Minimising diagnostic error in paediatric critical care: a checklist approach.

Caring for critically ill children presents unique challenges due to their rapid deterioration and the need for immediate, complex interventions. The assessment, diagnosis and treatment of deteriorating paediatric patients require a comprehensive and holistic, systematic approach. However, the dynamic nature of critical illness and the need for stabilisation can often lead to missed opportunities for assessment and intervention.

A narrative review on sexual wellbeing and dysfunctions: Research in the past 15 years.

Background: Psychosexual health is an important aspect of mental and physical wellbeing. Though Indian culture has a rich history of sexuality, over the years, our population has been reticent in talking about the same. With the advent of technology and new legislations protecting the rights of LGBTQIA population, awareness is also on the rise.

Depression, anxiety, stress, and coping among men with infertility seeking treatment at a tertiary care hospital in South India: A mixed-method study.

Background: Many studies in India and all over the world have focused on the psychological aspect of infertility in women, but only a few have explored it among men. To deal with psychological distress, sometimes, individuals may use maladaptive coping strategies which can further worsen the stress instead of reducing it.

Aim: To assess symptoms of depression, anxiety, stress, and various coping strategies adopted by men with infertility along with exploring their coping experiences.

Characterization of jamun () juice fortified with nanoemulsified vitamin D: and assessment of its nutraceutical value and anti-diabetic potential.

This study aimed to fortify Jamun () juice with vitamin D to address vitamin D deficiency and boost health. A nanoemulsion of vitamin D was fabricated using a low-temperature (4-20C) sonication method and incorporated into the juice. The vitamin D fortified jamun juice (VDFJJ) exhibited a total polyphenol content of 14.

Evaluation of the Quality of Educational Content of YouTube Videos on Silver Diamine Fluoride.

Aim: The aim of this research is to assess the accuracy and educational content concerning silver diamine fluoride (SDF) videos available on YouTube.

Materials And Methods: Videos were sought on YouTube using relevant keywords related to SDF in pediatric dentistry the Google Trends application. There were a total of 70 videos accessible.

ChatGPT-4.0 vs. Google: Which Provides More Academic Answers to Patients' Questions on Arthroscopic Meniscus Repair?

Purpose The purpose of this study was to evaluate the ability of a Chat Generative Pre-trained Transformer (ChatGPT) to provide academic answers to frequently asked questions using a comparison with Google web search FAQs and answers. This study attempted to determine what patients ask on Google and ChatGPT and whether ChatGPT and Google provide factual information for patients about arthroscopic meniscus repair. Method A cleanly installed Google Chrome browser and ChatGPT were used to ensure no individual cookies, browsing history, other side data, or sponsored sites.

Effect of Health Education on Knowledge and Attitudes Toward Reproductive Health Among Pre-university Girls in an Urban Area.

Background: For every woman, menstruation is a natural physiological process, and the adolescence period marks the beginning of the menstruation process. Investing the right knowledge in girls at a young age directs a better future for women, children, and families, thereby leading to intergenerational impact.

Objective: This study aims to evaluate the impact of health education on reproductive health among pre-university girls in an urban area.

Sociodemographic Factors and Awareness of Consanguineous Marriages in Rural Northern Karnataka: A Cross-Sectional Study.

Background Consanguineous marriages, defined as unions between closely related individuals, are influenced by a complex interplay of cultural, social, economic, religious, and demographic factors. These marriages are prevalent among communities such as Hindus, Muslims, Jews, Buddhists, Christians, and Parsis in Southern and Western Asia, with significant regional variations within India. There is a lack of appropriate decision-making among women in consanguineous unions, particularly those with a low level of educational attainment, which leads to an increase in the prevalence of consanguineous marriages.

Determinants of Improvement in Foot Bimalleolar Angle, Pirani Score, and Recurrence in Clubfoot Patients Treated With the Ponseti Technique.

