The Rate of Major Complications Following Distal Radial Fractures Treated With One Specific Volar Locking Plate: A Retrospective Study of 1,597 Consecutive Cases in 1,564 Patients.

Purpose: Current knowledge of complication rates after volar plating of distal radius fractures mainly relies on studies of low to moderate numbers and various implants. This study sought to find the incidence of complications leading to reoperation in a sample of distal radius fractures treated with one specific volar locking plate (VLP).

Methods: We retrospectively evaluated 1,597 distal radius fractures in 1,564 patients operated with a VLP from January 2011 to December 2017 for complications leading to a reoperation.

Systemic pro-inflammatory response following bronchoscopic lung volume reduction using endobronchial valves.

Rationale: Bronchoscopic lung volume reduction treatment using endobronchial valves (EBV) is an effective treatment for severe COPD patients by improving lung function and quality of life. However, little is known about its effects on systemic inflammation. Therefore, the aim of our study was to investigate whether EBV treatment impacts the inflammatory cytokine profile.

Immunological biomarkers at birth and later risk of celiac disease.

Background: The role of immune cell profiles at birth in determining the risk of celiac disease (CD) development is currently unestablished. This study aimed to determine the associations between T- and B-cell profiles at birth and pediatric CD.

Methods: This regional cohort study analyzed prospectively collected dried blood spots from 158 children with CD (median 7 years old at CD diagnosis) and two matched comparators each (n = 316).

Decompressive craniectomy in aneurysmal subarachnoid hemorrhage: can favorable outcome be achieved?

Background: Decompressive craniectomy (DC) is a last-tier treatment for managing refractory intracranial hypertension in patients with aneurysmal subarachnoid hemorrhage (aSAH), though concerns persist about whether it primarily prolongs survival in a state of severe disability. This study investigated patient characteristics, surgical indications, complications, and outcomes following DC in aSAH.

Methods: In this Swedish, retrospective multi-center study, 123 aSAH patients treated with DC between 2008-2022 were included.

Factors associated with the development of severe asthma - a nationwide study (FINASTHMA).

Background: Severe asthma presents a major challenge to healthcare and negatively affects the quality of life of the patients. Understanding on the factors predicting the development of severe asthma is limited.

Objective: This study aimed at characterizing patients with severe asthma and establishing risk factors for the development of severe asthma in a Finnish sample with a nationwide coverage of population, healthcare and drug register data.

Combination treatment with anti-RANKL and antibiotics for preventing joint destruction in septic arthritis.

Septic arthritis, the most severe joint disease, is frequently caused by Staphylococcus aureus (S. aureus). A substantial proportion of patients with septic arthritis experience poor joint outcomes, often necessitating joint replacement surgery.

Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries.

Importance: Age, sex, and apolipoprotein E (APOE) are the strongest risk factors for late-onset Alzheimer disease (AD). The role of APOE in AD varies with sex and ancestry. While the association of APOE with AD biomarkers also varies across sex and ancestry, no study has systematically investigated both sex-specific and ancestry differences of APOE on cerebrospinal fluid (CSF) biomarkers together, resulting in limited insights and generalizability.

Consensus statements on end-of-life care in ICU - A Scandinavian multidisciplinary Delphi study.

Background: End-of-life care in the Intensive Care Unit (ICU) is complex, requiring a balance of ethical, cultural and medical considerations while ensuring comfort and dignity for critically ill patients and their families.

Aim: We aimed to develop a set of core domains for end-of-life care at Scandinavian ICUs along with corresponding consensus statements from patients, families and multidisciplinary experts.

Methods: In a three-round Delphi study, a multidisciplinary advisory board from Norway, Sweden, Finland, Iceland and Denmark, including ICU physicians, ICU nurses, palliative care specialists and a former ICU patient and family, developed potential end-of-life care domains of interest.

Acute kidney injury after lung transplantation, incidence, risk factors, and effects: A Swedish nationwide study.

Background: Acute kidney injury (AKI) is a serious complication after lung transplantation, but the reported incidence varies in the literature. No data on AKI have been published from the Swedish lung transplantation program.

