MiR-142-5p mediated Nrf2 dysregulation in gestational diabetes mellitus and its impact on placental angiogenesis.

Introduction: Gestational diabetes mellitus (GDM) presents significant risks during pregnancy, including adverse perinatal outcomes and placental dysfunction. Impaired angiogenesis, involving crucial factors like Vascular Endothelial Growth Factor (VEGF), contributes to these complications. The Nrf2/Keap1 pathway, crucial for vascular redox homeostasis, has been linked to GDM-associated angiogenesis dysregulation.

An Uncommon Clinical Mystery: Systemic Lupus Erythematosus Masquerading as Aseptic Meningitis in a Male Patient.

Systemic lupus erythematosus (SLE) is an intricate autoimmune disease characterized by its impact on various organ systems, presenting with a wide range of clinical manifestations such as hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, immunologic, cardiac, pleuropulmonary, and renal symptoms. Although its etiology is primarily autoimmune, various triggers, such as pregnancy, certain drugs, and infections, can result in "flares" with frequent relapses. Although more common in females, SLE is not uncommon in males, with a significant proportion experiencing a high disease burden.

Assessing the Utility of the Metabolic Score for Insulin Resistance (METS-IR) in Evaluating Metabolic Risk Among Individuals Undergoing Master Health Checkups in a Tertiary Care Hospital in South India: A Retrospective Cohort Study.

Background The metabolic score for insulin resistance (METS-IR) is a neoteric score for assessing insulin resistance that has been used as a non-insulin-based, objectively measured method. It is an easily accessible tool that can be used on a large scale to detect insulin resistance in a community. Methods We conducted a retrospective cohort study to explore the utility of this score in identifying metabolic risk in those individuals attending a master health checkup in a tertiary care setting.

Perception of the Adoption of Artificial Intelligence in Healthcare Practices Among Healthcare Professionals in a Tertiary Care Hospital: A Cross-Sectional Study.

Background: Artificial intelligence (AI) has the potential to transform healthcare practices, but the successful adoption of AI depends on the perception and acceptance of healthcare professionals. This study aimed to assess the understanding of AI concepts, recognize the attitude toward AI integration, and identify the barriers to AI adoption among healthcare professionals in a tertiary care hospital.

Methods: A cross-sectional study was conducted among 200 healthcare professionals, including doctors, nurses, and paramedics, in a tertiary care teaching hospital in Chengalpattu district, India.

Pioneering diabetes screening tool: machine learning driven optical vascular signal analysis.

The escalating prevalence of diabetes mellitus underscores the critical need for non-invasive screening tools capable of early disease detection. Present diagnostic techniques depend on invasive procedures, which highlights the need for advancement of non-invasive alternatives for initial disease detection. Machine learning in integration with the optical sensing technology can effectively analyze the signal patterns associated with diabetes.

Eating habit, body image, and gender - is there any association? - A comparative study among medical students from southern India.

Background: An increase in overweight and obesity among young adults are major health concerns which can influence their self-perception about body image. Body image has received a great deal of attention among young people. Body dissatisfaction is an extremely powerful construct that pervades our self-esteem, resulting in psychological impact and disordered eating.

Evaluating Prostate Cancer: The Diagnostic Impact of MRI and Its Relationship With Transrectal Ultrasound (TRUS)-Guided Biopsy.

Background Prostate disorders, including benign enlargement and malignancy, are commonly evaluated through imaging techniques. Historically, transrectal ultrasound (TRUS) has been used for prostate imaging and biopsy. However, multiparametric MRI (mpMRI), which integrates structural and functional imaging methods, offers enhanced diagnostic capabilities.

Xanthogranulomatous Pyelonephritis Mimicking a Complex Renal Cyst: A Report of a Rare Case.

