Literature Commentary.

In this issue of JNO, Drs. Deborah I. Friedman and Mark L.

Specialty-specific Evaluation of Virtual care Outcomes: A retrospective QUality and safety analysis (S-EVOQUe).

The objective was to compare specialty-specific 7- and 30-day outcomes between virtual care visits and in-person visits which occurred during the SARS-CoV-2 pandemic. Using administrative data from provincial databases in Ontario, ambulatory care visits occurring virtually and in-person during specific timeframes within the pandemic were analyzed. Virtual care visits were matched with corresponding in-person visits based on multiple baseline patient characteristics.

eIF3 engages with 3'-UTR termini of highly translated mRNAs.

Stem cell differentiation involves a global increase in protein synthesis to meet the demands of specialized cell types. However, the molecular mechanisms underlying this translational burst and the involvement of initiation factors remains largely unknown. Here, we investigate the role of eukaryotic initiation factor 3 (eIF3) in early differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (NPCs).

Assessing the role of education level on climate change belief, concern and action: a multinational survey of healthcare professionals in nephrology.

Background: Climate change poses a significant risk to kidney health, and countries with lower national wealth are more vulnerable. Yet, citizens from lower-income countries demonstrate less concern for climate change than those from higher-income countries. Education is a key covariate.

Multiple Myeloma: Improved Outcomes Resulting from a Rapidly Expanding Number of Therapeutic Options.

Multiple myeloma (MM) is a bone-marrow-based cancer of plasma cells. Over the last 2 decades, marked treatment advances have led to improvements in the overall survival (OS) of patients with this disease. Key developments include the use of chemotherapy, immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies.

Worth your sweat: wearable microfluidic flow rate sensors for meaningful sweat analytics.

Wearable microfluidic sweat sensors could play a major role in the future of monitoring health and wellbeing. Sweat contains biomarkers to monitor health and hydration status, and it can provide information on drug intake, making it an interesting non-invasive alternative to blood. However, sweat is not created in excess, and this requires smart sweat collection strategies to handle small volumes.

Beam Scanning with Ultra-Low Sidelobes and In-Band Ultra-Low Scattering Characteristics Empowered by Single Space-Time-Coding Radiation-Scattering Metasurface.

The integrated modulation of radiation and scattering provides an unprecedented opportunity to reduce the number of electromagnetic (EM) apertures in the platform while simultaneously enhancing communication and stealth performance. Nevertheless, achieving full-polarization, arbitrary amplitude, and phase modulation of radiation scattering remains a challenge. In this paper, a strategy that realizes space-time coding of radiation scattering within the same frequency band, which enables the simultaneous and independent modulation of amplitude and phase, is proposed.

Refractory Psychosis as a Red Flag for End of Life in Individuals With Dementia With Lewy Bodies: A Case Series and Re-analysis of Prior Qualitative Data.

Objectives: Many individuals with dementia with Lewy bodies (DLB) die of disease-related complications, but predicting the end of life can be challenging. We identified a phenotype associated with approaching end of life.

Methods: We present 4 exemplar cases where individuals with DLB experienced refractory psychosis before death.

Telomemore enables single-cell analysis of cell cycle and chromatin condensation.

Single-cell RNA-seq methods can be used to delineate cell types and states at unprecedented resolution but do little to explain why certain genes are expressed. Single-cell ATAC-seq and multiome (ATAC + RNA) have emerged to give a complementary view of the cell state. It is however unclear what additional information can be extracted from ATAC-seq data besides transcription factor binding sites.

Samarium as a Catalytic Electron-Transfer Mediator in Electrocatalytic Nitrogen Reduction to Ammonia.

Samarium diiodide (SmI) exhibits high selectivity for NR catalyzed by molybdenum complexes; however, it has so far been employed only as a stoichiometric reagent (0.3 equiv of NH per Sm) combined with coordinating proton sources (e.g.

Treatment of Cutaneous Adnexal Carcinoma With Radiotherapy: A 20-Year, Single-Institution Experience in 49 Patients.

