Thermally stable strongly fluorescent multi-stimuli responsive carbazole zwitterionic fluorophores: Alkyl chain length dependent thermofluorochromism and latent fingerprinting.

Carbazole-picoline based π-conjugated zwitterionic fluorophores, (E)-3-(4-(4-(9H-carbazol-9-yl)styryl)pyridin-1-ium-1-yl)propane-1-sulfonate (Cz-PS) and (E)-4-(4-(4-(9H-carbazol-9-yl)styryl)pyridin-1-ium-1-yl)butane-1-sulfonate (Cz-BS) were synthesized and investigated the stimuli-responsive solid-state fluorescence properties. Cz-PS and Cz-BS displayed enhanced fluorescence in the solid-state (555 and 542 nm) with the quantum yield (Φ) of 32.9 and 28.

Analytical insights into the detoxification process and characterization of a traditional metallopharmaceutical formulation.

Metallopharmaceuticals possess unique medicinal properties and have been used since ancient times. In spite of the inclusion of several metals and minerals, there is an increased interest in metallo-drugs for clinical and research purposes because of their immense therapeutic efficiency and non-toxic claim, as they are processed in addition to specific poly herbals. is one of the traditional metallopharmaceuticals used in Siddha medicine to treat various respiratory diseases and other ailments, including antidote therapy for poisonous bites.

Carbazole fluorophore with an imidazole/thiazole unit: contrasting stimuli-induced fluorescence switching, water-sensing and deep-blue emission.

Carbazole-based, π-conjugated donor-acceptor fluorophores were synthesized by integrating imidazole/thiazole units. Then, we investigated the impact of subtle structural changes on fluorescence properties. Carbazole integrated with imidazole (Cz-I) and carbazole integrated with thiazole (Cz-T) showed strong fluorescence in solution (quantum yield ( ) = 0.

Highly enhanced electrocatalytic OER activity of water-coordinated copper complexes: effect of lattice water and bridging ligand.

The use of metal-organic compounds as electrocatalysts for water splitting reactions has gained increased attention; however, a fundamental understanding of the structural requirement for effective catalytic activity is still limited. Herein, we synthesized water-coordinated mono and bimetallic copper complexes (CuPz-HO·HO, CuPz-HO, CuBipy-HO·HO, and CuMorph-HO) with varied intermetallic spacing (pyrazine/4,4'-bipyridine) and explored the structure-dependent oxygen evolution reaction (OER) activity in alkaline medium. Single crystal structural studies revealed water-coordinated monometallic complexes (CuMorph-HO) and bimetallic complexes (CuPz-HO·HO, CuPz-HO, CuBipy-HO·HO).

Hybrid hydrogels derived from renewable resources as a smart stimuli responsive soft material for drug delivery applications.

The design and synthesis of amphiphilic molecules play a crucial role in fabricating smart functional materials self-assembly. Especially, biologically significant natural molecules and their structural analogues have inspired chemists and made a major contribution to the development of advanced smart materials. In this report, a series of amphiphilic -acyl amides were synthesized from natural precursors using a simple synthetic protocol.

Metal-free, regioselective, visible light activation of 4CzIPN for the arylation of 2-indazole derivatives.

Highly regioselective organo photocatalysis of 4CzIPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene) for the arylation of 2-indazole is demonstrated. The present synthetic route provides a highly safe and easily accessible aniline precursor as an arylation reagent. The photoactivated 4CzIPN organocatalyst is found to be more efficient for single electron transfer without any organic base for the radical reaction.

Evaluation of the Anticancer Activity of pH-Sensitive Polyketal Nanoparticles for Acute Myeloid Leukemia.

Polyketals are a class of acid-responsive polymers that have been relatively less explored for drug delivery applications compared to polyesters. The degradation of these polymers is accelerated in an acidic medium and does not result in acidic byproducts. Their biocompatibility depends on the diol used for the synthesis.

Quantitative analysis of hydrogen and chalcogen bonds in two pyrimidine-5-carbonitrile derivatives, potential DHFR inhibitors: an integrated crystallographic and theoretical study.

