Artrofoon as alternative preparation in the treatment of uncomplicated forms of nonspecific ulcerative colitis.

Therapy of uncomplicated nonspecific ulcerative colitis with artrofoon effectively reduces the duration and number of relapses. During remissions, the count of apudocytes, serotonin-, melatonin-, vasointestinal peptide-producing, and mast cells and the parameters of cell homeostasis against the background of artrofoon therapy were much closer to the normal than during treatment with salofalk.

Antiradical effect of allopurinol at early stages of experimental acute pancreatitis.

Pretreatment with allopurinol partly prevented generation of free oxygen radicals in the pancreas of dogs with experimental acute pancreatitis. Allopurinol holds promise for the prevention of acute postoperative pancreatitis.

[Formation of a vascular access in patients with terminal chronic renal insufficiency for hemodialysis based on the new general theory of circulation].

Between 1993 and 2002, 41 operations were performed for formation of a vascular access (VA) to conduct hemodialysis using vascular transplants: autogenous veins (8 cases) and PTFE allografts (33 cases). Experience gained with the use of autogenous veins and PTFE allografts for creation of a permanent VA to carry out hemodialysis was summarized and analyzed. An attempt was made to explain the causes of thrombosis of autogenous veins transplanted and allo-vessels implanted on the basis of the new general theory of circulation.

[Modification of the method of trypsin esterase activity determination].

Determination of esterase activity of trypsin in blood serum using the Erlanger's method leads to overestimation of enzyme activity due to the increased "dimness" of the reaction medium. V. A.

Generation of free oxygen radicals in the pathogenesis of experimental acute reflux pancreatitis.

In dogs with acute reflux pancreatitis specific activity of superoxide dismutase in the pancreas rapidly increased (over 15 min). Activation of this enzyme by free oxygen radicals was demonstrated in in vitro experiments. Treatment with allopurinol prevented activation of superoxide dismutase.

Free radical oxidation and activity of enzymes catalyzing biotransformation of xenobiotics in the liver of rats with experimental acute pancreatitis.

The development of experimental acute pancreatitis in rats was accompanied by intensification of lipid peroxidation, activation of superoxide dismutase and glutathione reductase, inhibition of glutathione transferase, and deceleration of aniline N-hydroxylation by cytochrome P-450 in the liver. Antioxidants inhibited lipid peroxidation and antioxidant enzymes, but did not prevent inhibition of detoxifying enzymes.