3 results match your criteria: "Saitama Ken-oh Hospital.[Affiliation]"
Sinodielide A exerts thermosensitizing effects and induces apoptosis and G2/M cell cycle arrest in DU145 human prostate cancer cells via the Ras/Raf/MAPK and PI3K/Akt signaling pathways.
Int J Mol Med
February 2014
Department of Experimental Radiology and Health Physics, Faculty of Medical Science, University of Fukui, Matsuokashimoaizuki, Fukui 910-1193, Japan.
Article Synopsis
- - Sinodielide A (SA), a natural compound from Sinodielsia yunnanensis roots used in traditional Chinese medicine, has shown potential in enhancing cancer treatment effectiveness, particularly against certain prostate cancer cell lines when combined with mild hyperthermia.
- - This study focused on how SA affects DU145 prostate cancer cells' sensitivity to hyperthermia, investigating mechanisms like apoptosis and cell cycle arrest through specific signaling pathways (ERK1/2, JNK MAPK, and PI3K/Akt).
- - Results indicated that combining SA with hyperthermia significantly increased cell death more than hyperthermia alone, highlighting the potential for using SA to improve cancer treatment strategies.
[Histopathologic changes due to combination of androgen deprivation and transurethral microwave thermotherapy in patients with localized prostate cancer].
Hinyokika Kiyo
February 2009
The Center for Urology and Nephrology, Saitama Ken-oh Hospital.
Fifty patients with localized prostate cancer, clinical stage T1-T2N0M0 were studied. The therapy started with androgen deprivation therapy for 3 months to reduce the volume of prostate about 35%. High-energy transurethral microwave thermotherapy (TUMT) was then performed.
View Article and Find Full Text PDF[Histopathological changes due to transurethural microwave thermotherapy associated with androgen deprivation therapy in patients with localized prostate cancer].
Nihon Hinyokika Gakkai Zasshi
March 2006
The Center for Urology and Nephrology, Saitama Ken-oh Hospital.
Purpose: The 2nd generation transurethral microwave thermotherapy (TUMT), equipped with high energy microwave generator and urethral cooling device is widely accepted as an less invasive effective modality to treat benign prostatic hyperplasia. For prostatic cancer, however, it is generally estimated as insufficient because of limitation in penetration of microwave into deep prostatic tissue. In this study, we examined histopathologic changes after androgen deprivation theraphy (ADT) and TUMT.
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