Contribution of neck ultrasonography to patient management in patients with differentiated thyroid carcinoma with excellent response to therapy.

Purpose: To assess the contribution of intense neck ultrasonography (US) follow-up in the clinical management of differentiated thyroid carcinoma (DTC) patients with the American Thyroid Association (ATA) low-intermediate-risk of recurrence and an excellent response after total thyroidectomy and radioiodine therapy.

Materials And Methods: Medical records of patients who underwent serial follow-up neck US examinations between 1996 and 2022 were analyzed retrospectively. The utility of serial US examinations in detecting structural recurrence was assessed in all patients and different subgroups-categorized per the initial risk of recurrence and stimulated thyroglobulin (sTg) level at 1-year response assessment.

Comparative analysis of TNF-α (-308) gene polymorphism in Turkish patients with type 2 diabetes developing nephropathy and/or neuropathy.

Type 2 diabetes (T2DM) is a group of chronic and systemic metabolic diseases. Nephropathy (NP) and neuropathy (NR) are two common complications that severely affect the quality of life of patients with T2DM. In this study, our aim was to investigate the association between TNF-alpha (-308) gene polymorphism and the risk of developing NP and NR in patients with T2DM We also aimed to determine the association between TNF-alpha (-308) gene polymorphism and several demographic characteristics and biochemical parameters of patients with T2DM developed NP and/or NR.

Prevalence, Pattern and Factors Associated with Consumption of Sweetened Beverages Among Adolescents in Ogun State, Nigeria.

Background: Globally, there has been an increase in the trend of sugar-sweetened beverages (SSB) consumption among adolescents and this has been implicated in the increased prevalence of diet-related NonCommunicable Diseases.

Objectives: This study compared the pattern of sweetened beverage consumption and factors associated with consumption among adolescents in rural and urban areas of Ogun State, Nigeria.

Methods: A comparative cross-sectional study was conducted among in-school adolescents in rural and urban areas of Ogun State.

Activity of CDK4/6 inhibitors and parameters affecting survival in elderly patients in age-subgroups: Turkish Oncology Group (TOG) retrospective study.

Highly selective inhibitors of cyclin-dependent kinase 4 and 6 (CDK4/6is) have emerged as a standart of care for first- and second-line therapies in combination with endocrine therapy (ET) for HR+/HER2- metastatic breast cancer (MBC) patients. It has been reported that combination therapy is more effective than ET alone and is safe in elderly patients as well as young patients. Nevertheless, elderly and very old patients with HR+/HER2-MBC treated with CDK4/6 inhibitor (CDK4/6i) combinations are relatively underrepresented in randomized controlled trials.

A comparation of three different anti-VEGF drugs in development of persistent avascular retina in premature children.

Our current prospective cross-sectional study aimed to investigate the effect of anti-vascular endothelial growth factor (VEGF) drugs used in the treatment of retinopathy of prematurity on retinal maturation and persistent avascular retina (PAR). Retinal imaging was performed with Optos confocal laser ophthalmoscopy for 100 patients aged 4 to 8 years who were screened and treated for retinopathy of prematurity (ROP) during the neonatal period. The ROP examination findings (stage and zone) and treatment history (age in weeks at time of treatment and anti-VEGF drug used) from the neonatal period were reviewed.

Evaluation of auditory pathways and comorbid inner ear malformations in pediatric patients with Duane retraction syndrome.

Aims And Objectives: This study aimed to investigate the presence, type, and severity of hearing losses in individuals with Duane Retraction Syndrome (DRS), and to ascertain if there are anomalies in the auditory pathways at the brainstem level in DRS, believed to arise from aberrant interaction between cranial nerves and brainstem nuclei.

Study Design: Cross-sectional observational study.

Setting: Tertiary referral centre.

Synthesis and molecular docking analysis of novel hydrazone and thiosemicarbazide derivatives incorporating a pyrimidine ring: exploring neuroprotective activity.

