52,129 results match your criteria: "Salmonella Infection"

In Salmonella Typhimurium, efflux pump proteins, such as AcrD actively expel drugs and hazardous chemicals from bacterial cells, resulting in treatment failure and the emergence of antibiotic-resistant variants. Focusing on AcrD may lead to the development of novel antimicrobials against multidrug-resistant bacteria. However, challenges persist in achieving high selectivity, low toxicity, and effective bacterial penetration.

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Pan-genome analysis and drug repurposing strategies for extensively drug-resistant Salmonella Typhi: Subtractive genomics and e-pharmacophore approaches.

Int J Biol Macromol

December 2024

Jamil-ur-Rahman Center for Genome Research, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address:

In the current study, we presented the genome sequence and taxonomic classification of the new extensively drug-resistant (XDR) Salmonella enterica serovar Typhi strain JRCGR-ST-AK02. Its genome size was found to be 4,780,534 bp, containing 4864 genes. Taxonomic classification was performed based on the Average Nucleotide Identity (ANI), Genome-to-Genome Distance Calculator (GGDC) and Average Amino Acid Identity (AAI) analysis.

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Salmonella is a poultry-borne pathogen causing numerous human outbreaks in the U.S. Consequently, Salmonella, along with other pathogens, can be found in wastewater generated from poultry processing.

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Multi-locus sequence typing of Salmonella enterica isolates from dog treats and raw meat-based dog food in Japan.

BMC Res Notes

December 2024

Department of Comparative Animal Science, College of Life Science, Kurashiki University of Science and The Arts, 2640 Tsurajimacho Nisinoura, Kurashiki-shi, Okayama, 712-8505, Japan.

Objective: Salmonella is an important zoonotic foodborne pathogen which is recognized as a major public health concern worldwide. Salmonella contamination are highly prevalent in dog treats and raw meat-based dog food (RMBDs). And dog treats and raw meat-based dog food are often implicated as main sources of human infection.

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Drug-loaded FeO/lignin nanoparticles to treat bacterial infections.

Int J Biol Macromol

December 2024

Applied Chemical Engineering Laboratory, Can Tho University, 3/2 street, Ninh Kieu district, Can Tho 94000, Viet Nam.

Lignin is a biopolymer employed for various biomedical applications. Nevertheless, the drug loading and release mechanism of FeO nanoparticles with surface functionalization by lignin has yet to be described. Hence, this study functionalizes FeO nanoparticles surface with lignin (FeO/Lig) for ciprofloxacin delivery and examines its adsorption-release mechanisms.

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Diagnosing gastrointestinal infections based on cycle threshold cut-offs of PCR.

Microbiol Spectr

December 2024

Clinical Microbiology Laboratory, Tzafon Medical Center (affiliated with Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel), Poriya, Israel.

This study compared the performance of molecular vs stool culture assays for gastrointestinal infection (GII) detection, with focus on defining cycle threshold (Ct) cut-off values for positive culture results. A total of 6,000 records of patients with suspected GII between October 2022 and February 2023 and registered at Clalit HealthCare Services in Haifa, Israel, were reviewed. Stool samples were collected from all patients with suspected GII.

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Rutin Synergizes with Colistin to Eradicate Salmonellosis in Mice by Enhancing the Efficacy and Reducing the Toxicity.

J Agric Food Chem

December 2024

Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics, Development and Safety Evaluation, South China Agricultural University, Guangzhou 510642, PR China.

The wide dissemination of multidrug-resistant (MDR) Gram-negative bacteria poses a significant global health and security concern. As developing new antibiotics is generally costly, fastidious, and time-consuming, there is an urgent need for alternative therapeutic strategies to address the gap in antibiotic discovery void. This study aimed to investigate the activity of colistin (CS) in combination with a natural product, rutin (RT), to combat against Typhimurium ( Tm) in vitro and in vivo.

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spp. are one of the leading causes of illness, and in the last years there is an increasing interest in the role of different wild animals as reservoir of , especially multidrug resistant strains. To establish preventive and action strategies, it is essential to monitor bacterial resistance profiles and systematically collect information.

