8,785 results match your criteria: "Saitama Medical University.[Affiliation]"
miR-4448/Girdin/Akt/AMPK axis inhibits EZH2-mediated EMT and tumorigenesis in small-cell lung cancer.
Cancer Med
October 2024
Department of Respiratory Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe-shi, Saitama, Japan.
Article Synopsis
- Small-cell lung cancer (SCLC) displays high levels of EZH2, which promotes a process called epithelial-mesenchymal transition (EMT), increasing the cancer's invasive ability.
- Researchers investigated the relationship between microRNAs (specifically miR-4448) and EZH2 in SCLC, discovering that the downregulation of EZH2 leads to increased miR-4448 expression, which appears to inhibit tumor growth and EMT.
- miR-4448 targets the girdin gene to suppress its expression, reducing Akt phosphorylation, which subsequently enhances the phosphorylation of AMPK and EZH2, ultimately preventing EZH2-mediated EMT and tumorigenesis in SCLC.
Feasibility and radial artery occlusion rate of sheathless distal transradial access using balloon guide catheters.
Neurosurg Rev
October 2024
Department of Endovascular Neurosurgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka City, Saitama Prefecture, 350-1298, Japan.
Article Synopsis
- Distal transradial access (dTRA) through the anatomical snuffbox offers benefits for endovascular treatments but faces challenges due to the small diameter of the radial artery affecting the use of balloon-guide catheters (BGCs).
- A study involving 170 patients treated with sheathless dTRA using an 8Fr Optimo BGC found a radial artery occlusion (RAO) rate of 28%, with a significant correlation between smaller artery diameter and higher RAO risk.
- The research suggests a threshold of 2.4 mm for radial artery diameter to predict RAO risk, indicating that careful evaluation of artery size is essential for choosing large-bore BGCs; further studies are needed for validation and
A phase II study of daily carboplatin plus irradiation followed by durvalumab therapy for older adults (≥75 years) with unresectable III non-small-cell lung cancer and performance status of 2: NEJ039A.
ESMO Open
October 2024
Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Article Synopsis
- The study investigates the effectiveness of durvalumab, an immunotherapy drug, after chemoradiotherapy in patients with unresectable locally advanced non-small-cell lung cancer (LA-NSCLC), particularly those with poorer performance status or older age.
- In a phase II trial with 86 participants, 61 received durvalumab after low-dose carboplatin and radiotherapy, showing a 12-month progression-free survival (PFS) rate of 51%, exceeding the expected 35%.
- The treatment was deemed effective, with a median overall survival of 28.1 months, but pneumonitis was noted as the most common severe side effect.*
Article Synopsis
- - In the KEYNOTE-826 study, pembrolizumab combined with chemotherapy significantly boosted overall survival (OS) and progression-free survival (PFS) in patients with advanced cervical cancer, with specific attention to those using bevacizumab.
- - The analysis included 617 patients, with a majority excluded from bevacizumab due to medical reasons; outcomes showed that those receiving pembrolizumab generally had better survival metrics, regardless of bevacizumab use.
- - Patients on pembrolizumab experienced a high rate of severe side effects, with 74% suffering grade ≥3 treatment-related adverse events in the bevacizumab group.
Association between Immune-Related Adverse Events and Atezolizumab in Previously Treated Patients with Unresectable Advanced or Recurrent Non-Small Cell Lung Cancer.
Cancer Res Commun
November 2024
Kindai Hospital Global Research Alliance Center and Thoracic Surgery, Kindai University, Osaka, Japan.
Article Synopsis
- The study aimed to investigate the relationship between immune-related adverse events (irAEs) and the effectiveness of immune checkpoint inhibitor therapy in cancer patients, particularly focusing on overall and progression-free survival.
- In a cohort of 1,002 Japanese patients with advanced non-small cell lung cancer treated with atezolizumab, 19% experienced irAEs, predominantly skin disorders and interstitial lung disease.
- Results showed that patients with irAEs had better overall survival compared to those without, especially those with low-grade irAEs, indicating potential clinical benefits from irAEs in real-world settings, except for high-grade events unrelated to skin or endocrine disorders.
Clinical inertia in onychomycosis treatment: results from the Illuminating Dialogues and Insights in Onychomycosis Management (IDIOM) survey.
J Dermatol
January 2025
Sato Pharmaceutical Co., Ltd, Tokyo, Japan.
Article Synopsis
- Onychomycosis is a persistent fungal nail infection that can spread and negatively impact a person's ability to walk and their quality of life, making treatment crucial, especially through long-term topical therapies.
- A study revealed that many patients are unhappy with the effectiveness of their topical treatments—over half saw no clear improvement after more than two years—and most wished to explore different options, yet few discussed this with their doctors.
