Adherence to clinical practice guidelines for pulmonary valve intervention after tetralogy of Fallot repair: A nationwide cohort study.

Objectives: To determine guideline adherence pertaining to pulmonary valve replacement (PVR) referral after tetralogy of Fallot (TOF) repair.

Methods: Children and adults with cardiovascular magnetic resonance imaging scans and at least moderate pulmonary regurgitation were prospectively enrolled in the Comprehensive Outcomes Registry Late After TOF Repair (CORRELATE). Individuals with previous PVR were excluded.

MCOCT: an experimentally and numerically validated, open-source Monte Carlo simulator for optical coherence tomography.

Here, we present MCOCT, a Monte Carlo simulator for optical coherence tomography (OCT), incorporating a Gaussian illumination scheme and bias to increase backscattered event collection. MCOCT optical fluence was numerically compared and validated to an established simulator (MCX) and showed concordance at the focus while diverging slightly with distance to it. MCOCT OCT signals were experimentally compared and validated to OCT signals acquired in tissue-mimicking phantoms with known optical properties and showed a similar attenuation pattern with increasing depth while diverging beyond 1.

Finite Element Model of the Shoulder with Active Rotator Cuff Muscles: Application to Wheelchair Propulsion.

The rotator cuff is prone to injury, remarkably so for manual wheelchair users. To understand its pathomechanisms, finite element models incorporating three-dimensional activated muscles are needed to predict soft tissue strains during given tasks. This study aimed to develop such a model to understand pathomechanisms associated with wheelchair propulsion.

Outcomes following surgical interventions for hypothalamic hamartomas: protocol for a systematic review and individual patient data meta-analysis.

Introduction: Hypothalamic hamartomas (HHs) are deep-seated congenital lesions that typically lead to pharmacoresistant epilepsy and a catastrophic encephalopathic syndrome characterised by severe neuropsychological impairment and decline in quality of life. A variety of surgical approaches and technologies are available for the treatment of HH-related pharmacoresistant epilepsy. There remains, however, a paucity of literature directly comparing their relative efficacy and safety.

Automated design of nighttime braces for adolescent idiopathic scoliosis with global shape optimization using a patient-specific finite element model.

Adolescent idiopathic scoliosis is a complex three-dimensional deformity of the spine, the moderate forms of which require treatment with an orthopedic brace. Existing brace design approaches rely mainly on empirical manual processes, vary considerably depending on the training and expertise of the orthotist, and do not always guarantee biomechanical effectiveness. To address these issues, we propose a new automated design method for creating bespoke nighttime braces requiring virtually no user input in the process.

Optimized braces for the treatment of adolescent idiopathic scoliosis: A study protocol of a prospective randomised controlled trial.

Introduction: Adolescent Idiopathic Scoliosis (AIS) is a 3D deformity of the spine that affects 3% of the adolescent population. Conservative treatments like bracing aim to halt the progression of the curve to the surgical threshold. Computer-aided design and manufacturing (CAD/CAM) methods for brace design and manufacturing are becoming increasingly used.

Multicenter Study of Long-Term Outcomes and Quality of Life in PHACE Syndrome after Age 10.

Objective: To characterize long-term outcomes of PHACE syndrome.

Study Design: Multicenter study with cross-sectional interviews and chart review of individuals with definite PHACE syndrome ≥10 years of age. Data from charts were collected across multiple PHACE-related topics.

White Matter Injury on Early-versus-Term-Equivalent Age Brain MRI in Infants Born Preterm.

Background And Purpose: White matter injury in infants born preterm is associated with adverse neurodevelopmental outcomes, depending on the extent and location. White matter injury can be visualized with MR imaging in the initial weeks following preterm birth but is more commonly defined at term-equivalent-age MR imaging. Our aim was to see how white matter injury detection in MR imaging compares between the 2 time points.