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This case report describes the unusual presentation of a 32-year-old male from Guayaquil, Ecuador, who was diagnosed with a rare triple infection caused by , , and . The patient presented with persistent high fever, severe gastrointestinal symptoms, abdominal pain, and jaundice, following the consumption of street food in a resource-limited area. Important clinical findings included hepatosplenomegaly and elevated liver enzymes, which initially complicated the differential diagnosis.

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Characterization and Implications of the Regionally Prevalent ST8333 Strains of Serotype 4,[5],12:i: - China, 2017-2023.

China CDC Wkly

November 2024

National Health Commission Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No.2019RU014), China National Center for Food Safety Risk Assessment, Beijing, China.

What Is Already Known About This Topic?: is a significant foodborne pathogen responsible for millions of infections and thousands of deaths worldwide each year. The increasing prevalence of the ST34 serotype 4,5,12:i:-(. 4,[5],12:i:-) poses a substantial public health threat in China.

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The predominant role of FliC contributes to the flagella-related pathogenicity of ST34 S. Typhimurium monophasic variant.

Vet Res

December 2024

Jiangsu Key Lab of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China.

Over the past two decades, the monophasic variant of Salmonella enterica serovar Typhimurium (S. Typhimurium) has rapidly emerged and increased worldwide. This upsurge is especially true for the European clone of the ST34 S.

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Salmonella enterica serotype Typhimurium (Salmonella) resides and multiplies intracellularly in cholesterol-rich compartments called Salmonella-containing vacuoles (SCVs) with actin-rich tubular extensions known as Salmonella-induced filaments (SIFs). SCV maturation depends on host-derived cholesterol, but the transport mechanism of low-density lipoprotein (LDL)-derived cholesterol to SCVs remains unclear. Here we find that peroxisomes are recruited to SCVs and function as pro-bacterial organelle.

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Anaerobic bacteria, such as Lactobacillus plantarum (LP), are known to play a significant role in maintaining gut health and protecting against enteric pathogens in animals. The present study aimed to develop a safe, affordable, and eco-friendly method for producing LP-based probiotics and evaluate their efficacy in mitigating Salmonella-induced diarrhea in broiler chickens. The study employed three different culture media (MRS, TSB, and Baird Parker) to grow LP, which was then dried using a spray-drying technique to produce a stable probiotic formulation.

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From October 2020 to February 2021, a total of 95 retail chicken meat products from 39 retail meat shops in Tokyo Metropolis and Kanagawa Prefecture, Japan, were collected and examined for the prevalence of Salmonella to assess public health implications. If a sample tested positive for Salmonella, a quantitative analysis was performed using the three-tube most probable number (MPN) method. Of 95 retail chicken meat products, Salmonella was isolated from 30 samples (31.

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Objectives: The severity of the diarrhea disease is exacerbated by co-infections that involve Enterotoxigenic Escherichia coli (ETEC) and other enteric pathogens, which complicate the diagnosis and treatment. This study explores the prevalence, clinical manifestations, and risk factors of ETEC and its co-infections in Dhaka, Bangladesh.

Methods: The study used data from the Diarrheal Disease Surveillance System at Dhaka Hospital, involving 16,276 patients from 2017-2022.

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Genomic and virulent characterization of a duck-associated Salmonella serovar Potsdam from China.

Poult Sci

December 2024

Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou 310058, China; Hainan Institute of Zhejiang University, Sanya 572025, China; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 31003, China; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. Electronic address:

Salmonella, a common zoonotic pathogen, is a significant concern for public health, particularly when it contaminates animal-borne products. The potential for Salmonella to infect duck embryos and disrupt their normal development not only causes substantial economic losses for the industry but also poses a severe threat to public health. However, there is a lack of understanding about the prevalence of Salmonella in duck embryos and their potential public health implications.

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Sirtuins are the major players in host immunometabolic regulation. However, the role of sirtuins in the modulation of the immune metabolism pertaining to salmonellosis is largely unknown. Here, our investigation focussed on the role of two important sirtuins, SIRT1 and SIRT3, shedding light on their impact on intracellular 's metabolic switch and pathogenesis establishment.

