928 results match your criteria: "SUN Yat-Sen Memorial Hospital of SUN Yat-Sen University[Affiliation]"
Comparison of high-intensity interval training and moderate-intensity continuous training on cardiopulmonary function, cardiac autonomic function and vascular function in adolescent boys with obesity: A randomized controlled trial.
Eur J Sport Sci
December 2024
College of Physical Education, Harbin Sport University, Harbin, Heilongjiang, China.
Article Synopsis
- Adolescent obesity negatively impacts heart and lung function, and this study investigates two exercise methods, moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT), to see which is more beneficial.
- 44 obese adolescent boys participated, dividing into HIIT and MICT groups for an 8-week training program, measuring outcomes such as VO (peak oxygen consumption), vascular elasticity, and heart rate variability.
- Results showed both exercise types improved VO equally, but HIIT produced significantly better outcomes for endothelial function and vago-sympathetic balance compared to MICT.
Tertiary lymphoid structure-related score as a predictor for survival prognosis and immunotherapy response in head and neck squamous cell carcinoma.
Front Immunol
November 2024
Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Article Synopsis
- Research indicates that tertiary lymphoid structures (TLS) are linked to cancer prognosis and responses to immunotherapy, but details about their predictive value and specific immune cells involved are not well understood.* -
- A new bioinformatics scoring system, called TLSscore, was developed using TLS-related genes to analyze head and neck squamous cell carcinoma, revealing that it can effectively predict survival, immune cell behavior, and how patients respond to treatments.* -
- The study identifies a specific subtype of T cells within TLS, called PD1CXCL13CD8T cells, which may play a crucial role in fighting tumors and could serve as a potential marker for prognosis and a target for future therapies.*
Associations of Depression, Antidepressants with Atrial Fibrillation Risk in HFpEF Patients.
Rev Cardiovasc Med
October 2024
Department of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, 330006 Nanchang, Jiangxi, China.
Article Synopsis
- The study investigates the relationship between atrial fibrillation (AF), major depression, and heart failure with preserved ejection fraction (HFpEF), highlighting a lack of prior research on this topic.
- In a trial involving 784 patients, 29.1% were found to have major depression, but having this condition did not increase the risk of developing AF; the analysis showed an adjusted hazard ratio of 0.82.
- Additionally, antidepressant use did not significantly affect AF incidence in patients with HFpEF and major depression, with an adjusted hazard ratio of 0.41.
Use of uterine electromyography in the prediction of preterm birth after transvaginal cervical cerclage.
BMC Pregnancy Childbirth
October 2024
Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangdong, China.
Article Synopsis
- - Preterm birth (PTB) is a significant issue, accounting for around 35% of neonatal deaths, and cervical insufficiency (CI) often leads to PTB, necessitating cervical cerclage to prevent early delivery.
- - A study involving 69 women who underwent cervical cerclage and uterine electromyography (uEMG) revealed that PTB risk was linked to past PTB history and contraction frequency, with uEMG showing a strong predictive value (AUC of 0.766) for determining PTB risk after cerclage.
- - The findings suggest that uEMG can serve as an effective method for predicting PTB in patients after cervical cerclage by monitoring contraction frequencies
Lactylation-Driven IGF2BP3-Mediated Serine Metabolism Reprogramming and RNA m6A-Modification Promotes Lenvatinib Resistance in HCC.
Adv Sci (Weinh)
December 2024
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei, 430030, China.
Article Synopsis
- * In lenvatinib-resistant models, increased glycolysis leads to the accumulation of lactate and promotes the lactylation of IGF2BP3, which enhances the expression of key mRNAs like PCK2 and NRF2.
- * Targeting IGF2BP3 with specific siRNAs or inhibiting glycolysis can restore sensitivity to lenvatinib, indicating that addressing metabolic and epigenetic pathways could provide new treatment strategies for HCC.
Dexmedetomidine vs. propofol on arrhythmia in cardiac surgery: a meta-analysis of randomized controlled trials.
Front Cardiovasc Med
October 2024
Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Background: Dexmedetomidine (DEX) and propofol are popular anesthetics, but it remains unknown whether DEX reduces the incidence of arrhythmias compared with propofol after cardiac surgery.
