Residual Mitral Regurgitation Interacts With Transmitral Mean Pressure Gradient to Modify the Association With Mortality Following Transcatheter Edge-to-Edge Repair.

Background: The association, if any, between the transmitral mean pressure gradient (TMPG) after mitral transcatheter edge-to-edge repair and 1-year mortality is controversial in patients undergoing mitral transcatheter edge-to-edge repair with the MitraClip system. We sought to estimate the association between intraoperatively measured residual mitral regurgitation (rMR) and TMPG and 1-year mortality among patients undergoing mitral transcatheter edge-to-edge repair to facilitate decisions on additional devices.

Methods: In patients with severe secondary (functional) MR, we analyzed registry data using generalized estimating equations.

Spatial multi-omics characterizes GPR35-relevant lipid metabolism signatures across liver zonation in MASLD.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disease that can progress to metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, and cancer. The zonal distribution of biomolecules in the liver is implicated in mediating the disease progression. Recently, G-protein-coupled receptor 35 (GPR35) has been highlighted to play a role in MASLD, but the precise mechanism is not fully understood, particularly, in a liver-zonal manner.

Unusual Cutaneous Manifestations in a Patient with a History of Hepatitis B: A Case of Scleromyxedema and Literature Review.

Scleromyxedema (SM) is a rare primary cutaneous mucinosis characterized by systemic papules and scleroderma-like manifestations, often associated with monoclonal gammopathy. We present the case of a 37-year-old male with SM who developed yellowish plaques on the neck and back over three years. Histopathological examination revealed mucin deposition, fibroblast proliferation, and fibrosis, supporting the diagnosis.

Long-chain acyl-CoA synthetase regulates systemic lipid homeostasis via glycosylation-dependent lipoprotein production.

Interorgan lipid transport is crucial for organism development and the maintenance of physiological function. Here, we demonstrate that long-chain acyl-CoA synthetase (dAcsl), which catalyzes the conversion of fatty acids into acyl-coenzyme As (acyl-CoAs), plays a critical role in regulating systemic lipid homeostasis. dAcsl deficiency in the fat body led to the ectopic accumulation of neutral lipids in the gut, along with significantly reduced lipoprotein contents in both the fat body and hemolymph.

High temperature ameliorates high-fat diet-induced obesity by promoting ceramide breakdown in skeletal muscle tissue.

Obesity is considered an epidemic often accompanied by insulin resistance (IR). Heat treatment (HT) has been shown to prevent high-fat diet-induced IR in skeletal muscle, but the underlying mechanisms are poorly understood. In this study, we discovered that high temperature alleviated the hallmarks of obesity by promoting glycogen synthesis and lowering blood glucose levels in skeletal muscle tissue (SMT).

Real-world usage and effectiveness of recombinant factor IX Fc in haemophilia B from the B-SURE study in France.

Background: More real-world data are needed to complement existing phase III studies on the efficacy and safety of recombinant factor IX Fc fusion protein (rFIXFc) in people with haemophilia B.

Objectives: We report final data from the B-SURE study, evaluating the real-world usage and effectiveness of rFIXFc in France.

Methods: Previously treated patients (all ages/severities) received on-demand or prophylactic rFIXFc during B-SURE.

Effect of alpha-lipoic acid and supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis.

Background: The treatment of metabolic dysfunction-associated steatotic liver disease (MASLD) has focused on the control of comorbidities. (SM) and alpha-lipoic acid (ALA) have shown antioxidant and adjuvant effects on the control of metabolic disorders.

Aim: To evaluate whether the SM-ALA formulation (LUDLEV), in combination with the Mediterranean diet (MD), could improve MASLD-related liver injury.

Ethanol-induced ammonium polyphosphate-silver gel paint: breaking the trade-off between conductivity, flame retardancy and adhesion in single-layer functional coatings.

Electrical fires pose significant threats to the lives and property safety of people. Although utilizing coatings to impart conductivity and flame retardancy to materials is convenient and reliable, traditional layer-by-layer preparation methods have the limitations of cost, convenience and scalability. Therefore, a single-layer coating that simultaneously imparts excellent conductivity and flame retardancy to materials presents broader application prospects.

Real-world assessment to estimate multiple attributes related to treatment cost driver for mantle cell lymphoma in Japan by econometric modeling.

This study was conducted using a nationwide health care database of Japan between 1 April 2008 and 30 September 2022 to evaluate the economic burden on patients with mantle cell lymphoma (MCL). Structural equation modeling (SEM) is an advanced multivariate analysis framework used to assess the relationships between observed and latent variables within predefined causal models. In this study, SEM was employed to identify cost drivers and estimate variables related to MCL treatment cost.

