98 results match your criteria: "Saint Andrews State General Hospital[Affiliation]"
Int J Cardiol
September 2014
Department of Cardiology, University of Patras Medical School, Patras, Achaia, Greece.
J Nat Sci Biol Med
July 2014
Department of Cardiology, University of Patras Medical School, Patras, Achaia, Greece.
Kounis syndrome is a condition that combines allergic, hypersensitivity, anaphylactic or anaphylactoid reactions with acute coronary syndromes including vasospastic angina, acute myocardial infarction and stent thrombosis. This syndrome is a ubiquitous disease affecting patients of any age, involving numerous and continuously increasing causes, with broadening clinical manifestations and covering a wide spectrum of mast cell activation disorders. Drugs, environmental exposures and various conditions are the main offenders.
View Article and Find Full Text PDFArch Toxicol
September 2014
Department of Neurology, "Saint Andrew's" State General Hospital of Patras, 26335, Patras, Greece,
This review paper provides a critical exploration of updates concerning the spectrum of characteristics and treatment options of bortezomib-induced peripheral neuropathy (BIPN). Emphasis is given on pathogenesis issues. Although the mechanism underlying BIPN still remains elusive, it is increasingly acknowledged that the inhibition of proteasome activity in dorsal root ganglia and peripheral nerves, the mitochondrial-mediated disruption of Ca⁺⁺ intracellular homeostasis and the disregulation in nuclear factor κB and brain-derived neurotrophic factor play a significant pathogenic role.
View Article and Find Full Text PDFInt J Cardiol
September 2014
Department of Medical Sciences, Northwestern Greece Highest Institute of Education and Technology, Patras, Achaia, Greece. Electronic address:
Cardiovasc Pathol
July 2015
Department of Medical Science, Northwestern Greece Highest Institute of Education and Technology, Patras, Achaia, Greece.
Indian Heart J
September 2015
Department of Cardiology, "Saint Andrews" State General Hospital, Patras, Achaia, Greece.
J Pharmacol Pharmacother
April 2014
Department of Cardiology, Saint Andrew's State General Hospital, Patras, Achaia, Greece.
Int J Cardiol
March 2014
Department of Medical Sciences, Patras Highest Institute of Education and Technology, Patras, Greece. Electronic address:
N Am J Med Sci
November 2013
Department of Cardiology, University of Patras Medical School, Rio, Patras, Greece.
Experiments have shown that anaphylaxis decreases cardiac output; increases left ventricular end diastolic pressure; induces severe early acute increase in respiratory resistance with pulmonary interstitial edema; and decreases splanchnic, cerebral, and myocardial blood flow more than what would be expected from severe arterial dilation and hypotension. This is attributed to the constrictive action of inflammatory mediators released during anaphylactic shock. Inflammatory mediators such as histamine, neutral proteases, arachidonic acid products, platelet-activating factor (PAF), and a variety of cytokines and chemokines constitute the pathophysiologic basis of Kounis hypersensitivity-associated acute coronary syndrome.
View Article and Find Full Text PDFInt Endod J
April 2014
Department of Cardiology, 'Saint Andrews' State General Hospital, Patras, Greece.
Anaphylactic shock is a real and life threatening medical emergency which is encountered in every field of medicine. The coronary arteries seem to be the primary target of anaphylaxis resulting in the development of Kounis syndrome. Kounis syndrome is a pan-arterial anaphylaxis -associated syndrome affecting patients of any age, involving numerous and continuously increasing causes, with broadening clinical manifestations and covering a wide spectrum of mast cell activation disorders.
View Article and Find Full Text PDFKorean Circ J
April 2013
Department of Medical Sciences Patras Highest Institute of Education and Technology, Patras, Greece and Department of Cardiology, Saint Andrews State General Hospital, Patras, Greece.
Int J Cardiol
September 2013
Department of Cardiology, "Saint Andrews" State General Hospital, Patras, Achaia, Greece.
Eur J Neurol
May 2013
Department of Neurology, Saint Andrew's State General Hospital of Patras, Patras, Greece.
Background And Purpose: The aim of this post hoc analysis of data extracted from a prospective, multicenter study is to test in a large homogenous population of chemotherapy-naïve patients with colorectal cancer (CRC) treated with oxaliplatin (OXA)-based chemotherapy whether advanced age increases the risk of developing OXA-induced peripheral neuropathy (OXAIPN).
Methods: One-hundred and forty-five patients with CRC, without other significant co-morbidities predisposing to peripheral neuropathy, were divided according to their age into two groups: patients aged between 50 and 68 years (group I, n = 75); and patients aged ≥ 69 years (group II, n = 70). Patients were prospectively monitored at baseline and followed-up during chemotherapy using the motor and neurosensory National Cancer Institute Common Toxicity criteria, the clinical version of the Total Neuropathy Score and neurophysiology.
