Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells.

CD226 plays a vital role in natural killer (NK) cell cytotoxicity, interacting with its ligands CD112 and CD155 to initiate immune synapse formation, primarily through leukocyte function-associated-1 (LFA-1). Our study examined the role of CD226 in NK cell surveillance of acute myeloid leukemia (AML). NK cells in patients with AML had lower expression of CD226.

OPMS - A web-based ocean pollution monitoring system.

Marine pollution poses significant risks to both marine ecosystems and human health, requiring effective monitoring and control measures. This study presents the Ocean Pollution Monitoring System (OPMS), a web application designed to visualize the seasonal and annual fluctuations of marine pollutants along coastal regions in Canada. The pollutants include fecal coliform and biotoxins such as paralytic shellfish poisoning (PSP), and amnesic shellfish poisoning (ASP).

Novel Orthosteric/Allosteric Ligands of Cannabinoid Receptors: An Unexpected Pharmacological Profile.

The design of dualsteric/bitopic receptor ligands as compounds capable of simultaneously interacting with both the orthosteric and an allosteric binding site has gained importance to achieve enhanced receptor specificity and minimize off-target effects. In this work, we reported the synthesis and biological evaluation of a new series of compounds, namely, the series, obtained by chemically combining the CB1R ago-positive allosteric modulators (PAM) with the cannabinoid receptors (CBRs) orthosteric agonist . Therefore, compounds were designed as dualsteric/bitopic ligands for CB1R with the aim of obtaining stronger CB1R agonists or ago-PAMs, with improved receptor subtype selectivity and reduction of central side effects.

Sub-zero soil CO respiration in biostimulated hydrocarbon-contaminated cold-climate soil can be linked to the soil-freezing characteristic curve.

Extending unfrozen water availability is critical for stress-tolerant bioremediation of contaminated soils in cold climates. This study employs the soil-freezing characteristic curves (SFCCs) of biostimulated, hydrocarbon-contaminated cold-climate soils to efficiently address the coupled effects of unfrozen water retention and freezing soil temperature on sub-zero soil respiration activity. Freezing-induced soil respiration experiments were conducted under the site-relevant freezing regime, programmed from 4 to - 10 °C at a seasonal soil-freezing rate of - 1 °C/day.

Anti-migraine medications safety during pregnancy in the US.

Background: Specific antimigraine medications (dihydroergotamine (DHE), triptans) have been associated with adverse pregnancy outcomes in individual studies but lack of consensus remains.

Objectives: Quantify the risk of prematurity, low birth weight (LBW), major congenital malformations (MCM), and spontaneous abortions (SA) associated with gestational use of DHE or triptans in a privately insured cohort of pregnant women in the US.

Methods: We conducted a cohort study within the US Merative MarketScan Research Database (2011-2021), composed of a nationally representative sample of patients with employer-provided health insurance.

Spread and Scale of the Integrated Nutrition Pathway for Acute Care Across Canada: Protocol for the Advancing Malnutrition Care Program.

Background: A high proportion of patients admitted to hospital are at nutritional risk or have malnutrition. However, this risk is often not identified at admission, which may result in longer hospital stays and increased likelihood of death. The Integrated Nutrition Pathway for Acute Care (INPAC) was developed to provide clinicians with a standardized approach to prevent, detect, and treat malnutrition in hospital.

Exact analytical Taub-NUT like solution in () gravity.

We construct exact analytical Taub-NUT solutions in the context of () gravity. We study the physical properties of the solutions, and compare them with those of the Taub-NUT solution in Einstein gravity.

Two cases of childhood linear immunoglobulin A bullous dermatosis following multivisceral transplant: A case report.

Childhood linear immunoglobulin A bullous dermatosis is a well-recognized autoimmune blistering dermatosis that can be idiopathic, drug-induced, secondary to autoimmune diseases, malignancies, infections, or gastrointestinal diseases including inflammatory bowel disease. However, it has not been previously associated with a history of organ transplantation. Here, we report two cases of childhood linear immunoglobulin A bullous dermatosis in young infants following multivisceral organ transplant, including one with a particularly recalcitrant course.

The G Protein-Coupled Receptor-Related Gene Signatures for Diagnosis and Prognosis in Glioblastoma: A Deep Learning Model Using RNA-Seq Data.

Background: Glioblastoma (GBM) is the most aggressive cancer in the central nervous system in glial cells. Finding novel biomarkers in GBM offers numerous advantages that can contribute to early detection, personalized treatment, improved patient outcomes, and advancements in cancer research and drug development. Integrating machine learning with RNAseq data in medicine holds significant potential for identifying novel biomarkers in various diseases, including cancer.

Evaluating the feasibility of estimating particulate mass emissions of older-model diesel vehicle using smoke opacity measurements.

Real-world emissions of particulate matter (PM) and smoke opacity were studied for an older-model diesel pickup truck during four types of driving tests, namely fixed-point test, snap-acceleration test, road test, and hill road test (uphill/downhill). A portable emissions measurement system (PEMS) and an opacimeter were used to measure real-time concentrations of PM and smoke opacity, respectively, and simultaneously. Correlation analysis showed a significant positive association between PM and opacity, suggesting the feasibility of using an opacimeter to estimate PM mass emissions from diesel vehicles.

A comparison of freeze- and air-dried chitosan salicylaldehyde/calcium oxide biocomposites for optimized removal of acid red 88 dye.

