269 results match your criteria: "Sabancı University Nanotechnology Research and Application Center[Affiliation]"

Myrrh oleo-gum-resin (MOGR) is a natural substance that has a rich history of medicinal use due to its anti-inflammatory, antimicrobial, and antioxidant properties. The present study reports on the fabrication and assessment of pectin and K-carrageenan composite films infused with varying proportions (0.3%, 0.

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Design of patient-specific mandibular reconstruction plates and a hybrid scaffold.

Comput Biol Med

January 2025

3D Bioprinting Laboratory, Sabanci University Nanotechnology Research and Application Center, Istanbul, 34956, Turkiye; Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, 34956, Turkiye. Electronic address:

Article Synopsis
  • Managing segmental mandibular defects is complex and requires a multidisciplinary approach, as traditional methods like reconstruction plates alone may not yield optimal results for patients.* -
  • The use of integrated hybrid scaffold systems, which combine various materials for better mechanical support and tissue healing, shows promise in enhancing recovery outcomes in mandibular reconstruction.* -
  • A study utilized 3D modeling and finite element analysis to develop and assess new reconstruction plates and a biomimetic bone scaffold, highlighting improvements in biomechanical performance for better treatment strategies.*
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A guide for blood-brain barrier models.

FEBS Lett

November 2024

Faculty of Engineering and Natural Sciences, Sabancı University, Istanbul, Turkey.

Understanding the intricate mechanisms underlying brain-related diseases hinges on unraveling the pivotal role of the blood-brain barrier (BBB), an essential dynamic interface crucial for maintaining brain equilibrium. This review offers a comprehensive analysis of BBB physiology, delving into its cellular and molecular components while exploring a wide range of in vivo and in vitro BBB models. Notably, recent advancements in 3D cell culture techniques are explicitly discussed, as they have significantly improved the fidelity of BBB modeling by enabling the replication of physiologically relevant environments under flow conditions.

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Manipulation of defect state emission in Zn chalcogenide quantum dots and their effects on chlorophyll spectral response.

Spectrochim Acta A Mol Biomol Spectrosc

February 2025

Department of Chemistry, Istanbul Technical University, Maslak 34469, Istanbul, Türkiye; Department of Polymer Science and Technology, Istanbul Technical University, Maslak 34469, Istanbul, Türkiye. Electronic address:

Water soluble Zn based quantum dots (QDs) are of interest due to their biocompatibility and less toxic features. They have been frequently used in studies related to biotechnology, especially in agriculture studies. However, to control the optical properties of Zn based QDs has still been a challenge.

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One-step synthesis of a piezoelectric hybrid BNNT/BaTiO composite and its application in bone tissue engineering.

J Mech Behav Biomed Mater

December 2024

Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul, 34956, Turkey; Department of Chemistry and Biochemistry, Augusta University, Augusta, GA, USA. Electronic address:

Nanomaterials with piezoelectric properties can significantly improve the applicability of polymers used in tissue engineering applications. In this study, we report the one-step synthesis of a novel hybrid piezoelectric composite comprising barium titanates and boron nitride nanotubes. This composite is distinguished by its unique microstructures, including nanoflakes, triangular boron nitride structures, and fiber-like boron nitride nanotube configurations, which contribute to its enhanced piezoelectric properties.

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Macrophages are among the most important components of the innate immune system where the interaction of pathogens and their phagocytosis occur as the first barrier of immunity. When nanomaterials interact with the human body, they have to face macrophages as well. Thus, understanding of nanomaterials-macrophage interactions and underlying mechanisms is crucial.

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With the increasing development of intelligent robots and wearable electronics, the demand for high-performance flexible energy storage devices is drastically increasing. In this study, flexible symmetric microsupercapacitors (MSCs) that could operate in a wide working voltage window were developed by combining laser-direct-writing graphene (LG) electrodes with a phosphoric acid-nonionic surfactant liquid crystal (PA-NI LC) gel electrolyte. To increase the flexibility and enhance the conformal ability of the MSC devices to anisotropic surfaces, after the interdigitated LG formed on the polyimide (PI) film surface, the devices were further transferred onto a flexible, stretchable and transparent polydimethylsiloxane (PDMS) substrate; this substrate displayed favorable flexibility and mechanical characteristics in the bending test.

