Biosimilars for the treatment of patients with psoriasis: A consensus statement from the Biosimilar Working Group of the International Psoriasis Council.

Background: As biosimilars have become available in various parts of the world, the International Psoriasis Council has reviewed aspects of their use.

Objective: To provide consensus statements from the Biosimilar Working Group about the use of biosimilars in patients with psoriasis.

Methods: A semiqualitative structured process was employed to approve the consensus statements on biosimilars using the nominal group technique.

Serum soluble CD25 as a risk factor of renal impairment in systemic lupus erythematosus - a prospective cohort study.

Objective Serum soluble CD25 (sCD25) could be used as a biomarker for disease activity in conditions associated with T-cell activation including various autoimmune diseases. This study aimed to explore the role of sCD25 as an indicator of disease activity and organ involvement in patients with systemic lupus erythematosus (SLE). Methods Serum samples were collected from 107 SLE patients and 92 age-matched healthy controls (HCs).

P2Y R deletion ameliorates sialadenitis in IL-14α-transgenic mice.

Objective: Interleukin-14α-transgenic (IL-14αTG) mice develop an autoimmune exocrinopathy with characteristics similar to Sjögren's syndrome, including sialadenitis and hyposalivation. The P2Y receptor (P2Y R) for extracellular ATP and UTP is upregulated during salivary gland inflammation (i.e.

Adolescent Sexuality: Updates to the Sexually Transmitted Infection Guidelines.

Adolescents are at high risk for acquisition and transmission of sexually transmitted infections (STI) secondary to both cognitive and biological susceptibility. The prevention, diagnosis, and treatment of STIs are a critical part of adolescent health care. This article discusses the most common bacterial, parasitic, and viral STIs encountered in this age group with an emphasis on new guidelines for screening and management.

Central role for marginal zone B cells in an animal model of Sjogren's syndrome.

Patients with Sjogren's syndrome (SS) have been shown to have abnormal B cell function and increased numbers of marginal zone B cells (MZB and MZB precursors. The current studies utilized the Interleukin 14 alpha transgenic mouse model (IL14aTG) for SS to investigate the roles of marginal zone B cells (MZB) of the innate immune system in the pathophysiology of the disease. Eliminating MZB from IL14aTG mice by B cell specific deletion of RBP-J resulted in complete elimination of all disease manifestations of SS.

Dermatopathologists' opinions about the quality of clinical information in the skin biopsy requisition form and the skin biopsy care process: a semiqualitative assessment.

Objectives: The skin biopsy care process is prone to communication failures. We sought to solicit dermatopathologists about their opinions on the quality of clinical information provided in the requisition form (RF) that accompanies skin specimens and their suggestions on how to improve the process.

Methods: A self-administered survey of the membership of the American Society of Dermatopathology was performed.

Common dermatologic manifestations of primary immune deficiencies.

The skin is the largest organ of our body; it consists of the epidermis, dermis, hair follicles, sweat glands, blood vessels, and connective tissue matrix. Its main function is to act as a barrier to the outside world and protect us from infections. Any component of the skin is subject to insults from the environment and/or from within the body.

The implications of mechanical alignment on soft tissue balancing in total knee arthroplasty.

Purpose: We hypothesized that the individual bone geometry is the most important variable to achieve acceptable soft tissue balancing during total knee arthroplasty.

Methods: Long-standing 3-foot films and computer navigation data from 90 patients with varus (n = 45) or valgus deformity (n = 45) were utilized who underwent navigated total knee arthroplasty. Mean age was 65 ± 8 years with 50 women and 40 men.

Influence of obesity on mortality of drivers in severe motor vehicle crashes.

Purpose: The purpose of the study was to investigate the relationship between obesity and mortality of drivers in severe motor vehicle crashes involving at least one fatality.

Basic Procedures: Fatalities were selected from 155,584 drivers included in the 2000-2005 Fatality Analysis Reporting System. Drivers were stratified by body mass index, confounders were adjusted for, and multiple logistic regression was used to determine the odds ratio (OR) of death in each body mass index class compared with normal weight.

Influence of recruitment and participation bias in neuropsychological research among MS patients.

The potential influence of recruitment context in neuropsychological (NP) research is seldom addressed in the literature. Our experience with a previous large-scale study of MS cognitive impairment led us to speculate that referral questions and motivation bias significantly impact conclusions drawn from NP testing. We re-analyzed data from Benedict et al.

Effect of vanadium(IV) compounds in the treatment of diabetes: in vivo and in vitro studies with vanadyl sulfate and bis(maltolato)oxovandium(IV).

Vanadyl sulfate (VOSO(4)) was given orally to 16 subjects with type 2 diabetes mellitus for 6 weeks at a dose of 25, 50, or 100 mg vanadium (V) daily [Goldfine et al., Metabolism 49 (2000) 1-12]. Elemental V was determined by graphite furnace atomic absorption spectrometry (GFAAS).

Adenosine and adenosine triphosphate modulate the substrate binding affinity of glucose transporter GLUT1 in vitro.

Evidence indicates that a large portion of the facilitative glucose transporter isoform GLUT1 in certain animal cells is kept inactive and activated in response to acute metabolic stresses. A reversible interaction of a certain inhibitor molecule with GLUT1 protein has been implicated in this process. In an effort to identify this putative GLUT1 inhibitor molecule, we studied here the effects of adenosine and adenosine triphosphate (ATP) on the binding of D-glucose to GLUT1 by assessing their abilities to displace cytochalasin B (CB), using purified GLUT1 in vesicles.

The prevalence of asthma in children of elementary school age in western New York.

To determine the prevalence of caregiver-reported asthma in children 4 to 13 years old in metropolitan western New York State, surveys were conducted during 1997-1999 in the Buffalo, Niagara Falls, Iroquois, and Gowanda school systems. Questionnaires (3,889) were sent to the homes of elementary school children in nine schools in western New York. The caregivers were asked to complete a 13-item questionnaire for the child.

Neurosurgical Invasive Techniques for Cancer Pain: A Pain Specialist's View.

Neurosurgical techniques for management of cancer pain can be divided into two categories: reconstructive and ablative. For patients with pain from spinal metastatic disease, the newer surgical methods of anterior decompression and stabilization provide reliable pain control while preventing serious neurologic progression. Minimally invasive techniques for vertebral stabilization, such as vertebroplasty, may also effectively relieve pain from spinal metastases associated with low morbidity.

Justification for visceral angiography prior to pancreaticoduodenectomy.

The hepatic arterial anatomy is aberrant in almost 50 per cent of all individuals. The most common anomalies include the right hepatic artery arising from the superior mesenteric artery (25%) and the left hepatic artery arising from the left gastric artery (25%). Anomalies of the common hepatic artery, usually a branch of the celiac artery, are rare.

An RGD containing peptide from HIV-1 Tat-(65-80) modulates protooncogene expression in human bronchoalveolar carcinoma cell line, A549.

Tat (transactivator of transcription) is essential for HIV-1 replication in vivo and in vitro. Tat-(65-80), an RGD containing domain, has been shown to regulate proliferative function of a variety of cell lines, including a human adenocarcinoma cell line, A549. The exact cellular and molecular mechanisms by which these effects are mediated, remain unknown.

Lesions of the jaws.

Jaw lesions are relatively common findings on imaging studies of the lower face. The intent of this article is to present an approach to the diagnosis of lesions involving the maxilla and mandible based on their radiographic appearance and location. The radiographic and computed tomographic appearances of a number of lesions occurring in the maxilla and mandible are presented.