- There is a notable disconnect in communication between patients and dermatologists regarding treatment efficacy, leading to a lack of adjustments in therapy despite patient dissatisfaction, highlighting the need for better collaboration in managing onychomycosis.
Comparison of different ANCA detection methods in a predominantly MPO-ANCA-associated vasculitis cohort.
Immunol Med
October 2024
Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Article Synopsis
- The study evaluated various ANCA detection methods in a group of 147 patients with untreated ANCA-associated vasculitis, focusing primarily on myeloperoxidase (MPO)-ANCA.
- Different testing methods were compared, including immunofluorescence (IIF) and several antigen-specific immunoassays (ELISA, CLEIA, FEIA, LTIA), revealing varying sensitivities and specificities for diagnosing AAV.
- Results indicated that while antigen-specific immunoassays performed well overall, using dual IIF and these immunoassays had limited benefits, and standardizing ANCA measurements across different methods remained challenging.
Relationship Between Participation of In-Hospital Cardiac Rehabilitation and Regional Characteristics in Japan - Insight From the Japanese Registry of All Cardiac and Vascular Diseases and the Diagnosis Procedure Combination.
Circ Rep
October 2024
Department of Cardiology, Fujita Health University Aichi Japan.
Article Synopsis
- The study explores how regional factors affect participation in cardiac rehabilitation (CR) and includes a large cohort of 2.7 million inpatients in Japan from 2012 to 2021.
- It categorizes hospitals into No-CR, High-CR, and Low-CR based on participation rates, finding that High-CR hospitals tend to have smaller service areas, more physicians per population, higher temperatures, and fewer primary industry workers.
- Key regional characteristics influencing High-CR hospitals include a lower consumer price index and a tendency for a younger population, thus highlighting the importance of local economic and demographic factors in CR participation.
Clival Fracture With Multiple Cranial Nerve Palsy Treated With a Halo Device: A Case Report and Literature Review.
Cureus
September 2024
Department of Emergency Medicine and Critical Care, Saitama Medical Center, Saitama Medical University, Kawagoe, JPN.
Article Synopsis
- A case study is presented of a 73-year-old man with a rare clival fracture after falling, leading to multiple lower cranial nerve palsies resembling Vernet or Collet-Sicard syndromes.
- The patient received external fixation with a halo device due to bilateral palsies of cranial nerves VI, IX, X, XI, and right XII, witnessing improvements over time.
- Although delirium developed during the treatment, the halo device was eventually removed, and significant recovery in cranial nerve functions was noted, allowing the patient to start swallowing training.
Multicenter clinical trial evaluating the safety and efficacy of mechanical thrombectomy using the Versi Retriever.
J Neurointerv Surg
October 2024
Neurovascular Research, Kobe City Medical Center General Hospital, Kobe, Japan.
Article Synopsis
- This study evaluated the safety and effectiveness of the Versi Retriever for mechanical thrombectomy in patients suffering from acute ischemic stroke (AIS) at 10 hospitals in Japan.
- It involved 58 patients, showing that 62% achieved a good recovery (mRS 0-2) after 90 days, and 100% had successful blood flow restoration.
- The procedure had an 8% mortality rate within 90 days and a significant occurrence of intracranial hemorrhage, indicating that while effective, some risks are involved.
Prevalence and outcomes of germline pathogenic variants of homologous recombination repair genes in ovarian cancer.
Cancer Sci
December 2024
Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.
Article Synopsis
- * In a study of 1,112 patients with EOC, 12.8% were found to have HRR-related PVs, which were linked to more severe disease characteristics, including serous carcinoma and advanced stages.
- * Patients with HRR-PV-positive status showed improved overall survival in later-stage disease, highlighting the need for genetic testing to tailor individual treatments, while the study also noted a limited use of certain therapies during the study period.
Preoperative risk-stratified analysis: External versus internal pancreatic stents in pancreatoduodenectomy.
Surgery
February 2025
Department of Gastroenterological Surgery, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.
Article Synopsis
- The study compared the effectiveness of external and internal pancreatic stents in preventing complications after pancreatoduodenectomy (PD), focusing on a risk-stratified approach based on a preoperative pancreatic fistula score (preFRS).
- Data from 285 patients showed that external stents significantly reduced the rate of clinically relevant pancreatic fistula and postpancreatectomy hemorrhage in high-risk patients compared to internal stents.
- The findings suggest that using external stents can improve postoperative outcomes, especially for patients at higher risk, and emphasize the need for better stent management strategies.
Capivasertib and fulvestrant for patients with HR-positive/HER2-negative advanced breast cancer: analysis of the subgroup of patients from Japan in the phase 3 CAPItello-291 trial.
Breast Cancer
January 2025
Tokyo Metropolitan Cancer and Infectious Disease Center, Komagome Hospital, Tokyo, Japan.
