196 results match your criteria: "Saint Petersburg University[Affiliation]"
J Helminthol
January 2025
Center of Parasitology of A.N. Severtsov Institute of Ecology and Evolution of the Russian Academy of Sciences, Leninskii Prospect 33, 117071, Moscow, Russia.
Studying complexes of cryptic or pseudocryptic species opens new horizons for the understanding of speciation processes, an important yet vague issue for the digeneans. We investigated a hemiuroidean trematode across a wide geographic range including the northern European seas (White, Barents, and Pechora), East Siberian Sea, and the Pacific Northwest (Sea of Okhotsk and Sea of Japan). The goals were to explore the genetic diversity within through mitochondrial ( and genes) and ribosomal (ITS1, ITS2, 28S rDNA) marker sequences, to study morphometry of maritae, and to revise the life cycle data.
View Article and Find Full Text PDFCancers (Basel)
November 2024
Blokhin National Medical Research Center of Oncology, 115522 Moscow, Russia.
Damage of the gastrointestinal mucosa is a major side effect of the anticancer drug 5-fluorouracil (5-FU). Insight into the molecular pathogenesis of 5-FU-induced gut mucositis is expected to justify the strategies of prophylaxis. We analyzed intestinal specimens obtained from Balb/c mice treated with 70 mg/kg 5-FU daily for up to 6 days.
View Article and Find Full Text PDFCells
November 2024
Institute of Translational Biomedicine, Saint-Petersburg State University, 199034 Saint-Petersburg, Russia.
The member of trace-amine associated receptor family, TAAR5 receptor was suggested to recognize tertiary amines, mostly in the olfactory system; however, knocking out the receptor TAAR5 in mice showed an enhancing effect on adult neurogenesis and dopamine neurotransmission in the striatum. To estimate the role of the TAAR5, we performed gene expression profiling of striatal samples from TAAR5 knockout (KO) mice and their wild-type littermates. The higher expression of several genes involved in dopaminergic signaling and the downregulation of genes associated with gliogenesis were revealed in TAAR5-KO mice.
View Article and Find Full Text PDFAnal Chim Acta
December 2024
Department of Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.
Background: Deep eutectic solvents (DES) have emerged as effective solvents that address many challenges in analytical chemistry, particularly in microextraction. However, until now, their use has been primarily focused on extraction processes. This has significantly limited their application in analytical chemistry, especially in flow analysis, where the high viscosity of DES has made their use difficult.
View Article and Find Full Text PDFBrain Res
February 2025
Almazov National Medical Research Centre, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia. Electronic address:
Traumatic brain injury (TBI) is a global medical concern and has a lasting impact on brain activity with high risks of mortality. Current treatments are inadequate for repairing damaged brain cells or correcting cognitive and behavioral disabilities in TBI patients. Mounting evidence links TBI to the activation of the Integrated Stress Response (ISR) signaling in the brain.
View Article and Find Full Text PDFSyst Parasitol
October 2024
Laboratory of Parasitic Worms and Protists, Zoological Institute, Russian Academy of Sciences, Saint Petersburg, Russia.
This study focuses on the opecoelid genus Podocotyle, particularly the species in the northern European seas (White, Barents and Pechora), with additional data from few isolates from the Far East. The research combines molecular analyses (28S, 5.8S+ITS2 rDNA, and cox1 mtDNA) and morphological examinations.
View Article and Find Full Text PDFTalanta
January 2025
Department of Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.
In this work, a novel deep eutectic solvent (DES) composed of thymol and 1-(o Tolyl)thiourea 9/1 (mol) is presented for the first time. This DES has not been described in the literature. This DES was first used as a stationary phase in an extraction column integrated into a flow injection analysis system for the simultaneous determination of mercury and copper in edible oils.
View Article and Find Full Text PDFJ Food Sci Technol
December 2024
Department of Analytical Chemistry, Institute of Chemistry, Saint-Petersburg University, Saint Petersburg State University, SPbSU, SPbU, 7/9 Universitetskaya nab, St. Petersburg, Russia 199034.
Unlabelled: For the rapid and efficient determination of acrylamide in food products by HPLC-UV, an environmentally friendly analytical approach has been developed, including liquid-phase extraction and subsequent liquid-liquid microextraction using a deep eutectic solvent. To automate the procedure, the flow-through "lab in a syringe" method was used. Acrylamide is considered a potential endocrine disrupting chemical and its main source is fried foods, which are widely consumed by both children and adults.
