Effect of soluble fiber supplementation on lipid parameters in subjects with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.

Background: There is no consensus in the existing literature regarding the effect of soluble fiber on the lipid profile of patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis of randomized controlled trials aimed to assess the effect of soluble fiber on triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in T2DM patients.

Methods: PubMed/MEDLINE, Scopus, and ISI Web of sciences were searched for RCTs up to 4 May 2024.

Exosomal signaling in gynecologic cancer development: The role of cancer-associated fibroblasts.

Gynecologic cancer, a prevalent and debilitating disease affecting women worldwide, is characterized by the uncontrolled proliferation of cells in the reproductive organs. The complex etiology of gynecologic cancer encompasses multiple subtypes, including cervical, ovarian, uterine, vaginal, and vulvar cancers. Despite optimal treatment strategies, which typically involve cytoreductive surgery and platinum-based chemotherapy, gynecologic cancer frequently exhibits recalcitrant relapse and poor prognosis.

The Professional Identity of STEM Faculty as Instructors of Course-based Research Experiences.

The professional identity of scientists has historically been cultivated to value research over teaching, which can undermine initiatives that aim to reform science education. Course-Based Research Experiences (CRE) and the inclusive Research and Education Communities (iREC) are two successful and impactful reform efforts that integrate research and teaching. The aim of this study is to explicate the professional identity of instructors who implement a CRE within an established iREC and to explore how this identity contributes to the success of these programs.

An Unbiased Approach to Identifying Cellular Reprogramming-Inducible Enhancers.

Cellular reprogramming of somatic cells towards induced pluripotency is a multistep stochastic process mediated by the transcription factors Oct4, Sox2, Klf4 and c-Myc (OSKM), which orchestrate global epigenetic and transcriptional changes. We performed a large-scale analysis of integrated ChIP-seq, ATAC-seq and RNA-seq data and revealed the spatiotemporal highly dynamic pattern of OSKM DNA binding during reprogramming. We found that OSKM show distinct temporal patterns of binding to different classes of pluripotency-related enhancers.

Chemical Characterization and Assessment of the Neuroprotective Potential of .

L., commonly known as eyebright, is a medicinal plant used in folk medicine for eye disorders and memory loss. Due to its abundance of compounds with proven neuroprotective properties, there has been growing interest in exploring eyebright's potential health benefits, particularly for preventing or treating neurodegenerative diseases like Alzheimer's disease.

Damage Investigation in PMMA Polymer: Experimental and Phase-Field Approaches.

The prediction of crack patterns is one of the main tasks in the field of fracture mechanics in order to prevent the total damage of various materials, particularly Methyl Methacrylate Polymer (PMMA). The few data in the literature underscores the need for additional experiments on PMMA to analyze the performance of the phase-field approach to predict crack trajectories. The main purpose of this study is to verify the accuracy of the phase-field approach with a staggered scheme, based on spectral decomposition, for predicting crack propagation in PMMA specimens by comparing it with the experimental results presented in this work.

Non-Native Flora of the Mediterranean Lesvos Island (East Aegean, Greece): Floristic Analysis, Traits, and Assessment.

A checklist of Lesvos Island's non-native vascular flora is presented. Through the literature and a roadside survey, we recorded 187 non-native plant taxa, representing 12% of the total regional flora. A total of 37 taxa were reported for the first time for Lesvos, including three taxa that are also new to the Greek non-native flora.

Nanoparticle biosensors for cardiovascular disease detection.

Early detection and management of cardiovascular diseases (CVDs) are crucial for patient survival and long-term health. CVD biomarkers such as cardiac Troponin-I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatine kinase MB (CK-MB), Galectin-3 (Gal-3), etc are released into the circulation following heart muscle injury, ie, acute myocardial infarction (AMI). Biosensor technology including the use of nanoparticles can be designed to target specific biomarkers associated with CVD, enabling early detection and more rapid intervention to decrease morbidity and mortality.