Article Synopsis
- - In the CAPItello-291 study, capivasertib combined with fulvestrant showed improved progression-free survival (PFS) compared to placebo in patients with advanced HR-positive/HER2-negative breast cancer, including those with specific genetic alterations (PIK3CA, AKT1, or PTEN).
- - Among the 708 total patients, 78 were from Japan, where results also indicated a numerical PFS benefit for the capivasertib-fulvestrant group, suggesting consistency with global findings.
- - The safety profile for the Japanese subgroup was similar to that of the worldwide population, indicating no new safety concerns, thus supporting the efficacy of the treatment approach.
Early-onset preeclampsia/gestational hypertension may be associated with a low incidence of cerebral palsy at 3 years old in singleton very low-birth-weight infants born at 28-31 weeks of gestation (EOPE-DQ study): a multi-center retrospective cohort study in 2013-2016.
Hypertens Res
January 2025
Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
Article Synopsis
- - The study aimed to assess how hypertensive disorders of pregnancy affect the risk of cerebral palsy (CP) and developmental delay (DD) in very low-birth-weight infants born at 24-31 weeks gestation.
- - Among the 529 VLBW infants analyzed, 56.1% were followed for CP and 54.1% for DD, revealing that infants with CP had significantly lower rates of hypertensive disorders compared to controls.
- - The research concluded that conditions like preeclampsia may be linked to a lower incidence of CP, whereas infants with DD showed higher rates of serious health complications compared to controls.
Genomic and transcriptomic profiling of pre- and postneoadjuvant chemotherapy triple negative breast cancer tumors.
Cancer Sci
December 2024
Tokyo Metropolitan Cancer and Infectious Disease Center, Komagome Hospital, Bunkyo-ku, Tokyo, Japan.
Article Synopsis
- Neoadjuvant treatment with microtubule inhibitors (MTIs) for triple negative breast cancer (TNBC) is not well understood, prompting a study that analyzed tumor samples to correlate genetic mutations with treatment response.
- The study found that tumors with high homologous recombination deficiency (HRD) and specific mutations (like BRCA2) had higher rates of complete response to MTIs like eribulin and paclitaxel.
- Transcriptomic profiling highlighted FGFR2 downregulation as a critical gene linked to treatment response and identified a significant pathway (glycan degradation) that could influence resistance to these therapies in TNBC patients.*
Effect of extending the period from oral administration of 5-aminolevulinic acid hydrochloride to photodynamic diagnosis during transurethral resection for non-muscle invasive bladder cancer on diagnostic accuracy and safety: a single-arm multicenter phase III trial.
Int J Clin Oncol
January 2025
Department of Urology, Keio University Hospital, Shinjuku, Tokyo, Japan.
Background: In Japan, the authorized period (2-4 h) between oral administration of 5-aminolevulinic acid hydrochloride (5-ALA) and transurethral resection for non-muscle invasive bladder cancer (NMIBC) may restrict photodynamic diagnosis (PDD) usage. Therefore, this prospective, single-arm, phase III study aimed to evaluate the diagnostic accuracy and safety of PDD at an extended administration period (4-8 h).
Methods: From January 2022 to May 2023, 161 patients with NMIBC were enrolled from eight hospitals.
Prevalence and associated factors of nontraumatic shoulder pain during spike and serve movements in male high school volleyball players: a cross-sectional study.
J Shoulder Elbow Surg
October 2024
Saitama Medical University Graduate School of Medicine, Saitama, Japan. Electronic address:
Article Synopsis
- Nontraumatic shoulder pain is common among male high school volleyball players, yet previous studies have not thoroughly assessed the various contributing factors to this issue.
- The study hypothesized that limited shoulder internal rotation, muscle strength imbalances, sensory issues, and joint stability are associated with shoulder pain, and many players do not report their pain to coaches.
- Among 49 players evaluated, 39% reported shoulder pain, particularly during jump serves; however, 95% of them failed to inform their coaches, prompting a need for better communication to enhance athlete care and prevention strategies.
Intracranial epidural hematoma after spinal anesthesia for cesarean section: a case report.
JA Clin Rep
October 2024
Department of Anesthesiology, Saitama Medical University Hospital, 38 Morohongo, Moroyamacho, Irumagun, Saitama, 350-0495, Japan.
Article Synopsis
- A 32-year-old woman had an emergency cesarean section at 35 weeks of pregnancy with spinal anesthesia, which generally has few complications.
- Shortly after the procedure, she experienced headache and nausea, leading to confusion, and a CT scan showed she had an intracranial epidural hematoma.
- The case underscores that even low-risk obstetric patients can develop rare but serious complications, such as an intracranial epidural hematoma after spinal anesthesia.
Diabetic gastroparesis with the marked efficacy of Rikkunshi-to.
Intern Med
October 2024
Department of Gastroenterology, Saitama Medical University, Japan.