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Microvascular surgery plays a crucial role in reconnecting micrometer-scale vessel ends. Suturing remains the gold standard technique for small vessels; however, suturing the collapsed lumen of microvessels is challenging and time-consuming, with the risk of misplaced sutures leading to failure. Although multiple solutions have been reported, the emphasis has predominantly been on resolving challenges related to arteries rather than veins, and none has proven superior.

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Electrophoretic deposition of MXenes and their composites: Toward a scalable approach.

Adv Colloid Interface Sci

September 2024

Sabanci University Nanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul 34956, Turkey.

Over the past decade, MXenes, a novel class of advanced 2D nanomaterials, have manifested as a prominent electrode material with diverse applications. Their unique layered structures, negative zeta potential, charge carrier mobility, mechanical properties, adjustable bandgap, hydrophilicity, metallic nature, and surface chemistry collectively contribute to the abundance of active redox sites on the surface and a reduction in the ion diffusion pathway. Despite such promising attributes of MXene, challenges like aggregation and restacking reduce the accessibility of active surface sites for electrolyte ions.

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To improve the translational and clinical applications of gold nanoparticles (GNPs) in medicine there is a need for better understanding of physicochemical properties of the nanoparticles in relation to the systemic parameters andperformance. This review presents the influence of physicochemical properties (surface charges and size) and route of administration on the biodistribution of GNPs. The role of protein corona (PC) (a unique biological identifier) as a barrier to biodistribution of GNPs, and the advances in engineered GNPs towards improving biodistribution are presented.

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Imbalances in hemoglobin (Hb) levels can lead to conditions such as anemia or polycythemia, emphasizing the importance of precise Hb extraction from blood. To address this, a novel synthetic imprinted polymer was meticulously developed for capturing and separating Hb. Poly(acrylamide-vinylimidazole) nanopolymer (poly(AAm-VIM)) was synthesized using acrylamide and vinyl imidazole as functional monomers through surfactant-free emulsion polymerization.

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GATA is one of the prominent transcription factor families conserved among many organisms in eukaryotes and has different biological roles in many pathways, particularly in light regulation in plants. Although GATA transcription factors (TFs) have been identified in different crop species, their roles in abiotic stress tolerance have not been studied in potato. In this study, we identified 32 GATA TFs in potato () by in silico analyses, and expression levels of selected six genes were investigated in drought-tolerant (Sante) and sensitive (Agria) cultivars under light, drought, and combined (light + drought) stress conditions.

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Remote Sensing Techniques: Hyperspectral Imaging and Data Analysis.

Methods Mol Biol

July 2024

School of Life Sciences, University of Essex, Wivenhoe Park, Colchester, UK.

Hyperspectral imaging is a remote sensing technique that enables remote, noninvasive measurement of plant traits. Here, we outline the procedures for camera setup, scanning, and calibration, along with the acquisition of black and white reference materials, which are the key steps in collecting hyperspectral imagery. We also discuss the development of predictive models such as partial least-squares regression, using both large and small datasets, which are used to predict plant traits from hyperspectral data.

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The flow pattern effects of hydrodynamic cavitation on waste activated sludge digestibility.

Chemosphere

June 2024

Istanbul Technical University, Civil Engineering Faculty, Environmental Engineering Department, Ayazaga Campus, Maslak, 34469, Istanbul, Turkey; National Research Center on Membrane Technologies, Istanbul Technical University, Ayazaga Campus, Maslak, 34469, Istanbul, Turkey.

The disintegration of raw sludge is of importance for enhancing biogas production and facilitates the degradation of substrates for microorganisms so that the efficiency of digestion can be increased. In this study, the effect of hydrodynamic cavitation (HC) as a pretreatment approach for waste activated sludge (WAS) was investigated at two upstream pressures (0.83 and 1.