Optical properties of repaired additively manufactured resin composites and zirconia and subtractively manufactured ceramics: a comparative study of composite resins.

Objective: This study aims to examine color properties of repairs made with various composites on restorations produced through additive-manufactured resin composites (AM-RC) and zirconia (AM-Z) or subtractive manufacturing (SM) after coffee thermocycling (CTC).

Materials And Methods: Disk-shaped specimens (Ø10 × 2 mm; N = 120) were fabricated using six different material groups: additively manufactured resin composite (AM-RC) materials (Crowntec [C], NextDent [ND]), additively manufactured zirconia (AM-Z) materials (Lithoz [LI], INNI-Cera [IN]), and subtractively manufactured (SM) materials (CEREC Tessera [ALD], Vita Enamic [EN]). Subsequently, each group was further subdivided into two subgroups (n = 10) based on the type of repair using two different composites resins: Clearfil Majesty Posterior (CL) (n = 60) and Filtek Z350 (FZ) (n = 60).

Facilitating active participation in anticoagulant decisions in advanced kidney disease: co-production of a question prompt list.

Background: People with chronic kidney disease are at increased risk of thrombotic and bleeding episodes making anticoagulant treatment decisions challenging. Currently, there are no support tools for people with chronic kidney disease regarding anticoagulant therapy decisions. This work aimed to co-produce materials to support shared-decision making when considering anticoagulant use in advanced chronic kidney disease.

Unraveling the Trade-Off Effect of Pyrogenic Carbons Between Biopseudocapacitors and Bioconductors During Anaerobic Methanogenesis.

Pyrogenic carbons (PCs), with varying structures depending on the materials and thermal treatment conditions, have been extensively used to enhance anaerobic digestion by mediating electron transfer. However, the underlying mechanism has yet to be explored. Herein, the redirection and enhancement of the direct interspecies electron transfer (DIET) pathway were evidenced, along with the upregulated electrochemical properties and structural proteins in the methanogenic consortia.

Integrons are anti-phage defence libraries in Vibrio parahaemolyticus.

Bacterial genomes have regions known as defence islands that encode diverse systems to protect against phage infection. Although genetic elements that capture and store gene cassettes in Vibrio species, called integrons, are known to play an important role in bacterial adaptation, a role in phage defence had not been defined. Here we combine bioinformatic and molecular techniques to show that the chromosomal integron of Vibrio parahaemolyticus is a hotspot for anti-phage defence genes.

Comparative Population Genetics of Two Alvinocaridid Shrimp Species in Chemosynthetic Ecosystems of the Western Pacific.

Deep-sea shrimps from the family Alvinocarididae are prominent inhabitants of chemosynthesis-based habitats worldwide. However, their genetic diversity and population connectivity remain poorly understood due to limited sampling. To fill these knowledge gaps, we compared the population genetics of two vent- and seep-dwelling alvinocaridid species with overlapped geographic ranges between the South China Sea and the Manus Basin.

Prediction of Radiation Therapy Induced Cardiovascular Toxicity from Pretreatment CT Images in Patients with Thoracic Malignancy via an Optimal Biomarker Approach.

Rationale And Objectives: Cardiovascular toxicity is a well-known complication of thoracic radiation therapy (RT), leading to increased morbidity and mortality, but existing techniques to predict cardiovascular toxicity have limitations. Predictive biomarkers of cardiovascular toxicity may help to maximize patient outcomes.

Methods: The machine learning optimal biomarker (OBM) method was employed to predict development of cardiotoxicity (based on serial echocardiographic measurements of left ventricular ejection fraction and longitudinal strain) from computed tomography (CT) images in patients with thoracic malignancy undergoing RT.

A solar-powered electrocoagulation process with a novel CNT/silver nanowire coated basalt fabric cathode for effective oil/water separation: From fundamentals to application.

Electrocoagulation (EC) has proven its high efficiency and environmental sustainability for treating several types of wastewaters. However, the primary drawbacks of the conventional EC process are the suitable electrode materials and the relatively high cost due to the requirement for electric energy. To overcome these practical challenges, this study investigated effective oil/water separation by a solar-powered electrocoagulation (SPEC) process using a novel highly conductive basalt fabric (BF) cathode.

The misalignment of incentives in academic publishing and implications for journal reform.

