Sustainable microwave-based eutectic mixture assisted purification of low-methoxy pectin and its role as an edible emulsifier in carrot jam preparation.

An optimized microwave-assisted low methoxyl pectin extraction procedure was described. Six task specific deep eutectic solvents (TDES) were used in the extraction of pectin from bilimbi (LMABP) and pomelo peels (LMCGP). Response surface methodology-based optimization of the parameters like feed-to-solvent ratio, extraction time, and microwave power level results in 72.

Influence of deep-eutectic and organic solvents on the recovery, molecular mass, and functional properties of dextran: Application using dextran film.

The novelty of this study is to examine the impact of different solvent systems, namely organic and deep eutectic solvents, on recovery yield, antioxidant activity, poly-dispersity index, and functional properties of microbial dextran. The optimized conditions for maximum dextran recovery were obtained using organic solvent found to be: supernatant: organic solvent - 1:4 v/v; organic solvents: ethanol, isopropanol, and acetone; temperature: 0 °C; and time: 16 h. Though a similar structure was obtained for dextran recovered using various solvents, the degree of branching varied, with DES-precipitated dextran having the highest branching of 20 % α-(1,3) linkages.

L-tryptophan carbon dots as a fluorescent probe for malachite green detection.

Development of a rapid and sensitive detection method for hazardous dyes attracts considerable research interest. In this work, L-Tryptophan-based Carbon dots were developed as a fluorescence sensor for the detection of Malachite green (MG). Green fluorescent L-Trp-C-dots were synthesized by a simple pyrolysis technique using L-Trp as the starting precursor.

Multimodal autism detection: Deep hybrid model with improved feature level fusion.

Objective: Social communication difficulties are a characteristic of autism spectrum disorder (ASD), a neurodevelopmental condition. The earlier method of diagnosing autism largely relied on error-prone behavioral observation of symptoms. More intelligence approaches are in progress to diagnose the disorder, which still demands improvement in prediction accuracy.

Enhancing diabetic retinopathy and macular edema detection through multi scale feature fusion using deep learning model.

Background: This work tackles the growing problem of early identification of diabetic retinopathy and diabetic macular edema. The deep neural network design utilizes multi-scale feature fusion to improve automated diagnostic accuracy. Methods This approach uses convolutional neural networks (CNN) and is designed to combine higher-level semantic inputs with low-level textural characteristics.

Profile of Falls and Its Associated Factors among Adults with Visual Impairment: A Cross-sectional Study from a Tertiary Eye Hospital.

Background: Falls among adults with visual impairment (VI) are underreported or underrepresented compared to elderly falls.

Objectives: To report falls among the young, middle-aged, and elderly adults with VI.

Materials And Methods: This cross-sectional study recruited subjects from a tertiary eye care center with VI aged ≥18 years based on clinical records.

Genomic analysis of colistin and carbapenem resistant Klebsiella pneumoniae GC29.

Objectives: This study aims to sequence and analyze a clinical strain of Klebsiella pneumoniae (GC29) focusing on its antibiotic resistance profiles, virulence traits, and evolutionary lineage. The goal is to provide insights into the challenges of combating multi-drug resistant K. pneumoniae and emphasize the necessity for targeted strategies to address this public health threat.

Evolutionary Analysis of the hnRNP Interactomes and Their Functions in Eukaryotes.

The heterogeneous nuclear ribonucleoproteins (hnRNPs) are central regulators of several fundamental biological processes across eukaryotes. hnRNPs have been implicated in transcriptional and post-transcriptional regulation, telomere maintenance, stem cell maintenance, among other processes in major model organisms. Though hnRNPs are known to be conserved in eukaryotes, the evolutionary conservation/diversification of their functions across species is yet to be understood.

Exponential Wiener index of some silicate networks.

Any graph that depicts a particular molecular structure can be given a topological graph index, also known as a molecular descriptor. This index can be used to examine numerical data and discover more about specific physical properties of molecules. Silicates are hard crystals that can be sliced into little pieces.

2-Methoxy-4-formylphenol suppresses methylglyoxal glycation mediated structural alterations and esterase activity of hemoglobin - A multi spectroscopic, biophysical and in-silico study.

Glycation is the non-enzymatic reaction of glucose or its metabolites to proteins, causing irreversible changes. Methylglyoxal, a dicarbonyl, affects the structure and function of physiologically important proteins. Being a major circulatory protein, hemoglobin is highly prone to glycation.

Zaluzanin-D enriched extract mediated copper oxide nanoparticles synthesis and their anti-oxidant, anti-inflammatory and DNA methylation altering properties.

Metal oxide nanoparticles synthesized with the aid of medicinal plant extracts are showing potential as treatment options for inflammatory diseases. Two key benefits of this synthesis method is: the synthesis process is environmentally benign and the utilization of medicinal plant-derived extracts adds to the medicinal value of the synthesized nanoparticle. Earlier, sesquiterpene lactone zaluzanin-D (ZD) has been isolated from leaves of .

Significantly Enhanced Thermoelectric Performance of -Type MgSb via Zn Substitution on Mg(2) Site: Optimization of Hole Concentration Through Ag Doping.