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Lanthanide-doped fluoride nanocrystals (NCs) exhibit excellent optical features, including upconversion and downconversion luminescence (UCL and DCL), that can be utilized in a variety of applications. In this study, we have successfully demonstrated the photoluminescence behavior of triple-doped NaYF: Yb, Er, PrNCs in the Vis-NIR region. Herein, highly monodisperse hexagonal phase NaYF: Yb, Er, Prnanocrystals in various Pr(x = 0, 0.

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Single-walled carbon nanotubes (SWCNTs) outperform other materials due to their high conductivity, large specific surface area, and chemical resistance. They have numerous biomedical applications, including the magnetization of the SWCNT (mSWCNT). The drug loading and release properties of see-through pectin hydrogels doped with SWCNTs and mSWCNTs were evaluated in this study.

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Bombarding WS multilayered nanoparticles and nanotubes with focused ion beams of Ga ions at high doses, larger than 10 cm, leads to drastic structural changes and melting of the material. At lower doses, when the damage is negligible or significantly smaller, the amount of implanted Ga is very small. A substantial increase in the amount of implanted Ga, and not appreciable structural damage, are observed in nanoparticles previously hydrogenated by a radio-frequency activated hydrogen plasma.

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Photosynthesis relies on the absorption of sunlight by photosynthetic pigments (PPs) such as chlorophylls and carotenoids. While these pigments are outstanding at harvesting light, their natural structure restricts their ability to harvest light at specific wavelengths. In this study, Oleic acid-capped CdSeS and CdTeS ternary quantum dots (QDs) were synthesized using a novel two-phase synthesis method.

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The present study investigated the antioxidant profile together with the antibacterial potential of Apricot L. with the aim to find a functional food based anti-infective lead. Additionally the study evaluated the biofilm and QS inhibitory potential of the plant using (ATCC 15442) and (DSM 30191) respectively.

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The present study aimed to develop food packaging films by using a combination of pectin (PE) and sodium alginate (SA) enriched with Acetyl-11-keto-beta-boswellic acid (AKBA) as a functional or active ingredient. The fabricated films underwent comprehensive evaluation of their morphological, chemical, mechanical, barrier, optical, thermal, antioxidant, and antimicrobial properties. SEM and FTIR analysis showed that AKBA had good compatibility with film-forming components.

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The development of thermally conductive rubber nanocomposites for heat management poses a formidable challenge in numerous applications, notably within the realm of tire technology. Notably, rubber materials are characterized by their inherently low thermal conductivity. Consequently, it becomes imperative to incorporate diverse conductive fillers to mitigate the propensity for heat build-up.

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Whitish-blue light emitting fluorescent ZIF-8 structures were synthesized by means of bis-carboxylate functional calix[4]pyrrole (BCCP) modification. The calix[4]pyrrole concentration was also manipulated to tune the sizes of the ZIF-8 structures. Moreover, the BCCP-modified ZIF-8 samples exhibited enhanced organic micropollutant removal capacity from aqueous solutions.

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Microstructural Characterization of PCL-HA Bone Scaffolds Based on Nonsolvent-Induced Phase Separation.

ACS Omega

December 2023

Department of Mechatronics, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, Turkey.

Composite materials containing pores play a crucial role in the field of bone tissue engineering. The nonsolvent-induced phase separation (NIPS) technique, commonly used for manufacturing membranes, has proven to be an effective method for fabricating composite scaffolds with tunable porosity. To explore this potential, we produced 10% (w/v) poly(caprolactone) (PCL)-nanohydroxyapatite (HA) composite porous film scaffolds with varying HA contents (0/10/15/20 wt %) and two thicknesses (corresponding to 1 and 2 mL of solution resulting in 800-900 and 1600-1800 μm thickness, respectively) using the NIPS method.

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Sorbus torminalis (L.) Crantz has a rich history of versatile applications spanning the fields of medicine and nutrition. It is noteworthy that the decoction obtained from S.

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Nanomaterials can provide unique solutions for the problems experienced in tissue engineering by improving a scaffold's physico-bio-chemical properties. With its piezoelectric property, bone is an active tissue with easy adaptation and remodeling through complicated mechanisms of electromechanical operations. Although poly(-caprolactone) (PCL) is an excellent polymer for bone tissue engineering, it is lack of conductivity.

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