Introduction: Foot bimalleolar angle (FBM angle) and Pirani score are recognized as assessment and prognostic tools for objective assessment of clubfoot (congenital talipes equinovarus, or CTEV) treatment. The present study proposed to study various factors that determine the improvement in FBM angle and Pirani score in patients treated by the Ponseti technique.

Materials And Methods: This prospective observational study was conducted after obtaining ethical clearance, and 42 children with CTEV (60 feet) were enrolled.

Optimizing Premenopausal Hormone Receptor-Positive Human Epidermal Growth Factor Receptor 2-Negative Early Breast Cancer Management in India: Insights From Expert Consensus.

This research aims to optimize adjuvant ovarian function suppression (OFS) for premenopausal Indian women with hormone receptor-positive (HR+) /human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (eBC). To address specific challenges identified in clinical practice, a comprehensive questionnaire consisting of 21 statements was developed. These statements were reviewed and validated by a scientific committee, ensuring their accuracy and relevance to the study's objectives.

Avoidant/Restrictive Food Intake Disorder in a Pediatric Obese Patient.

Avoidant/restrictive food intake disorder (ARFID) can present with limited food variety, intake, or aversions. The symptoms can manifest at any age and typically appear in the first few years of life. The prevalence of ARFID varies widely among clinical and non-clinical populations, and its diagnosis requires trained health professionals to ensure early detection and prevention of poor outcomes.

Significance of Misoprostol-Induced Cervical Ripening Prior to Hysteroscopy.

Background Hysteroscopy, a minimally invasive procedure for diagnosing and treating intrauterine pathologies, can be challenging due to inadequate cervical dilation, leading to procedural difficulties and patient discomfort. Misoprostol, a synthetic prostaglandin E1 analog, is increasingly used for cervical ripening to ease hysteroscopic procedures. Objective To evaluate the efficacy and safety of misoprostol for cervical ripening prior to hysteroscopy.

Continuation Versus Interruption of Anticoagulation During Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-Analysis.

Transcatheter aortic valve implantation (TAVI) involves complex decisions regarding perioperative anticoagulation, with continuation or interruption of oral anticoagulation presenting distinct risks and benefits. This systematic review and meta-analysis compared the clinical outcomes of these two strategies during TAVI. We conducted a comprehensive literature search across multiple electronic databases, including PubMed, Embase, Cochrane Library, and Web of Science, from inception to November 2024.

Allergic Rhinitis Symptoms and Impact Assessment (ARSIA) of Public Community in Saudi Arabia: A National Cross-Sectional Study.

Introduction Allergic rhinitis (AR) is a common inflammatory condition of the nasal mucosa in Saudi Arabia, triggered by various allergens. It significantly impacts daily life, affecting sleep quality, social interactions, and productivity. Despite its prevalence, AR is often underdiagnosed and undertreated in the region.

Malaria and Dengue Co-infection: A Comprehensive Study in Peshawar, Pakistan.

Background: Malaria and dengue are significant mosquito-borne diseases prevalent in tropical and subtropical climates, with increasing reports of co-infections. This study aimed to determine the frequency, patterns, and risk factors of these co-infections in Peshawar.

Methods: A cross-sectional study was conducted from June to December 2023 in three tertiary care hospitals in Peshawar.

Obturation of Simulated Internal Resorption Cavities With Four Different Techniques and a Hydraulic Root Canal Sealer: A Comparative Stereomicroscopic Evaluation.

Aim To compare the quality of obturation using WVC (warm vertical compaction), CLC (cold lateral compaction), injectable (iFill), and Thermafil (GuttaCore) techniques, along with hydraulic condensation of bioceramic (BC) sealer, and evaluating the percentage of gutta-percha (GP), sealer, and voids in simulated internal resorptive lesions, using an advanced stereomicroscope with ImageJ software (National Institutes of Health, Bethesda, MD, USA). Methods and material In this study, 40 freshly extracted maxillary incisors were collected, and endodontic instrumentation was done to working length using hand K-files. Simulated internal resorption cavities were created in the middle-apical third of the roots after horizontal sectioning and were re-cemented.

