Revitalizing the Smile: A Case Report on the Modified Apexification Procedure for Discolored Non-Vital Immature Teeth With Periapical Lesions.

Apexification is the process of forming mineralized tissue at the apical portion of a tooth with an incompletely formed root. Although various materials and techniques for the endodontic treatment of such teeth have been employed for some time, selecting the appropriate material remains challenging due to limited literature. This report presents a case that evaluates the efficacy of a modified apexification procedure using mineral trioxide aggregate (MTA), followed by a walking-bleach technique to address discoloration resulting from trauma to anterior teeth.

Assessment of quality of life in follow-up patients with COVID-19 pneumonia: A prospective, observational study from a tertiary care center.

Background: This study intended to assess the quality of life (QOL) with telephonic interview using the Short Form 12 (SF-12) Scale in follow-up patients admitted to the intensive care unit (ICU) with COVID-19 pneumonia.

Methods: This prospective, noninterventional follow-up study was conducted at a tertiary care center. COVID-19 pneumonia patients discharged from ICU were recruited for telephonic interviews.

Prevalence and patterns of workplace cyberbullying among dental and medical undergraduate students. A cross-sectional study.

Background: Cyberbullying is an act of bullying that is conducted through the use of technology in an online mode such as over social media platforms or via text-based messages. It is an intentionally repeated aggressive activity in which harm is inflicted on a person using electronic media. This study aimed to evaluate the prevalence and pattern of workplace cyberbullying in undergraduate students inmedical and dental streams.

Correlation of Leptin Concentration in Gingival Crevicular Fluid on the Rate of Orthodontic Tooth Movement - A Prospective Study.

Background: The evaluation of genetic markers in the gingival crevicular fluid (GCF) and their connection to tooth movement can be helpful.

Aim: The objective of this research is to assess the relationship involving leptin levels and orthodontic tooth movement (OTM).

Study Setting And Design: Thirty individuals reporting to the Department of Orthodontics participated in an observational prospective study.

Comparative Evaluation of Success of NeoPutty Mineral Trioxide Aggregate ® with Formocresol as Pulpotomy Medicaments in Primary Molars: A Clinical Study.

Objective: This clinical study was aimed to investigate the clinical and radiographic outcomes of NeoPutty MTA ® (Nusmile), a novel mineral trioxide aggregate (MTA) pulpotomy material, in primary teeth of children aged 4-6 years.

Methods: An in vivo study was done in children aged 4-6 years old. A total of 50 primary second molar teeth were included in the study, with 25 of them undergoing treatment with formocresol (FC) and 25 receiving treatment with NeoPutty MTA ® .

Linking periodontal pathogens with endoperio lesions.

Endodontic-periodontal diseases pose difficulties for the practitioner in diagnosing and predicting the success of the affected teeth. Therefore, it is of interest to correlate between periodontal infections and endodontic periodontal disorders. 50 patients of both sexes were included in this study.

Facile fabrication of B-rGO/ZnFeO p-n heterojunction-based S-scheme exciton engineering for photocatalytic Cr(vi) reduction: kinetics, influencing parameters and detailed mechanism.

The fabrication of p-n heterostructures was found to be an effective strategy to stimulate the interfacial exciton shipment and photocatalytic reactions. Herein, we report a p-n junction synthesized by combining p-type boron-doped reduced graphene oxide (B-rGO) with an n-type ZnFeO semiconducting material for Cr(vi) reduction under LED light irradiation. The band structures of ZnFeO and B-rGO were evaluated using UV-vis spectroscopy, Mott-Schottky (M-S) plots and photocurrent studies.

Ecotourism or ecological concerns? Tracing the impact of economic policy uncertainty and natural resources on tourism-driven ecological footprints.

The influence of tourism development and economic policy uncertainties on environmental sustainability is substantial. Promoting responsible tourism and using sustainable tourism practises, like offering eco-friendly lodging, is a key part of protecting natural habitats and lowering carbon footprints. Hence, this study tries to examine the relationship between tourism development, economic policy uncertainty, renewable energy, and natural resources on the ecological footprint of India during 1990-2022.

A systematic review and meta-analysis of randomized controlled trials with trial sequence analysis of remdesivir for COVID-19 treatment.

Remdesivir is one of the proposed therapies for the corona virus disease 2019 (COVID-19). To assess the effect of remdesivir on mortality, need for invasive mechanical ventilation (IMV) and extracorporeal membrane oxygenation (ECMO), time to clinical improvement, and significant adverse effects. The study protocol was prospectively registered with The International Prospective Register of Systematic Reviews (Registration #CRD42021283221).

AI-driven estimation of O6 methylguanine-DNA-methyltransferase (MGMT) promoter methylation in glioblastoma patients: a systematic review with bias analysis.

Background: Accurate and non-invasive estimation of MGMT promoter methylation status in glioblastoma (GBM) patients is of paramount clinical importance, as it is a predictive biomarker associated with improved overall survival (OS). In response to the clinical need, recent studies have focused on the development of non-invasive artificial intelligence (AI)-based methods for MGMT estimation. In this systematic review, we not only delve into the technical aspects of these AI-driven MGMT estimation methods but also emphasize their profound clinical implications.

Genomics empowering conservation action and improvement of celery in the face of climate change.

Integration of genomic approaches like whole genome sequencing, functional genomics, evolutionary genomics, and CRISPR/Cas9-based genome editing has accelerated the improvement of crop plants including leafy vegetables like celery in the face of climate change. The anthropogenic climate change is a real peril to the existence of life forms on our planet, including human and plant life. Climate change is predicted to be a significant threat to biodiversity and food security in the coming decades and is rapidly transforming global farming systems.

