Comprehensive analysis of microRNAs and their target genes in oral submucous fibrosis.

The objective of the study is to understand the role of experimentally validated microRNAs (miRNAs) contributing to the acquisition of oncogenic phenotype in oral submucous fibrosis (OSF) by computational analysis. A comprehensive review was carried out to corroborate and summarize altered miRNA expression in OSF by retrieving relevant publications querying MEDLINE, Web of Science, Embase, and Scopus. The association between the miRNA-mRNA was performed using miRTarBase 8.

Bilateral hilar sialoliths in a child: A rare occurrence.

Salivary sialolithiasis is a well-known cause for obstructive disease of the submandibular and parotid glands. However, the condition frequently occurs unilaterally, and it is uncommon to find a patient reporting with stones in both submandibular or parotid glands. Children below the age of 16 years rarely suffer from salivary stones.

Co-Occurrence of Taurodontism in Nonsyndromic Cleft Lip and Palate Patients in Subset of Indian Population: A Case-Control Study Using CBCT.

The present study aimed to assess the co-occurrence of taurodontism in nonsyndromic cleft lip and palate (NSCLP) patients in a subset of Indian population using cone beam computed tomography (CBCT). The study was a retrospective case-control kinds assessing 1500 CBCT scans over a period of 2 years; 67 scans out of 1500 showed cleft lip and palate (CLP). After fulfilling the inclusion and exclusion criteria, 38 subjects out of 67 comprised the case group; 80 randomly selected subjects constituted the control group.

Effect of nonsurgical periodontal therapy on gingival crevicular fluid levels of Interleukin-35 in patients with periodontitis.

Objective: Interleukin (IL)-35 is a comparatively novel immunosuppressive cytokine produced by T-regulatory cells, the purpose of which in periodontal well being and disease still eludes the researchers. This study intends to measure and compare the levels of IL-35 in gingival crevicular fluid (GCF) taken from periodontitis patients before and at first, second and third week post non-surgical periodontal therapy.

Methodology: ology: Twenty patients having generalized chronic periodontitis (mean age of 36.

Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy.

Sarsasapogenin is a natural steroidal sapogenin molecule obtained mainly from Bunge. Among the various phytosteroids present, sarsasapogenin has emerged as a promising molecule due to the fact of its diverse pharmacological activities. In this review, the chemistry, biosynthesis and pharmacological potentials of sarsasapogenin are summarised.

Effect of trans retinoic acid on patients with oral submucous fibrosis-randomized single-blind monocentric study.

Various treatment modalities have been practiced for the suppression of premalignant conditions such as oral submucous fibrosis (OSMF) to prevent their differentiation into malignant lesions. Conventional treatment includes steroids, enzymes like hyaluronidase, trypsin, chymotrypsin and placental extracts which are advocated intralesionally and oral drugs like carotenoids, alpha lipoic acid, lycopene, vitamins, microelements and tea pigments have also been advocated.In this study, a total number of 30 patients with OSMF were taken and randomly divided into two groups with 15 patients each according to Khanna and Andrade group of classification 1995.

Characterization of Microwave-Controlled Polyacrylamide Graft Copolymer of Tamarind Seed Polysaccharide.

The main objective of the study was to prepare tamarind seed polysaccharide grafted copolymers of polyacrylamide (TSP-g-Am) using a 3 factorial design. Tamarind seed polysaccharide (TSP) was extracted, and grafted copolymer of TSP was prepared using polyacrylamide as copolymer and ceric ammonium nitrate as initiator. Various batches (F1-F9) of TSP-g-Am were prepared, among which F1 showed highest grafting efficiency; hence, the prepared TSP-g-Am (F1) was evaluated for grafting efficiency, conversion, effect of initiator and further characterized using SEM analysis, contact angle determination, DSC analysis, swelling index, swelling and deswelling, and chemical resistance.

Oral health indicators of oral health related quality of life among Indian elderly: A cross-sectional study.

Aim: To assess the impact of tooth loss and periodontal status on oral health related quality of life among Indian elderly.