Pt@WS Mott-Schottky Heterojunction Boosts Light-Driven Active Ion Transport for Enhanced Ionic Power Harvesting.

Bioinspired light-driven ion transport in two-dimensional (2D) nanofluidics offers exciting prospects for solar energy harvesting. Current single-component nanofluidic membranes often suffer from low light-induced driving forces due to the easy recombination of photogenerated electron-hole pairs. Herein, we present a Pt@WS Mott-Schottky heterojunction-based 2D nanofluidic membrane for boosting light-driven active ion transport and solar enhanced ionic power harvesting.

Antimicrobial Resistance Surveillance in Human Pathogens in Ahmedabad: A One-Year Prospective Study.

Antimicrobial resistance (AMR) is an escalating global concern, particularly in developing countries like India. A 1-year prospective study was conducted on AMR in human pathogens from Ahmedabad, India. The study aimed to generate an evidence-based database on the AMR profile of pathogens in this region.

Improved exponential smoothing grey-holt models for electricity price forecasting using whale optimization.

This study introduces a ground-breaking approach, the Whale Optimization Algorithm (WOA)-based multivariate exponential smoothing Grey-Holt (GMHES) model, designed for electricity price forecasting. Key features of the proposed WOA-GMHES(1,N) model include leveraging historical data to comprehend the underlying trends in electricity prices and utilizing the WOA algorithm for adaptive optimization of model parameters to capture evolving market dynamics. Evaluating the model on authentic high- and low-voltage electricity price data from Cameroon demonstrates its superiority over competing models.

Hydrogeochemical investigation and water quality assessment of the Indus River in the semiarid region of Ladakh, India.

The decline in water quality, particularly in river water, is a significant concern, especially in semi-arid areas and tourist destinations such as Ladakh. Periodic assessment of water quality could be a crucial step for ensuring its potability and serve as a foundation for formulating effective policies for sustainable water resource management. Consequently, this research aimed to analyze the periodic variations in the water quality of Indus River for domestic and agricultural use, focusing on the impact of geochemical processes within the basin.

Non-Hospitalized Patients With Post-COVID Condition and Myopathic Electromyography Findings Show no Difference in Symptom Severity and Clinical Manifestations Compared to Those Without Myopathic Findings.

Introduction: The COVID-19 pandemic has resulted in a post-infectious syndrome designated as long-COVID or post-COVID condition (PCC) that presents with numerous symptoms including fatigue and myalgias. This study evaluated myopathic electromyography (EMG) findings in non-hospitalized PCC patients in relation to symptom severity, quality of life (QoL), and physical function.

Methods: Twenty-nine PCC patients with persistent symptoms ≥ 3 months after laboratory-confirmed SARS-CoV-2 infection, without hospitalization or comorbidities, were included.

Doping dependency of chitosan and PAA controlled CdSe quantum dots for catalytic and bactericidal behavior by inhibiting DNA gyrase and DHFR through molecular docking.

The presence of toxic dyes in industrial waste dramatically diminishes the beneficial effects of remediation efforts. To overcome the hazardous impacts of dyes on biodiversity and environment, we integrated polymers into nanoparticles to substantially enhance their functionality and performance. 2 and 4 wt% of chitosan (CS) and 3 wt% of polyacrylic acid (PAA) doped cadmium selenide (CdSe) nanostructures (NSs) were prepared by co-precipitation approach.

Development of validated HPTLC methods for determination of triterpenoids and flavan-3-ols in leaf and stembark of Dubard.

Dubard is a highly reputed medicinal plant of Ayurveda. In the current study, High-performance Thin-layer chromatographic (HPTLC) techniques were established for the analysis of triterpenoids like lupeol (LU), betulinic acid (BA), epimeric flavan-3-ols (+)-catechin (CA), and (-)-epicatechin (ECA), in its leaf and stembark. HPTLC separation was performed using petroleum ether: ethyl acetate: toluene: formic acid (7:2:1:0.

Prostate cancer burden in South Asia: A systematic analysis of global burden of disease data (1990-2021).