For most researchers, academic publishing serves two goals that are often misaligned-knowledge dissemination and establishing scientific credentials. While both goals can encourage research with significant depth and scope, the latter can also pressure scholars to maximize publication metrics. Commercial publishing companies have capitalized on the centrality of publishing to the scientific enterprises of knowledge dissemination and academic recognition to extract large profits from academia by leveraging unpaid services from reviewers, creating financial barriers to research dissemination, and imposing substantial fees for open access.

Transient Ischemic Attack in Women: Real-World Hospitalization Incidence, Outcomes, and Risk of Hemorrhage and Stroke.

Background: Sex-specific differences in stroke risk factors, clinical presentation, and outcomes are well documented. However, little is known about real-world differences in transient ischemic attack (TIA) hospitalizations and outcomes between men and women.

Methods: This was a retrospective cohort study of the 2016 to 2021 Nationwide Readmissions Database in the United States.

Autoantibody clusters in childhood-onset systemic lupus erythematosus: Insights from a multicenter study with 912 patients.

To identify clusters of autoantibodies in a large cSLE population and to verify possible associations between different autoantibody clusters and the following variables: demographic data, cumulative clinical and laboratory manifestations, disease activity, cumulative damage and mortality. A cross-sectional study was performed in 27 Pediatric Rheumatology University centers, including 912 cSLE patients. The frequencies of seven selected autoantibodies (anti-dsDNA, anti-Ro/SSA, anti-La/SSB, anti-Sm, anti-RNP, aCL IgM and/or IgG and LA) were used for cluster analysis using the K-means method.

Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection.

Locomotion is controlled by spinal circuits that interact with supraspinal drives and sensory feedback from the limbs. These sensorimotor interactions are disrupted following spinal cord injury. The thoracic lateral hemisection represents an experimental model of an incomplete spinal cord injury, where connections between the brain and spinal cord are abolished on one side of the cord.

Bimetallic Sulfides CrVS with Loosely Packed Structure: Exploring the Boundary of Conversion and Intercalation Sodium-Ion Storage Mechanism.

Metal sulfide electrodes for sodium-ion batteries face trade-offs among high capacity, fast kinetics, and stability. The challenge lies in breaking and restoring metal-sulfur bonds and allowing rapid ionic transport. Here we explore the boundary of conversion- and intercalation-type metal sulfides to develop ideal sodium-ion storage materials.

Assessment of cold resistance in tobacco varieties using JIP-test parameters and seedling growth.

Cold stress (CS) is a significant natural hazard, and distinguishing between plant cold resistance and sensitivity is critical for cultivar breeding and the development of germplasm resources. This study used 205 tobacco (Nicotiana tabacum L.) varieties from around the world to investigate the changes in the chlorophyll a fluorescence (OJIP) transients, JIP-test parameters, and seedling growth caused by seven days of CS (5°C) treatment.

Humoral and cellular response to SARS-CoV-2 mRNA vaccine in paediatric heart transplant recipients.

Objective: The aim of this prospective cohort study is to analyse the humoral and cellular vaccine responses in paediatric heart transplant recipients (HTR, n = 12), and compare it with the response in healthy controls (HC, n = 14). All participants were 5-18 years old and vaccinated with mRNA vaccine against SARS-CoV-2 between December 2021 and May 2022.

Methods: The humoral response was measured by quantifying antibody titers against SARS-CoV-2 spike protein (anti-S).

Immunotherapy in gastric cancer-A systematic review.

Background: Gastric Cancer (GC) is the 5th most prevalent and 4th most deadly neoplasm globally. Immunotherapy has emerged as a promising treatment approach in GC, potentially improving positive clinical outcomes while addressing the limitations of conventional therapies. GC immunotherapy modalities consist of adoptive cell therapy (ACT), cancer vaccines, and immune checkpoint inhibitors (ICI).

Copy Number Variant Does Not Influence Stroke Severity in 2 C57BL/6J Mouse Models nor in Humans: An Exploratory Study.

Background: Contrary to the common belief, the most commonly used laboratory C57BL/6J mouse inbred strain presents a distinctive genetic and phenotypic variability, and for several traits, the genotype-phenotype link remains still unknown. Recently, we characterized the most important stroke survival factor such as brain collateral plasticity in 2 brain ischemia C57BL/6J mouse models (bilateral common carotid artery stenosis and middle cerebral artery occlusion) and observed a Mendelian-like fashion of inheritance of the posterior communicating artery (PcomA) patency. Interestingly, a copy number variant (CNV) spanning locus was reported to segregate in an analogous Mendelian-like pattern in the C57BL/6J colonies of the Jackson Laboratory.