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Article Synopsis
  • Ovarian cancer is often diagnosed late with high mortality rates, prompting a need for deeper genetic profiling beyond BRCA1 and BRCA2 mutations to find additional diagnostic and therapeutic targets.
  • The study analyzed 27 genes in 50 ovarian cancer patients using next-generation sequencing, identifying mutations particularly in BRCA1, CDK4, MSH2, and PTEN, with some unique to the Pakistani cohort.
  • Functional analyses demonstrated that these mutations led to reduced expression of the respective proteins and positional biomarkers, while Resveratrol was predicted as a potential therapeutic agent through molecular docking studies.
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