Phytochemical Profiling, Acute Toxicity, and Hepatoprotective Effects of in Thioacetamide-Induced Liver Cirrhosis in Rats.

Evaluation of of the family Boraginaceae during previous investigations determined numerous therapeutic potentials against inflammatory-related diseases. The present study evaluates the phytochemical, acute toxicity, and hepatoprotective effects of methanolic extracts of (MEAL) against thioacetamide (TAA)-induced liver injury in rats. The phytochemical profiling of MEAL followed a Folin-Ciocalteu and 10% AlCl3 procedure using a spectrophotometer.

Corrigendum: The impact of non-coding RNAs in the epithelial to mesenchymal transition.

[This corrects the article DOI: 10.3389/fmolb.2021.

Melatonin attenuates responses to angiotensin II in isolated aortic rings of STZ-induced type 1-like DM rats.

Background: In patients with diabetes mellitus (DM), vascular endothelial dysfunction (VED) is the main reason for impaired life expectancy. Melatonin (MEL) demonstrates wide-ranging effects across various organs and exhibits pleiotropic characteristics. The current study aims to investigate the modulatory roles of MEL vascular response to angiotensin II (Ang II) and its receptors including angiotensin type 1 receptor (AT-1 R) and angiotensin type 2 receptor (AT-2 R) in isolated thoracic aorta of non-diabetes (non-DM) and diabetes (DM) rats.

Genome Analysis of SARS-CoV-2 Delta variant in the Kurdistan region of Iraq.

Introduction: Since its isolation in the UK, the SARS-CoV-2 Delta variant has become an epidemic. This study aimed to decipher the viral appearance and genomic characterization of the Delta variant isolated from patients in the Kurdistan region of Iraq.

Methodology: Samples were collected from the West Erbil Emergency Hospital, and infection by SARS-CoV2 was confirmed using Real-Time PCR.

Recent advances in carbon-based materials derived from diverse green biowaste for sensing applications: a comprehensive overview from the perspective of synthesis method and application.

The rapid increase in global waste, driven by population growth, has raised significant environmental concerns. Among different types of wastes, green biowastes (BWs) containing organic matter have attracted considerable attention. The conversion of BW, particularly from herbaceous and animal sources, to carbon-based materials (CBMs) introduces a suitable platform for waste management and resource recovery.

Interaction of CO, CO, CSO, HO, NO, NO, NO, O, ONH, and SO gases onto BNNT(m,n)_x, (m = 3, 5, 7; n = 0, 3, 5, 7; x = 3-9).

Context: This research investigates two critical areas, providing valuable insights into the properties and interactions of boron nitride nanotubes (BNNTs). Initially, a variety of BNNT structures (BNNT(m,n)_x, where m = 3, 5, 7; n = 0, 3, 5, 7; x = 3-9) with different lengths and diameters are explored to understand their electronic properties. The study then examines the interactions between these nanotubes and several gases (CO, CO, CSO, HO, NO, NO, NO, O, ONH, and SO) to identify the most stable molecular configurations using the bee colony algorithm for global optimization.

Prevalence of intestinal parasites in Erbil, Iraq.

Background: Infections with intestinal parasites are the major cause of infectious disease globally and have been described as a public health issue in developing countries.

Objective: This study aimed to determine prevalence of intestinal parasitic infections and their associated factors among the population of Erbil province in Iraq over the period 2011-2021.

Methods: The results of 614455 stool examinations of all public health facilities of the province were collected from the register in the directorate of preventive health affairs and the data were analyzed.

Targeting Neuroinflammation and Apoptosis: Cardamonin's Cognitive Benefits in Alzheimer's 5XFAD Mice.

This study aimed to evaluate the cognitive-enhancing and neuroprotective effects of cardamonin in the 5XFAD transgenic mouse model of Alzheimer's disease (AD). We treated six-month-old female 5XFAD mice with cardamonin at 5 mg/kg, 10 mg/kg, and 20 mg/kg. Cognitive function was assessed using the Morris Water Maze (MWM) and Novel Object Recognition (NOR) tests.

Fe-Doped Red Fluorescent Carbon Dots for Caffeine Analysis in Energy Drinks Using a Paper-Based Sensor.

This study introduces a highly sensitive and selective method for detecting caffeine in energy drinks by using red florescence iron and nitrogen co doped carbon dots (Fe-NCDs) as a florescent prob. The Fe-NCDs were synthesized by using an eco-friendly hydrothermal. Providing uniform, quasi-spherical nanoparticles.