Methodology: This study was a cross-sectional study conducted among 1200 elderly subjects of Faridabad district of Haryana. Study subjects were selected by a combination of systematic, cluster and multistage sampling techniques.

Does the presence and amount of epinephrine in 2% lidocaine affect its anesthetic efficacy in the management of symptomatic maxillary molars with irreversible pulpitis?

Background: This was a randomized controlled clinical trial that aimed to evaluate the anesthetic efficacy of 2% lidocaine combined with different concentrations of epinephrine (plain, 1:200,000 and 1:80,000) during endodontic treatment of maxillary molars with symptomatic irreversible pulpitis.

Methods: The trial included 144 adult patients who were randomly allocated to three treatment groups. All patients received buccal-plus-palatal infiltration.

Treatment of Class II division I malocclusion having severe crowding, proclination with noncomplaint fixed functional appliance therapy, and frictionless mechanics.

Our Objective was to treat a patient having proclined, protruded teeth along with a Class II Skeletal malocclusion. 0.022 × 0.

Arch Measurements, Bigonial Width, Dental Caries, and Their Effect on Occurrence of Mandibular Incisors Crowding in Early Mixed Dentition Period.

Aim And Objective: To assess the effect of various arch parameters, bigonial angle, and caries occurrence on mandibular incisors crowding during the early mixed dentition period.

Materials And Methods: Sixty children (mean age of 7.5 years) with mandibular anterior incisors crowding and class I molar relationship in early mixed dentition were selected.

Evaluation of Knowledge, Attitude, Awareness, Fear, and Anxiety Levels in Pateints Visisting the Routine Dental Outpatient Department during COVID 19 Pandemic - A Cross-sectional Hospital-Based Observational Research.

Background: Since the COVID 19 pandemic has hit worldwide wide being one of the biggest psychological menace that had an impact on all socioeconomic strata as well age group of society. Looking at the present scenario of confusion and anxiety a cross-sectional research was planned to see the level of fear and anxiety among a patient who is already having concern about his oral health and when he comes to a dental outpatient department (OPD) what are his main areas of concern and anxiety.

Methodology: Cross-sectional study was planned in faculty of dental sciences, all the patients coming to dental OPD over a period of 3 months from November 2020 to March 2021 were asked to self-fill or fill with assistance a google form compromising of 10 multiple response questionnaire validated according to previous studies and surveys.

Management of patients with allergy to local anesthetics: two case reports.

Lidocaine is the most commonly used local anesthetic (LA) agent in various dental as well as oral and maxillofacial procedures. Although rare, adverse effects and allergic reactions to lidocaine have been reported. In patients with suspected allergy to LA or a history of such reaction, careful history-taking and allergy testing should be performed to choose an alternative LA agent to avoid any adverse effects.

Understanding the mechanism of commonly occurring COVID-19-associated oral lesions.

Covid-19 pandemic is a novel disease with gradual emergence of its signs and symptoms. Oral healthcare providers had a setback in their dental practices due to the high rate of infectivity and the risk of contracting the disease through the patients carrying the virus. Once the dental practice resumed to its normalcy the dental surgeons came across a variety of oral manifestations in patients with a history of Covid and post recovery.

Periodontal health of the geriatric population in old-age homes of Delhi, India.

Background: Periodontal disease is one of the leading causes of tooth loss in the geriatric population. Assessment of periodontal disease in a population is an important step in planning effective prevention and control programs for periodontal disease. Therefore, a study was carried out in old-age homes of Delhi to assess the periodontal status of 65-74-year-old elderly and recommend interventions to improve their periodontal health.

Functional outcome of two different grafting techniques in the surgical management of oral submucous fibrosis: a comparative evaluation.

Objective: To evaluate the functional efficacy of two different grafting techniques following the fibrotomy among subjects with oral submucous fibrosis (OSMF).

Design: Forty consecutively treated OSMF subjects between 20 and 40 years who had grades 3 and 4a OSMF and mouth opening < 15 mm were included in the present study. All the subjects were randomly divided into two groups.

Assessment of Relationship of ABO Blood Groups in Oral Cancer Patients - A Retrospective Study.

