Breaking boundaries: Ticagrelor monotherapy in high-risk patients.

Atherosclerotic plaque formation is a leading cause of arterial thrombosis that significantly impacts global health by instigating major adverse cardiovascular events (MACE) like myocardial infarction (MI) and stroke. Platelets are central to this process, leading to the development of antiplatelet therapies, to mitigate MACE risks. The combination of aspirin with a potent P2Y inhibitor known as dual antiplatelet therapy (DAPT) is the standard for post-percutaneous coronary intervention (PCI) aimed at reducing ischemic events.

Bioinspired Carbonized Polymer Microspheres for Full-Color Whispering Gallery Mode Emission for White Light Emission, Unclonable Anticounterfeiting, and Chemical Sensing Applications.

Light-element-based fluorescent materials, colloidal graphene quantum dots, and carbon dots (CDs) have sparked an immense amount of scientific interest in the past decade. However, a significant challenge in practical applications has emerged concerning the development of solid-state fluorescence (SSF) materials. This study addresses this knowledge gap by exploring the unexplored photonic facets of C-based solid-state microphotonic emitters.

EEF1A2 promotes HIF1A mediated breast cancer angiogenesis in normoxia and participates in a positive feedback loop with HIF1A in hypoxia.

Background: The eukaryotic elongation factor, EEF1A2, has been identified as an oncogene in various solid tumors. Here, we have identified a novel function of EEF1A2 in angiogenesis.

Methods: Chick chorioallantoic membrane, tubulogenesis, aortic ring, Matrigel plug, and skin wound healing assays established EEF1A2's role in angiogenesis.

Fluorescence probing and molecular docking analysis of the binding interaction of bovine serum albumin (BSA) with the polarity probe AICCN.

In this work, the fluorescent probe 2-amino-4-(1-indol-3-yl)-4-chromene-3-carbonitrile (AICCN) has been used to evaluate its potential as a prospective polarity probe. From detailed fluorescence studies of the probe, it could be shown that AICCN can indeed function as an effective polarity probe. The calculated dipole moments of AICCN in both the ground state and excited state in various solvents lend support to the steady state fluorescence results.

Cooperation and competition in the collective drive by motor proteins: mean active force, fluctuations, and self-load.

We consider the dynamics of a bio-filament under the collective drive of motor proteins. They are attached irreversibly to a substrate and undergo stochastic attachment-detachment with the filament to produce a directed force on it. We establish the dependence of the mean directed force and force correlations on the parameters describing the individual motor proteins using analytical theory and direct numerical simulations.

Rural child health in India: the persistent nature of deprivation, undernutrition and the 2030 Agenda.

The 2030 Agenda for sustainable development was launched to achieve Sustainable Development Goals (SDGs) across the globe. This paper is based on the primary database to assess the nutritional status of 5-10 years children and the incidence of deprivation in their households of a backward district (Purulia), India in the context of the first two SDGs, no poverty and zero hunger. We conclude that around 74% of children are undernourished.

A drug repurposing endeavor to discover a multi-targeting ligand against RhlR and LasR proteins from opportunistic human pathogen Pseudomonas aeruginosa.

Pseudomonas aeruginosa is an opportunistic human pathogen. It synthesizes the poison called Hydrogen Cyanide (HCN). The synthesis of HCN is mediated by the enzyme HCN synthase which is obtained from the hcnABC operon and the transcription of the hcnABC operon is mediated by three proteins LasR, RhlR, and ANR.

Significant reduction of carbon stocks and changes of ecosystem service valuation of Indian Sundarban.

The Sundarban mangrove or tidal influenced natural ecosystem is extremely productive and providing multiple goods and services to millions of people. In the last few decades, the quality and quantity of mangrove ecosystem are being deteriorated. The main objectives of this current research are (i) to investigate the ecosystem service values (ESVs) using a time series satellite data (1975, 2000 and 2020) and different unit values (ii) to analyze the dynamic pattern of carbon sequestration through InVEST model and (iii) determination of ESVs change hotspots by Getis-Ord Gi method.

Self-Assembled TMD Nanoparticles on N-Doped Carbon Nanostructures for Oxygen Reduction Reaction and Electrochemical Oxygen Sensing Thereof.

Here, we report on a universal carbothermal reduction strategy for the synthesis of well-dispersed WS nanoparticles (∼1.7 nm) supported on a N-doped carbon (NC) nanostructure and the electrocatalytic activity toward oxygen reduction reaction (ORR). Bulk WS powder (2 μm) is the source for WS nanoparticles, and dicyandiamide is the source for NC and carbothermal reduction.