The increasing global prevalence of Alzheimer's disease necessitates the development of novel therapeutic approaches. Neurodegenerative diseases are associated with increased oxidative stress and levels of cholinesterase enzymes. Hence, the development of cholinesterase inhibitors and antioxidants may provide neuroprotective effects.

Resected gastric volume/number of staplers fired ratio as a tool in predicting complication and midterm results in sleeve gastrectomy.

Laparoscopic sleeve gastrectomy is a restrictive surgery that aims to decrease the gastric volume of the patient. This study hypothesized that a higher resected gastric volume to the number of fired staplers ratio is associated with improved postoperative 12th-month outcomes. To analyze the effects of resected gastric volume to the number of fired staplers ratio on postoperative results in patients who underwent sleeve gastrectomy.

Implementing digital respiratory technologies for people with respiratory conditions: A protocol for a scoping review.

The value of 'data-enabled', digital healthcare is evolving rapidly, as demonstrated in the COVID-19 pandemic, and its successful implementation remains complex and challenging. Harmonisation (within/between healthcare systems) of infrastructure and implementation strategies has the potential to promote safe, equitable and accessible digital healthcare, but guidance for implementation is lacking. Using respiratory technologies as an example, our scoping review process will capture and review the published research between 12th December 2013 to 12th December 2023.

Protective Effect of Escin Against Kidney Injury: Histopathological and Biochemical Evaluations.

The purpose of the current study was to find out whether escin (ES) safeguarded experimental rats against cyclophosphamide (CP)-induced kidney injury. Twenty-four rats were randomly divided into four groups ( = 6). After the examination, histological and biochemical analyses were performed to assess the alterations in kidney tissue.

Three-Year Assault Cases Performed on the Emergency Trauma Center.

Objective: This study aims to compare the results of cases with a history of assault presented to our emergency department over a period of three years with literature data and to share our experiences with colleagues.

Methods: Demographic characteristics, trauma findings, clinical conditions, surgical interventions, mortality, and outcomes of patients with a history of assault to the emergency department between 2020 and 2022 were retrospectively examined. The results were analyzed using the Number Cruncher Statistical System 2007 Statistical Software package program (Utah, USA).

Tuberous sclerosis: a survey in the canton of Vaud, Switzerland.

Aim Of The Study: Tuberous sclerosis complex (TSC) is a genetic and multisystemic disorder that affects between 1/6'000 and 1/10'000 of newborns. Clinical criteria and/or genetic analysis establish the diagnosis. The mechanistic target of rapamycin (mTOR) inhibitors everolimus or sirolimus reduce the severity of several TSC-related clinical traits.

Clinical Implications of Pan-Immune-inflammatory Values in Patients with Hypertrophic Cardiomyopathy.

Objective: Despite significant advances in understanding hypertrophic cardiomyopathy (HCM) in recent years, there is a need to improve risk stratification for patients at high risk of adverse outcomes. The relationship between inflammation and disease severity in HCM patients is known. Recently, a new inflammation parameter called the pan-immune inflammation value (PIV) has been introduced.

Achieving malaria-free: Egypt's journey to WHO certification and global implications for disease control.

Egypt's recent malaria-free certification by the World Health Organization (WHO) marks a significant achievement in public health, underscoring the effectiveness of sustained national efforts in disease eradication. This milestone, achieved after nearly a century of strategic intervention, highlights the importance of integrated public health programmes and cross-sector collaboration. Egypt's journey involved early initiatives to reduce human-mosquito contact, the establishment of malaria control stations, and comprehensive outbreak management strategies.

Mobile app communication to prevent ER visits post-circumcision: a prospective observational study.

Purpose: To assess the impact of a mobile phone application facilitating real-time visual and verbal communication on reducing emergency-room admissions following circumcision.

Methods: This prospective observational study included circumcision surgeries performed by one surgeon at our clinic between April and June 2024, after obtaining parental consent. Parents were divided into two groups: one received a mobile app phone number, while the other did not.

Psychiatric Sequelae in Adult Open Globe Injury Patients.