Methods: The aim of our study was to investigate the incidence, perioperative risk factors, and effects of early postoperative acute kidney injury (Kidney Disease Improving Global Outcomes [KDIGO] criteria) after lung transplantation.

Comparative analysis of ultrasound and magnetic resonance imaging in diagnosing pain in the posterolateral region of the ankle.

Aim: The purpose of this study was to evaluate the diagnostic value of ultrasound compared to magnetic resonance imaging (MRI) as a reference in detecting peroneus brevis split ruptures.

Material And Methods: We re-reviewed 112 ultrasound examinations performed between 2020 and 2021 by three musculoskeletal radiologists with 8-10 years of experience. Patients were referred due to pain lasting at least 8 months in the posterolateral ankle.

EMD missense variant causes X-linked isolated dilated cardiomyopathy with myocardial emerin deficiency.

Pathogenic variants in the EMD gene cause X-linked Emery-Dreifuss muscular dystrophy type 1 (EDMD1), typically presenting with joint contractures and skeletal muscle atrophy, followed by atrial arrhythmias, cardiac conduction defects, and atrial dilatation. Although an association with isolated dilated cardiomyopathy (DCM) has been suggested, evidence is currently insufficient to verify the gene-disease association. We investigated the causality of a missense variant, c.

Identification of Predictive Factors for the Development of In-Transit Metastasis in Patients with Melanoma.

Background: In patients with melanoma, in-transit metastasis (ITM) can develop. This study aimed to identify the risk for a first recurrence of ITM and associated predictive clinical factors in a large international cohort of patients with melanoma.

Methods: Patients with primary cutaneous melanoma who underwent wide local excision (WLE) and sentinel lymph node biopsy (SLNB) were identified from the Sentinel Lymph Node Working Group (SLNWG) database between January 1993 and February 2023.

Feasibility of a single-day protocol for SPECT and PET assessment of dopamine transporter availability, cardiac innervation and metabolic patterns in patients with movement disorders.

Purpose: Due to new advances in molecular and imaging biomarkers, a biological classification of Parkinson's disease (PD) called SyNeurGe (Hoglinger et al. Lancet Neurol 2024;23:191-204) has been proposed for research use recently. [I]ioflupane dopamine transporter single-photon-emission-computed tomography (DaT-SPECT) and cardiac [I]meta-iodobenzylguanidine (MIBG) scintigraphy are included in this biological classification scheme together with 2-[F]fluoro-2-deoxy-D-glucose (FDG-PET) as central imaging biomarkers for the assessment of dopaminergic function, cardiac sympathetic denervation, and metabolic patterns in brain.

Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases.

Background And Objectives: Plasma biomarkers of Alzheimer disease (AD), neuroinflammation, and neurodegeneration are increasingly being used in clinical trials for diagnosis and monitoring of dementia. However, their association with longitudinal structural brain MRI changes, an important outcome measure across neurodegenerative and cerebrovascular diseases, is less known. We investigated how baseline plasma biomarkers reflect MRI markers of progression over time in patients with neurodegenerative and cerebrovascular diseases.

Haplotype-based analysis distinguishes maternal-fetal genetic contribution to pregnancy-related outcomes.

Genotype-based approaches for the estimation of SNP-based narrow-sense heritability ([Formula: see text]) have limited utility in pregnancy-related outcomes due to confounding by the shared alleles between mother and child. Here, we propose a haplotype-based approach to estimate the genetic variance attributable to three haplotypes - maternal transmitted ([Formula: see text]), maternal non-transmitted ([Formula: see text]) and paternal transmitted ([Formula: see text]) in mother-child pairs. We show through extensive simulations that our haplotype-based approach outperforms the conventional and contemporary approaches for resolving the contribution of maternal and fetal effects, particularly when m1 and p1 have different effects in the offspring.

Infective Endocarditis Caused by Non-HACEK Gram-Negative Bacteria, a Registry-Based Comparative Study.

Background: Infective endocarditis (IE) caused by non-HACEK gram-negative bacteria (nHGNB) is uncommon. In the 2023 Duke-ISCVID diagnostic criteria, and were added as "typical" pathogens. We examine the consequences of this addition, the risk of IE in bacteremia from nHGNB species, and the features of IE caused by nHGNB.

