Continuous Positive and Negative Pressure Dressing - A Novel Approach in the Treatment of Auricular Seroma.

Introduction: Auricular seroma is a benign ear condition characterized by the accumulation of sterile serous fluid between the perichondrium and auricular cartilage. It presents as a painless, solitary or diffuse, and fluctuant swelling, diagnosis hinges on these distinctive features. Treating this condition is challenging due to its high recurrence rate.

Development and impact of a structured training module for surgical painting and draping among interns.

Background: Surgical site infections (SSIs) are a global concern affecting patient recovery, prolonging hospital stay and raising healthcare costs.

Aim: To address this, a structured training module was implemented to enhance the efficacy of surgical painting and draping among the interns, reducing SSI risk.

Methods: A questionnaire was distributed to 194 interns, covering fundamental inquiries on SSIs, aseptic practices and an assessment of the participant's knowledge regarding preoperative skin preparation and draping.

Prevalence, trends, and outcomes of metabolically healthy obesity or overweight in stroke hospitalizations of elderly patients: A 2016-2019 US population analysis.

Introduction: Obesity and overweight have been associated with an increase in the risk of stroke and poor outcomes. Meanwhile, Metabolically healthy obesity and overweight (MHOO) trends are understudied in association with stroke. This study aims to analyze the MHO trends and outcomes concerning stroke.

The see-saw effect of neuroactive steroids and endocrine disrupting compounds on maternal mental health status.

Background: Antepartum depression, a non-psychotic mood disturbance occurring during pregnancy, is influenced by hormonal fluctuations and environmental endocrine disruptors. Despite its association with adverse postpartum outcomes, it has been studied to a limited extent. Hence, this study aims to investigate the association of neuroactive steroids, endocrine-disrupting compounds, and nutritional status of pregnant women with the manifestations of antepartum depressive symptoms.

Cardiac Efficiency and Work Performance Variations Across Menstrual Cycle Phases: A Bicycle Ergometric Study in Young Women.

Background Menstrual cycle-related physiological variations represent a complex, multifaceted phenomenon with significant implications for female work performance and cardiovascular function. This study aimed to systematically evaluate the influence of menstrual cycle phases on cardiac efficiency and work performance among young women, utilizing a comprehensive bicycle ergometric assessment methodology. The research sought to quantify physiological variations during mid-follicular and mid-luteal phases, providing nuanced insights into hormonal dynamics and performance metrics.

Multistrain Probiotics and Telomere Length in Type 2 Diabetes: A 24-Week Randomized Controlled Trial.

Background: This 24-week randomized controlled trial aimed to evaluate the impact of multistrain probiotic supplementation on telomere length in patients with type 2 diabetes (T2DM). The study also assessed secondary outcomes including high-sensitivity C-reactive protein (hs-CRP) and glycated hemoglobin (HbA1c).

Methods: A total of 124 participants with T2DM were randomly assigned to either a probiotic group ( = 62) or a placebo group ( = 62).

Development and Validation of a Noninvasive Diffuse Reflectance Spectroscopic Method for Bilirubin Estimation in Neonates.

Jaundice due to excess bilirubin buildup in neonates remains an alarming problem, especially during the very first week of postnatal life. The common method of measuring total serum bilirubin (TSB) levels involves invasive blood testing, which is time-consuming and uncomfortable for neonates. While noninvasive transcutaneous bilirubinometers (TcB) are available, that often lack accuracy due to interference from other biological chromophores.

Tooth morbidity and its impact on oral related quality of life in elderly tribal population-The Irula experience.

Introduction: Oral diseases are a major global health challenge, posing health and economic burdens that have profound impacts on the quality of life, disproportionately affecting marginalized populations such as tribal communities. Among scheduled tribes in India, the Irula community belongs to one of the tribes most vulnerable by poor access to health care and education. The elders in the population have increased incidence and prevalence rates of tooth morbidities-an increased incidence of caries, non-carious lesions, and periodontitis-related conditions that affect oral health related quality of life (OHQOL) dimensions.

Exploring the regulatory role of mtTFA on inflammation, oxidative stress, and epigenetic alterations in COPD progressed NSCLC patients with smoking history.

Oxidative stress and inflammation are pivotal in linking COPD to NSCLC progression, with dysregulated cytokine levels in inflamed COPD airways correlating with disease severity and lung cancer advancement. CD4 T helper cells, pivotal in the inflammatory response, exhibit altered gene expression patterns in COPD and NSCLC, emphasizing their role in disease pathogenesis. Mitochondrial transcription factor A (mtTFA) dysregulation is implicated in inflammation and oxidative stress, affecting COPD and NSCLC progression.

Classical Ehlers-Danlos syndrome with cranio-cervical instability in an infant due to a novel COL5A1 gene mutation.

Ehlers-Danlos syndromes (EDSs) are a group of connective tissue disorders with diverse clinical and genetic profiles. Classical Ehlers-Danlos syndrome (cEDS), the second most common type, is characterised by skin hyperextensibility, atrophic scars and joint hypermobility, primarily due to mutations in COL5A1 and COL5A2 genes. We report a case of an infant with severe cEDS presenting with motor developmental delay, joint hyperextensibility and cranio-cervical instability.

Association of Vitamin D Deficiency as an Independent Risk Factor for Myocardial Infarction and Its Therapeutic Implications: A Systematic Review.