View Article and Find Full Text PDFPharmaceutics
September 2024
World-Class Research Center "Center for Personalized Medicine", Federal State Budgetary Institution of Science "Institute of Experimental Medicine", 197376 Saint Petersburg, Russia.
Glioblastomas (GBMs) are the most malignant and intractable of all cancers, with an unfavorable clinical prognosis for affected patients. The objective was to analyze the sensitivity of GBM cells to the antimicrobial peptides (AMPs) cathelicidin (LL-37) and protegrin-1 (PG-1), both alone and in combination with chemotherapy, to predict overall survival (OS) in the patients. The study was conducted on 27 GBM patients treated in the neurosurgical department of the Almazov Medical Research Centre (Saint Petersburg, Russia) from 2021 to 2024.
View Article and Find Full Text PDFBiomedicines
September 2024
Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg 199034, Russia.
Dopamine dysfunction (DA) is a hallmark of many neurological disorders. In this case, the mechanism of changes in dopamine transmission on behavior remains unclear. This study is a look into the intricate link between disrupted DA signaling, neuronal activity patterns, and behavioral abnormalities in a hyperdopaminergic animal model.
View Article and Find Full Text PDFGels
August 2024
Center for Nonlinear Chemistry, Immanuel Kant Baltic Federal University, 14 A. Nevskogo Street, Kaliningrad 236016, Russia.
We report the synthesis of novel cobalt complexes-based catalysts designed for the oscillatory Belousov-Zhabotinsky (BZ) reaction. For the first time, we introduce cobalt complex-based self-oscillating gels that demonstrate autonomous color oscillations within a BZ reagent solution, functioning without the need for any external stimuli. We created acrylamide-based self-oscillating gels containing immobilized tris(2,2'-bipyridine)cobalt(II) or tris(1,10-phenanthroline)cobalt(II) complexes and gels containing covalently bound (5-acrylamido-1,10-phenanthroline)bis(2,2'-bipyridine)cobalt(II), (5-acrylamido-1,10-phenanthroline)bis(1,10-phenanthroline) cobalt(II), or tris(5-acrylamido-1,10-phenanthroline)cobalt(II) complexes.
View Article and Find Full Text PDFOrg Biomol Chem
October 2024
Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia.
Structurally diverse pyrroles, indoles and imidazoles bearing an -ω-azidoalkyl moiety and an aldehyde or ketone function were prepared and successfully introduced into imine generation the intramolecular Staudinger/aza-Wittig tandem reaction. Reduction of the generated imines led to medicinally relevant nitrogen-containing fused heterocycles such as tetrahydropyrrolo[1,2-]pyrazines and diazepines. Rare 8-membered hexahydropyrrolo[1,2-][1,4]diazocine and 9-membered dihydro-4,8-(metheno)pyrrolo[1,2-][1,4]diazacycloundecine were also synthesized.
View Article and Find Full Text PDFTalanta
November 2024
Department of Analytical Chemistry, Institute of Chemistry, Saint-Petersburg University St. Petersburg State University, 7/9 Universitetskaya Nab., St. Petersburg, 199034, Russia.
In this work, coacervation in primary amines solutions with hydrophobic natural deep eutectic solvents based on terpenoids and carboxylic acids was demonstrated for the first time. A liquid-phase microextraction approach was developed based on supramolecular solvent formation with primary amine acting as amphiphile and hydrophobic deep eutectic solvent making up mixed vesicles and serving as coacervation agent. Such supramolecular solvents could be used to separate wide range of substances from different aqueous media, such as food products, biological liquids and wastewaters.
View Article and Find Full Text PDFLaterality
May 2024
Department of Vertebrate Zoology, Sankt-Peterburgskij gosudarstvennyj universitet (Saint Petersburg University), Saint Petersburg, Russia.
The brain's sensory lateralization involves the processing of information from the sensory organs primarily in one hemisphere. This can improve brain efficiency by reducing interference and duplication of neural circuits. For species that rely on successful interaction among family partners, such as geese, lateralization can be advantageous.
View Article and Find Full Text PDFBiomedicines
June 2024
Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg 199034, Russia.
