Lesions of the jaws.

Jaw lesions are relatively common findings on imaging studies of the lower face. The intent of this article is to present an approach to the diagnosis of lesions involving the maxilla and mandible based on their radiographic appearance and location. The radiographic and computed tomographic appearances of a number of lesions occurring in the maxilla and mandible are presented.

Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells.

The transforming growth factors-beta (TGFs-beta) family of genes plays important roles in cell growth and differentiation in many cell types. TGF beta modulates the synthesis and accumulation of extracellular matrix (ECM) components and the expression of cell surface receptors for ECM components. TGF beta is increased in alveolar lining fluid during inflammatory reactions of the lung and has been identified in alveolar epithelial cells of developing lungs and hyperplastic type II cells during repair.

Positive-outcome bias: comparison of emergency medicine and general medicine literatures.

Objective: The existence of positive-outcome bias in the medical literature is well established. Positive-outcome bias in two emergency medicine journals was compared with that found in two general medicine journals.

Methods: Published original contributions from Annals of Emergency Medicine, American Journal of Emergency Medicine, JAMA, and New England Journal of Medicine were reviewed.

A Mn(2+)-enhanced, RGD-dependent adhesion technique for isolation of adult rat type II alveolar epithelial cells for immediate functional studies.

This report describes a Mn(2+)-enhanced, RGD-dependent adhesion technique for isolation of adult rat type II cells for immediate functional studies. Lung cells were dissociated by 30 U/ml porcine pancreatic elastase and 50 micrograms/ml trypsin instilled in the airways. Macrophages were selectively removed by adhesion on purified normal goat IgG-coated petri dishes.

Treatment of brain tumors in babies and very young children.

Approximately 13% of brain tumors in childhood occur in children less than 2 years of age. Although the survivals of older children with certain forms of brain tumors have increased over the past 20 years, this treatment has been least effective in very young children with brain tumors. These poor survival rates may be due in part to the highly malignant nature of the neoplasms; the delay in diagnosis because of low index of suspicion; the large bulk of tumor found at presentation, and the reduction in radiation dosage to the central nervous system.