Ann Oncol
December 2012
Department of Neurology-Unit of Neuro-Oncology, University Hospital of Bellvitge-ICO Duran i Reynals, Barcelona, Spain. Electronic address:
Background: To report our prospective experience on the incidence and pattern of oxaliplatin (OXA)-induced peripheral neuropathy (OXA-IPN) in patients with colorectal cancer (CRC) treated with either FOLFOX-4 or XELoda + OXaliplatin (XELOX).
Patients And Methods: One hundred and fifty patients scheduled to be treated with either FOLFOX or XELOX for CRC were prospectively monitored at baseline and followed-up during chemotherapy. The incidence and severity of symptoms secondary to OXA-IPN were recorded using three different types of assessment, i.
J Pain Symptom Manage
December 2011
Department of Neurology, Saint Andrew's State General Hospital of Patras, Patras, Greece.
Context: Epothilones, belonging to the family of microtubule stabilizing agents, have shown prolonged remissions and improved survival in various types of refractory, treatment-resistant cancer. Ixabepilone (BMS-247550) is the main representative of these compounds. Peripheral neuropathy is a significant toxicity of epothilones, eventually resulting in dose modification and changes in the treatment plan.
View Article and Find Full Text PDFQual Life Res
December 2011
Department of Neurology, Saint Andrew's State General Hospital of Patras, 26335 Patras, Greece.
Purpose: Our aim was to assess the perceived emotional burden and quality of life (QOL) in a sample of Greek primary caregivers of patients with multiple sclerosis (MS).
Methods: Twenty-two male and 13 female primary caregivers (mean age 47.3 ± 12.
J Pain Symptom Manage
October 2011
Department of Neurology, Saint Andrew's State General Hospital of Patras, Patras, Greece.
Context: Several studies have investigated the prevalence of sleep disorders in patients suffering from multiple sclerosis (MS) and have shown that up to 54% of patients may have significantly more sleep problems than the general population. To our knowledge, however, no data are available about the quality of sleep of the primary caregivers of patients with MS.
Objectives: The objectives of the current cross-sectional study were to assess the quality of sleep in Greek primary caregivers of patients with MS and to investigate its relationship with the degree of caregivers' emotional distress.
J Neurol
June 2011
Department of Neurology, Saint Andrew's State General Hospital of Patras, 26335, Patras, Greece.
The first objective of the current observational study was to assess the degree of religiosity in Greek Christian Orthodox primary caregivers of patients with multiple sclerosis (MS). The second objective was to evaluate the interrelations between religiosity and quality of life (QOL) and to identify the determinants of QOL, an endpoint of considerable importance in clinical research and practice. Twenty-two male and 13 female primary caregivers (mean age 47.
View Article and Find Full Text PDFNeurodegener Dis
July 2011
Department of Neurology, Saint Andrew's State General Hospital of Patras, Patras, Greece.
To our knowledge, we describe for the first time the case of a male patient with sporadic young-onset amyotrophic lateral sclerosis, most likely attributed to chronic regular cocaine use and abuse. Our case supports the view that cocaine use and abuse may trigger a process of motor neuron degeneration by mechanisms implicating alterations in the neurobiology of the excitatory neurotransmitter glutamate and its receptors.
View Article and Find Full Text PDFJ Clin Neurophysiol
April 2010
EMG Laboratory, Department of Neurology, Saint Andrew's State General Hospital of Patras, Patras, Greece.
We sought to identify significant ulnar nerve conduction abnormalities and also to detect ulnar F-wave variable changes in patients with secondary progressive multiple sclerosis (MS). Conventional conduction study was performed unilaterally to ulnar nerves of eight men and 12 women with secondary progressive MS (mean age, 47.5 +/- 6.
View Article and Find Full Text PDFMol Med
September 2009
Department of Neurology, Saint Andrew's State General Hospital of Patras, Greece.
Conventional treatment options, including corticosteroids, intravenous immunoglobulin, or plasma exchange, often fail to treat dysimmune neuropathies, such as chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, and monoclonal gammopathy with its subtypes. Therefore, a significant percentage of patients require adjunctive immunosuppressive therapies. Considering that even immunosuppressive agents often are ineffective and/or associated with significant toxicities, the need for the development of safe and effective new treatment options is rising.
View Article and Find Full Text PDFEur J Intern Med
May 2006
Department of Internal Medicine, "Saint Andrews" State General Hospital, Patras, Greece.
A 60-year-old male was bitten by a venomous snake (Vipera ammodytes) and gradually developed signs of an allergic reaction including generalized itching, generalized rash, and chest discomfort. This was followed by severe retrosternal pain with electrocardiographic evidence of an inferior myocardial ischemia progressing to acute myocardial infarction. Cardiac enzymes and troponin, serum tryptase, and histamine were elevated.
View Article and Find Full Text PDFEur J Intern Med
January 2006
Department of Internal Medicine, Saint Andrews State General Hospital, Patras, Greece.
Background: Snake venom poisoning is a medical emergency requiring immediate attention. Bites from poisonous European snakes can lead to local tissue damage and systemic symptoms. Vipera ammodytes accounts for the most envenomation in Greece.
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