Objectives: Cutaneous adnexal carcinomas (CACs) are rare skin cancers with no established treatment guidelines. Given the limited data, this study aims to explore the characteristics and outcomes of patients with CAC treated with radiation therapy (RT).

Methods: Patients diagnosed with CAC between 2000 and 2020 who received RT were included.

Ecdysteroids in Native Trees and Callus Cultures of the Genus Vitex L. of the Flora of Russia and Vietnam.

Introduction: Vitex L. is a large genus of tropical and subtropical trees used in medicine of many nations. Some species are used in gynecology due to flavonoids, iridoids, and diterpenes.

Cost-effective analysis focused on hypoglycemia of intermittent-scanning continuous glucose monitoring in type 1 diabetes adults: a ISCHIA randomized clinical trial.

Background: This study aimed to compare the economic value of intermittent-scanning continuous glucose monitoring (isCGM) with self-monitoring of blood glucose (SMBG) in adults with type 1 diabetes (T1D).

Methods: Participants were placed on either an isCGM or SMBG arm for 84 days, in a randomized, crossover setup with a 28-day washout period. Clinically relevant hypoglycemia (<54 mg/dL) and severe hypoglycemia (SH) risks were calculated by analyzing the data from isCGM.

Characterization of patients with clonal mast cells in the bone marrow with clinical significance not otherwise specified.

Background: Systemic mastocytosis (SM) diagnosis requires the presence of 3 minor criteria or 1 major and 1 minor criterion according to the WHO 2016 classification. The aim of this study was to characterize patients with 1 or 2 minor SM criteria including mutation and/or aberrant expression of CD2 and/or CD25 on bone marrow (BM) mast cells (MCs), but without MC activation syndrome (MCAS) criteria.

Methods: We included eligible patients from two countries diagnosed between 2011 and 2021.

Spatial-division multiplexing self-homodyne coherent transmission over 19-/24-core fibers assisted by homemade fan-in/fan-out 3D photonic devices.

The self-homodyne detection (SHD) is a promising solution to achieve low-cost and low-power-consumption fiber-optic communications. In this work, we propose and demonstrate a high-capacity spatial-division multiplexing (SDM) system with SHD technology by employing single-mode multi-core fibers (SM-MCFs), where the fan-in/fan-out (FIFO) 3D photonic devices are designed and fabricated based on the femtosecond laser direct writing technique, enabling high-efficiency coupling between single-mode fibers (SMFs) and SM-MCFs. The FIFO 3D photonic devices, serving as the SDM (de)multiplexer, facilitate superior performance of low insertion loss and low inter-channel crosstalk.

Iron Overload, Oxidative Stress, and Somatic Mutations in MDS: What Is the Association?

Introduction: Iron overload (IOL) accumulates in myelodysplastic syndromes (MDS) from expanded erythropoiesis and transfusions. Somatic mutations (SM) are frequent in MDS and stratify patient risk. MDS treatments reversing or limiting transfusion dependence are limited.

FIGG at 5: An update on U.S. public perspectives on forensic investigative genetic genealogy five years after its introduction to criminal investigations.

In 2018, after law enforcement announced it had used a technique called forensic investigative genetic genealogy (FIGG) to identify the Golden State Killer, we conducted a U.S. general population survey and found most respondents supported using FIGG to solve violent crimes.

High-Conductivity, Self-Healing, and Adhesive Ionic Hydrogels for Health Monitoring and Human-Machine Interactions Under Extreme Cold Conditions.

Ionic conductive hydrogels (ICHs) are emerging as key materials for advanced human-machine interactions and health monitoring systems due to their unique combination of flexibility, biocompatibility, and electrical conductivity. However, a major challenge remains in developing ICHs that simultaneously exhibit high ionic conductivity, self-healing, and strong adhesion, particularly under extreme low-temperature conditions. In this study, a novel ICH composed of sulfobetaine methacrylate, methacrylic acid, TEMPO-oxidized cellulose nanofibers, sodium alginate, and lithium chloride is presented.

