296 results match your criteria: "SASTRA Deemed to-be University[Affiliation]"

A cleaner process of deinking waste paper pulp using Pseudomonas mendocina ED9 lipase supplemented enzyme cocktail.

Environ Sci Pollut Res Int

October 2020

Research Centre, Department of Botany and Microbiology, Lady Doak College, Madurai, Tamil Nadu, 625002, India.

Lipase enzyme has a critical role in deinking process along with other lignocellulosic enzymes. In this paper, we try to demonstrate the role of lipase in the enzyme cocktail used for enzymatic deinking. For this, we identified a potential lipolytic bacterium, Pseudomonas mendocina ED9 isolated from elephant dung with a molecular weight of 35 kDa.

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In recent years, the deployment of sensors and other ancillary technologies has turned out to be vital in the investigation of tribological behavioral patterns of composites. The tribological behavioral patterns of AA7075 hybrid metal matrix composites (MMCs) reinforced with multi-wall carbon nanotubes (MWCNTs), and pulverized fuel ash (PFA) were investigated in this work. The stir casting technique was used to fabricate the composites.

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Copper mediates mitochondrial biogenesis in retinal pigment epithelial cells.

Biochim Biophys Acta Mol Basis Dis

October 2020

R S Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO, Vision Research Foundation, Sankara Nethralaya, College Road, Nungambakkam, Chennai - 6, India. Electronic address:

Age related macular degeneration (AMD) is a multifactorial disease with genetic, biochemical and environmental risk factors. We observed a significant increase in copper levels in choroid-RPE from donor eyeballs with AMD. Adult retinal pigment epithelial cells (ARPE19 cells) exposed to copper in-vitro showed a 2-fold increase in copper influx transporter CTR1 and copper uptake at 50 μM concentration.

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Pulmonary fibrosis (PF) is a chronic and irreversible scarring disease in the lung with limited treatment options. Therefore, it is critical to identify new therapeutic options. This study was undertaken to identify the effects of tannic acid (TA), a naturally occurring dietary polyphenol, in a mouse model of PF.

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Semi supervised data mining model for the prognosis of pre-diabetic conditions in type 2 Diabetes Mellitus.

Bioinformation

December 2019

Department of Computer Science Engineering, SASTRA Deemed To be University, Srinivasa Ramanujan Centre (SRC), Kumbakonam, Tamil Nadu, India.

Diabetic Mellitus is the leading disease in the world irrespective of age and geographical location. It is estimated that 43% of the overall population is affected by the disease. The reasons for the disease include inappropriate diet lifestyle with allied symptoms like obesity.

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Vanadium oxide nanostructures for chemiresistive gas and vapour sensing: a review on state of the art.

Mikrochim Acta

March 2020

Functional Nanomaterials & Devices Laboratory, Centre for Nanotechnology & Advanced Biomaterials and School of Electrical & Electronics Engineering, SASTRA Deemed to be University, Thanjavur, Tamil Nadu, 613 401, India.

This review (with 200 references) summarises the state of the art of gas and vapour sensors based on the use of vanadium oxide (VO; with V occurring in various valencies) nanostructures. Following an introduction that covers the discussion of VO and their stable forms, the first large section covers experimental techniques employed for preparing VO nanostructures, with methods such as precipitation, hydrothermal synthesis, electrospinning, polyol techniques, laser deposition, and magnetron sputtering. The next section deals with VO-based sensors for oxidising gases such as nitrogen dioxide, carbon dioxide, oxygen, and ozone.

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Clinical complications of biodegradable screws for ligament injuries.

Mater Sci Eng C Mater Biol Appl

April 2020

Department of Orthopaedics, UConn Health, Farmington, CT, 06030, USA. Electronic address:

Article Synopsis
  • The anterior cruciate ligament (ACL) is essential for knee stability, and untreated injuries can cause further damage like meniscus tears and osteoarthritis.
  • Metal interference screws, used for graft fixation, have drawbacks such as mechanical mismatches and complications during post-operative imaging.
  • Biodegradable polymeric screws offer benefits but show long-term complications, emphasizing the need for better material engineering in orthopedic screw development for effective ligament repairs.
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The ineffective immunosuppressant's and targeted strategies to neutralize inflammatory mediators have worsened the scenario of heart failure and have opened many questions for debate. Stem cell therapy has proven to be a promising approach for treating heart following myocardial infarction (MI). Adult stem cells, induced pluripotent stem cells and embryonic stem cells are possible cell types and have successfully shown to regenerate damaged myocardial tissue in pre-clinical and clinical studies.