Chitosan salicylaldehyde/calcium oxide nanoparticle (CS-SL/CaO) was synthesized by hydrothermal process and isolated via different drying processes, namely, air-drying (AD) and freeze-drying (FD). The physicochemical properties of freeze-dried CS-SL/CaO nanoparticle (CS-SL/CaO-FD) and air-dried CS-SL/CaO nanoparticle (CS-SL/CaO-AD) were compared. In particular, the adsorption properties reveal that the specific surface area of CS-SL/CaO-FD increased by ca.

Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs.

Innate-like splenic marginal zone (MZ) B (MZB) cells play unique roles in immunity due to their rapid responsiveness to blood-borne microbes. How MZB cells integrate cell-extrinsic and -intrinsic processes to achieve accelerated responsiveness is unclear. We found that Delta-like1 (Dll1) Notch ligands in splenic fibroblasts regulated MZB cell pool size, migration, and function.

Vascular Air Embolism in Neonates: A Literature Review.

Neonatal vascular air embolism is a rare but often fatal condition. The literature comprises mostly case reports and a few dated systematic reviews. Our objective was to review all case reports of neonatal vascular air embolism to date and provide up-to-date information about patient characteristics, clinical presentations, outcomes, pathogenesis, diagnosis, prevention, treatment, and prognosis.

Navigating Awareness and Strategies to Support Dementia Advocacy on Social Media During World Alzheimer's Month: Infodemiology Study.

Background: Understanding advocacy strategies is essential to improving dementia awareness, reducing stigma, supporting cognitive health promotion, and influencing policy to support people living with dementia. However, there is a dearth of evidence-based research on advocacy strategies used to support dementia awareness.

Objective: This study aimed to use posts from X (formerly known as Twitter) to understand dementia advocacy strategies during World Alzheimer's Awareness Month in September 2022.

Family Physicians' Feedback on the Feature Design of a Digital Health Platform to Streamline the Care of Older Adults.

: Family physicians are essential to a well-functioning healthcare system; however, they face significant administrative and cognitive burdens that contribute to their burnout and reduce the quality of patient care they provide. Digital health tools offer potential solutions to these problems. This study examined the interface design and features of a digital health platform, Carmi, designed to mitigate administrative inefficiencies and cognitive overload by asynchronous patient data gathering and automated report generation.

Hybrid Chitosan Biosorbents: Tunable Adsorption at Surface and Micropore Domains.

Herein, we report a study that provides new insight on the knowledge gaps that relate to the role of biopolymer structure and adsorption properties for chitosan adsorbents that are cross-linked with glutaraldehyde. The systematic modification of chitosan cross-linked with glutaraldehyde (CG) and its quaternized forms (QCG) was studied in relation to the reaction conditions: mole ratios of reactants and pH conditions. Complementary adsorbent characterization employed C NMR/FTIR spectroscopy, TGA and DSC, point-zero-charge (PZC), solvent swelling, and sorption studies using selected dye probes.

Patterns of Nabilone Prescriptions in Canadian Long-Term Care Facilities.

The purpose of the current study was to understand the prevalence and patterns of cannabinoid use among LTC residents across Canada. We gathered data on cannabinoid prescriptions among LTC residents for one year before and after recreational cannabis legalization. Multi-level modelling was used to examine the effects of demographic and diagnostic characteristics on rates of cannabinoid prescription over time.

Behind the scenes with genomics researchers.

Although lab-coat genomics scientists are highly skilled and involved in pioneering work, few studies have examined their perceptions on what they do, and how they relate with others in interdisciplinary work. Recognizing that gap, we were curious to talk with scientists about their current work and positionalities related to the use of genomics for bioremediation. Using unstructured open-ended interviews and thematic analysis, we interviewed researchers with diverse genomics-related expertise.

Decoding Brain Development and Aging: Pioneering Insights From MRI Techniques.

The aging process induces a variety of changes in the brain detectable by magnetic resonance imaging (MRI). These changes include alterations in brain volume, fluid-attenuated inversion recovery (FLAIR) white matter hyperintense lesions, and variations in tissue properties such as relaxivity, myelin, iron content, neurite density, and other microstructures. Each MRI technique offers unique insights into the structural and compositional changes occurring in the brain due to normal aging or neurodegenerative diseases.

Recurring incursions and dissemination of novel Eurasian-origin H5Nx avian influenza viruses in Atlantic Canada.

Wild birds are important hosts of influenza A viruses (IAVs) and play an important role in their ecology. The emergence of the A/goose/Guangdong/1/1996 H5N1 (Gs/GD) lineage marked a shift in IAV ecology, leading to recurrent outbreaks and mortality in wild birds from 2002 onwards. This lineage has evolved and diversified over time, with a recent important derivative being the 2.

Influence of maternal nutrition and one-carbon metabolites supplementation on bovine antimicrobial peptides in fetal and maternal tissues.

Introduction: Maternal nutrition during pregnancy critically influences offspring development and immune function. One-carbon metabolites (OCM) are epigenetic modifiers that may modulate antimicrobial peptide (AMP) expression, which is vital for innate immunity. This study investigated the effects of maternal nutrient restriction and OCM supplementation on mRNA expression of AMP in fetal and maternal lung, mammary gland, and small intestine of beef cattle.

Internet-delivered cognitive behaviour therapy for university students: Preference trial for various course durations.

Background: Internet-delivered cognitive behaviour therapy (ICBT) is an accessible and effective treatment option for post-secondary students, but engagement and completion rates are less favourable than in non-student populations in routine care. Studies on students' treatment preferences suggest that a range of options should be offered. Examining students' engagement and outcomes associated with ICBT course options of varying durations can help inform how to optimally deliver ICBT to university students in routine care.