Hematopoietic stem cell transplantation and immunosuppressive therapy: implications of clonal haematopoiesis.

Aplastic anemia (AA) is a life-threatening bone marrow failure syndrome. The advent of next-generation sequencing (NGS) has shed light on the link between somatic mutations (SM) and the efficacy of immunosuppressive therapy (IST) in AA patients. However, the relationship between SM and hematopoietic stem cell transplantation (HSCT) has not been extensively explored.

Exploring the luminescent and thermometric potentials of samarium(III) diketonate complexes with extended fluoroalkyl chains.

We synthesized and investigated a new series of Sm 1,3-diketonate complexes with CF-homologous thiophene-containing ligands. A clear correlation was found between the number of fluorine atoms in the 1,3-diketone's carbon chain and the luminescent properties of the samarium(III) complexes. The ligand modification method employed facilitates targeted and significant enhancements in the photoluminescence quantum yield (PLQY).

Cadmium-rich intermetallic phases RhCd - structure, magnetic behavior, Eu Mössbauer and Cd solid-state NMR spectroscopy.

The cadmium-rich intermetallic compounds RhCd ( = Ca, Sr, Y, La-Nd, Sm-Lu) were synthesized from the elements in sealed tantalum tubes. The elements were reacted in an induction furnace and the samples were post-annealed to increase phase purity and crystallinity. The RhCd phases crystallize with the cubic CeCrAl type structure, space group 3̄.

PET-Based Dual-Modal Probes for In Vivo Imaging.

Molecular imaging has significantly advanced the detection and analysis of in vivo metabolic processes, while single-modal techniques remain limited. Dual-modal imaging, particularly positron emission tomography (PET)-based combinations has emerged as a powerful solution, offering enhanced capabilities through integration with magnetic resonance imaging (MRI) or near-infrared fluorescence (NIRF) imaging. This review highlights recent progress in PET-based dual-modal imaging, focusing on the development of various bimodal probes derived from antibodies, nanoparticles, and peptides, and key applications including image-guided surgery and disease assessment.

Effectiveness of Fenugreek as an Adjuvant in the Management of Oral Potentially Malignant Disorders: A Randomized Controlled Trial.

Aim: This study aimed to evaluate the effectiveness of fenugreek as an adjuvant in managing oral potentially malignant disorders (OPMDs), specifically leukoplakia, lichen planus, and oral submucous fibrosis (OSMF).

Materials And Methods: Twenty-one participants prediagnosed with OPMDs were randomly divided into a study group (SG) and a control group (CG), with 10 participants in SG and 11 in CG, respectively. The SG received 2 gm of fenugreek as an adjuvant with standard systemic treatments tailored to the respective lesions: intralesional injection of vitamin A 1,00,000 IU (Aquasol A) and topical application of triamcinolone acetonide 0.

Bioinspired Conductivity-Enhanced, Self-Healing, and Renewable Silk Fibroin Hydrogel for Wearable Sensors with High Sensitivity.

The development of silk fibroin-based hydrogels with excellent biocompatibility, aqueous processability, and facile controllability in structure is indeed an exciting advancement for biological research and strain sensor applications. However, silk fibroin-based hydrogel strain sensors that combine high conductivity, high stretchability, reusability, and high selectivity are still desired. Herein, we report a simple method for preparing double-network hydrogels including silk fibroin and poly(acrylic acid) sodium-polyacrylate (PAA-PAAS) networks.

Mixed-Bridging 2D Luminescent Coordination Polymer: Structure, Selective Sensing of Pollutants in Water, and Fabrication of Photoresponsive Electronic Device.

Pyrazine (tppz) and 5-sulfosalicylic acid (HSSA) mixed-bridging Cd(II)-CP, {[Cd(HSSA)(tppz)]} (), is highly luminescent, and the emission has been quenched selectively by Al in the presence of other cations, with a limit of detection (LOD) of 43.9 nM (1.18 ppb).