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Investigation on CH sensing characteristics of hierarchical VO nanoflowers operated at relatively low temperature using chemiresistive approach.

Anal Chim Acta

April 2020

Functional Nanomaterials & Devices Lab, Centre for Nanotechnology & Advanced Biomaterials, School of Electrical & Electronics Engineering, SASTRA Deemed to be University, Thanjavur, 613 401, India. Electronic address:

Methane (CH) gas, the second most potent greenhouse gas share a substantial role in contributing to the global warming and it is a necessary pre-requisite to detect the release of CH into the environment at its early stage to combat climate change. In that front, this work is focussed to develop an effective CH gas sensor using vanadium pentoxide (VO) thin films that works at an operating temperature of ∼100 °C. To understand the effect of sputtering power towards the structural characteristics of VO films, X-ray diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM) analysis were performed from which the orthorhombic polycrystalline structure of VO thin films was confirmed with varied texture co-efficient.

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Effect of advanced glycation end product on paraoxonase 2 expression: Its impact on endoplasmic reticulum stress and inflammation in HUVECs.

Life Sci

April 2020

R.S. Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO, Vision Research Foundation, Chennai 600006, India. Electronic address:

Background: Paraoxonase (PON), an antioxidant enzyme, comprises of three members (PON1, 2 and 3). Hyperglycemia accelerates formation of AGE in diabetes which mediates endothelial dysfunction. PON1 is studied in diabetes due to its association with HDL, lipid peroxidation and vascular complications but PON2 is not explored much.

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Background: Traditional medicinal preparations have not received global acceptance, and their therapeutic benefits remain disputed due to lack of scientific evidence on their mechanism of action. Microarray analysis has emerged as a powerful technique that can aid in understanding the complex signaling networks activated by these formulations and thereby assess their beneficial as well as adverse effects.

Aim: The present work aims to investigate the differential influence of , formulation used in the treatment of diabetes, anemia, urinary, respiratory, skin and liver disorders.

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Precise positioning of nucleosomes at the gene regulatory elements mediated by the SWI/SNF family of remodelling complex is important for the transcriptional regulation of genes. A wide set of genes are either positively or negatively regulated by SWI/SNF. In higher eukaryotes, around thirty genes were found to code for SWI/SNF subunits.

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The present research investigates on task-specific deep eutectic solvents (TDES) based aqueous two-phase extraction and purification of immunoglobulins by chromatography from quail egg. The synthesis of TDES was accomplished with quaternary ammonium salt as hydrogen bond acceptor (HBA) and glycerol as hydrogen bond donor (HBD). Aqueous two-phase (ATPS) formation of TDESs with various salts was established and phase partitioning ability was evaluated using standard bovine immunoglobulin.

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Antibiotics like colistin are the last resort to deal with infections by carbapenem-resistant Enterobacteriaceae (CREB). Resistance to colistin severely restricts therapeutic options. To tackle this dire situation, urgent measures to restore colistin sensitivity are needed.

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Myelin Oligodendrocyte glycoprotein (MOG) is found to play an important role in providing structural integrity to myelin sheath at the same time it acts as an auto-antigen which might lead to Multiple Sclerosis (MS). What causes this specific property of being an auto-antigen is still not known. Here we present molecular dynamics simulation studies of unfolding and folding of the protein MOG in both the absence and presence of N-glycan in order to understand the role of glycosylation in the stability and flexibility of the protein.

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Metabolic syndrome is a condition that results from dysfunction of different metabolic pathways leading to increased risk of disorders such as hyperglycemia, atherosclerosis, cardiovascular diseases, cancer, neurodegenerative disorders etc. As this condition cannot be diagnosed based on a single marker, multiple markers need to be detected and quantified to assess the risk facing an individual of metabolic syndrome. In this context, chemical- and bio-sensors capable of detecting multiple analytes may provide an appropriate diagnostic strategy.

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Pesticide application inhibit the microbial carbonic anhydrase-mediated carbon sequestration in a soil microcosm.

Environ Sci Pollut Res Int

February 2020

CSIR-National Institute Oceanography, Regional Centre, Dr. Salim Ali Road, Post Box No. 1913, Kochi, 682 018, India.

Heterotrophic system for carbon sequestration is gaining importance in the recent decades. Carbonic anhydrase (CA) is a major enzyme involved in carbon sequestration and biomineralization process. In this paper, we evaluate the effect of pesticide on CA activity using inhibitory assay.