Variation and dispersal of PM and PM during COVID-19 lockdown over Kolkata metropolitan city, India investigated through HYSPLIT model.

The higher concentration of PM and PM in the lower atmosphere is severely harmful for human health and it also makes visibility diminution along with weather and climate modifications. The main objective is to find out the spatiotemporal variation and dispersal of PM and PM along with COVID-19 infection in the dusty city Kolkata. The consecutive two years PM and PM data of different stations have been obtained from State Pollution Control Board, Govt.

Effects of COVID-19 lockdown and unlock on health of Bhutan-India-Bangladesh trans-boundary rivers.

The COVID-19 pandemic significantly destructs the rhythm of global modern human civilization but worldwide lockdown radically recovers the health of the total environment. The Himalayan trans-boundary rivers provide huge provisional, regulatory and cultural ecosystem services to millions of people throughout the year but in the recent years the water quality is being deteriorated due to multiple reasons. In the last decade, India-Bangladesh political relationship has been slightly broken down due to water sharing and environmental flow of rivers.

PM concentration prediction during COVID-19 lockdown over Kolkata metropolitan city, India using MLR and ANN models.

Kolkata is the third densely populated city of India and Kolkata stands in the World's 25 most polluted cities along with 10 worse polluted cities in India. The relevant study claims that due to the imposition of lockdown during COVID-19 pandemic, the atmospheric pollution level has been significantly reduced over the metropolitan city Kolkata like other cities of the world. The main objective of this study is to predict the concentration of PM using multiple linear regression (MLR) and artificial neural network (ANN) models and similarly, to compare the accuracy level of two models.

Schottky junction devices by using bio-molecule DNA template-based one dimensional CdS-nanostructures.

Creating a well-defined nanostructure through de-oxyribo nucleic acid (DNA)-nanotechnology, and specifically the development of metal/inorganic semiconductor junctions on DNA-assembled nanostructures, is an emerging research area. Herein, we investigate the electrical properties of biomolecule DNA-template based one-dimensional nanowires (NWs)-CdS/Au and without-template based nanoparticles (NPs)-CdS/Au devices grown on the Indium Tin Oxide (ITO) glass substrates. More importantly, the NWs-CdS/Au device displays a dramatic augmentation of current flow and also a striking change in threshold voltage (~55 mV) in comparison to NPs (~190 mV) and reported bulk-CdS/Au (~680 mV) devices.

Variation and correlation between ultraviolet index and tropospheric ozone during COVID-19 lockdown over megacities of India.

Worldwide spread out of COVID-19 in a short-time has brought a significant decline of road traffic, tourist flow and industrial ventures. During this emergency period, the restricted human dealings with nature have appeared as blessing for health of the total environment. The variation of atmospheric O may modulate the range of UV index (UVI) at any region of the earth.

Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status.

IQGAP2, a member of the IQGAP family, functions as a tumor suppressor in most of the cancers. Unlike IQGAP1 and IQGAP3, which function as oncogenes in breast cancer, the role of IQGAP2 is still unexplored. Here we report a reduced expression of IQGAP2, which was associated with lymph node positivity, lymphovascular invasion, and higher age in breast cancer patients.

Mixed-valent antimony-induced disorder in substituted antiferromagnetic MnSnS.

Among MII2AIVQ4 (M = transition metal; A = Si, Ge, and Sn; Q = S, Se, and Te)-type compounds, most of which crystallize in an olivine or spinel structure, Mn2SnS4 is a unique compound that crystallizes in the orthorhombic space group Cmmm and exhibits complex magnetic properties. In this article, we report synthesis and study of the effect of Sb substitution (up to 20%) on the magnetic properties of Mn2SnS4. All the compounds were found to be in a single phase and indexed with the orthorhombic parent structure.

Expression pattern of EEF1A2 in brain tumors: Histological analysis and functional role as a promoter of EMT.

Aims: Glioblastomas are highly aggressive brain tumors with a very poor survival rate. EEF1A2, the proto-oncogenic isoform of the EEF1A translation factor family, has been found to be overexpressed and promoting tumorigenesis in multiple cancers. Interestingly, recent studies reported reduced expression of this protein in brain tumors, drawing our attention to find the functional role and mechanism of this protein in brain tumor progression.

Universe's Worth of Electrons to Probe Long-Range Interactions of High-Energy Astrophysical Neutrinos.