Association of methotrexate polyglutamates concentration with methotrexate efficacy and safety in patients with rheumatoid arthritis treated with predefined dose: results from the MIRACLE trial.
Ann Rheum Dis
October 2024
Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Article Synopsis
- The study aimed to determine how methotrexate-polyglutamates (MTX-PGs) concentrations relate to treatment effectiveness and safety in patients new to methotrexate for rheumatoid arthritis.
- In a clinical trial involving 300 patients, researchers measured MTX-PGs levels as they adjusted methotrexate dosages over 24 weeks, finding that higher MTX-PGs were linked to lower disease activity but were also associated with increased risk of liver damage.
- Results indicated that while higher MTX-PGs initially correlated with better treatment outcomes, this link diminished when patients also received another medication, adalimumab, highlighting the complex interplay between drug dosages and patient responses.
Factors associated with the change of antimicrobial prescription before and after the national action plan on antimicrobial resistance: Additional analysis of a nationwide survey conducted by the Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases.
J Infect Chemother
October 2024
The Research Committee of the Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases on Antimicrobial Stewardship in Clinics, Japan; Disease Control and Prevention Center, National Center for Global Health and Medicine Hospital, Tokyo, Japan; AMR Clinical Reference Center, National Center for Global Health and Medicine Hospital, Tokyo, Japan.
Article Synopsis
- A 2020 survey by Japanese health organizations examined doctors' prescribing habits for antimicrobials, focusing on changes after the National Action Plan on Antimicrobial Resistance (NAPAR) was implemented.
- Out of 3,000 clinics surveyed, 632 responses showed that greater familiarity with antimicrobial stewardship guidelines and awareness of NAPAR correlated with reduced antimicrobial prescriptions.
- The study suggests that while educational interventions may help lower prescriptions, additional targeted strategies are needed for high-prescription groups to effectively combat antimicrobial resistance.
Preoperative prognostic stratification and prediction of long-term outcomes after pancreatoduodenectomy for distal cholangiocarcinoma.
Eur J Surg Oncol
December 2024
Department of Gastroenterological Surgery, Saitama Medical University International Medical Center, Yamane, Hidaka-City, Saitama-Pref, Japan.
Article Synopsis
- Patients with distal cholangiocarcinoma (DCC) often receive chemotherapy, but predicting their survival risk during treatment selection is difficult.
- This study analyzed 170 DCC patients who underwent pancreatoduodenectomy between 2009 and 2022, using various clinical parameters to identify overall survival (OS) risk factors through Cox regression analysis.
- Key findings showed that tumor size ≥15 mm and main pancreatic duct dilatation (≥3 mm) significantly impacted OS; patients with two risk factors had a poor 5-year OS of only 8%, suggesting that more aggressive treatment options should be considered for these individuals.
Roles of ZEB1 and ZEB2 in E-cadherin expression and cell aggressiveness in head and neck cancer.
Genes Cells
December 2024
Department of Biochemistry, University of Yamanashi, Chuo, Yamanashi, Japan.
Article Synopsis
- ZEB1 is a crucial factor in cancer cell behavior, particularly in differentiation and metastasis, while the role of ZEB2 in head and neck squamous cell carcinoma (HNSCC) is less understood.
- In experiments with mouse oral cancer (MOC) cells, both ZEB1 and ZEB2 overexpression led to a loss of epithelial traits and promoted aggressive cell behaviors.
- Interestingly, ZEB1 overexpression was found to increase ZEB2 levels and vice versa, but ZEB2 exhibited greater potential for aggressive growth than ZEB1 in lab conditions.
Endoscopic Ventriculocisternostomy with Stent Placement for Trapped Temporal Horn.
World Neurosurg
December 2024
Department of Neurosurgery, The University of Tokyo, Tokyo, Japan.
Article Synopsis
- * Conducted from 2013 to 2021, the research included 10 patients, all of whom showed symptom improvement and a significant reduction in the size of the trapped ventricle, with no major complications reported during the procedure.
- * The findings suggest that EVSP is a reliable and safer alternative to the traditional ventriculoperitoneal shunt (VPS) for treating TTH, emphasizing its potential to minimize risks associated with shunt failure and infection.
Videoconference-Delivered Cognitive Behavioral Therapy for Parents of Adolescents With Internet Addiction: Pilot Randomized Controlled Trial.
JMIR Pediatr Parent
October 2024
Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba City, Japan.
Background: The rise in internet addiction, including web-based gaming and social networking services, is a serious concern. Even with access to medical institutions and counseling services, individuals with internet addiction, particularly adolescents, often refuse medical treatment or counseling. Parent-focused psychological intervention may lead to positive outcomes by improving the parent-adolescent relationship and helping parents identify and modify their adolescent's problematic behaviors, including internet addiction.
View Article and Find Full Text PDF