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Lowered Decorin With Aberrant Extracellular Matrix Remodeling in Aqueous Humor and Tenon's Tissue From Primary Glaucoma Patients.

Invest Ophthalmol Vis Sci

November 2019

R.S. Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO, Vision Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: To evaluate the inflammatory cytokine, growth factors, extracellular matrix (ECM) remodeling genes, profibrotic and antifibrotic molecules in patients undergoing glaucoma filtration surgery (GFS). Additionally, the effect of preoperative antiglaucoma medications (AGMs) and postoperative bleb status were related to these parameters.

Methods: Tenon's tissue and aqueous humour (AH) were collected from 207 patients undergoing GFS with primary open-angle glaucoma (POAG) (n = 77), primary angle-closure glaucoma (PACG) (n = 62), and cataract controls (n = 68).

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Isolation and characterization of cellulose nanocrystals from jackfruit peel.

Sci Rep

November 2019

Bioprospecting Laboratory, Centre for Bioenergy, School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, 613 401, India.

In the present work, sustainable nanomaterials, cellulose, and spherical cellulose nanocrystals (SCNCs) were isolated from the non-edible parts of jackfruit (Artocarpus heterophyllus). Of the three different methods tested, sodium chlorite treatment produced the highest yield of cellulose, 20.08 ± 0.

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The Pumilio (Pum)/Puf family proteins are ubiquitously present across eukaryotes, including yeast, plants and humans. They generally bind to the 3' untranslated regions of single stranded RNA targets in a sequence specific manner and destabilize them, although a few reports suggest their role in stabilizing the target transcripts. The Pum isoforms are implicated in a wide array of biological processes including stem cell maintenance, development, ribosome biogenesis as well as human diseases.

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Profile of the Intervention Potential of the Phylum Actinobacteria Toward Quorum Sensing and Other Microbial Virulence Strategies.

Front Microbiol

October 2019

Quorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, India.

The rapid dissemination of antimicrobial resistance amongst microorganisms and their deleterious effect on public health has propelled the exploration of alternative interventions that target microbial virulence rather than viability. In several microorganisms, the expression of virulence factors is controlled by quorum sensing systems. A comprehensive understanding into microbial quorum sensing systems, virulence strategies and pathogenesis has exposed potential targets whose attenuation may alleviate infectious diseases.

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Highly Selective Dimethylamine Sensing Performance of TiO₂ Thin Films at Room Temperature.

J Nanosci Nanotechnol

May 2020

Functional Nanomaterials & Devices Lab, Centre for Nanotechnology & Advanced Biomaterials and School of Electrical & Electronics Engineering, SASTRA Deemed to be University, Thanjavur 613401, India.

To date, reports on metal oxide semiconductors for selective detection of dimethylamine (DMA) is in scarce. Hence in our study, we report titanium oxide (TiO₂) as a promising candidate for tuned selectivity towards DMA. Highly uniform TiO₂ thin films were successfully deposited on glass substrates using reactive dc magnetron sputtering at various substrate temperatures.

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NASA cleanrooms are certified by particle counts and are humidity-controlled, temperature-regulated, and oligotrophic in nature for assembling spacecraft subsystems. Microorganisms, which are not part of the cleanroom certification metrics, should not be overlooked when assessing the cleanliness of the facility since they can enter through soil or air, shed from humans, adapt to the oligotrophic conditions, and subsequently could contaminate spacecraft. These biogenic particles need to be identified to extend our knowledge of biological contamination for future NASA mission use.

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Background: Polarized macrophages induce fibrosis through multiple mechanisms, including a process termed epithelial-to-mesenchymal transition (EMT). Mesenchymal cells contribute to the excessive accumulation of fibrous connective tissues, leading to organ failure. This study was aimed to investigate the effect of tannic acid (TA), a natural dietary polyphenol on M1 macrophage-induced EMT and its underlying mechanisms.

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Background And Objectives: The computational prediction of drug responses based on the analysis of multiple clinical features of the tumor will be a novel strategy for accomplishing the long-term goal of precision medicine in oncology. The cancer patients will be benefitted if we computationally account all the tumor characteristics (data) for the selection of most effective and precise therapeutic drug. In this study, we developed and validated few computational models to predict anticancer drug efficacy based on molecular, cellular and clinical features of 31 oral squamous cell carcinoma (OSCC) cohort using computational methods.

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