oxidations of low-density lipoprotein and RAW 264.7 cells with lipophilic O(P)-precursors.

A beneficial property of photogenerated reactive oxygen species (ROS) is the capability of oxidant generation within a specific location or organelle inside a cell. Dibenzothiophene -oxide (DBTO), which is known to undergo a photodeoxygenation reaction to generate ground state atomic oxygen [O(P)] upon irradiation, was functionalized to afford localization within the plasma membrane of cells. The photochemistry, as it relates to oxidant generation, was studied and demonstrated that the functionalized DBTO derivatives generated O(P).