-Type MgSb-based thermoelectric materials have recently garnered significant interest due to their superior thermoelectric efficiency. Yet, the advancement of -type MgSb for thermoelectric applications is impeded by its lower dimensionless figure of merit (). In this study, we demonstrate the improved thermoelectric performance of -type MgSb through the strategic optimization of Zn content and Ag doping on the Mg/Zn(2) site.

Comprehensive insights into UTIs: from pathophysiology to precision diagnosis and management.

Urinary tract infections (UTIs) are the second most common infectious disease, predominantly impacting women with 150 million individuals affected globally. It increases the socio-economic burden of society and is mainly caused by , , , spp., and spp.

Microbially Induced Calcium Carbonate Precipitation Using Lysinibacillus sp.: A Ureolytic Bacterium from Uttarakhand for Soil Stabilization.

Microbially induced calcium carbonate precipitation (MICP) is a soil remediation method that has emerged as a viable and long-term solution for enhancing soil mechanical qualities. The technique of MICP that has been extensively researched is urea hydrolysis, which occurs naturally in the environment by urease-producing bacteria as part of their fundamental metabolic processes. The objectives of the current study include screening and identifying native ureolytic bacteria from soil in Uttarakhand, optimizing growth factors for increased urease activity, and calcite precipitation by the bacteria using response surface methodology.

Monoallelic loss of RB1 enhances osteogenic differentiation and delays DNA repair without inducing tumorigenicity.

The Retinoblastoma (RB1) gene plays a pivotal role in osteogenic differentiation. Our previous study, employing temporal gene expression analysis using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), revealed the deregulation of osteogenic differentiation in patient-derived heterozygous RB1 mutant orbital adipose-derived mesenchymal stem cells (OAMSCs). The study revealed increased Alizarin Red staining, suggesting heightened mineralization without a corresponding increase in osteogenic lineage-specific gene expression.

Human Antigen R -mediated modulation of Transforming Growth Factor Beta 1 expression in retinal pathological milieu.

The fate and stability of messenger RNA (mRNA), from transcription to degradation is regulated by a dynamic shuttle of epigenetic modifications and RNA binding proteins in maintaining healthy cellular homeostasis and disease development. While Transforming Growth Factor Beta 1 (TGFβ1) has been implicated as a key regulator for diabetic retinopathy, a microvascular complication of diabetes, the RNA binding proteins post-transcriptionally regulating its expression remain unreported in the ocular context. Further, dysfunction of TGFβ1 signalling is also strongly associated with angiogenesis, inflammatory responses and tissue fibrosis in many eye conditions leading to vision loss.

Implementing heuristic-based multiscale depth-wise separable adaptive temporal convolutional network for ambient air quality prediction using real time data.

In many emerging nations, rapid industrialization and urbanization have led to heightened levels of air pollution. This sudden rise in air pollution, which affects global sustainability and human health, has become a significant concern for citizens and governments. While most current methods for predicting air quality rely on shallow models and often yield unsatisfactory results, our study explores a deep architectural model for forecasting air quality.

Correlated changes in stress resistance and biochemical parameters in response to long-term protein restriction in .

Studies in fruit flies, , have observed considerable variation in the effect of dietary protein restriction (PR) on various fitness traits. In addition, not only are there inconsistent results relating lifespan to stress resistance, but also the long-term effects of PR are unexplored. We study PR implementation across generations (long term) hypothesizing that it will be beneficial for fitness traits, stress resistance and storage reserves due to nutritional plasticity transferred by parents to offspring in earlier studies.

Microcrystalline Cellulose-A Green Alternative to Conventional Soil Stabilizers.

Biopolymers are polymers of natural origin and are environmentally friendly, carbon neutral and less energy-intense additives that can be used for various geotechnical applications. Biopolymers like xanthan gum, carrageenan, chitosan, agar, gellan gum and gelatin have shown potential for improving subgrade strength, erosion resistance, and as canal liners and in slope stabilization. But minimal research has been carried out on cellulose-based biopolymers, particularly microcrystalline cellulose (MCC), for their application in geotechnical and geo-environmental engineering.

Biogenic amine tryptamine in human vaginal probiotic isolates mediates matrix inhibition and thwarts uropathogenic E. coli biofilm.

Probiotics offer a promising prophylactic approach against various pathogens and represent an alternative strategy to combat biofilm-related infections. In this study, we isolated vaginal commensal microbiota from 54 healthy Indian women to investigate their probiotic traits. We primarily explored the ability of cell-free supernatant (CFS) from Lactobacilli to prevent Uropathogenic Escherichia coli (UPEC) colonization and biofilm formation.

Designing optimal prototype filters for maximally decimated Cosine Modulated filter banks with rapid convergence.

An analytic design of a prototype filter for M-channel maximally decimated cosine-modulated Near Perfect Reconstruction (NPR) filter banks is proposed in this work. The prototype filter is created using the least-square (CLS) method with weighted constraints, which is one-dimensional and requires single-parameter optimization. Compared to existing approaches, this suggested method achieves rapid convergence by analytically determining the optimal step size, ensuring the 3 dB cutoff frequency at π/2 M.