Objectives: The objectives of this study were to analyze trends in prostate cancer incidence, incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021 via data from the Global Burden of Disease (GBD) study in South Asia. Additionally, the study projects future prostate cancer incidence rates up to 2031 to inform public health interventions in South Asia.

Methods: Data covering South Asian countries such as Bangladesh, Bhutan, India, Nepal, and Pakistan were obtained from the GBD 2021 portal.

DNA methylation patterns of circadian and ultradian genes are altered in the peripheral blood of patients with hidradenitis suppurativa.

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects hair follicles in areas with apocrine sweat glands, such as the underarms, groin, and buttocks. The pathogenesis of HS is not fully understood, but considering the key role played by the biological clock in the control of immune/inflammatory processes the derangement of circadian and ultradian pathways could be hypothesized.

Methods: We analyzed genome-wide DNA methylation patterns in peripheral blood from 24 HS cases and 24 controls using the Infinium HumanMethylation450 BeadChip array (Illumina), followed by bioinformatics and statistical analyses.

Tripartite motif (TRIM) proteins roles in the regulation of immune system responses: Focus on autoimmune diseases.

The tripartite motif (TRIM) proteins are well-studied as essential modulators of many processes, including the modulation of several pathways linked to immunological reactions. Most TRIM family members can polyubiquitinate the targeted proteins by acting as E3 ubiquitin ligases. According to current research, TRIMs play a critical role in innate immune response via modifying transcription factors, pattern recognition receptors (PRRs), and key adaptor proteins within innate immunity.

The ability of teleost fishes to recognize individual faces suggests an early evolutionary origin in vertebrates.

The face is the most important area on the human body for visually differentiating between individuals. When encountering another person, humans initially gaze at and perceive the face holistically, utilizing relational information and specific neural systems. Information such as identity and emotional state are then obtained from the face by distinguishing between small inter-individual differences, i.

Ferroptosis: when metabolism meets cell death.

We present here a comprehensive update on recent advancements in the field of ferroptosis, with a particular emphasis on its metabolic underpinnings and physiological impacts. After briefly introducing landmark studies that have helped to shape the concept of ferroptosis as a distinct form of cell death, we critically evaluate the key metabolic determinants involved in its regulation. These include the metabolism of essential trace elements such as selenium and iron; amino acids such as cyst(e)ine, methionine, glutamine/glutamate, and tryptophan; and carbohydrates, covering glycolysis, the citric acid cycle, the electron transport chain, and the pentose phosphate pathway.

Robinin Isolated From Solanum Asperum Exhibits Pharmacological Actions in the Central Nervous System of Adult Zebrafish (Danio rerio).

This study investigated the anxiolytic, anticonvulsant and memory preservation effects of the flavonoid robinin. The compound, administered at doses of 4, 20 and 40 mg/kg, did not show toxicity after 96 h of monitoring. In behavioural experiments with zebrafish, robinin did not cause significant changes in motor functions, but it impairs locomotor activity and demonstrates anxiolytic properties, evidenced by the increase in the time spent in the clean zone of the protector.

Research Priorities for Autonomous Sensory Meridian Response: An Interdisciplinary Delphi Study.

Autonomous Sensory Meridian Response (ASMR) is a multisensory experience most often associated with feelings of relaxation and altered consciousness, elicited by stimuli which include whispering, repetitive movements, and close personal attention. Since 2015, ASMR research has grown rapidly, spanning disciplines from neuroscience to media studies but lacking a collaborative or interdisciplinary approach. To build a cohesive and connected structure for ASMR research moving forwards, a modified Delphi study was conducted with ASMR experts, practitioners, community members, and researchers from various disciplines.

Tear film stability in children: Age and sex associations explored through non-invasive tear break-up time.

Purpose: The stability of the tear film is crucial for maintaining good ocular health. Its assessment provides valuable insights into paediatric eye conditions. This study investigates the stability of the tear film in children and its association with predictive factors such as age and sex, for a better understanding of tear film dynamics in a paediatric population.