and 3 continents. Patients were stratified into favorable, intermediate, and poor prognostic subgroups (I, II, III) using Kaplan-Meier analysis (Cox proportional model and hazard ratios [HR]).

Imaging-guided bioresorbable acoustic hydrogel microrobots.

Micro- and nanorobots excel in navigating the intricate and often inaccessible areas of the human body, offering immense potential for applications such as disease diagnosis, precision drug delivery, detoxification, and minimally invasive surgery. Despite their promise, practical deployment faces hurdles, including achieving stable propulsion in complex in vivo biological environments, real-time imaging and localization through deep tissue, and precise remote control for targeted therapy and ensuring high therapeutic efficacy. To overcome these obstacles, we introduce a hydrogel-based, imaging-guided, bioresorbable acoustic microrobot (BAM) designed to navigate the human body with high stability.

Green flowers need yellow to get noticed in a green world.

Background And Aims: Flower colour is a key feature in plant-pollinator interactions that make the flowers visible amid the surrounding green vegetation. Green flowers are expected to be scarcely conspicuous to pollinators; however, many of them are visited by pollinators even in the absence of other traits that might attract pollinators (e.g.

Hope as a bridge to post-traumatic growth.

Post-traumatic growth (PTG) has been characterized as the subjective appraisal of growth, or personal development, following a confrontation with an array of high-impact challenges in life (Psychol Inq 15:1-18, 2004). Song et al. found that patients with cancer may be described by three profiles with regard to symptom burden and PTG.

Ageism and Ableism in Individuals Aging with Intellectual and Developmental Disabilities.

Biomedical and structural factors impact oral health for people with intellectual and developmental disabilities (IDD). The onset of age prevalent chronic diseases and conditions can result in new cognitive or physical disabilities leaving individuals with IDD to contend with ageism as well as ableism and further exclusion from the oral health care systems. Environments and attitudes that inform how health care systems are built and maintained significantly impact quality of life and outcomes, more than the fact of being disabled or old.

Immigration Policy and Latinx/é Children from Mixed-Status Families: Mental Health Consequences and Recommendations for Mental Health Providers.

The impact of immigration policies on Latinx/é mixed-status families and their children is undeniable. Changes in immigration policy, focused on increased deportation enforcement, within the last three decades have led to an increased fear of deportation and unique circumstances mixed-status families must navigate. These circumstances, combined with fear of deportation, have had deleterious effects on the psychological well-being of the family, in general, and the children, in particular.

The Go/No-Go P3 and Depressive Symptoms in Adolescents: Trial-Level Change and Mean Amplitude Relate Differently to Anhedonic Versus Negative Mood Symptoms.

Prior studies have found an association between reduced P3 brain responses-a neural marker of task engagement-and increased depressive symptoms during adolescence. However, it is unclear whether P3 correlates with depression globally, or with certain facets. Existing depression studies have also typically quantified P3 as a cross-trial average, neglecting possible trial-by-trial effects.

Queer- and trans-inclusive faculty hiring-A call for change.

As queer and trans scientists, we face varied and systemic barriers to our professional success, resulting in our relative absence from faculty ranks at many institutions. In this Perspective, we call for a change in faculty hiring practices and present concrete guidance to make it a more inclusive process.

Adolescent seizure impacts oligodendrocyte maturation, neuronal-glial circuit Formation, and myelination in the mammalian forebrain.

Oligodendrocyte progenitor cells differentiate into oligodendrocytes, which myelinate axons during development and following demyelinating injury. However, the mechanisms that drive the timing and specificity of developmental myelination are not well understood. We hypothesized that oligodendrocyte progenitor cell proliferation and differentiation would be affected by pathological neuronal activity during adolescent development when developmental myelination is occurring and that this would also impact neuron-to-oligodendrocyte progenitor cell connectivity and myelination.

Breast Cancer Detection on Dual-View Sonography via Data-Centric Deep Learning.

This study aims to enhance AI-assisted breast cancer diagnosis through dual-view sonography using a data-centric approach. We customize a DenseNet-based model on our exclusive dual-view breast ultrasound dataset to enhance the model's ability to differentiate between malignant and benign masses. Various assembly strategies are designed to integrate the dual views into the model input, contrasting with the use of single views alone, with a goal to maximize performance.