Introduction: India is a high-risk region for oropharyngeal cancer (OC) due to high prevalence of tobacco, betel nut, and alcohol and accounts for 30% of all new cases of oral cancer annually.

Materials And Methods: Records of all 73 diagnosed cases of different types of OC and oropharynx patients were analyzed who reported in "Tobacco cessation center"' of the Institute between January 2017 and December 2019. The patients' demographic details, blood groups, oral habits, and clinicohistological records were obtained from the medical records available in the hospital.

Clinical Efficacy of Resin Infiltration Technique Alone or in Combination with Micro Abrasion and in-Office Bleaching in Adults with Mild-to-Moderate Fluorosis Stains.

Background: The present study was conducted to evaluate the clinical efficacy of resin infiltration technique alone or in combination with microabrasion and in-office bleaching in adults with mild-to-moderate fluorosis stains on permanent maxillary anterior teeth at the end of 1 month.

Materials And Methods: A total of 30 patients with nonpitted fluorosis stains on maxillary anterior were classified as mild ( = 15) and moderate ( = 15). Each grade is subdivided into three groups as Group A, Group B, and Group C.

Three-Dimensional Evaluation of the Tongue Volume in Different Dentoskeletal Patterns - A Cone Beam Computed Tomographic Study.

Aim: The aim of this study is to evaluate tongue volume using cone-beam computed tomographic (CBCT) and its correlation to different growth patterns in patients.

Materials And Methods: Sixty preorthodontic records of CBCT scans of subjects ranging from 14 to 25 age group from retrospective data of department were selected for the study. Patients were classified into three groups based on angle FMA; Group I ( = 20) with average growth pattern (FMA 22°-28°); Group II ( = 20) vertical growth pattern (FMA >28°); Group III ( = 25) horizontal growth pattern (FMA <20°).

Effect of Craniofacial Morphology on Pharyngeal Airway Volume Measured Using Cone-Beam Computed Tomography (CBCT)-A Retrospective Pilot Study.

Background: The present study aimed to determine the correlation between pharyngeal airway volume and craniofacial morphology through cone-beam computed tomography (CBCT). Additionally, the study analyzed the influence of gender on pharyngeal airway volume. (2) Methods: 80 CBCT scans of 40 male and 40 female patients (mean age: 15.

Association between Parental Behavior and Child's Oral Health among 3-5-year-old Children in Bengaluru City.

Aim: Parental behavior is known to influence the well-being and disease outcomes in children. The environment which they create for the child can influence oral health behaviors and status. Hence, the present study aimed to determine the association of parental behavior with oral health status among 3-5-year-old children in Bengaluru city.

Perception and willingness toward oral pathology and histology as a subject and profession among Indian dental undergraduates.

Background: Oral pathology, a branch of dentistry which is often termed as a nonclinical branch deserves a better description as fundamental knowledge of oral pathology is essential to become a successful dental clinician. This study was conducted to analyze the approach toward Oral Pathology and Histology as a subject and profession among dental undergraduates.

Materials And Methods: A questionnaire-based, cross-sectional study was conducted among 200 students which included the 3 year, 4 year and interns studying in a Dental College in Gurugram, Haryana.

Association of sense of coherence with oral health behaviors and gingival bleeding among adolescents.

Context: Adolescents experience many types of gingival and periodontal diseases, including gingivitis, localized or generalized aggressive periodontitis, and periodontal complications of various systemic diseases. The occurrence of periodontal diseases is not only related to biotic factors but may also be affected by nonbiotic factors such as oral health behaviors and practices. Various factors that influence an individual's health-related behaviors include a psychosocial construct named sense of coherence (SOC).

Antiviral Essential Oil Components Against SARS-CoV-2 in Pre-procedural Mouth Rinses for Dental Settings During COVID-19: A Computational Study.

COVID-19 mainly spreads through cough or sneeze droplets produced by an infected person. The viral particles are mostly present in the oral cavity. The risk of contracting COVID-19 is high in the dental profession due to the nature of procedures involved that produce aerosols.