Background: The aim of this study was to investigate psychiatric sequelae in open globe injury patients and to identify the risk factors associated with these sequelae.

Methods: After a complete ophthalmologic examination, Davidson Trauma Scale (DTS), State-Trait Anxiety Inventory (STAI), and Zung Depression Scale (ZDS) scores were administered to all patients. Patients were divided into 5 groups according to final best corrected visual acuity (BCVA): group 1 (no perception of light, NPL), group 2 [perception of light (PL) or hand movements (HM)], group 3 (1/200 to 19/200), group 4 (20/200 to 20/50), and group 5 (20/40 or above).

Clinicopathologic Characteristics of Breast Cancer Patients Who Had a Pathologic Complete Response after Neoadjuvant Treatment.

Aim: Breast cancer is the most common cancer in women and is a leading cause of cancer-related mortality. The role of neoadjuvant therapy (NAT) in conjunction with surgical intervention is becoming increasingly prominent in the field of oncology. NAT enhance the probability of breast-conserving surgery in cases of locally advanced breast cancer and in patients with metastatic or inoperable disease.

An Analysis of Operated Mediastinal Cysts and Masses.

Aim: This study had two aims: to analyze surgical patients with mediastinal cysts and masses according to clinical, histopathological, and surgical types; and compare the impact of the coronavirus disease 2019 (COVID-19) pandemic on these cases.

Methods: A retrospective analysis was conducted on 132 patients who had undergone surgical intervention for mediastinal cysts and masses. Demographic, clinical, and histopathologic data were recorded.

Acceptance of COVID-19 vaccine and its related determinants in Nigeria: An online survey.

Background: Vaccine hesitancy is a major challenge in the fight against the coronavirus disease 2019 (COVID-19) pandemic. Identifying the sociodemographic factors associated with vaccine acceptance among Nigerians is crucial for improving vaccine uptake.

Aim: To assess the acceptance rate of COVID-19 vaccine and its related determinants among Nigerians.

Reality of Zuckerkandl tubercle and relationship with other anatomical variations.

Aim: The tubercle of Zuckerkandl (TZ) is considered to be the fusion point of the ultimabranchial body and the median thyroid body. We aimed to evaluate the frequency of TZ and its relationship with other anatomical variations and recurrent laryngeal nerve (RLN) paralysis.

Material And Methods: Data regarding the thyroid lobe and RLN of patients with thyroidectomy between June 2016 and December 2019 were retrospectively evaluated.

Evaluation of angiotensin converting enzyme insertion/deletion, alpha adducin (ADD1) G460W, and IL-10 gene polymorphisms, and determination of prognostic effects in idiopathic sudden sensorineural hearing loss.

Objective: The aim of this study was to examine angiotensin converting enzyme (ACE) insertion/deletion, alpha adducin, and interleukin-10 (IL-10) gene polymorphisms (GPs) in terms of both idiopathic sudden sensorineural hearing loss (ISSNHL) risk and their potential prognostic effects.

Methods: The study group consisted of 70 patients and the control group consisted of 50 patients. Venous blood samples were analyzed for relevant GPs via kompetitive allele-specific polymerase chain reaction.

A new scoring system to predict febrile urinary tract infection after retrograde intrarenal surgery.

The current study aimed to determine the risk factors and define a new scoring system for predicting febrile urinary tract infection (F-UTI) following retrograde intrarenal surgery (RIRS) by using machine learning methods. We retrospectively analyzed the medical records of patients who underwent RIRS and 511 patients were included in the study. The patients were divided into two groups: Group 1 consisted of 34 patients who developed postoperative F-UTI, and Group 2 consisted of 477 patients who did not.

Effect of the modified NUTRIC score in predicting the prognosis of patients admitted to intensive care units.

Background: Nutritional deficiency is common in critically ill hospitalized patients. This condition may be aggravated by increased dietary requirements and deficiencies in nutrient absorption. This study aimed to evaluate the associations between the modified Nutritional Risk in Critically ill (mNUTRIC) score and mortality and morbidity in patients with sepsis.