11 results match your criteria: "Sainte-Anne Hospital and Paris Descartes University[Affiliation]"
Unlabelled: Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this finding remains unknown. We assessed clinical outcomes, tumor sequencing, and tissue/cerebrospinal fluid (CSF) correlate samples from patients treated in two completed multisite clinical studies.
View Article and Find Full Text PDFMediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients With Acute Ischemic Stroke.
JAMA Neurol
February 2019
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, location AMC, Amsterdam, the Netherlands.
Importance: The positive treatment effect of endovascular therapy (EVT) is assumed to be caused by the preservation of brain tissue. It remains unclear to what extent the treatment-related reduction in follow-up infarct volume (FIV) explains the improved functional outcome after EVT in patients with acute ischemic stroke.
Objective: To study whether FIV mediates the relationship between EVT and functional outcome in patients with acute ischemic stroke.
Recanalization before Thrombectomy in Tenecteplase vs. Alteplase-Treated Drip-and-Ship Patients.
J Stroke
January 2019
Neurology Department, Sainte-Anne Hospital and Paris Descartes University, INSERM U894, Paris, France.
Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data.
Lancet Neurol
January 2019
Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Background: CT perfusion (CTP) and diffusion or perfusion MRI might assist patient selection for endovascular thrombectomy. We aimed to establish whether imaging assessments of irreversibly injured ischaemic core and potentially salvageable penumbra volumes were associated with functional outcome and whether they interacted with the treatment effect of endovascular thrombectomy on functional outcome.
Methods: In this systematic review and meta-analysis, the HERMES collaboration pooled patient-level data from all randomised controlled trials that compared endovascular thrombectomy (predominantly using stent retrievers) with standard medical therapy in patients with anterior circulation ischaemic stroke, published in PubMed from Jan 1, 2010, to May 31, 2017.
Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data.
Lancet Neurol
October 2018
Department of Clinical Neurosciences and Radiology, Cumming School of Medicine, University of Calgary, Foothills Hospital, Calgary, AB, Canada. Electronic address:
Background: Evidence regarding whether imaging can be used effectively to select patients for endovascular thrombectomy (EVT) is scarce. We aimed to investigate the association between baseline imaging features and safety and efficacy of EVT in acute ischaemic stroke caused by anterior large-vessel occlusion.
Methods: In this meta-analysis of individual patient-level data, the HERMES collaboration identified in PubMed seven randomised trials in endovascular stroke that compared EVT with standard medical therapy, published between Jan 1, 2010, and Oct 31, 2017.
Childhood supratentorial ependymomas with YAP1-MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features.
Brain Pathol
March 2019
Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany.
Article Synopsis
- * The tumors display characteristic features such as high cellularity, perivascular pseudo-rosettes, and notable cytoplasmic expression of epithelial membrane antigen, with MRI showing large multinodular tumors.
- * Most affected patients are young girls under 3 years, and despite one surgical fatality, the rest remain alive and disease-free, indicating a generally favorable prognosis after treatment.
Pretreatment lesional volume impacts clinical outcome and thrombectomy efficacy.
Ann Neurol
January 2018
IADI, U1254, INSERM, Université de Lorraine, CHRU Nancy, Nancy, France.
Objective: We aimed to characterize the association between pretreatment lesional volume measured on diffusion-weighted images and functional outcome, and estimate the impact on thrombectomy efficacy for ischemic stroke with anterior proximal intracranial arterial occlusion.
Methods: Anterior circulation ischemic stroke patients who had pretreatment diffusion-weighted imaging in the THRACE study were included. Lesional volume was semiautomatically segmented.
Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data.
Lancet Neurol
January 2018
Department of Radiology, University of Melbourne, Parkville, VIC, Australia.
Background: General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care.
Methods: For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration).
Diffuse intrinsic pontine gliomas (DIPG) at recurrence: is there a window to test new therapies in some patients?
J Neurooncol
March 2018
Department of Pediatric and Adolescent Oncology, Gustave Roussy and University Paris-Saclay, Villejuif, France.
Children with diffuse intrinsic pontine glioma (DIPG) need new and more efficient treatments. They can be developed at relapse or at diagnosis, but therefore they must be combined with radiotherapy. Survival of children after recurrence and its predictors were studied to inform the possibility to design early phase clinical trials for DIPG at this stage.
View Article and Find Full Text PDFMechanical thrombectomy after intravenous thrombolysis for acute ischaemic stroke - Authors' reply.
Lancet Neurol
February 2017
Department of Neruology, Sainte-Anne Hospital and Paris-Descartes University, INSERM U894, Paris, France.
Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial.
Lancet Neurol
October 2016
Department of Clinical Epidemiology, INSERM CIC-EC 1433, University of Lorraine and University Hospital of Nancy, Nancy, France.
Background: Intravenous thrombolysis with alteplase alone cannot reperfuse most large-artery strokes. We aimed to determine whether mechanical thrombectomy in addition to intravenous thrombolysis improves clinical outcome in patients with acute ischaemic stroke.
Methods: THRACE is a randomised controlled trial done in 26 centres in France.