173 results match your criteria: "SGT Dental College Hospital & Research Institute[Affiliation]"

Novel transcripts of EMT driving the malignant transformation of oral submucous fibrosis.

Sci Rep

January 2025

Department of Oral and Maxillofacial Pathology and Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.

Oral submucous fibrosis (OSF) is a chronic, progressive, and fibrotic condition of the oral mucosa that carries an elevated risk of malignant transformation. We aimed to identify and validate novel genes associated with the regulation of epithelial-to-mesenchymal transition (EMT) in OSF. Genes regulating EMT were identified through differential gene expression analysis, using a LogFC threshold of -1 and + 1 and a padj value < 0.

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Development of Synthetic Antimicrobial Peptides Based on Genomic Analysis of Streptococcus salivarius.

J Clin Lab Anal

January 2025

Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Background: In the oral environment, the production of bacteriocins or antimicrobial peptides (AMPs) plays a crucial role in maintaining ecological balance by impeding the proliferation of closely related microorganisms. This study aims to conduct in silico genome screening of Streptococcus salivarius to identify potential antimicrobial compounds existing as hypothetical peptides, with the goal of developing novel synthetic antimicrobial peptides.

Methods: Draft genomes of various oral Streptococcus salivarius strains were obtained from the NCBI database and subjected to analysis using bioinformatic tools, viz.

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Salivary gland tumors (SGTs) are diverse lesions with varying morphological and clinical characteristics. Limited data exist on the distribution of SGTs in Saudi Arabia. We aimed to fill this gap by examining the distribution of SGTs across four tertiary hospitals in Riyadh.

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Background: Thalassemia is a hemoglobinopathy-associated genetic disease resulting due to defective synthesis of globin chains, causing defects in the skeletal and oral structures.

Aim: This cross-sectional study was designed to analyze the prevalence of dental caries, oral health status, malocclusion status, and dental treatment needs in thalassemic children.

Materials And Methods: Institutional Ethical committee clearance was obtained before starting the study.

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Background: Oral cancer is the sixth most common cancer, and 90% of them are oral squamous cell carcinomas (OSCC). As most OSCC are asymptomatic and are only detected at an advanced stage, the 5-year survival rate is only 50%. Thus, using novel prognosticators can minimise mortality and morbidity associated with OSCC.

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Article Synopsis
  • Dental surgeons can enhance patient awareness of oral hygiene by using plaque-disclosing solutions and teaching proper brushing techniques.
  • The study showed that these methods significantly improve self-performed dental plaque control, which is crucial as plaque contributes to many oral diseases.
  • A case report highlighted an adolescent's oral hygiene progress over four weeks, with a noticeable reduction in plaque and gingival index scores after implementing the techniques.
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Immune privilege is the ability to tolerate foreign antigens without eliciting an inflammatory immune response. Several mechanisms explain a structure's immune privilege status, which is regulated by innate and adaptive immune responses. The role of myofibroblasts in perpetuating fibrosis by acquiring an immune privileged phenotype against the backdrop of oral submucous fibrosis (OSF) is evolving.

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  • This study evaluated the mechanical properties and surface characteristics of four archwire materials: stainless steel, nickel-titanium, beta-titanium, and esthetic archwires, focusing on tensile strength, yield strength, modulus of elasticity, surface roughness, and frictional properties.
  • Stainless steel had the best mechanical properties, including the highest tensile strength (900 N), yield strength (780 N), and modulus of elasticity (200 GPa), while esthetic archwires showed the highest surface roughness (0.40 µm) and frictional forces.
  • The findings highlight that selecting the right archwire material is crucial for achieving effective and efficient tooth movement in orthodontic treatment.
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Periodontitis, a prevalent chronic inflammatory condition affecting the supporting structures of teeth, is closely associated with oxidative stress, characterized by an imbalance between reactive oxygen species generation and antioxidant defense mechanisms. Antioxidants have garnered significant attention as potential therapeutic agents in periodontal management due to their ability to counteract oxidative damage and inflammation. This brief review provides an overview of the role of antioxidants in periodontitis, highlighting recent developments.

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  • Salivary gland tumors (SGTs) are challenging to diagnose due to their many types and differing behaviors, making clinical management complex.* -
  • A study analyzed 150 SGT cases from 2017-2022, finding that 70% were benign and 30% malignant, with pleomorphic adenoma and adenoid cystic carcinoma being the most common subtypes.* -
  • Surgical resection was the primary treatment, leading to varied recurrence rates; the study suggests that further research is necessary to enhance treatment strategies and patient outcomes.*
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  • The study aimed to assess the impact of pre-cooling on children's pain experiences during local anesthetic injections for dental procedures.
  • Participants included 60 child patients, divided into two groups: a control group that did not receive pre-cooling and a pre-cooling group that had the injection site chilled for one minute.
  • Results showed that the pre-cooling group experienced significantly lower pain levels, suggesting that this technique can enhance comfort for pediatric patients undergoing dental treatments, particularly those with anxiety or fear of needles.
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Background: Temporomandibular joint (TMJ) ankylosis frequently results in mandibular asymmetry, which impairs an affected person's ability to function and look good. Because of the intricacy of TMJ ankylosis and the variety of surgical procedures available, correcting mandibular asymmetry surgically can be difficult.

Methods: Patients with mandibular asymmetry and TMJ ankylosis who had surgery at a tertiary care facility between certain periods were the subject of a retrospective investigation.

