6 results match your criteria: "Saint Louis University School of Science and Engineering[Affiliation]"
Survey of Laboratory Stewardship Governance at US Academic Medical Centers.
J Appl Lab Med
January 2025
Divison of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Background: Efforts to appropriately utilize laboratory tests have been underway for several decades. However, limited information is available regarding the status of laboratory stewardship at academic medical centers. Prior to initiating a laboratory stewardship committee, a study was initiated to gain insights from peer institutions.
View Article and Find Full Text PDFAppraising the evolving landscape of protease inhibition in osteoarthritis.
Nat Rev Rheumatol
December 2024
Department of Biological Sciences, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates.
Carbonic anhydrase 2 is important for articular chondrocyte function and metabolic homeostasis.
Bone
January 2025
Department of Biological Sciences, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates; Center for Biotechnology, Khalifa University, Abu Dhabi, United Arab Emirates; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Biomedical Engineering, Saint Louis University School of Science and Engineering, St. Louis, MO, USA. Electronic address:
Article Synopsis
- Aberrant chondrocyte metabolism plays a key role in cartilage degeneration and osteoarthritis (OA), with carbonic anhydrase 2 (CA2) showing increased expression in OA chondrocytes, though its specific functions are not fully understood.
- This study utilized RNA sequencing on CA2-deficient cells to identify affected metabolic pathways and assessed CA2's influence on chondrocyte metabolism during normal and hypoxic/inflammatory conditions.
- Results revealed that CA2 deficiency impacted glycolysis and cellular functions, highlighting CA2's potential role as a critical regulator of chondrocyte energy metabolism and inflammation in OA, warranting further investigation in animal models.
Loss of periostin function impairs ligament fibroblast activity and facilitates ROS-mediated cellular senescence.
FASEB J
August 2024
Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Anterior cruciate ligament (ACL) injuries pose a significant challenge due to their limited healing potential, often resulting in premature arthritis. The factors and mechanisms contributing to this inadequate healing process remain elusive. During the acute phase of injury, ACL tissues express elevated periostin levels that decline over time.
View Article and Find Full Text PDFTargeting CXCR4, VLA-4, and CXCR2 for hematopoietic stem cell mobilization.
Blood Adv
March 2024
Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO.
Osteoarthritis year in review 2023: genetics, genomics, and epigenetics.
Osteoarthritis Cartilage
February 2024
Department of Anatomy and Cellular Biology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Department of Biomedical Engineering, Saint Louis University School of Science and Engineering, St. Louis, MO, United States. Electronic address:
Objective: To elucidate the scientific advances made in the last 12 months within the realm of osteoarthritis genetics, genomics, and epigenetics. This review paper highlights major research publications that enhance our current understanding of the role of genetics, genomics, and epigenetics in osteoarthritis.
Methods: A systematic literature search was conducted on pubmed.