Multi-environment evaluation of rice genotypes: impact of weather and culm biochemical parameters against sheath blight infection.

Introduction: Sheath blight caused by is one of the major diseases of rice, causing widespread crop losses. The use of semi-dwarf rice varieties in the ongoing nutrient-intensive rice cultivation system has further accentuated the incidence of the disease. An ideal solution to this problem would be identifying a stable sheath blight-tolerant genotype.

Smart high-yield tomato cultivation: precision irrigation system using the Internet of Things.

The Internet of Things (IOT)-based smart farming promises ultrafast speeds and near real-time response. Precision farming enabled by the Internet of Things has the potential to boost efficiency and output while reducing water use. Therefore, IoT devices can aid farmers in keeping track crop health and development while also automating a variety of tasks (such as moisture level prediction, irrigation system, crop development, and nutrient levels).

The impact of climate change on paediatric dentistry.

The effects of global warming and climate change are happening at a faster rate than expected, and they are going to get worse. Global climate change has already started to show the effects on environment-fast melting glaciers, accelerated sea level rise and base shifting of native flora and fauna. There has been an increase in temperature globally with a few countries already showing intense heat waves and extreme cold temperatures.

Spectrum of high-resolution computed tomography pattern in lungs in patients with connective tissue disorders.

Background: Connective tissue disease associated with interstitial lung disease, or CT-ILD, is a lung condition that affects a large number of patients with a connective tissue disease.

Objective: Our aim in this study is to correlation between images of high-resolution computed tomography (HRCT) of different connective tissue diseases associated interstitial lung diseases (CTD-ILDs).

Methods: We shall be aiming to investigate the feasibility of HRCT imaging and thereby avoid lung biopsy in such patients.

Risk Factors Associated With Hypertension in Young Adults: A Systematic Review.

On a global scale, hypertension ranks third among the six major risk factors for cardiovascular disease. The risk of heart disease, stroke, and renal failure is all significantly increased by hypertension. We looked for papers on risk factors associated with hypertension in young adults on Google Scholar and PubMed.

Airway Management of Type-III Arnold Chiari Malformation: An Anaesthetic Challenge.

Arnold Chiari malformation (ACM) is defined as protrusion of the meninges and brain components into a congenital defect in the cranium or in the vertebral column. It was originally described by Austrian pathologist Hans Chiari. Among the four types, type-III ACM is the rarest and may associate with encephalocele.

Inhalational Induction: A Safe Anaesthetic Management in a Patient with Crouzon Syndrome.

Crouzon syndrome is a rare genetic disorder involving craniofacial skeleton development. It's characterized by a triad of cranial deformities: premature craniosynostosis, facial anomalies (mid-facial hypoplasia), and exophthalmia. The anaesthetic management challenges include the presence of a difficult airway, history of obstructive sleep apnea, congenital cardiac disorders, hypothermia, blood loss, and venous air embolism.

Fused deep learning paradigm for the prediction of o6-methylguanine-DNA methyltransferase genotype in glioblastoma patients: A neuro-oncological investigation.

Background: The O6-methylguanine-DNA methyltransferase (MGMT) is a deoxyribonucleic acid (DNA) repairing enzyme that has been established as an essential clinical brain tumor biomarker for Glioblastoma Multiforme (GBM). Knowing the status of MGMT methylation biomarkers using multi-parametric MRI (mp-MRI) helps neuro-oncologists to analyze GBM and its treatment plan.

Method: The hand-crafted radiomics feature extraction of GBM's subregions, such as edema(ED), tumor core (TC), and enhancing tumor (ET) in the machine learning (ML) framework, was investigated using support vector machine(SVM), K-Nearest Neighbours (KNN), random forest (RF), LightGBM, and extreme gradient boosting (XGB).

Application of Machine Learning Techniques for Characterization of Ischemic Stroke with MRI Images: A Review.

Magnetic resonance imaging (MRI) is a standard tool for the diagnosis of stroke, but its manual interpretation by experts is arduous and time-consuming. Thus, there is a need for computer-aided-diagnosis (CAD) models for the automatic segmentation and classification of stroke on brain MRI. The heterogeneity of stroke pathogenesis, morphology, image acquisition modalities, sequences, and intralesional tissue signal intensity, as well as lesion-to-normal tissue contrast, pose significant challenges to the development of such systems.

NBLAST: a graphical user interface-based two-way BLAST software with a dot plot viewer.

BLAST, a basic bioinformatics tool for searching local sequence similarity, has been one of the most widely used bioinformatics programs since its introduction in 1990. Users generally use the web-based NCBI-BLAST program for BLAST analysis. However, users with large sequence data are often faced with a problem of upload size limitation while using the web-based BLAST program.

Comparative Evaluation of Efficacy of Bioactive Glass, Tricalcium Phosphate, and Ozone Remineralizing Agents on Artificial Carious Lesion.

Objectives: Evaluation of efficacy of bioactive glass (BAG), tricalcium phosphate, and ozone remineralizing agents on artificial carious lesion.

Materials And Methods: Freshly extracted 48 human premolar teeth were included for this study. Remineralization of demineralized teeth was done with respective remineralizing agents (Group A - calcium sodium phosphosilicate [BAG], Group B - tricalcium phosphate [Clinpro Tooth Crème], Group C - ozone remineralizing agents, and control group: Group D - deionized water) three times a day for 12 days for 4 min.