Methods: We performed a comprehensive search for RCTs (Randomized Controlled Trials) that compared the incidence of arrhythmias between DEX and propofol in adults who had undergone cardiac surgery across three databases (PubMed, Embase, the Cochrane Library), and ClinicalTrials.gov up to October 3, 2023.
The role of vitamin D in diabetic foot ulcer; an umbrella review of meta-analyses.
Front Nutr
October 2024
Department of Orthopedics, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Article Synopsis
- - The study reviews the relationship between vitamin D serum levels and diabetic foot ulcers (DFU), noting that DFU patients generally have significantly lower vitamin D levels compared to those with diabetes without DFU.
- - Eight meta-analyses were analyzed, indicating that severe vitamin D deficiency increases the risk of developing DFU by at least 1.82 times and that vitamin D supplementation may improve ulcer outcomes.
- - The findings suggest a potential benefit of vitamin D for DFU patients, but the reliability of the data is questioned due to possible biases in the studies examined.
Effect of paternal overweight or obesity on semen parameters, clinical pregnancy and live birth outcomes in men treated with intrauterine insemination (IUI).
Transl Androl Urol
September 2024
Reproductive Medicine Center, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
Background: Overweight and obese individuals are steadily increasing in recent years. Male overweight or obesity has adverse impact on reproductive functions. The study aimed to evaluate the potential impact of paternal overweight or obesity on sperm quality and clinical pregnancy outcome in patients undergoing intrauterine insemination (IUI) treatment.
View Article and Find Full Text PDFAssociation between trajectory of systolic blood pressure and outcomes in heart failure patients with preserved ejection fraction (HFpEF).
Eur J Intern Med
January 2025
Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China; Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, Guangdong Province, China; Guangzhou Key Laboratory of Molecular Mechanism and Translation in Major Cardiovascular Disease, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China. Electronic address:
Article Synopsis
- - The study investigates systolic blood pressure (SBP) trajectories in heart failure patients with preserved ejection fraction (HFpEF) to determine how these patterns impact patient outcomes, focusing on cardiovascular death, cardiac arrest, and hospital admissions.
- - From a sample of 3,388 patients, three SBP trajectory groups were identified: stable (128 mmHg), decreasing (from 129 to 125 mmHg), and increasing (from 132 to 143 mmHg) over 6 years; those in the increasing and decreasing groups faced higher risks of adverse health events.
- - The findings suggest that maintaining a stable SBP around 130 mmHg is associated with lower rates of cardiovascular events and mortality, highlighting the need for
Intense simplified strategy for newly diagnosed type 2 diabetes in patients with severe hyperglycaemia: multicentre, open label, randomised trial.
BMJ
October 2024
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
Objective: To evaluate whether the intense simplified strategy, which comprises short term intensive insulin therapy (SIIT) followed by subsequent oral antihyperglycaemic regimens, could improve long term glycaemic outcomes in patients with newly diagnosed type 2 diabetes mellitus and severe hyperglycaemia.
Design: Multicentre, open label, randomised trial.
Setting: 15 hospitals in China between December 2017 and December 2020.
Guiding induction chemotherapy of locoregionally advanced nasopharyngeal carcinoma with ternary classification of predicted individual treatment effect.
Radiother Oncol
December 2024
Department of Radiology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. Electronic address:
Article Synopsis
- Induction chemotherapy (IC) doesn’t always improve survival for patients with locoregionally advanced nasopharyngeal carcinoma (LANPC), and traditional methods of choosing IC often lead to poor treatment decisions.
- This study developed a new system called projected individual treatment effect (PITE) to better personalize IC recommendations, analyzing data from 1,213 patients using imaging and clinical data to predict individual survival chances.
- The results showed that PITE could effectively categorize patients into three groups, leading to better outcomes: IC significantly improved survival for those who should receive it, had no effect on some, and even worsened survival for others where it wasn't suitable.
Patterns of intrinsic capacity trajectory and onset of activities of daily living disability among community-dwelling older adults.
J Glob Health
October 2024
School of Nursing, Capital Medical University, Beijing, China.
