Assessing gene significance from cDNA microarray expression data via mixed models.

The determination of a list of differentially expressed genes is a basic objective in many cDNA microarray experiments. We present a statistical approach that allows direct control over the percentage of false positives in such a list and, under certain reasonable assumptions, improves on existing methods with respect to the percentage of false negatives. The method accommodates a wide variety of experimental designs and can simultaneously assess significant differences between multiple types of biological samples.

A computationally efficient method for obtaining standard error estimates for the promax and related solutions.

A computationally efficient algorithm for computing the asymptotic standard errors for the promax factor solution is proposed. The algorithm covers promax rotation with or without row normalization of the pre-rotated factor matrix. It also covers situations with either even- or odd-powered promax targets.

Multivariate non-parametric methods for Mann-Whitney statistics to analyse cross-over studies with two treatment sequences.

A non-parametric strategy for the analysis of ordinal data from cross-over studies with two treatment sequences and d(> or = 2) periods is examined through Mann-Whitney rank measures of association. For each period, these statistics estimate the probability of larger response for a randomly selected patient in one group relative to a randomly selected patient in the other group. Such estimates are as well formed for comparisons between groups for u pairs of periods with the same treatment.

An example of using mixed models and PROC MIXED for longitudinal data.

Longitudinal data, or data that are repeated measurements on various subjects across time, are commonplace in biostatistical studies. The general linear mixed model is a useful statistical tool for analyzing such data and drawing meaningful inferences about them. This paper discusses some of the most common mixed models and fits them to a prototypical example involving repeated measures on blood pressure.

The workplace: an innovative and cost-effective practice site.

A significant portion of our nation's health care is financed by employer-sponsored health care benefit plans. Employers now realize the importance of devising cost-saving measures beyond restrictions on coverage for services. In 1984 a corporation in the Southeast United States established a nurse practitioner-managed health care center on-site for employees and certain dependents.