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Assessment of Temporomandibular Joint Disorders: Retrospective Study of Clinical Presentations.

J Pharm Bioallied Sci

July 2024

Department of Oral and Maxillofacial Surgery, SGT University, Gurugram, Badli, Jhajjar, Haryana, India.

Objective: This retrospective research aimed to assess the clinical presentations and management strategies for "temporomandibular joint (TMJ)" disorders.

Methods: Medical records of patients diagnosed with TMJ disorders between 2017 and 2022 were retrospectively analyzed. Data collected included demographic information, clinical symptoms, radiographic findings, treatment modalities, and treatment outcomes.

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Background: Because of its high rates of morbidity and death, oral squamous cell carcinoma (OSCC) poses a serious threat to world health. To maximize patient care and direct clinical decision-making, it is important to comprehend treatment results and survival rates.

Methods: Treatment results and survival rates for OSCC patients treated at a tertiary care facility between 2010 and 2022 were assessed in this retrospective research.

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Background: A common sleep problem linked to poor cardiovascular outcomes and death is " (SL)." Nevertheless, little is known about how SL affects cardiovascular health in the long run. The purpose of this research was to investigate the relationship between a tertiary care center's long-term cohort's cardiovascular morbidity and mortality and the severity of their SL.

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Background: The COVID-19 epidemic has affected all facets of patient care, including dentistry services, and placed hitherto unheard-of demands on healthcare systems throughout the world. More and more emphasis is being paid to psychological discomfort and dental anxiety that epidemic patients face when seeking dental care. The purpose of this research was to examine the psychological distress and dental anxiety levels of patients receiving dental care during the COVID-19 pandemic in a tertiary care setting between 2021 and 2022.

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Article Synopsis
  • Cone beam computed tomography (CBCT) is crucial in oral and maxillofacial radiology due to its 3D imaging abilities and lower radiation exposure compared to traditional CT scans.
  • A retrospective study over 5 years analyzed 500 CBCT scans, focusing on patient demographics and the reasons for scans, such as implant planning and impacted tooth assessment.
  • The findings revealed a steady increase in CBCT usage, especially for implant planning, and highlighted patterns based on age and specific indications, indicating CBCT's growing role in enhancing diagnostic accuracy and treatment planning in clinical practice.
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  • Local anesthesia can cause anxiety and pain in children during dental procedures, making it important to find ways to reduce discomfort.
  • A study involving 30 children aged 6 to 10 compared a vibrating device to traditional techniques to see which was more effective in alleviating pain during local anesthesia administration.
  • Results showed that using the vibrating device significantly decreased pain and discomfort, as measured by the Wong-Baker FACES Pain Rating Scale and the FLACC scale.
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Background: Sutures are essential components of wound closure in oral surgery, and the mechanical properties of suture materials play a crucial role in determining surgical outcomes. Understanding the tensile strengths of various suture materials is vital for selecting the most appropriate material for specific clinical applications.

Objective: This study aimed to assess the tensile strength of suture materials commonly used in oral surgery through an in vitro tensile strength study.

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Aim: The aim of this case report is to present three different patients who had horizontal and vertical root fractures of young permanent teeth, its diagnosis, clinical and radiographic findings, treatment, and long-term follow-up and success rate.

Background: Root fractures are relatively rare with the prevalence of 0.5-7% in permanent and 2-4% in deciduous dentition.

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Belly dancer's dyskinesia (BDD) is characterized by involuntary abdominal wall movements that are rhythmic, repetitive, and dyskinetic. The present study aims to review BDD's etiology, pathophysiology, and management. We searched six databases to locate existing reports on BDD published from 1990 to October 2023 in electronic form.

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Current implant therapy is a frequently employed treatment for individuals who have lost teeth, as it offers functional and biological advantages over old prostheses. Concurrently, active exploration of intervention strategies aims to prevent the progression of peri-implant diseases and manage the existing peri-implant tissue damage. Indian Society of Periodontology has recognized the need for systematic documents to update the everyday clinical practice of general dental practitioners and has provided evidence-based consensus documents, namely good clinical practice recommendations from time to time to raise the oral health-related awareness and standards of oral health-care delivery across the country.

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Malocclusion is the mal-relationship of dental arches with or without an irregularity of the teeth. Therefore, it is of interest to estimate the rate of occurrence of malocclusion within the population of Agartala city, Tripura, India. The study included 850 individuals ranging from 16 to 24 years of age, which were categorized into five distinct classifications, namely normal occlusion, Angle's Class I malocclusion, Class II Division 1, Class II Division 2, and Class III malocclusion.

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Background The research delves into the intricate relationship between periodontal health and specific blood biomarkers in pregnant women during their second trimester. It specifically focuses on the levels of interleukin-6 (IL-6), lactate dehydrogenase (LDH), and C-reactive protein (CRP) in those suffering from chronic periodontitis compared to healthy controls. Methodology A detailed approach was taken involving 60 pregnant women categorized into two groups based on the presence or absence of chronic periodontitis.

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Platelet-rich fibrin (PRF) is a biocompatible fibrin matrix that acts as a resorbable membrane, collecting platelet cytokines, growth factors, and cells and releasing them. It is easily extracted from blood. Many dentists use PRF, a concentrated growth factor solution, to treat various lesions and regenerate tooth and oral tissues.

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