Xanthogranulomatous pyelonephritis (XGPN) is a chronic granulomatous inflammatory condition that affects the kidney and can often be hard to diagnose preoperatively due to its varying clinical presentations. We present here a rare case of a 36-year-old man with focal XGPN with preoperative CT imaging showing a large heterogenous lesion (computer tomography Hounsfield unit (CT HU) + 20) of size ~ 8.6 x 8.

Trotter Procedure with Harmonic Scalpel : A Unique Approach to Mucoepidermoid Carcinoma of Tongue Base Revisited.

Mucoepidermoid carcinoma (MEC) is a malignant locally invasive tumour of salivary glands, presumed to arise from reserve cells of salivary gland ducts. It accounts approximately 35% of all malignancies of major and minor salivary glands [1]. MEC arising in minor salivary glands can be located in different areas such as palate, retromolar trigone, floor of mouth, buccal mucosa, lips and tongue.

Assessing Binaural Auditory Processing in Native Tamil Speaking Children.

The objective of this study is to develop and validate the Binaural Fusion Test (BFT) in the Tamil language for children with learning disability. As many children with learning disability exhibit an auditory processing deficit there is a need for language specific assessment tool for these children. The BFT in Tamil comprises 100 words organized into four lists, with each list containing 25 words.

Benign Giant Phyllodes Tumours Presenting as Fungating Breast Masses.

Breast masses presenting as fungating growths usually represent advanced malignancy. One remarkable exception is a benign phyllodes tumour. These tumours of stromal origin often exhibit rapid growth, resulting in pressure necrosis at the summit of the tumor causing fungation.

Magnesium as an Adjuvant to Rocuronium to Improve Intubation Conditions and Shorten the Intubation Time: A Randomized Controlled Study.

Aim And Objective: The purpose of the study is to compare the effects of rocuronium priming with the combined technique of magnesium pretreatment and rocuronium priming and to investigate whether this pretreatment could further accelerate the onset of neuromuscular blockade during intubation.

Materials And Methods:  A double-blinded randomized controlled trial (RCT) clinical study was done on patients at a tertiary care center for six months after obtaining approval from the institutional ethical committee. A total of 150 patients were randomly allocated as Group MP (infusion of 50 mg/kg of MgSo4 over 10 min was given 10 mins prior to premedication and dose of rocuronium 0.

Two Interesting Cases of Thyroid Gland Tuberculosis.

Tuberculosis involving the thyroid gland is an exceptionally rare condition with varied clinical presentations, often leading to diagnostic challenges. We report two cases: a 9-year-old male with necrotic tuberculous cervical lymphadenopathy secondarily involving the thyroid gland, and a 40-year-old male with disseminated tuberculosis affecting multiple organ systems, including the thyroid gland. Both cases presented with swelling over the neck region and were evaluated using ultrasonography and contrast-enhanced computed tomography (CECT), which revealed characteristic imaging findings of thyroid involvement.

Parenting Style of Elderly Parents and Its Impact on Adolescent Behavior: A Case Report.

Adolescence is a critical transition period between childhood and adulthood. They experience biological, emotional, and social changes and require constant affection, support, and supervision during this period. Adolescents often face stressors from various sources, which can exacerbate behavioral issues.

Kocuria rosea Sepsis in an Immunocompromised Patient: A Case Report.

species, classified within the phylum , class , order  family , are Gram-positive coccoid bacteria. They bear morphological resemblance to and which often leads to misidentification and oversight as contaminants, given their presence as normal flora on human and animal skin and mucous membranes. Accurate identification of these organisms typically relies on automated systems such as MALDI-TOF-MS, Vitek-2 System, and 16S rRNA studies.

Exploring the Association of VEGF-A and ANGPTL2 with the Prognosis of Non-proliferative and Proliferative Diabetic Retinopathy.

Introduction Diabetic retinopathy (DR) is a microvascular ailment that can arise from the long-term effects of diabetes mellitus. It can potentially cause retinal damage that could endanger vision and cause blindness. The worsening of DR is mainly linked to poor glycemic control, uncontrolled hypertension, and dyslipidemia.