A novel fluorescence probe using Brown HT precursor carbon dots for highly selective and ultrasensitive quantitation of potassium ion in some staple food samples.

Potassium ions (K) perform a variety of functions in biological systems, including the regulation of blood pressure, enzyme activation, maintenance of muscular strength, regulation of extracellular osmolarity and facilitation of nerve transmission. Thus, a one-step hydrothermal-assisted method was used to prepare small-sized photoluminescent carbon dots (CDs) from Chocolate Brown HT food dye for the first time. The resulting CDs exhibited strong blue emission, with sizes ranging from 1.

Seroepidemiological study of Neospora caninum in equids using c-ELISA in Erbil Province, Iraq.

Equine neosporosis is an intracellular protozoan disease with a global distribution, affecting a diverse range of warm-blooded animals. Neospora caninum Dubey, Carpenter, Speer, Topper et Uggla, 1988 is associated with foetal loss, neurological disease and abortion in equids. No information was available regarding equine N.

Ethnobotany, bioactive compounds and pharmacology of Syzygium guineense (Willd.) DC: A review.

Ethnopharmacological Relevance: Plants possess the ability to synthesize a diverse array of primary and secondary metabolites. Secondary metabolites are of great importance as a result of their status as natural substances that have the potential to provide therapeutic benefits for human health. Due to its many uses in traditional medicine, Syzygium guineense (Willd.

(Stef.) Extract Induces Lung Cancer Apoptosis via Mitochondrial-Dependent Apoptosis Pathway.

Non-small-cell lung carcinoma remains a significant health concern due to its high incidence and mortality rates. Traditional medicines play a central role in cancer therapy, with plant-derived bioactive compounds being studied for their potential to offer fewer side effects than conventional treatments. In traditional Kurdish medicine, different species are used to treat burns, inflammation, and other conditions.

The impact of noise-induced hearing loss on individual job performance: exploring the role of aggression and work-related quality of life.

Background: Noise-Induced Hearing Loss (NIHL) may have a significant effect on individual job performance (IJP). These effects may exert through aggression and work-related quality of life (WRQoL). Hence, the present study was conducted to investigate the modeling of the impact of NIHL on IJP by exploring the role of aggression and WRQoL.

Outbreak of SARS-CoV-2 variants in Iraqi Kurdistan region.

Introduction: Coronavirus disease 2019 (COVID-19) first appeared in Iraq, including the Iraqi Kurdistan region governorates, in March 2020.

Methodology: 48,494 samples were collected from public hospitals in the Kurdish governates from February 2021 to May 2022. Viral RNA was extracted, and real time quantitative polymerase chain reaction (RT-PCR) was used to detect the COVID-19 variants.

Revolutionizing medicine: Recent developments and future prospects in stem-cell therapy.

Stem-cell therapy is a revolutionary frontier in modern medicine, offering enormous capacity to transform the treatment landscape of numerous debilitating illnesses and injuries. This review examines the revolutionary frontier of treatments utilizing stem cells, highlighting the distinctive abilities of stem cells to undergo regeneration and specialized cell differentiation into a wide variety of phenotypes. This paper aims to guide researchers, physicians, and stakeholders through the intricate terrain of stem-cell therapy, examining the processes, applications, and challenges inherent in utilizing stem cells across diverse medical disciplines.

Decoding the intricacies: a comprehensive analysis of microRNAs in the pathogenesis, diagnosis, prognosis and therapeutic strategies for COVID-19.

The pandemic of coronavirus disease-19 (COVID-19), provoked by the appearance of a novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), required a worldwide healthcare emergency. This has elicited an immediate need for accelerated research into its mechanisms of disease, criteria for diagnosis, methods for forecasting outcomes, and treatment approaches. microRNAs (miRNAs), are diminutive RNA molecules, that are non-coding and participate in gene expression regulation post-transcriptionally, having an important participation in regulating immune processes.

Biomarkers of type 2 and non-type 2 inflammation in asthma exacerbations.

Introduction: In adult-onset asthma, two major endotypes have been proposed: T2 with eosinophilia and non-T2 characterised by neutrophils and interleukin (IL)-17. The objective of the study was to examine the endotype marker profile in patients with severe asthma who were hospitalized for exacerbations, with a focus on differentiating between viral and non-viral triggers.

Material And Methods: Forty-nine patients with asthma, admitted for exacerbations, and 51 healthy controls (HCs) were recruited.