5 results match your criteria: "Sakurajuji Hospital[Affiliation]"
Validation study of the JSHBPS nomogram for patients with colorectal liver metastases who underwent hepatic resection in the recent era - a nationwide survey in Japan.
J Hepatobiliary Pancreat Sci
May 2023
Department of Surgery, Tokyo Metropolitan Health and Hospitals Corporation Ohkubo Hospital, Shinjuku-ku, Japan.
Article Synopsis
- Scientists created a tool called the JSHBPS nomogram to help predict how long patients with liver cancer can stay healthy after surgery.
- They studied two groups of patients: one that had surgery right away and another that had chemotherapy before surgery.
- The results showed that the nomogram works well for patients who had surgery first, but not as well for those who had chemotherapy first, especially if their risk score was high.
Proposal of a novel H category-based classification of colorectal liver metastases based on a Japanese nationwide survey.
J Hepatobiliary Pancreat Sci
April 2021
Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Bunkyo-ku, Japan.
Background: The conventional H category-based classification for colorectal liver metastases (CRLM) was created by equal weighting of tumor number and tumor size; however, our previous nomogram to predict postoperative disease-free survival demonstrated that CRLM ≥5 as a parameter provided 4.5 times greater impact compared with a largest CRLM size >5 cm.
Methods: A total of 3815 patients newly diagnosed with CRLM between 2005 and 2007, including 2220 resectable cases, were investigated.
Does laparoscopic liver resection for colorectal liver metastases provide a true survival benefit compared with open liver resection?
Hepatobiliary Surg Nutr
October 2020
Adviser, Sakurajuji Hospital, Kumamoto, Japan.
Regulation of growth hormone biosynthesis by Cdk5 regulatory subunit associated protein 1-like 1 (CDKAL1) in pituitary adenomas.
Endocr J
September 2019
Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1) is a tRNA-modifying enzyme that catalyzes 2-methylthiolation (ms) and has been implicated in the development of type 2 diabetes (T2D). CDKAL1-mediated ms is important for efficient protein translation and regulates insulin biosynthesis in pancreatic cells. Interestingly, an association between T2D and release of growth hormone (GH) has been reported in humans.
View Article and Find Full Text PDFClinical significance of polyglutamylation in primary central nervous system lymphoma.
Acta Neuropathol Commun
February 2018
Department of Neurosurgery, Kumamoto University Hospital, 1-1-1 Honjo Chuo-ku, Kumamoto, 860-8556, Japan.
The therapeutic response to high-dose methotrexate (HD-MTX) therapy for primary central nervous system lymphoma (PCNSL) varies. Polyglutamylation is a reversible protein modification with a high occurrence rate in tumor cells. MTX incorporated into cells is polyglutamylated and strongly binds to dihydrofolate reductase without competitive inhibition by leucovorin (LV).
View Article and Find Full Text PDF