Performance of machine learning algorithms in spectroscopic ellipsometry data analysis of ZnTiO nanocomposite.

In this research, the optical properties of the PVP: ZnTiO nanocomposite are studied using the spectroscopic ellipsometry technique. The preparation procedure of the ZnTiO nanocomposite is explained in detail. The absorbance/transmittance, surface morphology, structural information, chemical identification, and surface topography of the ZnTiO nanocomposite is studied using UV-Vis spectroscopy, field-emission scanning electron microscopy, Raman spectroscopy, Fourier transform infra-red, and atomic force microscopy, respectively.

Machine learning approach for predicting electrical features of Schottky structures with graphene and ZnTiO nanostructures doped in PVP interfacial layer.

In this research, for some different Schottky type structures with and without a nanocomposite interfacial layer, the current-voltage (I-V) characteristics have been investigated by using different Machine Learning (ML) algorithms to predict and analyze the structures' principal electric parameters such as leakage current (I), barrier height ([Formula: see text]), ideality factor (n), series resistance (R), shunt resistance (R), rectifying ratio (RR), and interface states density (N). The interfacial nanocomposite layer is made by composing polyvinyl-pyrrolidone (PVP), zinc titanate (ZnTiO), and graphene (Gr) nanostructures. The Gaussian Process Regression (GPR), Kernel Ridge Regression (KRR), Support Vector Regression (SVR), and Artificial Neural Network (ANN) are used as ML algorithms.

Can anti-parasitic drugs help control COVID-19?

Novel COVID-19 is a public health emergency that poses a serious threat to people worldwide. Given the virus spreading so quickly, novel antiviral medications are desperately needed. Repurposing existing drugs is the first strategy.

Importance of Nano Medicine and New Drug Therapies for Cancer.

Cancer is one of the deadly diseases leading to approximately 7.6 million deaths worldwide, with the mortality rate of 13%, and the number of deaths is expected to increase to 13.1 million within the next 10 years.

Role of sperm apoptosis and oxidative stress in male infertility: A narrative review.

Activation of caspase, externalization of phosphatidyl serine, change in the mitochondrial membrane potential, and DNA fragmentation are apoptosis markers found in human ejaculated spermatozoa. Also, reactive oxygen species (ROS) play a vital role in the different types of male infertility. In this review, data sources including Google Scholar, Scopus, PubMed, and Science Direct were searched for publications with no particular time restriction to get a holistic and comprehensive view of the research.

Cerium oxide nanoparticles as a new neuroprotective agent to promote functional recovery in a rat model of sciatic nerve crush injury.

Background: Peripheral nerve injury is a common clinical disorder. The aim of the present study was to investigate the role of cerium oxide nanoparticles on axonal regeneration and functional recovery of the sciatic nerve after a crush injury in the rat model.

Method: A total of 40 adult male Wistar rats were divided into four groups.

In situ preparation of g-CN nanosheet/FeOCl: Achievement and promoted photocatalytic nitrogen fixation activity.

Climate change, global warming, and population growth have led researchers to use eco-sociable procedures for the N reduction reaction. It has discovered that N molecule can be transformed into NH in ambient circumstances with nanocomposites upon visible irradiation. In this research paper, a new visible-light-driven photocatalyst was constructed, with various weight percents of FeOCl particles (10, 20, 30, and 40%) that have adhered on NS-CN.

Protective effects of acetyl-L-carnitine against serum and glucose deprivation-induced apoptosis in rat adipose-derived mesenchymal stem cells.

Low survival rate of grafted mesenchymal stem cells (MSC) in injured tissue is one of the major limitations of stem cell therapy. One of the most important factors that limits the MSCs survival rate and retention is ischemic stress, which can lead to damage to all components of the cell. In particular, it can damage mitochondria, that play an important role in apoptosis with releasing apoptotic factors.

Rosuvastatin enhanced functional recovery after sciatic nerve injury in the rat.