CNS Inflammation as the First Sign of Complement Factor I Deficiency: A Severe Myelitis Treated With Intense Immunotherapy and Eculizumab.

Objectives: Complement factor I (CFI) deficiency is a rare autosomal recessive inborn error of immunity. In this report, we highlight that complete CFI deficiency may present with isolated and severe CNS inflammation without associated systemic features nor prior non-CNS episodes. This inflammation may respond to complement blockade therapy.

A novel method for assigning bone material properties to a comprehensive patient-specific pelvic finite element model using biplanar multi-energy radiographs.

The increasing prevalence of adult spinal deformity requires long spino-pelvic instrumentation, but pelvic fixation faces challenges due to distal forces and reduced bone quality. Bi-planar multi-energy X-rays (BMEX) were used to develop a patient-specific finite element model (FEM) for evaluating pelvic fixation. Calibration involved 10 patients, and an 81-year-old female test case was used for FEM customization and pullout simulation validation.

Active time at work following the introduction of a standing and a cycling workstation into worker's office space.

. Active workstations have been proposed to counteract sedentary behavior at work. This study describes office workers' use of and perceptions toward standing and cycling workstations, and assesses whether the two active workstations were sufficient to break sitting time and replace it with 2-4 h of light activity per workday.

Multicenter Canadian case series of pediatric patients less than 12 years of age with moderate-to-severe atopic dermatitis treated with dupilumab.

Background: Dupilumab is approved for moderate-severe atopic dermatitis (AD) in patients aged ≥6 months by the US Food and Drug Administration and Health Canada; however, there are little real-world data because providers have limited practical experience with this recently approved therapy.

Objectives: To describe the real-world effectiveness and safety in patients aged <12 years with moderate-severe AD currently receiving or previously having received dupilumab.

Methods: A multicenter retrospective study was conducted at six Canadian sites.

Relationship between 4-month functional brain network topology and 24-month neurodevelopmental outcome in children with congenital heart disease.

Survivors of complex forms of congenital heart disease (CHD)∗ are at high risk of neurodevelopmental disabilities. Neuroimaging studies have pointed to brain anomalies and immature networks in infants with CHD, yet less is known about their functional network topology and associations with neurodevelopment. To characterize the functional network topology in 4-month-old infants with repaired CHD, we compared graph theory metrics measured using resting-state functional near-infrared spectroscopy (rs-fNIRS) between infants with CHD (n = 22) and healthy controls (n = 30).

HAPI Fit: An Exercise Intervention to Improve Peak Aerobic Capacity in Young Adults Born Very Preterm.

Introduction: Individuals born preterm have reduced aerobic capacity, which could be related to impaired organ development. Their capacity to improve aerobic capacity with exercise training could therefore be limited, but this remains unknown. We aimed to test an exercise intervention to improve cardiorespiratory fitness in adults born preterm.

A Novel Methodology to Estimate Bone Mechanical Properties Using Dual-Energy Imaging to Improve Pedicle Screw Fixation.

Objective: To develop a methodology to improve the representation of the mechanical properties of a vertebral finite element model (FEM) based on a new dual-energy (DE) imaging technology to improve pedicle screw fixation.

Methods: Bone-calibrated radiographs were generated with dual-energy imaging technology in order to estimate the mechanical properties of the trabecular bone. Properties were included in regions of interest in four vertebral FEMs representing heterogeneity and homogeneity, as a realistic and reference model, respectively.

A Population-Based Analysis of the Temporal Association of Screen Time and Aggressive Behaviors in Adolescents.

Objective: The recent widespread diffusion of screen-based devices among adolescents has raised questions about the effects of screen time on adolescent behavior, including aggressive behaviors. However, previous studies have been methodologically limited in their ability to distinguish between common vulnerability, concurrency, and lasting associations between screen time and aggression among adolescents, and findings are still inconsistent. To address this gap in the literature, time-varying direct and indirect associations between screen time and aggression were investigated.