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Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin.
J Immunol
June 2008
Department of Medicine, Division of Dermatology, University of California, San Diego and Veteran's Affairs Medical Center San Diego, CA 92161, USA.
Mast cells (MC) express cathelicidin antimicrobial peptides that act as broad-spectrum antibiotics and influence the immune defense of multiple epithelial surfaces. We hypothesized that MC help protect against skin infection through the expression of cathelicidin. The susceptibility of MC-deficient mice (Kit Wsh(-/-)) to invasive group A streptococcus (GAS) was compared with control mice.
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