Posttraumatic nerve recovery remains a challenge in regenerative medicine. As such, there is a need for agents that limit nerve damage and enhance nerve regeneration. Here we investigate rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase inhibitor, with anti-inflammatory and antioxidant properties.

Biosynthesis, characterization and evaluation of the supportive properties and biocompatibility of DBM nanoparticles on a tissue-engineered nerve conduit from decellularized sciatic nerve.

In this study, we examined the supporting effects of nano-demineralized bone matrix on the cultivation of Wharton's jelly stem cells on acellularized nerve scaffold. Demineralized bone matrix nanoparticles were prepared and characterized by several experiments. Decellularized sciatic nerve scaffolds were prepared and their efficiency was evaluated using histological stainings and biomechanical testing.

Hair follicle stem cells differentiation into bone cells on collagen scaffold.

The hair follicle is a dynamic structure which contains different niches for stem cells, therefore; it has been considered as valuable and rich sources of stem cells, due to easy access, multipotency and non-oncogenic properties. In the present study, the differentiation capacities of hair follicle stem cells into bone cells on the natural collagen scaffolds were investigated. The stem cells were extracted from the hair follicle bulge area of male Wistar rats' whisker and cultured until 3rd passage, then osteogenic differentiations were induced by culturing the cells in the specific osteogenic medium.

Increasing DNA binding affinity of doxorubicin by loading on FeO nanoparticles: A multi-spectroscopic study.

Magnetic FeO nanoparticles were synthesized successfully by co-precipitation method and characterized using XRD, SEM and EDS analyses. Then doxorubicin (DOX, a known anticancer drug) was loaded onto nanoparticles. In vitro DNA interaction of free DOX and loaded DOX onto FeO nanoparticles (DOX-FeO) was investigated by DNA-viscosity measurements, UV-visible and fluorescence spectroscopies.

Synergistic Effects of Acetyl-l-Carnitine and Adipose-Derived Stromal Cells on Improving Regenerative Capacity of Acellular Nerve Allograft in Sciatic Nerve Defect.

The combination of decellularized nerve allograft and adipose-derived stromal cells (ASCs) represents a good alternative to nerve autograft for bridging peripheral nerve defects by providing physical guidance and biologic cues. However, the regeneration outcome of acellular nerve allograft (ANA) is often inferior to autograft. Therefore, we hypothesized that acetyl-l-carnitine (ALCAR) treatment and implantation of ASC-embedded ANA would work synergistically to promote nerve regeneration.

In vitro binding interaction of atorvastatin with calf thymus DNA: multispectroscopic, gel electrophoresis and molecular docking studies.

The interaction of atorvastatin with calf thymus DNA (CT-DNA) was investigated in vitro under simulated physiological conditions by using absorption and emission spectroscopy, viscosity measurements, gel electrophoresis and molecular docking studies. Analysis of UV-vis absorbance spectra indicates the formation of complex between atorvastatin and CT-DNA, and obtained binding constant (K = 8.2×10 L.

PMLPR: A novel method for predicting subcellular localization based on recommender systems.

The importance of protein subcellular localization problem is due to the importance of protein's functions in different cell parts. Moreover, prediction of subcellular locations helps to identify the potential molecular targets for drugs and has an important role in genome annotation. Most of the existing prediction methods assign only one location for each protein.

Ultrasound induced strain in ultrasmall CoFeO@polyvinyl alcohol nanocomposites.

Cobalt ferrite/Polyvinyl alcohol (PVA) nanocomposites were prepared with and without ultrasonic treatment by co-precipitation technique, characterized by X-ray diffraction (XRD), Vibrating sample magnetometer (VSM), Fourier transform infrared spectroscopy (FT-IR) and Transmission Electron Microscopy (TEM). The obtained results revealed that ultrasound irradiation induces strain in the structure and increases the magnetic anisotropy energy of the 7nm magnetic nanoparticles (MNPs). The diffraction peak broadening and shift to lower angle due to the lattice strain were analyzed by means of Williamson-Hall (W-H) method.