Article Synopsis
- * Using data from the China Health and Retirement Longitudinal Study, researchers identified three classes of IC trajectories: moderate health, at-risk, and optimal health, revealing that emotional problems and poor living standards significantly affect these classifications.
- * Findings indicate that 17.25% of participants developed disabilities in daily living activities, emphasizing the importance of monitoring IC to promote healthy aging and mitigate risks of dependency in older populations.
Enhanced prognostic signature for lung adenocarcinoma through integration of adjacent normal and tumor gene expressions.
Heliyon
October 2024
Senior Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Article Synopsis
- This study explored the construction of prognostic models for lung adenocarcinoma (LUAD) using gene expression profiles from tumor tissues, normal tissues, and a combination of both, aiming to evaluate which approach yields the best performance for cancer prognosis.
- The findings revealed that while the tumor-derived model had superior overall performance, especially in initial applications, the combined model (COM) ultimately outperformed others in validation datasets, particularly in extending survival times for patients.
- Despite the tumor-derived model being beneficial for long-term predictions, it often underestimated survival rates, while the COM model demonstrated strong clinical significance and reliability in various prediction analyses.
HNRNPC mediates lymphatic metastasis of cervical cancer through m6A-dependent alternative splicing of FOXM1.
Cell Death Dis
October 2024
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Article Synopsis
- Cervical cancer patients with lymph node metastasis have poor outcomes, and the role of N6-methyladenosine (mA) modification in this condition has been unclear.
- The study identifies HNRNPC, an mA reader and alternative splicing factor, as a key player in promoting lymphatic metastasis in cervical cancer by increasing tumor-related RNA variants.
- The research shows that HNRNPC overexpression correlates with worse prognosis, while its knockdown reduces cancer cell migration and invasion, highlighting its potential as a target for new treatment strategies.
Effects of the Zishen Yutai Pill on live births compared with placebo among infertile women with frozen-thawed embryo transfer cycle: A multicentre double-blind randomized controlled trial.
Phytomedicine
December 2024
Center for Reproductive Medicine, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. Electronic address:
Article Synopsis
- The study investigated the effects of Zishen Yutai Pill (ZYP) on live birth rates in infertile women undergoing frozen embryo transfer (FET) cycles after showing benefits in fresh cycles.
- Conducted at 11 centers in China, 880 eligible participants were randomly assigned to receive either ZYP or a placebo, focusing on various pregnancy outcomes.
- While the overall increase in live birth rates with ZYP compared to placebo was not statistically significant, specific subgroups, including women with a history of miscarriage and those of advanced maternal age, showed promising results.
A narrative review of advances in the management of urothelial cancer: Diagnostics and treatments.
Bladder (San Franc)
August 2024
Department of Urology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
Urothelial carcinoma (UC) refers to the malignancies originating from transitional epithelium located on the upper and lower urinary tract. Precise diagnosis of UC is crucial since it dictates the treatment efficacy and prognosis of UC patients. Conventional diagnostic approaches of UC mainly fall into four types, including liquid biopsy, imaging examination, endoscopic examination, and histopathological assessment, among others, each of them has contributed to a more accurate diagnosis of the condition.
View Article and Find Full Text PDFSerum Procalcitonin, Hematology Parameters, and Cell Morphology in Multiple Clinical Conditions and Sepsis.
J Clin Lab Anal
October 2024
Division of the In Vitro Diagnostics, Mindray Corporation, Shenzhen, Guangdong, China.
Background: The clinical value of procalcitonin (PCT) in infection diagnosis and antibiotic stewardship is still unclear. This study aimed to investigate the association between serum PCT and different clinical conditions as well as other infectious/inflammatory parameters in different septic patients in order to elucidate the value of PCT detection in infection management.
Methods: Chemiluminescence immunoassay was used for serum PCT analysis.
SUV39H1 epigenetically modulates the MCPIP1-AURKA signaling axis to enhance neuroblastoma tumorigenesis.
Oncogene
November 2024
Department of Pediatric Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Article Synopsis
- Epigenetic regulation plays a crucial role in neuroblastoma development, and research is focused on finding new treatment options targeting epigenetic factors like SUV39H1, which is involved in tumor growth across various cancers.