Playing a key role in the organization of striatal motor output, the dopamine (DA)-ergic system regulates both innate and complex learned behaviors. Growing evidence clearly indicates the involvement of the DA-ergic system in different forms of repetitive (perseverative) behavior. Some of these behaviors accompany such disorders as obsessive-compulsive disorder (OCD), Tourette's syndrome, schizophrenia, and addiction.
View Article and Find Full Text PDFBiomedicines
June 2024
Institute of Translational Biomedicine, Saint-Petersburg State University, 199034 St. Petersburg, Russia.
Depression is a common mental illness of great concern. Current therapy for depression is only suitable for 80% of patients and is often associated with unwanted side effects. In this regard, the search for and development of new antidepressant agents remains an urgent task.
View Article and Find Full Text PDFInd Psychiatry J
December 2023
Institute for Physical Activity and Nutrition, Deakin University, Melbourne, Australia.
Int Immunopharmacol
June 2024
Department of Pharmacology and Toxicology, pharmacy program, Saint Petersburg University in Cairo, Cairo, Egypt.
Although colistin has a crucial antibacterial activity in treating multidrug-resistant gram-negative bacteria strains; it exhibited renal and neuronal toxicities rendering its use a challenge. Previous studies investigated the incretin hormones either glucose-dependent insulinotropic polypeptide (GIP) or glucagonlike peptide-1 (GLP-1) for their neuroprotective and nephroprotective effectiveness. The present study focused on investigating Tirzepatide (Tirze), a dual GLP-1/GIP agonist, as an adjuvant therapy in the colistin treatment protocol for attenuating its renal and neuronal complications.
View Article and Find Full Text PDFComp Biochem Physiol C Toxicol Pharmacol
August 2024
Core Facility Imaging, ZMF, Johannes Kepler University, Linz, Austria.
Mollusks, including snails, possess two chambered hearts. The heart and cardiomyocytes of snails have many similarities with those of mammals. Also, the biophysics and pharmacology of Ca, K, and Na ion channels resemble.
View Article and Find Full Text PDFInt J Mol Sci
April 2024
Research Center of Neurology, Volokolamskoye Shosse 80, 125367 Moscow, Russia.
Cardiotonic steroids (CTSs), such as digoxin, are used for heart failure treatment. However, digoxin permeates the brain-blood barrier (BBB), affecting central nervous system (CNS) functions. Finding a CTS that does not pass through the BBB would increase CTSs' applicability in the clinic and decrease the risk of side effects on the CNS.
View Article and Find Full Text PDFInt J Parasitol
June 2024
Laboratory of Evolutionary Genomics and Paleogenomics, Zoological Institute, Russian Academy of Sciences, Russia.
There are several species of gymnophallid digeneans in the genus Parvatrema that are unique in developing metacercariae that reproduce by parthenogenesis in the second intermediate host. Transmission of these digeneans takes place in coastal ecosystems of the North Pacific and North Atlantic seas. The first intermediate hosts are bivalves, the second ones are gastropods, and the definitive hosts are migratory birds.
View Article and Find Full Text PDFAnalyst
March 2024
Laboratory of Solution Chemistry of Advanced Materials and Technologies, ITMO University, 9 Lomonosova Str., 191002, St. Petersburg, Russian Federation.
Advancements in DNA computation have unlocked molecular-scale information processing possibilities, utilizing the intrinsic properties of DNA for complex logical operations with transformative applications in biomedicine. DNA computation shows promise in molecular diagnostics, enabling precise and sensitive detection of genetic mutations and disease biomarkers. Moreover, it holds potential for targeted gene regulation, facilitating personalized therapeutic interventions with enhanced efficacy and reduced side effects.
View Article and Find Full Text PDFPLoS One
January 2024
Laboratory of Amyloid Biology, Saint Petersburg University, St. Petersburg, Russia.
Preeclampsia is a disorder that can occur during pregnancy and is one of the leading causes of death among pregnant women. This disorder occurs after the 20th week of pregnancy and is characterized by arterial hypertension, proteinuria, fetoplacental, and multiple organ dysfunctions. Despite the long history of studying preeclampsia, its etiology and pathogenesis remain poorly understood, and therapy is symptomatic.
View Article and Find Full Text PDFJ Electrocardiol
January 2024
Department of Cardiology, Clinical Sciences, Lund University, Skåne University Hospital, SE-221 85 Lund, Sweden. Electronic address: