326 results match your criteria: "SBU Dışkapı Yıldırım Beyazıt Training and Research Hospital[Affiliation]"

Neurocysticercosis (NCC) has been classified as a neglected tropical disease by the World Health Organization (WHO), with the condition being regarded as the most significant parasitic disease affecting the nervous system. Hence, the aim of this study was to conduct a review of previously published case reports on this topic in order to ascertain whether there is an increasing trend of NCC worldwide and evaluate the cases that have been presented. After a comprehensive search of the Web of Science Core Collection using the keywords "neurocysticercosis" and "case reports", studies were selected by applying inclusion criteria.

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Introduction: To assess and compare the knowledge of ChatGPT and Google Gemini in answering public-based and scientific questions about peripheral artery disease (PAD).

Methods: Frequently asked questions (FAQs) about PAD were generated by evaluating posts on social media, and the latest edition of the European Society of Cardiology (ESC) guideline was evaluated and recommendations about PAD were translated into questions. All questions were prepared in English and were asked to ChatGPT 4 and Google Gemini (formerly Google Bard) applications.

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The role of partial splenic artery embolization in the management of refractory esophageal variceal bleeding due to portal vein thrombosis.

BMC Pediatr

January 2025

Liver Transplantation & Hepatopancreatobiliary Surgery Unit, Department of General Surgery, Istanbul Faculty of Medicine, Istanbul, Türkiye.

Background: Gastro-esophageal variceal hemorrhage (GEVH) is one of the major causes of life-threatening gastrointestinal bleeding in children. Medical, endoscopic, angiographic, and surgical interventions can be utilized in treatment. In this case report, we describe partial splenic artery embolization for refractory GEVH due to portal vein thrombosis.

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Background: Rare bleeding disorders (RBDs) include fibrinogen (Factor I), prothrombin (Factor II), Factor V(FV), combined Factor V and Factor VIII, Factor VII, Factor X, Factor XI, Factor XII, and Factor XIII deficiencies. This group accounts for 3-5% of all factor deficiencies. Different symptoms may occur, ranging from mild or moderate bleeding to serious and life-threatening bleeding, which may not be related to the factor level.

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The psychometric properties of the Four Square Step Test in older adults with mild cognitive impairment.

Geriatr Nurs

December 2024

University of Health Sciences, Gulhane Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Ankara, Türkiye. Electronic address:

Purpose: The study aimed to determine the test-retest, interrater, and minimum detectable change, concurrent and known-groups validity in older adults with mild cognitive impairment. Minimal detectable change values are the degree of change needed to exceed a measurement's error within a confidence limit.

Methods: A total of 46 older adults with mild cognitive impairment and 34 healthy controls were included.

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Can fecal calprotectin be used as a biomarker of non-alcoholic fatty liver disease in obese adolescents?

BMC Pediatr

December 2024

Department of Pediatrics, Division of Pediatric Gastroenterology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Background: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing with obesity, and it is believed that the ongoing low-grade inflammation in obesity and alterations in the enterohepatic axis contributing this process. This study aimed to determine the role of fecal calprotectin (FC) as inflammatory biomarker in obesity and NAFLD.

Methods: Between November 2022-August 2023, 31 obese and 10 healthy adolescents aged between 10 and 18 years enrolled in this prospective controlled study.

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Background: The role of NT-proBNP as a cardiac biomarker for predicting short-term major adverse cardiovascular events (MACEs) in acute coronary syndrome (ACS) remains unclear.

Aims: This study investigated the utility of the NT-proBNP level for predicting MACEs within a 6-month period in patients with ACS.

Methods: This prospective study included 241 consecutively enrolled adults with ACS between September 2023 and February 2024.

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Acute treadmill exercise induces mitochondrial unfolded protein response in skeletal muscle of male rats.

Biochim Biophys Acta Bioenerg

December 2024

Division of Exercise Nutrition and Metabolism, Faculty of Sport Sciences, Hacettepe University, Ankara, Turkey.

Mitochondria are often referred to as the energy centers of the cell and are recognized as key players in signal transduction, sensing, and responding to internal and external stimuli. Under stress conditions, the mitochondrial unfolded protein response (UPR), a conserved mitochondrial quality control mechanism, is activated to maintain mitochondrial and cellular homeostasis. As a physiological stimulus, exercise-induced mitochondrial perturbations trigger UPR, coordinating mitochondria-to-nucleus communication and initiating a transcriptional program to restore mitochondrial function.

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Objective: The aim of the study was to determine the prevalence, risk, and predisposing factors of diabetic foot ulcers in adults with diabetes.

Methods: This study is multi-centered descriptive cross-sectional research. Data were collected between June 2022 and November 2022 in seven cities, including five teaching and research hospitals and two public hospitals.

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Hydatid disease: imaging, treatment, and beyond.

Clin Radiol

January 2025

Istanbul University Faculty of Medicine, Department of Radiology, Istanbul, Turkey. Electronic address:

Hydatidosis is an endemic parasitic disease that can occur in almost any part of the body. It presents in two different forms according to the type of tapeworm: Echinococcus granulosus (hydatid disease [HD]) and Echinococcus multilocularis (alveolar HD). Radiological imaging can reveal the type of cyst, disease activity and progression, and complications, with features depending on the HD stage, the organ involved, and complications.