Vitamin D deficiency is a highly prevalent condition globally and has emerged as a significant risk factor for the development of coronary artery disease (CAD). Although its role in the regulation of phospho-calcic metabolism is well established, its involvement in the evolution of myocardial infarction (MI) is yet to be fully understood. Vitamin D deficiency is a manageable condition, and a reasonable time to assess and commence treatment is crucial, as the patient presents with acute myocardial infarction (AMI).

Association of Hypocapnia With Febrile Seizures: A Cross-Sectional Observational Study.

Background: Febrile seizures are a benign condition with unexplained pathophysiology. Respiratory alkalosis due to increased temperature can cause cerebral alkalosis and seizures.

Objectives: The objective of this study is to assess the association of hypocapnia and respiratory alkalosis with the time of presentation after febrile seizures.

Assessment of Hemodialysis Adequacy by Online Clearance Monitoring.

Measuring the uremic solute clearance is an important factor in analyzing the adequacy of maintenance hemodialysis (MHD) therapy. Conventionally hemodialysis (HD) adequacy was measured by urea removal through the Daugirdas single pool kt/V (spKt/V) formula. We aimed in our study to correlate online clearance monitoring (OCM) spKt/V to the Urea Reduction Ratio (URR) and Daugirdas spKt/V in maintenance hemodialysis patients.

The role of gut microbiota and bacterial translocation in the pathogenesis and management of type 2 diabetes mellitus: Mechanisms, impacts, and dietary therapeutic strategies.

Purpose Of Review: The influence of gut microbiota on Type 2 Diabetes Mellitus (T2DM) is an emerging area of research. This review investigates the relationship between gut microbiota dysbiosis, bacterial translocation, and T2DM. It aims to elucidate how microbial imbalances contribute to the progression of T2DM through bacterial translocation and to evaluate dietary and therapeutic strategies to manage these effects.

Investigating tooth morbidity risks, prevalence, and interventions in tribal setting: a study protocol focused on the Irula community in Tamil Nadu.

Aim: Dentistry is uniquely positioned as a healthcare profession, distinguished from allied health or paramedical fields. It operates within a university-based structure, maintaining primary care responsibilities. Oral diseases impose a substantial worldwide health and economic burden, profoundly affecting the well-being of those affected.

Integrating electrocardiogram and fundus images for early detection of cardiovascular diseases.

Cardiovascular diseases (CVD) are a predominant health concern globally, emphasizing the need for advanced diagnostic techniques. In our research, we present an avant-garde methodology that synergistically integrates ECG readings and retinal fundus images to facilitate the early disease tagging as well as triaging of the CVDs in the order of disease priority. Recognizing the intricate vascular network of the retina as a reflection of the cardiovascular system, alongwith the dynamic cardiac insights from ECG, we sought to provide a holistic diagnostic perspective.

Association of Kisspeptin and KISS Gene Polymorphism (rs35431622) with Circulating Sex Hormones and Male Infertility.

This research delves into the association of Kisspeptin and the KISS gene (rs35431622) single nucleotide polymorphism with circulating sex hormones and semen parameters in males diagnosed with infertility. Eighty male participants were recruited from fertility clinic, were divided into two groups: Group A, characterized by normal sperm count and Group B, exhibiting low count. The analysis involved assessing hormone levels Kisspeptin, follicle stimulating hormone, luteinizing hormone, total testosterone and sex hormone binding globulin by utilizing ELISA, investigating the association of the KISS gene SNP with these variables through Tetra amplification refractory mutation system-PCR and Gel Electrophoresis.

Barriers to and facilitators of healthcare professionals in ADR reporting in a tertiary care hospital in India.

Introduction: Several adverse drug reactions (ADRs) go unreported within a healthcare setting despite the risks they cause. We therefore decided to conduct this study in order to recognize the obstacles that hinder the healthcare professionals (HCPs) in a tertiary care hospital in Kattankulathur, Tamil Nadu from reporting ADRs and what strategies ought to be implemented.

Methods: We carried out a cross-sectional study among the HCPs such as doctors, pharmacists and nurses within our institution.

Varied Clinical Features and Outcomes of Autoimmune Encephalitis: A Retrospective Case Series.

Introduction: This study discusses the various clinical profiles, investigatory findings, treatment responses, and prognosticating factors in seven cases of autoimmune encephalitis (AE).

Methods: The clinical records of seven AE patients admitted to the Neurology Department, SRM Medical College Hospital and Research Centre, Chennai, from July 2022 to December 2023 were retrospectively analyzed.

Results: The patients' ages ranged from 18 to 35, and all experienced seizures.

The Life and Work of Prof. Dr. Antapur Venkoba Rao: The Enduring Legacy of an Innovative Mind.

Dr. Antapur Venkoba Rao, born on August 20, 1927, in Andhra Pradesh, was a pioneering figure in Indian psychiatry, often recognized as the "Father of Indian Psychiatry" and the "Father of Geriatric Mental Health." His exceptional academic achievements led him to specialize in psychiatry, where he made substantial contributions, particularly in the study of depressive disorders.

Adaptive insights: dynamic assessment for speech sound intervention in a child with cleft lip and palate.

Dynamic assessment (DA) is a new approach to evaluating speech and language disorders, focusing on the learning process over static abilities. It involves a test-teach-retest format and uses the mediated learning experience (MLE) to measure a child's modifiability through intervention efforts. This method is especially relevant for children with cleft lip and palate (CLP).