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infection poses a significant public health challenge in the developing world. However, lack of a widely available mouse model that replicates human shigellosis creates a major bottleneck to better understanding of disease pathogenesis and development of newer drugs and vaccines. BALB/c mice pre-treated with streptomycin and iron (FeCl) plus desferrioxamine intraperitoneally followed by oral infection with virulent resulted in diarrhea, loss of body weight, bacterial colonization and progressive colitis characterized by disruption of epithelial lining, loss of crypt architecture with goblet cell depletion, increased polymorphonuclear infiltration into the mucosa, submucosal swelling (edema), and raised proinflammatory cytokines and chemokines in the large intestine.

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Background: Infections are a major cause of morbidity and mortality in juvenile systemic lupus erythematosus (SLE). We assessed the incidence and risk factors for major infections in juvenile SLE.

Methods: A retrospective review of 225 patients of juvenile SLE (ACR 1997 criteria) with age <18 years visiting the rheumatology clinic at a single centre between 2000 to 2020 was done from case records and the hospital electronic health records.

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bacteria is a component of normal intestinal microflora of humans and animals, but can also be found in hospital settings causing urinary tract infections and sepsis. The problem of treating such infections is complicated by multidrug-resistant isolates producing extended spectrum beta-lactamases (ESBL), and the number of ESBL-carrying strains has significantly increased recently. This study presents a detailed analysis of 12 multidrug-resistant isolates obtained from the wounds of different patients in one surgical department of a multidisciplinary hospital in Moscow, Russia, using the short- and long-read whole genome sequencing.

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Genome sequencing and analysis of Salmonella enterica subsp. enterica serotype Enteritidis PT4 578: insights into pathogenicity and virulence.

Access Microbiol

November 2024

Departamento de Microbiologia, Universidade Federal de Viçosa (UFV), Av. Peter Henry Rolfs, Viçosa, 36570-900, Minas Gerais, Brazil.

Article Synopsis
  • Enteritidis PT4 is a versatile bacteria that infects various hosts and is a leading cause of gastroenteritis, especially linked to consuming poultry products like chicken meat and eggs.
  • The genome of Enteritidis PT4 strain 578 contains 165 virulence factor genes that aid in its ability to invade cells and survive within the host, including 12 pathogenicity islands crucial for its pathogenicity.
  • Comparative analysis with other Enteritidis and Typhimurium strains highlights unique metabolic and structural differences, improving our understanding of the pathogenic mechanisms involved.
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Multidrug-resistant (MDR) remains a significant global health threat. This study aimed to explore the potential of essential oil components as novel inhibitors of the MDR efflux pumps AcrAB and AcrD. isolates were characterized for serotype, antibiotic resistance, and efflux pump activity.

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and Salmonellosis in Wild Birds.

Animals (Basel)

December 2024

Bristol Veterinary School, University of Bristol, Bristol B40 5DU, UK.

is an important bacterial pathogen in humans and warm-blooded animals. Wild bird species represent both a potential reservoir for zoonotic infection and as a susceptible host to infection by host-adapted variants. Historically, wild birds were considered to be a major source of infection in livestock, but in recent years, it has been more apparent that birds are more likely to act as a reservoir for recycling infection on farms rather than as the primary source of infection.

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Integron-Mediated Antimicrobial Resistance and Virulence Factors in Typhimurium Isolated from Poultry.

Animals (Basel)

December 2024

Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

This study investigates antimicrobial-resistant (AMR) Typhimurium in poultry, focusing on how class I integrons contribute to AMR and virulence. Using whole genome sequencing, researchers analyzed 26 Typhimurium isolates from U.S.

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Dynamic Changes in the Intraepithelial Lymphocyte Numbers Following Typhimurium Infection in Broiler Chickens.

Animals (Basel)

November 2024

Department of Animal Sciences, College of Food Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH 44691, USA.

At day 21 of age, Ross-308 broilers were orally gavaged with 7.5 × 10 CFU/mL S. Typhimurium (n = 30), and another 30 birds were kept as the control.

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