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Introduction: The workload of physicians increased due to the number of patients presenting with suspicion of coronavirus 2019 (COVID-19) and the prolonged wait times in the emergency department during the COVID-19 pandemic. Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) is a protein present in platelets and endothelial cells; it is activated by inflammation from COVID-19 and may be associated with COVID-19's known thrombotic risk. We aimed to determine whether SCUBE-1 levels are diagnostically correlated in suspected COVID-19 patients, and whether SCUBE-1 correlated with severity of disease and, therefore, might be useful to guide hospitalization/discharge decisions.

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Purpose: In this study, the effects of insulin resistance and the role of the endothelial dysfunction marker YKL-40 in male infertility were investigated.

Methods: This study was conducted with male patients who underwent fertility investigations in the in vitro fertilization (IVF) unit of a tertiary center. Semen samples were evaluated after two to five days of sexual abstinence.

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Article Synopsis
  • This study investigated if intravenous calcium pretreatment can help prevent hypotension caused by diltiazem in adults with atrial fibrillation or flutter and fast heart rates.
  • A total of 217 patients participated, being assigned to either a placebo group or groups receiving different doses of IV calcium before treatment with diltiazem.
  • Results showed that calcium pretreatment was effective in preventing hypotension without reducing the effectiveness of diltiazem in controlling heart rates, and no significant side effects were noted between groups.
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Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C).

J Exp Med

December 2024

Section of Paediatric Infectious Disease, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.

Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel statistical framework of gene burden analysis, "burdenMC," which identified an enrichment for rare predicted-deleterious variants in BTNL8 (OR = 4.

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Objective: Chronic use of glucocorticoids during childhood can lead to a decrease in hormone release, including ACTH, GH, TSH, and LH, as well as reduced IGF-1 activity. This can result in osteoporotic changes and hinder growth in height. Resveratrol, an antioxidant with phytoestrogen properties, may improve bone health by increasing bone mineral density in postmenopausal women.

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With a 5-year survival of ˂ 10%, pancreatic cancer is one of the leading causes of cancer-related deaths. Given the role of the distribution of tumor-infiltrating lymphocyte (TILs) subtypes in the tumor and its microenvironment in predicting prognosis, the development of new targeted therapies based on T-cell adaptive response has gained considerable attention. This study aimed to examine the peritumoral spread of TILs and its relationship with other prognostic parameters and survival.

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Article Synopsis
  • * Researchers collected 1,346 nasopharyngeal swab samples, isolating 879 high-quality genomes for analysis, focusing on clades, lineages, age-related associations, and mutations over a 10-month period.
  • * Specific variants like B.1.1.7 (Alpha) and B.1.617.2 (Delta) were identified, along with unique mutations linked to the later Omicron variant, emphasizing the need for ongoing genetic monitoring to improve COVID-19 prevention strategies.
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Extrapulmonary tuberculosis (EPTB) is an important public health problem due to its diverse clinical presentations, diagnostic complexities, and significant impact on patient outcomes and public health. Our study aimed to understand the sociodemographic, clinical, and laboratory characteristics as well as diagnostic and treatment modalities of adult patients with EPTB. This is a multicentric retrospective study that covers patients with EPTB cases followed up from January 2015 to December 2022 among tuberculosis (TB) dispensaries and Infectious Diseases and Clinical Microbiology clinics of 15 hospitals located in various regions of Turkey.

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Purpose: We investigated the efficacy and safety of a high-flow nasal cannula (HFNC) at different flow rates compared to noninvasive ventilation (NIV) in patients with acute chronic obstructive pulmonary disease (COPD) exacerbations.

Methods: This prospective, randomized, single-blind study assigned patients to one of three study groups. The NIV group (n = 47) received bilevel positive airway pressure.

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Predictive Significance of Laboratory Tests in Bacteremic Brucellosis.

Iran J Public Health

April 2024

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Kırşehir Ahi Evran, Kırşehir, Van, Türkiye.

Background: Brucellosis is one of the most common zoonotic infections. Although culture is the gold standard diagnostic method, bacterial growth in blood cultures may not always occur due to various factors. We aimed to investigate demographic, clinical, and laboratory findings that may have predictive significance for bacteremia in brucellosis.

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Prognostic role of serum copeptin levels in adults with graded traumatic brain injury.

Ir J Med Sci

October 2024

Department of Emergency Medicine, University of Health Sciences, Haseki Training and Research Hospital, Ugur Mumcu, Atatürk Street 54, 34265, Sultangazi, Istanbul, Turkey.

Article Synopsis
  • * Results show that patients with moderate to severe TBI have significantly higher copeptin levels than those with mild injuries, with a specific cutoff value indicating more severe trauma.
  • * Elevated copeptin levels also correlate with abnormal CT scans and higher mortality rates within 28 days, suggesting that it can be a useful biomarker in managing head trauma patients.
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