- A high-throughput screen identified chaetocin as a potent inhibitor of neuroblastoma by targeting SUV39H1, impacting cell growth, movement, and survival, while also showing effectiveness in animal models with manageable side effects.
- The study found that inhibiting SUV39H1 reduces key cancer-related genes like AURKA through a newly identified tumor suppressor, MCPIP1, highlighting the significant role of the SUV39H1-MCPIP1-A
Development and validation of a novel immune‒metabolic-Based classifier for hepatocellular carcinoma.
Heliyon
September 2024
Department of Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Article Synopsis
- The study investigates the diverse immune cells and metabolic pathways in hepatocellular carcinoma (HCC) patients to improve treatment outcomes by creating a new immune‒metabolic classifier.
- Using data from large patient datasets, they identified three distinct HCC groups based on metabolic activity and immune cell presence, which could influence treatment strategies.
- The findings suggest that patients in group S1 may benefit from immunotherapy, group S2 from transcatheter arterial chemoembolization (TACE), and group S3 from tyrosine kinase inhibitors, aiming for more personalized and effective treatment options.
Corrigendum to "IL-32 aggravates metabolic disturbance in human nucleus pulposus cells by activating FAT4-mediated Hippo/YAP signaling" [Int. Immunopharmacol. 141 (2024) 112966].
Int Immunopharmacol
December 2024
Department of Orthopedic Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:
[Keeping abreast of the times, the Chinese guidelines for the diagnosis and management of chronic coronary syndrome].
Zhonghua Xin Xue Guan Bing Za Zhi
September 2024
Department of Cardiology, General Hospital of Northern Theater Command, Shenyang 110016, China.
Differences in preimplantation blastocyst chromosomal aberrations between polycystic ovary syndrome women and controls: a multi-center retrospective cohort study.
J Assist Reprod Genet
November 2024
Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, 410083, China.
Purpose: Comprehensive chromosomal status of blastocyst from women with polycystic ovary syndrome (PCOS) was limited. This study aimed to identify possible differences in the preimplantation blastocyst chromosome aberrations between PCOS women and controls receiving preimplantation genetic testing (PGT).
Methods: This was a multi-center retrospective cohort study including a total of 707 blastocysts from 147 PCOS women and 3006 blastocysts from 821 control women receiving PGT between 2015 and 2021.
Sagittal morphometry of intervertebral spaces in subaxial cervical region of asymptomatic Chinese.
Eur Spine J
October 2024
Department of Orthopedics, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Yingfeng Road No.33, Guangzhou, China.
Article Synopsis
- The study aimed to analyze the intervertebral space between cervical units in the Chinese population using radiographic imaging, which can assist spine surgeons in anterior cervical discectomy and fusion (ACDF) procedures.
- A total of 102 participants were divided into three age groups, and various parameters like intervertebral height, lordosis, and endplate dimensions were measured and compared among these groups, revealing notable differences based on age and gender.
- The findings indicated that the C6/7 region had the largest measurements for both intervertebral height and lordosis, while males generally exhibited greater measurements than females across all cervical levels.
The m6A Reader IGF2BP2 Promotes Oral Squamous Cell Carcinoma Progression by Maintaining UCA1 Stability.
Recent Pat Anticancer Drug Discov
August 2024
Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Introduction: N6-methyladenosine (m6A) modifications of RNAs are associated with many cancer types. Nevertheless, the function of the m6A reader IGF2BP2 in oral squamous cell carcinoma (OSCC) has yet to be ascertained.
Aims: The objective of this investigation was to elucidate the role of IGF2BP2 in OSCC and delineate the associated mechanisms.
IL-32 aggravates metabolic disturbance in human nucleus pulposus cells by activating FAT4-mediated Hippo/YAP signaling.
Int Immunopharmacol
November 2024
Department of Orthopedic Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:
Extracellular matrix (ECM) metabolism disorders in the inflammatory microenvironment play a key role in the pathogenesis of intervertebral disc degeneration (IDD). Interleukin-32 (IL-32) has been reported to be involved in the progression of various inflammatory diseases; however, it remains unclear whether it participates in the matrix metabolism of nucleus pulposus (NP) cells. Therefore, this study aimed to investigate the mechanism of IL-32 on regulating the ECM metabolism in the inflammatory microenvironment.
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