Kinematics and performance of team-handball throwing: effects of age and skill level.

To assess the influence of age and skill level on handball throwing kinematics and performance, 126 participants were distributed into groups according to their skill level (elite or recreational) and age group (U12, U16 or +18). Each participant performed three sets of 10 throws, aiming to hit a target (40 × 40 cm) located in the right corner of the goal. During testing, kinematic data were recorded and throwing performance (accuracy and velocity) was measured.

Hospitalization trends and chronobiology for mental disorders in Spain from 2005 to 2015.

Rhythm research has had a long tradition in psychiatry, especially in affective disorders. The study of trends in incidence plays a central role in epidemiology and public health. The aims of this research were to describe the socio-demographic and clinical characteristics of persons admitted for psychiatric hospitalization and their trends and periodicity in cases (global and by groups) in Spain over the 11 year study span.

A Prospective Study of Costs Associated with the Evaluation of β-Lactam Allergy in Children.

Objective: To evaluate the costs associated with evaluation of β-lactam allergy in children labeled as allergic.

Study Design: We performed a prospective year-long real life observational study designed to evaluate all pediatric patients with suspected β-lactam allergy who consulted for allergy evaluation. Direct and indirect costs were systematically recorded.

Real-World Outcomes in First-Line Treatment of Metastatic Castration-Resistant Prostate Cancer: The Prostate Cancer Registry.

Background: Metastatic prostate cancer has a 30% 5-year survival rate despite recent therapeutic advances. There is a need to improve the clinical understanding and treatment of this disease, particularly in the real-world setting and among patients who are under-represented in clinical trials.

Objective: We aimed to evaluate the characteristics and clinical outcomes of patients who received their first treatment for metastatic castration-resistant prostate cancer (mCRPC) in routine clinical practice, independent of treatment used, including subgroups with baseline cardiac disease, diabetes mellitus, or visceral metastases.

FENOMA Study: Achieving Full Control in Patients with Severe Allergic Asthma.

Introduction: A Spanish real-world study in patients with severe persistent asthma who achieved asthma control after a one-year treatment with omalizumab highlighted the phenotypic heterogeneity of these patients (FENOMA study). In this subanalysis, we describe the clinical improvement in patients with severe allergic asthma in this study (positive skin test and IgE level 30-1500 IU/mL); n=240.

Patients And Methods: FENOMA was an observational, multicentre, retrospective study in 345 patients achieving asthma control according to Spanish guidelines (GEMA).

Genetics and Epigenetics of Atopic Dermatitis: An Updated Systematic Review.

Background: Atopic dermatitis is a common inflammatory skin disorder that affects up to 15-20% of the population and is characterized by recurrent eczematous lesions with intense itching. As a heterogeneous disease, multiple factors have been suggested to explain the nature of atopic dermatitis (AD), and its high prevalence makes it necessary to periodically compile and update the new information available. In this systematic review, the focus is set at the genetic and epigenetic studies carried out in the last years.

Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose-Response Relationships.

Background: Despite smoking being a well-established risk factor for pancreatic cancer, there is a need to further characterize pancreatic cancer risk according to lifespan smoking patterns and other smoking features, such as tobacco type. Our aim was to deeply investigate them within a large European case-control study.

Methods: Tobacco smoking habits and other relevant information were obtained from 2,009 cases and 1,532 controls recruited in the PanGenEU study using standardized tools.

Spontaneous rupture of a mechanical valve in a mitral position (On-X) with migration-embolization to aortic bifurcation from the perspective of the vascular surgeon.

We report on the case of spontaneous rupture of an On-X-pure pyrolytic carbon mechanical valve prosthesis implanted seven years earlier, in a mitral position, at our hospital. The patient was admitted with valvular dysfunction and acute pulmonary edema requiring emergency surgery (prosthesis replacement); the absence of a leaflet was confirmed intraoperatively. The patient presented severe respiratory failure, which prolonged the postoperative period.

Quality Control in Anatomical Lung Resection. Major Postoperative Complications vs Failure to Rescue.

Objectives: Failure to rescue (FTR) is defined by the number of deaths among patients experiencing major complications after surgery. In this report we analyze FTR and apply a cumulative sum control chart (CUSUM) methodology for monitoring performance in a large series of operated lung carcinoma patients.

Methods: Prospectively stored records of cases undergoing anatomical lung resection in one center were reviewed.

Correction: Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Severe asthma phenotypes in patients controlled with omalizumab: A real-world study.

Background: The appropriate identification of asthma phenotypes of responders to omalizumab would optimize the selection of treatment.

Objective: To describe the most frequent clinical phenotypes in patients with severe asthma responding to omalizumab and their clinical and pulmonary function improvement.

Methods: This was an observational, retrospective, multicenter study.

Thoracic customized modular titanium-printed prosthesis.

Tridimensional custom-made titanium-printed prosthesis have gained certain relevance as an alternative for chest wall reconstruction although different limitations such as uncomfortable intraoperative placement, long manufacturing time or high costs hinder its use when compared to other standard devices. Trying to overcome these problems, we developed a new model of customized modular titanium-printed prosthesis (CM-TPP) for chest wall reconstruction after breast metastasis resection that seems to offer some advantages over other custom-made reconstructive devices.

A Comprehensive Prospective Study of the Costs Associated With Evaluation of ß-Lactam Allergy.

Background And Objective: Being labeled as allergic to penicillin (unverified ß-lactam allergy) can result in patients receiving broader-spectrum antibiotics than necessary that may be more toxic, less effective, and/or more expensive than alternative options. Objective: We aimed to evaluate the real costs of evaluating ß-lactam allergy.

Methods: We performed a prospective real-life observational study designed to evaluate all adult patients who consulted for suspected ß-lactam allergy over a 1-year period.

Spinal anesthesia compared with general anesthesia for neonates with hypertrophic pyloric stenosis. A retrospective study.

Background: Studies of spinal anesthesia in children are limited to a reduced group of high-risk patients and it remains relatively underused compared with general anesthesia in this age group in most institutions. In our experience, spinal anesthesia appears to be a good alternative to general anesthesia during pyloromyotomy in neonates and infants.

Aims: The purpose of this study was to retrospectively evaluate respiratory morbidity of spinal anesthesia compared to general anesthesia in infants undergoing pyloromyotomy.