The Impact of Patient-Centered, Structured Interdisciplinary Bedside Rounds on Medical Staff Satisfaction, Education, and Experience.

Background Daily interdisciplinary rounds in hospitals are becoming standardized to maximize the multidisciplinary approach to hospitalized patient care. We hypothesize that structured Interdisciplinary Bedside Rounds (IDRs) increase the satisfaction, education, and experience of medical staff and thus detail actionable recommendations for IDR implementation or delineate measurable long-term impacts. Methods This observational study was performed in a 300-bed community hospital.

Nurses' self-efficacy and outcome expectancy in evidence-based practice: Translation, construct validity and internal consistency of the Dutch scales.

Background: Evidence-based practice (EBP) is crucial for appropriate, effective, and affordable care. Despite EBP education, barriers like low self-efficacy and outcome expectancy limit nurses' engagement in EBP. Reliable scales are essential to evaluate interventions aimed at improving self-efficacy and outcome expectancy in EBP.

Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head.

Osteonecrosis of the femoral head (ONFH) is a prevalent orthopedic disorder characterized primarily by compromised blood supply. This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse of the femoral head at late stage, significantly impairing joint function. While MRI is a highly effective tool for diagnosing ONFH in its early stages, challenges remain due to the limited availability and high cost of MRI, as well as the absence of routine MRI screening in asymptomatic patients.

Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets.

Introduction: To further advance our understanding of Muscular Dystrophies (MDs) and Spinocerebellar Ataxias (SCAs), it is necessary to identify the biological patterns associated with disease pathology. Although progress has been made in the fields of genetics and transcriptomics, there is a need for proteomics and metabolomics studies. The present study aimed to be the first to document serum metabolic signatures of MDs (DMD, BMD, and LGMD 2A) SCAs (SCA 1-3), from a South Asian perspective.

Gender influence on career trajectory as a shoulder and elbow surgeon.

Background: Women continue to make up a minority of orthopedic surgeons, especially shoulder and elbow surgeons. There exists no study that investigates the effect of gender on one's academic career as a shoulder and elbow orthopedic surgeon, which was the purpose of this cross-sectional study.

Methods: The American Shoulder and Elbow Surgeons website was used to identify surgeons.

Bridging bioengineering and nanotechnology: Bone marrow derived mesenchymal stem cell-exosome solutions for peripheral nerve injury.

Peripheral nerve injury (PNI) is a common disease that is difficult to nerve regeneration with current therapies. Fortunately, Zou demonstrated the role and mechanism of bone marrow derived mesenchymal stem cells (BMSCs) in promoting nerve regeneration, revealing broad prospects for BMSCs transplantation in alleviating PNI. We confirmed the fact that BMSCs significantly alleviate PNI, but there are shortcomings such as low cell survival rate and immune rejection, which limit the wide application of BMSCs.

Microvesicles derived from mesenchymal stem cells: A promising therapeutic strategy for acute respiratory distress syndrome-related pulmonary fibrosis?

Pulmonary fibrosis significantly contributes to the pathogenesis of acute respiratory distress syndrome (ARDS), markedly increasing patient mortality. Despite the established anti-fibrotic effects of mesenchymal stem cells (MSCs), numerous challenges hinder their clinical application. A recent study demonstrated that microvesicles (MVs) from MSCs (MSC-MVs) could attenuate ARDS-related pulmonary fibrosis and enhance lung function hepatocyte growth factor mRNA transcription.

Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models.

Background: Uterine injury can cause uterine scarring, leading to a series of complications that threaten women's health. Uterine healing is a complex process, and there are currently no effective treatments. Although our previous studies have shown that bone marrow mesenchymal stem cells (BMSCs) promote uterine damage repair, the underlying mechanisms remain unclear.