Two potential bioactive pyrimidine-5-carbonitrile derivatives have been synthesized and characterized by spectroscopic techniques (H and C-NMR) and the three dimensional structures were elucidated by single crystal X-ray diffraction at low temperature (160 K). In both structures, the molecular conformation is locked by an intramolecular C-H⋯C interaction involving the cyano and CH of the thiophene and phenyl rings. The intermolecular interactions were analyzed in a qualitative manner based on the Hirshfeld surface and 2D-fingerprint plots.

Substrate controlled, regioselective carbopalladation for the one-pot synthesis of C4-substituted tetrahydroisoquinoline analogues.

6- cyclization reaction through regioselective carbopalladation was demonstrated with -(2-halobenzyl)--allylamines to furnish the corresponding C4-substituted tetrahydroisoquinoline derivatives. The scope of the reaction was extended to the synthesis of C4-quaternary tetrahydroisoquinoline derivatives also. The nature of the substituent on the olefin moiety dictates the course of the carbopalladation sequence.

Quantitative assessment of the nature of noncovalent interactions in -substituted-5-(adamantan-1-yl)-1,3,4-thiadiazole-2-amines: insights from crystallographic and QTAIM analysis.

Three adamantane-1,3,4-thiadiazole hybrid derivatives namely; -ethyl-5-(adamantan-1-yl)-1,3,4-thiadiazole-2-amine I, -(4-fluorophenyl)-5-(adamantan-1-yl)-1,3,4-thiadiazole-2-amine II and (4-bromophenyl)-5-(adamantan-1-yl)--1,3,4-thiadiazole-2-amine III, have been synthesized and crystal structures have been determined at low temperature. The structures revealed that the orientation of the amino group is different in non-halogenated structures. Intra- and intermolecular interactions were characterized on the basis of the quantum theory of atoms-in-molecules (QTAIM) approach.

Oxidant-free, three-component synthesis of 7-amino-6-benzo[]chromen-6-ones under green conditions.

An oxidant-free three-component synthesis of biologically significant 7-amino-6-benzo[]chromen-6-ones was established involving a Sc(OTf) catalyzed three-component reaction between primary amines, β-ketoesters and 2-hydroxychalcones under green conditions. In this strategy, both the B and C rings of 6-benzo[]chromen-6-ones were constructed simultaneously starting from acyclic precursors by generating four new bonds including two C-C, one C-N and one C-O in a single synthetic operation. The mechanism of this sequential cascade process involves the initial formation of a β-enaminone intermediate followed by Michael addition with 2-hydroxychalcone, intramolecular cyclization, dehydration, lactonization and aromatization steps.

Water soluble cadmium selenide quantum dots for ultrasensitive detection of organic, inorganic and elemental mercury in biological fluids and live cells.

Mercury exists in organic, inorganic, and elemental forms; all of them are highly toxic. A sensor which could detect all forms of mercury below the permissible level in environmental and biological samples would be advantageous. A facile method to synthesize -acetyl cysteine capped cadmium selenide quantum dots (CdSe QDs) with an emission at 554 nm was reported.

Enzymatic synthesis and self-assembly of glycolipids: robust self-healing and wound closure performance of assembled soft materials.

In developing countries, wounds are a major health concern and pose a significant problem. Hence, the development of new materials that can act as scaffolds for tissue regeneration and regrowth is necessary. In this report, we present a new class of injectable oleogel and composite gel derived from glycolipids that provide reversible interlinked 3D fiberous network architecture for effective wound closure by tissue regrowth and regeneration.

Synthesis, supramolecular organization and thermotropic phase behaviour of -acyltris(hydroxymethyl)aminomethane.

Herein, we reported the supramolecular organization of -acyltris(hydroxymethyl)aminomethane (NATM) in the solid state as well as in aqueous solution. Single crystal X-ray diffraction revealed that NATM adopts a fully interdigitized structure. The thermodynamic parameters associated with thermotropic phase behaviour of NATM was determined by differential scanning calorimetry.