National trends of wrist arthroscopy in Italy: Analysis from 2001 to 2016.

Purpose: This study aimed to evaluate the demographic features of patients undergoing wrist arthroscopy in Italy. A secondary aim was to perform an economic analysis of this type of surgery.

Methods: The National Hospital Discharge Records database was employed to conduct the analysis.

The Battleship technique: A reliable method to quantify intraarticular distance maps patterns and correlate hindfoot alignment.

Purpose: Weight-bearing computed tomography (WBCT) creates colour-coded distance maps (DM) to analyze intraarticular contact areas, offering a detailed assessment of joint surface interactions. However, clinical applications of DM remain underexplored. This study introduces the 'Battleship technique (BST)' to evaluate contact area patterns in patients with osteoarthritis (OA) of the talar dome, producing a single point representing the distance map weighted sum (DMWS).

Prevalence and Factors Associated With Symptom Profiles of Disorders of Gut-Brain Interaction in Obesity Before and After Treatment.

Background & Aims: Disorders of gut-brain interaction (DGBI) in obesity could impair health outcomes. Therefore, we aimed to study the prevalence and burden of symptoms compatible with a DGBI in obesity and assess the effect of obesity treatment on comorbid DGBI.

Methods: We used baseline and two-year follow-up data from a prospective non-randomized cohort study including patients with obesity referred for obesity treatment.

Survival trends of adults with congenital heart disease after heart surgery in Sweden.

Objective: Congenital heart disease is the most common congenital anomaly. This study evaluated long-term mortality in patients who underwent childhood heart surgery and survived to adulthood.

Methods: Using Swedish national registries, we identified 24,774 adults with congenital heart disease born between 1970 and 1999 who were alive at 18 years.

Time Trends and Sex Differences in Invasive Treatment of Infra-inguinal Intermittent Claudication in Sweden During 2009 - 2022: Results From the Swedish Vascular Registry (Swedvasc).

Objective: This study aimed to report changes in the annual incidence of invasive treatment, changes in invasive treatment modalities, and sex differences in patients treated for intermittent claudication (IC) due to infra-inguinal lesions in Sweden between 2009 and 2022.

Methods: Data were collected from the Swedish Vascular Registry (Swedvasc), including all registrations of invasive treatment for infra-inguinal IC in Sweden between 2009 and 2022.

Results: The annual incidence of invasive treatments showed no statistically significant change between 2009 and 2022 (p = .

Nurses' experiences of providing digital and in-person healthcare support to children living with complex chronic conditions.

Objectives: To demonstrate how nurses in pediatric care provide information and maintain access to health care for children with complex chronic conditions utilizing e-health or in-person support methods.

Methods: The study involved 12 nurses/specialist nurses from the medical departments at Queen Silvia Children's Hospital in Gothenburg. A qualitative method was employed, using individual interviews with a semi-structured guide and analyzed using a reflexive thematic analysis method.

Associations of parental air pollution and greenness exposures with offspring asthma outcomes.

Background: Air pollution and greenness impact respiratory health, but intergenerational effects remain unclear.We investigated whether pre-conception parental residential exposure to air pollution and greenness at age 20-44 years is associated with offspring asthma outcomes in the Lifespan and inter-generational respiratory effects of exposures to greenness and air pollution (Life-GAP) project.

Methods: We analyzed data on 3684 RHINESSA study participants born after the year 1990 (mean age 19, standard deviation 4), offspring of 2689 RHINE study participants.

Antisecretory factor for treatment of peritumoral edema in glioblastoma patients.

Purpose: Glioblastoma (GBM) is an aggressive brain tumor often accompanied by a vasogenic peritumoral edema, which contributes to symptoms both at diagnosis and during later stages of the disease. Previous studies have suggested effectiveness of the endogenous protein, Antisecretory Factor (AF), in reducing the intracranial pressure in cytotoxic brain edema after trauma. Interestingly, AF also seems to carry antineoplastic effects in experimental GBM models.