Astrophysical searches for new long-range interactions complement collider searches for new short-range interactions. Conveniently, neutrino flavor oscillations are keenly sensitive to the existence of long-ranged flavored interactions between neutrinos and electrons, motivated by lepton-number symmetries of the standard model. For the first time, we probe them using TeV-PeV astrophysical neutrinos and accounting for all large electron repositories in the local and distant Universe.

Antibiotic resistance determinants and clonal relationships among multidrug-resistant isolates of Klebsiella pneumoniae.

In the present study, we performed PCR based screening to determine the presence of antibiotic resistance genes and sequencing to find mutation in QRDR region among fourteen isolates of K. pneumoniae. Association analysis was conducted to detect the co-resistance among the isolates.

Octant of θ_{23} in Danger with a Light Sterile Neutrino.

Present global fits of world neutrino data hint towards nonmaximal θ_{23} with two nearly degenerate solutions, one in the lower octant (θ_{23}<π/4), and the other in the higher octant (θ_{23}>π/4). This octant ambiguity of θ_{23} is one of the fundamental issues in the neutrino sector, and its resolution is a crucial goal of next-generation long-baseline (LBL) experiments. In this Letter, we address, for the first time, the impact of a light eV-scale sterile neutrino towards such a measurement, taking the Deep Underground Neutrino Experiment as a case study.

Ethnobiological treatments of neurological conditions in the Chota Nagpur Plateau, India.

Ethnopharmacological Relevance: World Health Organization (WHO) has recognized the contribution of traditional medicine in the primary health care system. WHO also considers neurological disorders as one of the prime concern to the public health. Inadequate and inaccessible health facilities in the rural and underprivileged areas have forced the various tribal and non-tribal communities to use ethno-phyto and ethno-zoo therapeutics against different ailments.

Observation of Slow Relaxation and Single-Molecule Toroidal Behavior in a Family of Butterfly-Shaped Ln Complexes.

A family of five isostructural butterfly complexes with a tetranuclear [Ln ] core of the general formula [Ln (LH) (μ -η η Piv)(η -Piv)(μ -OH) ]⋅x H O⋅y MeOH⋅z CHCl (1: Ln=Dy , x=2, y=2, z=0; 2: Ln=Tb , x=0, y=0, z=6; 3: Ln=Er , x=2, y=2, z=0; 4: Ln=Ho , x=2, y=2, z=0; 5: Ln=Yb , x=2, y=2, z=0; LH =6-{[bis(2-hydroxyethyl)amino]methyl}-N'-(2-hydroxy-3-methoxybenzylidene)picolinohydrazide; PivH=pivalic acid) was isolated and characterized both structurally and magnetically. Complexes 1-5 were probed by direct and alternating current (dc and ac) magnetic susceptibility measurements and, except for 1, they did not display single-molecule magnetism (SMM) behavior. The ac magnetic susceptibility measurements show frequency-dependent out-of-phase signals with one relaxation process for complex 1 and the estimated effective energy barrier for the relaxation process was found to be 49 K.

Octanuclear Heterobimetallic {Ni4Ln4} Assemblies Possessing Ln4 Square Grid [2 × 2] Motifs: Synthesis, Structure, and Magnetism.

Octanuclear heterobimetallic complexes, [Ln4Ni4(H3L)4(μ3-OH)4(μ2-OH)4]4Cl·xH2O·yCHCl3 (Dy(3+), x = 30.6, y = 2 (1); Tb(3+), x = 28, y = 0 (2) ; Gd(3+), x = 25.3, y = 0 (3); Ho(3+), x = 30.

Unrelated renal transplantation: an ethical enigma.

End-stage renal disease (ESRD) is a condition better discussed than suffered. People suffering from ESRD are at a disadvantage not only financially, but also emotionally and in terms of the quality of their lives. The majority of their productive time is spent in hospital, on dialysis machines, or in the search for a suitable kidney donor, so that they may be able to improve upon the quality of their remaining lifespan.

Noradrenergic inputs from locus coeruleus to posterior ventral tegmental area are essential to support ethanol reinforcement.

Although dysregulation of the dopaminergic mesolimbic system is generally considered central to addiction, the involvement of other circuits is increasingly being appreciated. An interaction between locus coeruleus (LC) noradrenergic neurons and the posterior ventral tegmental area (pVTA) dopaminergic system, in the processing of drug-triggered reward, has been suggested, but not demonstrated in behaving animals. Herein, we try to tease out the precise role of noradrenergic neurons in the LC-VTA circuit in mediating reward and reinforcement behavior associated with ethanol.